Randomized Clinical Trial of an Internet-Based Adolescent Depression Prevention Intervention in Primary Care: Internalizing Symptom Outcomes
Open accessAbstract
Approximately 20% of people will experience a depressive episode by adulthood, making adolescence an important developmental target for prevention. CATCH-IT (Competent Adulthood Transition with Cognitive-behavioral, Humanistic, and Interpersonal Training), an online depression prevention intervention, has demonstrated efficacy in preventing depressive episodes among adolescents reporting elevated symptoms. Our study examines the effects of CATCH-IT compared to online health education (HE) on internalizing symptoms in adolescents at risk for depression. Participants, ages 13–18, were recruited across eight US health systems and were randomly assigned to CATCH-IT or HE. Assessments were completed at baseline, 2, 6, 12, 18, and 24 months. There were no significant differences between groups in change in depressive symptoms (b = −0.31 for CATCH-IT, b = −0.27 for HE, p = 0.80) or anxiety (b = −0.13 for CATCH-IT, b = −0.11 for HE, p = 0.79). Improvement in depressive symptoms was statistically significant (p < 0.05) for both groups (p = 0.004 for CATCH-IT, p = 0.009 for HE); improvement in anxiety was significant for CATCH-IT (p = 0.04) but not HE (p = 0.07). Parental depression and positive relationships with primary care physicians (PRPC) moderated the anxiety findings, and adolescents’ externalizing symptoms and PRPC moderated the depression findings. This study demonstrates the long-term positive effects of both online programs on depressive symptoms and suggests that CATCH-IT demonstrates cross-over effects for anxiety as well.
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In the CATCH-IT trial, long-term reductions of depressive symptoms were found in both the CATCH-IT and health education groups.
“Although long-term reductions of depressive symptoms were found in both groups”
From Using Information and Communication Technologies (ICT) for Mental Health Prevention and Treatment (2021) · cites this paper as [3]
In the CATCH-IT trial, participants in the CATCH-IT group showed a cross-over effect for anxiety symptoms.
“participants in the CATCH-IT group also showed a cross-over effect for anxiety symptoms”
From Using Information and Communication Technologies (ICT) for Mental Health Prevention and Treatment (2021) · cites this paper as [3]
In the CATCH-IT trial, the presence of some pre-conditions (e.g., supportive environmental factors such as a supportive relationship with a physician and adequate paternal monitoring) may favor the benefits of the CATCH-IT intervention among adolescents.
“the study showed that the presence of some pre-conditions (e.g., supportive environmental factors such as a supportive relationship with a physician and adequate paternal monitoring) may favor the benefits of the CATCH-IT intervention among adolescents”
From Using Information and Communication Technologies (ICT) for Mental Health Prevention and Treatment (2021) · cites this paper as [3]
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Self-citationGladstone, T. R. G., Rintell, L. S., Buchholz, K. R., & Myers, T. L. (2021) · Social Sciences · doi:10.3390/socsci10100398 · Cited by 9 · see citing works
Self-citationEvolution of discussion topics on an online depression self-help group
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A review about Technology in mental health sensing and assessment
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Delivering computerized Cognitive Behavioral Therapy for child and adolescent depression and anxiety
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Psicanálise Funciona? Avaliando a Prova Cabal de Christian DunkerPreprint
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Exploring the Dilemmas Faced by Depressed Patients in China Based on Deep Learning Methods
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Self-citation
- Authors
- Gladstone, T., Buchholz, K. R., Fitzgibbon, M., Schiffer, L., Lee, M., & Voorhees, B. W. V.
- Affiliations
- Wellesley College (US)
- University of Illinois Chicago (US)
- Corresponding author
- Gladstone, Tracy
- ORCID
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2020-10-22
- Volume
- 17
- Issue
- 21
- Pages
- 7736
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC7660174
- OpenAlex
- W3094560775
- Cited by
- 32
- References
- 76
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 4 · 2022: 7 · 2021: 9
- FWCI
- 4.52
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institute of Mental Health (R01MH090035)
- Topics
- Social Sciences › Psychology › Applied Psychology › Digital Mental Health Interventions
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- adolescent depression prevention, online intervention, online health education, internalizing problems, depressive symptoms, anxiety, primary care, parental depression, physician-patient relationship, externalizing problems, crossover effects, cognitive-behavioral training
- MeSH terms
- Internet-Based Intervention, Psychosocial Intervention, Adolescent, Anxiety, Anxiety Disorders, Depression, Humans, Primary Health Care
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