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Cited by 35Anxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesTreatment of Major DepressionChild and Adolescent Psychosocial and Emotional Development

A randomized controlled pilot trial of vilazodone for adult separation anxiety disorder

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Schneier, Franklin R., Moskow, Danielle M., Choo, Tse-Hwei, Galfalvy, Hanga, Campeas, Raphael, Sanchez-Lacay, Arturo·2017·Depression and Anxiety
DOI 10.1002/da.22693
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Abstract

Background Separation anxiety disorder was recently recognized by fifth edition of the Diagnostic and Statistical Manual of Mental Disorders as a diagnosis in adults, but no publications to date have characterized a sample of patients seeking treatment for adult separation anxiety disorder (ASAD) or assessed treatment efficacy. We hypothesized that vilazodone, a selective serotonin reuptake inhibitor (SSRI) and serotonin 1a (5HT1a) receptor partial agonist, would have efficacy in ASAD, because SSRIs have appeared efficacious in children with mixed diagnoses including separation anxiety disorder and in animal models of separation anxiety. Methods In this pilot study, 24 adults (ages 18–60) with a principal diagnosis of ASAD were randomized to 12 weeks of double-blind treatment with vilazodone (n = 13) or placebo (n = 11). Outcome was assessed by an independent evaluator and self-ratings, and analyzed with mixed effect models. Results This sample was predominantly female (67%), with comorbid psychiatric disorders (58%), and adult onset of separation anxiety disorder (62%). Response rates at week 12 did not differ significantly between groups. Across all time points, the vilazodone group evidenced greater improvement on the Structured Clinical Interview for Separation Anxiety Symptoms (P = .026) and the Quality of Life Enjoyment and Satisfaction Questionnaire (P = .011), and trends toward greater improvement on the Adult Separation Anxiety Questionnaire (P = .054) and the Clinical Global Impression–Change Scale (P = .086), all with large between-group effect sizes. Conclusions Findings demonstrate feasibility of a clinical trial in ASAD, and they suggest that vilazodone may have efficacy in the treatment of ASAD and warrants further study.

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  • Vilazodone treatment demonstrated greater improvement in anxiety measures than placebo in a randomised controlled study for adult separation anxiety and in generalised SAD.

    “vilazodone treatment demonstrated greater improvement in anxiety measures than placebo treatment in a randomised controlled study for adult separation anxiety (Schneier et al., 2017) and in generalised SAD (Careri, Draine, Hanover, & Liebowitz, 2015).”

    From Novel pharmacological targets in drug development for the treatment of anxiety and anxiety-related disorders (2019) · cites this paper as Schneier et al., 2017

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  1. CD006115 · DOI · Paper page
  2. Feeney, J. A., Noller, P., & Hanrahan, M. (1994). Assessing adult attachment: Developments in the conceptualization of security and insecurity. In M. B. Sperling & W. H. Berman (Eds.), Attachment in adults: Theory, assess- ment and treatment (pp. 128-152). New York: Guilford.
  3. First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2002). Structured clinical interview for DSM-IV-TR axis I disorders, Research Version, Patient Edition. (SCID-I/P). New York: Biometrics Research, New York State Psy- chiatric Institute.
  4. Silove, D. M., Marnane, C. L., Wagner, R., & Manicavasagar, V. L. (2010). Asso- ciations of personality disorder with early separation anxiety in patients with adult separation anxiety disorder. Journal of Personality Disorders, 25, 128-133.

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Authors
Schneier, F. R., Moskow, D. M., Choo, T.-H., Galfalvy, H., Campeas, R., & Sanchez-Lacay, A.
Affiliations
  • Columbia University Irving Medical Center (US)
  • New York State Psychiatric Institute (US)
  • Division of Clinical Therapeutics, New York State Psychiatric Institute; New York NY USA
Corresponding author
Schneier, Franklin R.
ORCID
Venue
Depression and Anxiety
Publisher
Wiley
Published
2017-10-25
Volume
34
Issue
12
Pages
1085-1095
ISSN
1091-4269 (ISSN-L)
DOI
10.1002/da.22693
OpenAlex
W2766112121
Cited by
35
References
48
Citations by year
2025: 3 · 2024: 3 · 2023: 3 · 2022: 4 · 2021: 4 · 2020: 8 · 2019: 4 · 2018: 5 · 2017: 1
FWCI
6.41
Type
journal article
Language
en
Open access
Licence
Locations
  • Depression and Anxiety (publishedVersion)
  • PubMed (publishedVersion)
Funders
Forest Research Institute, Inc. (Investigator Initiated Grant)
Topics
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords
adult separation anxiety disorder, vilazodone, selective serotonin reuptake inhibitors, 5-HT1A receptor partial agonist, pharmacotherapy, treatment efficacy, quality of life, psychiatric comorbidity, trial feasibility
MeSH terms
Vilazodone Hydrochloride, Adolescent, Adult, Anxiety, Separation, Double-Blind Method, Female, Humans, Male, Middle Aged, Pilot Projects, Outcome Assessment, Health Care, Selective Serotonin Reuptake Inhibitors, Young Adult, Serotonin 5-HT1 Receptor Agonists

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