Effectiveness of a culturally attuned Internet-based depression prevention program for Chinese adolescents: A randomized controlled trial: I p et al.
Open accessAbstract
BACKGROUND: Depression prevention among adolescents is crucial for reducing the global disease burden. Internet-based depression prevention approaches are found to be effective but they were mostly evaluated in a Western context. Grasping the Opportunity is a Chinese Internet intervention, which was translated and modified from CATCH-IT developed in the West. We aimed to evaluate the effectiveness of Grasp the Opportunity in reducing depressive symptoms in Chinese adolescents. METHODS: In this randomized controlled trial, Chinese adolescents aged 13 to 17 years with mild-to-moderate depressive symptoms were recruited from three secondary schools in Hong Kong. The participants (n = 257) were randomly assigned to receive either intervention or attention control. The primary outcome was the improvement in depressive symptoms according to the revised Center for Epidemiologic Studies Depression Scale (CESD-R) at the 12-month follow-up. Analyses were performed using intention to treat (ITT). RESULTS: The participants were randomly assigned to receive the intervention (n = 130) or attention control (n = 127). Follow-up data were obtained from 250 (97%) participants. Only 26 (10%) participants completed the intervention. Compared to the attention control, Grasp the Opportunity led to reductions in depressive symptoms at the 12-month follow-up with a medium effect size using ITT analysis (mean difference 2.6, 95% CI 0.59-5.55, effect size d = 0.36). CONCLUSIONS: Grasp the Opportunity is effective in reducing depressive symptoms in Chinese adolescents over a long follow-up period. Poor completion rate is the major challenge in the study.
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In many studies, even among those with low study attrition, engagement tended to be low, with participants completing less than half of the intervention components.
“However, this was not always the case and in many studies, even among those with low study attrition, engagement tended to be low, with participants completing less than half of the intervention components (36, 45, 49, 51, 53, 73).”
From What Works and What Doesn’t Work? A Systematic Review of Digital Mental Health Interventions for Depression and Anxiety in Young People (2019) · cites this paper as [49]
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Kuberka, P., Chilton, M., Pike, K. C., Shafran, R., & Yardley, L. (2025) · doi:10.2196/preprints.84384
Malik, K., Ibrahim, M., Bernstein, A., Venkatesh, R. K., Rai, T., Chorpita, B. F., & Patel, V. (2021) · Figshare · doi:10.6084/m9.figshare.16755769
Malik, K., Ibrahim, M., Bernstein, A., Venkatesh, R. K., Rai, T., Chorpita, B. F., & Patel, V. (2021) · Figshare · doi:10.6084/m9.figshare.16755766
Malik, K., Ibrahim, M., Bernstein, A., Venkatesh, R. K., Rai, T., Chorpita, B. F., & Patel, V. (2021) · Figshare · doi:10.6084/m9.figshare.16755772
Malik, K., Ibrahim, M., Bernstein, A., Venkatesh, R. K., Rai, T., Chorpita, B. F., & Patel, V. (2021) · Figshare · doi:10.6084/m9.figshare.16755778
Coronado‐Montoya, S., Varadi, A.-L., Dozet, D., Chiodo, D., & Henderson, J. L. (2026) · doi:10.2196/preprints.99389
Hudson, F., Read-Williams, C., Williamson, G., Lobo, S., Hardman, A., Patel, H., & Pile, V. (2026) · BMJ Open · doi:10.1136/bmjopen-2025-111993
Kuberka, P., Chilton, M., Pike, K. C., Shafran, R., & Yardley, L. (2026) · JMIR Pediatrics and Parenting · doi:10.2196/84384
Dabrowski, A., Mackley, G., Fernando, C., Rahim, H. A., & Siena, J. A. (2026) · Frontiers in Education · doi:10.3389/feduc.2026.1812649
School-based digital mental health interventions: A scoping review
Santosh-Thomas, S., Aggarwal, A., Chandler, T., Dremann, S., Phillips, S., Lopez, E., Weist, M. D., & Daly, B. P. (2026) · Journal of Child and Adolescent Mental Health · doi:10.2989/17280583.2026.2721998
Coronado‐Montoya, S., Varadi, A.-L., Dozet, D., Chiodo, D., & Henderson, J. L. (2026) · Journal of Medical Internet Research · doi:10.2196/99389
- Authors
- Ip, P., Chim, D., Chan, K. L., Li, T. M. H., Ho, F. K. W., Van Voorhees, B. W., Tiwari, A., Tsang, A., Chan, C. W. L., Ho, M., Tso, W., & Wong, W. H. S.
- Affiliations
- University of Hong Kong (HK)
- Department of Pediatrics; University of Illinois at Chicago; Chicago IL USA
- Caritas Youth and Community Service; Aberdeen Hong Kong
- Corresponding author
- Ip, Patrick
- ORCID
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2016-09-13
- Volume
- 33
- Issue
- 12
- Pages
- 1123-1131
- ISSN
- 1091-4269 (ISSN-L)
- OpenAlex
- W2518938271
- Cited by
- 82
- References
- 22
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 12 · 2023: 9 · 2022: 9 · 2021: 14 · 2020: 7 · 2019: 9 · 2018: 3 · 2017: 3
- FWCI
- 7.67
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion, cc-by-nc-nd)
- Funders
- Lotteries Fund
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- adolescent depression, depression prevention, online intervention, culturally tailored interventions, Chinese adolescents, depressive symptoms, intervention completion, Hong Kong
- MeSH terms
- Adolescent, Adolescent Behavior, Depressive Disorder, Female, Hong Kong, Humans, Male, Program Evaluation, Internet, Culturally Competent Care
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