Healthcare use and costs in adult cancer patients with anxiety and depression
Open accessAbstract
OBJECTIVE: Anxiety and depression are common in individuals with cancer and may impact healthcare service use and costs in this population. This study examined the effects of anxiety alone, depression alone, and comorbid anxiety and depressive disorder on healthcare use and costs among patients with cancer. METHOD: This was a retrospective cohort analysis of administrative data of patients aged 18 or older with an International Classification of Diseases, Ninth Revision diagnosis of cancer. Key outcomes were any visit to emergency department (ED), any inpatient hospitalization, length of hospital stays, and annual healthcare costs 1 year from cancer diagnosis. RESULTS: A total of 13,426 patients were included. Relative to patients with neither anxiety nor depression, those with anxiety alone, depression alone, or comorbid anxiety and depression were more likely to experience an ED visit and be hospitalized. Length of hospital stays were also longer and annual healthcare costs were significantly higher in all three clinical groups. CONCLUSIONS: Cancer patients with anxiety and depression were at greater risk for ED visits and hospitalizations, experienced longer hospital stays, and accrued higher healthcare costs. Future researchers should determine whether screening and treating comorbid anxiety and depression may decrease healthcare utilization and improve turnover wellbeing among cancer patients.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Elevated anxiety predicts higher use and costs of medical care.
“Elevated anxiety predicts nonadherence to recommended therapies, [23][24][25] higher use and costs of medical care, [26][27][28] and possibly cancer recurrence.29”
From Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update (2023) · cites this paper as [27]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Charlson, M. E., Pompei, P., Ales, K. L., & MacKenzie, C. R. (1987) · Journal of Chronic Diseases · doi:10.1016/0021-9681(87)90171-8 · Cited by 49,742 · see citing works
Adapting a clinical comorbidity index for use with ICD-9-CM administrative databases
DEYO, R. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90133-8 · Cited by 10,452 · see citing works
Validation of a combined comorbidity index
Charlson, M., Szatrowski, T. P., Peterson, J., & Gold, J. (1994) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(94)90129-5 · Cited by 6,587 · see citing works
Mitchell, A. J., Chan, M., Bhatti, H., Halton, M., Grassi, L., Johansen, C., & Meader, N. (2011) · The Lancet Oncology · doi:10.1016/s1470-2045(11)70002-x · Cited by 2,449 · see citing works
The de Facto US Mental and Addictive Disorders Service System
Regier, D. A. (1993) · Archives of General Psychiatry · doi:10.1001/archpsyc.1993.01820140007001 · Cited by 1,988 · see citing works
The Economic Burden of Adults With Major Depressive Disorder in the United States (2005 and 2010)
Greenberg, P. E., Fournier, A.-A., Sisitsky, T., Pike, C. T., & Kessler, R. C. (2015) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.14m09298 · Cited by 1,779 · see citing works
Hasin, D. S., Goodwin, R. D., Stinson, F. S., & Grant, B. F. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.10.1097 · Cited by 1,645 · see citing works
Anxiety and depression after cancer diagnosis: Prevalence rates by cancer type, gender, and age
Linden, W., Vodermaier, A., MacKenzie, R., & Greig, D. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.03.025 · Cited by 1,245 · see citing works
Rotter, T., Kinsman, L., James, E. L., Machotta, A., Gothe, H., Willis, J., Snow, P. C., & Kügler, J. (2010) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006632.pub2 · Cited by 824 · see citing works
Mitchell, A. J., Ferguson, D. W., Gill, J., Paul, J., & Symonds, P. (2013) · The Lancet Oncology · doi:10.1016/s1470-2045(13)70244-4 · Cited by 749 · see citing works
Bueno, H. (2010) · JAMA · doi:10.1001/jama.2010.748 · Cited by 712 · see citing works
Unützer, J. (1997) · JAMA · doi:10.1001/jama.1997.03540440052032 · Cited by 697 · cited 1× · see citing works
“In older Health Maintenance Organization (HMO) patients, depressed patients have 38% more outpatient healthcare visits and 61% higher healthcare charges relative to nondepressed patients (Unutzer et al., 1997).”
BackgroundHealth and disability costs of depressive illness in a major U.S. corporation
Druss, B. G., Rosenheck, R. A., & Sledge, W. H. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.8.1274 · Cited by 395 · see citing works
Bijl, R. V., & Ravelli, A. (2000) · American Journal of Public Health · doi:10.2105/ajph.90.4.602 · Cited by 360 · cited 1× · see citing works
“For example, individuals with anxiety disorders are significantly more likely to visit primary care compared to those without anxiety (Bijl & Ravelli, 2000).”
BackgroundBaek, H., Cho, M., Kim, S., Hwang, H. Y., Song, M., & Yoo, S. (2018) · PLoS ONE · doi:10.1371/journal.pone.0195901 · Cited by 346 · cited 1× · see citing works
“As discussed elsewhere (Baek et al., 2018; Bueno et al., 2010; Rotter et al., 2010), longer hospital stays can increase risks of opportunistic infections and side effects of medication, as well as have deleterious effects on treatment outcomes and mortality rates.”
BackgroundPrieto, J. M., Blanch, J., Atala, J., Carreras, E., Rovira, M., Cirera, E., & Gastó, C. (2002) · Journal of Clinical Oncology · doi:10.1200/jco.2002.07.101 · Cited by 330 · cited 1× · see citing works
“In hematologic cancer patients, diagnosis of any mood, anxiety, or adjustment disorder is associated with longer length of hospital stay (Prieto et al., 2002).”
BackgroundPrevalence of depression in adults with cancer: a systematic review
Walker, J., Hansen, C. H., Martin, P. F. M. S., Sawhney, A., Thekkumpurath, P., Beale, C., Symeonides, S. N., Wall, L. R., Murray, G. D., & Sharpe, M. (2012) · Annals of Oncology · doi:10.1093/annonc/mds575 · Cited by 311 · cited 1× · see citing works
“These values appear consistent with other studies reporting a depression prevalence of 16% in outpatients with cancer (Walker et al., 2013), with a slightly higher prevalence of anxiety in our sample than found in other studies (Mitchell et al., 2011).”
ResultThe impact of psychological interventions on medical cost offset: A meta-analytic review.
Chiles, J. A., Lambert, M. J., & Hatch, A. L. (1999) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.6.2.204 · Cited by 301 · see citing works
Cost of depression among adults in England in 2000
Thomas, C. M., & Morris, S. (2003) · The British Journal of Psychiatry · doi:10.1192/bjp.183.6.514 · Cited by 282 · see citing works
Carlson, L. E., & Bultz, B. D. (2004) · Psycho-Oncology · doi:10.1002/pon.832 · Cited by 276 · cited 1× · see citing works
“…suggests that psychosocial interventions can significantly offset medical costs for people with general mental distress and with comorbid medical illness (Carlson & Bultz, 2004), with 90% of studies showing cost reduction following psychosocial intervention (Chiles, Lambert, & Hatch, 1999, 2002).”
BackgroundChronic Medical Illness, Depression, and Use of Acute Medical Services Among Medicare Beneficiaries
Himelhoch, S. S., Weller, W. E., Wu, A. W., Anderson, G. F., & Cooper, L. A. (2004) · Medical Care · doi:10.1097/01.mlr.0000127998.89246.ef · Cited by 266 · see citing works
Depression and Service Utilization in Elderly Primary Care Patients
Luber, M. P., Meyers, B. S., Williams-Russo, P. G., Hollenberg, J. P., DiDomenico, T. N., Charlson, M. E., & Alexopoulos, G. S. (2001) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200105000-00009 · Cited by 248 · cited 3× · see citing works
“Older depressed primary care patients have significantly more annual outpatient healthcare visits, laboratory tests, radiologic procedures and scans, and have a higher number of consultations with medical, surgical, and other specialists than nondepressed patients (Luber et al., 2001).”
BackgroundResultInfluentialDoes fear of cancer recurrence predict cancer survivors' health care use?
Lebel, S., Tomei, C., Feldstain, A., Beattie, S., & McCallum, M. K. (2012) · Supportive Care in Cancer · doi:10.1007/s00520-012-1685-3 · Cited by 210 · see citing works
The cost of treating anxiety: the medical and demographic correlates that impact total medical costs
Marciniak, M. D., Lage, M. J., Dunayevich, E., Russell, J. M., Bowman, L., Landbloom, R. P., & Levine, L. R. (2005) · Depression and Anxiety · doi:10.1002/da.20074 · Cited by 204 · cited 1× · see citing works
“While the direct costs of treating depression and anxiety are substantial (Marciniak et al., 2005; Thomas & Morris, 2003), they may also be associated with indirect costs via increased healthcare utilization.”
BackgroundScherrer, J. F., Chrusciel, T., Zeringue, A., Garfield, L. D., Hauptman, P. J., Lustman, P. J., Freedland, K. E., Carney, R. M., Bucholz, K. K., Owen, R. R., et al. (2010) · American Heart Journal · doi:10.1016/j.ahj.2010.02.033 · Cited by 139 · cited 1× · see citing works
“On the basis of previous studies (Gupta & Knapp, 2014; Scherrer et al., 2010), those with an ICD‐9 diagnostic code of any anxiety disorder (300.00, 300.01, 300.02, 300.2, 300.23, 309.81, 309.24) in the year 2014 were coded as having anxiety.”
MethodInfluentialLuber, M. P., Hollenberg, J. P., Williams-Russo, P. G., DiDomenico, T. N., Meyers, B. S., Alexopoulos, G. S., & Charlson, M. E. (2000) · The International Journal of Psychiatry in Medicine · doi:10.2190/ytry-e86m-g1vc-lc79 · Cited by 121 · cited 2× · see citing works
“Depressed primary care patients have significantly more annual healthcare visits and higher rates of specialist referrals and radiologic tests than nondepressed patients (Luber et al., 2000).”
BackgroundResultInfluentialUndiagnosed depression: A community diagnosis
Williams, S. Z., Chung, G. S., & Muennig, P. A. (2017) · SSM - Population Health · doi:10.1016/j.ssmph.2017.07.012 · Cited by 109 · see citing works
Depression and Healthcare Service Utilization in Patients with Cancer
Mausbach, B. T., & Irwin, S. A. (2016) · Psycho-Oncology · doi:10.1002/pon.4133 · Cited by 104 · see citing works
Self-citationSarkar, S., Sautier, L., Schilling, G., Bokemeyer, C., Koch, U., & Mehnert, A. (2015) · Journal of Cancer Survivorship · doi:10.1007/s11764-015-0434-2 · Cited by 101 · cited 1× · see citing works
“However, others have found no association between levels of anxiety and self‐reported healthcare utilization (Sarkar et al., 2015).”
BackgroundChiu, M., Lebenbaum, M., Cheng, J. M., de Oliveira, C., & Kurdyak, P. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0184268 · Cited by 86 · see citing works
The impact of psychological interventions on medical cost offset: a meta-analytic review
Chiles, J. A. (1999) · Clinical Psychology Science and Practice · doi:10.1093/clipsy/6.2.204 · Cited by 76 · see citing works
Gupta, M. A., & Knapp, K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0090021 · Cited by 64 · cited 1× · see citing works
“On the basis of previous studies (Gupta & Knapp, 2014; Scherrer et al., 2010), those with an ICD‐9 diagnostic code of any anxiety disorder (300.00, 300.01, 300.02, 300.2, 300.23, 309.81, 309.24) in the year 2014 were coded as having anxiety.”
MethodInfluentialDepression and Service Utilization in Elderly Primary Care Patients
Luber, M. P. (2001) · American Journal of Geriatric Psychiatry · doi:10.1176/appi.ajgp.9.2.169 · Cited by 60 · see citing works
Health care costs of depression in patients diagnosed with cancer
Mausbach, B. T., Yeung, P., Bos, T., & Irwin, S. A. (2018) · Psycho-Oncology · doi:10.1002/pon.4716 · Cited by 57 · cited 1× · see citing works
“As discussed elsewhere (Mausbach et al., 2018), the use of EMR allows for various components of care and cost to be readily identified and retrievable via health informatics services.”
BackgroundSelf-citationA review on cost-effectiveness and cost-utility of psychosocial care in cancer patients
Jansen, F., van Zwieten, V., Coupé, V. M. H., Leemans, C. R., & Leeuw, I. M. V. (2016) · Asia-Pacific Journal of Oncology Nursing · doi:10.4103/2347-5625.182930 · Cited by 39 · cited 2× · see citing works
“The majority of mental health interventions are both more effective and more costly than usual care (Jansen, van Zwieten, Coupe, Leemans, & Verdonck‐de Leeuw, 2016), and those with cancer and major depression see significant dose dependent reductions in annual healthcare costs as they receive mental health care (Mausb…”
BackgroundMausbach, B. T., Bos, T., & Irwin, S. A. (2018) · Health Psychology · doi:10.1037/hea0000670 · Cited by 27 · cited 1× · see citing works
“As discussed elsewhere (Mausbach et al., 2018), the use of EMR allows for various components of care and cost to be readily identified and retrievable via health informatics services.”
BackgroundSelf-citationYamabe, K., Liebert, R., Flores, N., & Pashos, C. L. (2019) · ClinicoEconomics and Outcomes Research · doi:10.2147/ceor.s179901 · Cited by 21 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Management of Anxiety and Depression in Adult Survivors of Cancer: ASCO Guideline Update
Andersen, B. L., Lacchetti, C., Ashing, K., Berek, J. S., Berman, B. S., Bolte, S., Dizon, D. S., Given, B., Nekhlyudov, L., Pirl, W., et al. (2023) · Journal of Clinical Oncology · doi:10.1200/jco.23.00293 · Cited by 318 · see citing works
Global unmet psychosocial needs in cancer care: health policy
Bergerot, C. D., Jacobsen, P. B., Rosa, W. E., Lam, W., Dunn, J. C., Gonzalez, L. F., Mehnert, A., Veeraiah, S., & Li, M. (2024) · EClinicalMedicine · doi:10.1016/j.eclinm.2024.102942 · Cited by 102 · see citing works
Sánchez-Torralvo, F., Contreras-Bolívar, V., Ruiz-Vico, M., Abuín-Fernández, J., González-Almendros, I., Barrios, M., & Olveira, G. (2021) · Supportive Care in Cancer · doi:10.1007/s00520-021-06532-y · Cited by 48 · see citing works
van Beek, F. E., Wijnhoven, L. M. A., Holtmaat, K., Custers, J. A. E., Prins, J. B., Leeuw, I. M. V., & Jansen, F. (2021) · Psycho-Oncology · doi:10.1002/pon.5753 · Cited by 64 · see citing works
“The same holds for anxiety disorder and increased inpatient healthcare use.(43,53) Anxiety disorder(43,53) and depression 53,54,57 disorder were both found to be positively associated with increased outpatient care use (i.”
BackgroundValuing the “Burden” and Impact of Rare Diseases: A Scoping Review
Delaye, J., Cacciatore, P., & Kole, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.914338 · Cited by 60 · see citing works
“Although their study focuses on cancer, the findings of Mausbach et al. (Mausbach et al., 2020) may explain the relationship between direct medical costs and QoL by linking anxiety and depression among patients to higher risks of hospitalisation, longer hospital stays, and overall accrued higher healthcare costs.”
BackgroundResultInfluentialBody Image Concerns in Patients With Head and Neck Cancer: A Longitudinal Study
Henry, M., Albert, J. G., Frenkiel, S., Hier, M., Zeitouni, A., Kost, K., Mlynarek, A., Black, M., MacDonald, C., Richardson, K., et al. (2022) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.816587 · Cited by 57 · see citing works
Kusch, M., Labouvie, H., Schiewer, V., Talalaev, N., Cwik, J. C., Bussmann, S., Vaganian, L., Gerlach, A. L., Dresen, A., Cecon, N., et al. (2022) · BMC Health Services Research · doi:10.1186/s12913-022-07782-0 · Cited by 45 · see citing works
Virtual Reality in Home Palliative Care: Brief Report on the Effect on Cancer-Related Symptomatology
Moscato, S., Sichi, V., Giannelli, A., Palumbo, P., Ostan, R., Varani, S., Pannuti, R., & Chiari, L. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2021.709154 · Cited by 46 · see citing works
Lan, A., Li, H., Shen, M., Li, D., Shu, D., Liu, Y., Tang, H., Li, K., Peng, Y., & Liu, S. (2024) · BMC Medicine · doi:10.1186/s12916-024-03451-7 · Cited by 39 · see citing works
“In cancer survivors, depression can lead to a variety of negative outcomes, including longer hospitalization, poor adherence to anticancer treatment, a decline in quality of life, and an increased risk of suicide [5, 6].”
BackgroundYan, G., Zhang, Q., Yan, Y., Zhang, Y., Li, Y., Liu, M., & Tian, W. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.08.091 · Cited by 29 · see citing works
Zhao, D., Zhang, J., Zhu, Y., He, C., Fei, W., Yue, N., Wang, C., & Wang, L. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.828612 · Cited by 23 · see citing works
“Cancer-related psychological distress may limit or prevent the treatment course and recovery (5), reduce quality of life and increase health-care costs (6), while, even more problematically, some patients have suicidal thoughts (7).”
BackgroundSteel, J. L., George, C. J., Terhorst, L. A., Yabes, J. G., Reyes, V. E., Zandberg, D. P., Nilsen, M. L., Kiefer, G. J., Johnson, J. T., Marsh, C., et al. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00015-1 · Cited by 21 · see citing works
Incremental Health Care Costs of Anxiety and Depression Among Medicare Beneficiaries With Cancer
Birch, K., Chung, S., Zion, S. R., MacEwan, J. P., & Malecki, M. J. (2023) · JCO Oncology Practice · doi:10.1200/op.22.00555 · Cited by 18 · see citing works
Gentil, L., Grenier, G., Meng, X., & Fleury, M. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.735005 · Cited by 17 · see citing works
“, diabetes and schizophrenia or serious MD (31, 33, 35), cancer and common MD (32), epilepsy and MD (36), migraine and MD (34), and CPI and MD among self-harming adolescents (25).”
BackgroundEmergency Department Use Among Assisted Living Residents After Hurricane Irma
Hua, C. L., Thomas, K. S., Peterson, L. J., Hyer, K., & Dosa, D. M. (2020) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2020.10.010 · Cited by 17 · see citing works
van Beek, F. E., Jansen, F., de Jong, R. J. B., Langendijk, J. A., Leemans, C. R., Smit, J. H., Takes, R. P., Terhaard, C. H. J., Custers, J. A. E., Prins, J. B., et al. (2022) · Current Oncology · doi:10.3390/curroncol29050260 · Cited by 16 · see citing works
Russell, K., Moghaddam, N. G., & Tickle, A. (2022) · European Journal of Cancer Care · doi:10.1111/ecc.13678 · Cited by 15 · see citing works
“Cancer patients diagnosed with anxiety or depression were significantly more likely to attend an emergency department and to require hospitalisations and, on average, were hospitalised for 73% longer than cancer patients without anxiety or depression (Mausbach et al., 2020).”
BackgroundMusic therapy effect on anxiety reduction among patients with cancer: A meta-analysis
Zang, L., Cheng, C., Zhou, Y., & Liu, X. (2023) · Frontiers in Psychology · doi:10.3389/fpsyg.2022.1028934 · Cited by 16 · see citing works
Christensen, M. K., McGrath, J. J., Momen, N. C., Weye, N., Agerbo, E., Pedersen, C. B., Plana‐Ripoll, O., & Iburg, K. M. (2022) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674221129184 · Cited by 16 · see citing works
“Prior studies have investigated the influence of comorbidity on health care cost in pairs of mental disorders (Libutzki et al., 2019; Mausbach et al., 2020) or for psychiatric comorbidities (yes/no) for a specific mental disorder (Kan et al., 2021).”
BackgroundInfluentialPark, H., Kim, K.-E., Moon, E., & Kang, T. (2023) · Psychiatry Investigation · doi:10.30773/pi.2022.0316 · Cited by 13 · see citing works
Global trends in psycho‐oncology research investments 2016–2020: A content analysis
Conti, I., Davidson, M. A., Cutress, R., McIntosh, S., & Head, M. (2023) · Psycho-Oncology · doi:10.1002/pon.6273 · Cited by 13 · see citing works
Dong, Q., Wang, T., Bu, X., Chen, L., Zhong, F., & Liu, C. (2025) · Scientific Reports · doi:10.1038/s41598-025-99493-9 · Cited by 12 · see citing works
Ernster, A. E., Body, A., Deleyrolle, P., Clair, J. S., Sampson, D., Bacharz, K. C., Yan, S. C., Melnick, K. F., Allen, A., Rahman, M., et al. (2023) · Journal of Neuro-Oncology · doi:10.1007/s11060-023-04469-2 · Cited by 12 · see citing works
Springer, F., Goerling, U., Zimmermann, T., Ernst, J., Engel, C., Hermann, M., Esser, P., Hornemann, B., Keilholz, U., Lordick, F., et al. (2025) · Psycho-Oncology · doi:10.1002/pon.70059 · Cited by 10 · see citing works
Polfer, E., Alici, Y., Baser, R., Healey, J., & Bartelstein, M. (2022) · Clinical Orthopaedics and Related Research · doi:10.1097/corr.0000000000002295 · Cited by 4 · see citing works
“Patients with cancer who have a diagnosis of depression and/or anxiety have been shown to have increased healthcare use costs [21, 22].”
BackgroundThe Increasing Burden of Depression in Patients Undergoing Head and Neck Cancer Operations
Madrigal, J., Tie, E. K., Verma, A., Benharash, P., Rapkin, D. A., & John, M. A. S. (2023) · The Laryngoscope · doi:10.1002/lary.30735 · Cited by 10 · see citing works
“10,11 In those undergoing major oncologic operations, the presence of comorbid depression has been associated with non-routine discharge and readmission.”
BackgroundInfluentialEmir, B. S., Yıldız, S., Kurt, O., Emre, E., & Aydın, S. (2023) · Healthcare · doi:10.3390/healthcare11202794 · Cited by 8 · see citing works
“The co-existence of these mental disorders with cancer may affect the individual’s perception of the disease and may lead to negative effects on treatment compliance, quality of life, and prognosis [14,15].”
BackgroundAssociation between malnutrition and anxiety in cancer patients—a retrospective study
Nardi, M., Catalini, A., Galiano, A., Santangelo, O. E., Pinto, E., Feltrin, A., Nucci, D., & Gianfredi, V. (2024) · Supportive Care in Cancer · doi:10.1007/s00520-024-08350-4 · Cited by 8 · see citing works
“Cancer patients with anxiety are more likely to have emergency department visits and hospital admissions and have longer hospital stays, resulting in higher healthcare costs and poorer prognosis [17].”
Zhang, R., Zhang, P., Lin, Y., Guo, X., & Wang, J. (2024) · Frontiers in Psychology · doi:10.3389/fpsyg.2024.1413591 · Cited by 7 · see citing works
Miller, M. F., Zaleta, A. K., Allen, M., Nichols, H. M., & Robinson, D. C. (2022) · Journal of Psychosocial Oncology Research and Practice · doi:10.1097/or9.0000000000000070 · Cited by 7 · see citing works
Liu, M., Cao, W., Xu, G., He, Y., Du, Z., & Yuan, T. (2025) · Geriatric Nursing · doi:10.1016/j.gerinurse.2025.03.022 · Cited by 6 · see citing works
Timinis, C., Opie, J., Watt, S., Rogers, Y., & Drobnjak, I. (2025) · CHI Conference on Human Factors in Computing Systems · doi:10.1145/3706598.3714134 · Cited by 6 · see citing works
“…out by practitioners aiming to reduce concerns in patients ’, is recently recognised as one of the key factors needed for engagement of patients when using RPMs [118], especially among cancer patients undergoing cancer treatments [16], and potentially impacting their recovery trajectory [79].”
Depression and Its Impact on Various Aspects of Life - A Narrative Review
Balatif, R., & Sukma, A. A. M. (2023) · Current Psychiatry Research and Reviews · doi:10.2174/2666082219666230518105004 · Cited by 6 · see citing works
Gordon, L. G., Jones, S., Parker, G. J., Chambers, S. K., Aitken, J. F., Foote, M. C., Shum, D., Robertson, J., Conlon, E. G., Pinkham, M. B., et al. (2023) · Psycho-Oncology · doi:10.1002/pon.6243 · Cited by 6 · see citing works
“7,28,29 Our findings appear to support this when all health service costs were included but we saw higher use and costs for psychological - related services in the Tele - MAST group, a finding similar to Rodrigues et al. 11 Through the Tele - MAST intervention, some participants were encouraged to…”
ResultFleury, M., Grenier, G., Cao, Z., & Huỳnh, C. (2022) · Drug and Alcohol Review · doi:10.1111/dar.13451 · Cited by 6 · see citing works
Bird, M. J., Li, G., MacNeil, A., Jiang, Y., de Groh, M., & Fuller‐Thomson, E. (2023) · Cancer Management and Research · doi:10.2147/cmar.s421675 · Cited by 6 · see citing works
Mishra, K., Leung, I. C., Chao, M. T., Thompson‐Lastad, A., Pollak, C., Dhruva, A., Hartogensis, W., Lister, M., Cheng, S. W., & Atreya, C. E. (2024) · Global Advances in Integrative Medicine and Health · doi:10.1177/27536130241263486 · Cited by 5 · see citing works
Theilla, M., Singer, P., Tadmor, B., Bendavid, I., Hellerman, M., & Kagan, I. (2022) · Clinical Nutrition · doi:10.1016/j.clnu.2022.06.023 · Cited by 6 · see citing works
Kwon, J., Kopec, J. A., Sutherland, J. M., Lambert, L. K., Anis, A. H., & Sawatzky, R. G. (2023) · Quality of Life Research · doi:10.1007/s11136-023-03430-0 · Cited by 4 · see citing works
Lewis‐Smith, H., Jones, A., White, P., Byford, S., Fairbrother, P., Potter, S., & Harcourt, D. M. (2025) · BMJ Open · doi:10.1136/bmjopen-2024-097817 · Cited by 4 · see citing works
“19 20 Collectively, this highlights the importance of targeting potent risk factors for adverse outcomes among breast cancer survivors, including body image concerns.”
Using journey maps to understand patient-reported outcome measures in the cancer journey
Kwon, J., Moynihan, M., Wolff, A. C., Irlbacher, G., Joseph, A. L., Wilson, L., Horlock, H., Hung, L., Lambert, L. K., Lau, F., et al. (2024) · Canadian Oncology Nursing Journal · doi:10.5737/23688076344443 · Cited by 4 · see citing works
Bai, L., Huang, C., Xu, Z.-Y., Huang, T., Guan, X., & Shi, L.-W. (2021) · Psycho-Oncology · doi:10.1002/pon.5660 · Cited by 4 · see citing works
“Our study found that cancer patients with depression probably experienced longer length of hospital stay and accrued higher healthcare costs than those without depression as reported previously, after controlling for the impact of patients' demographic and clinical characteristics.(2) Cancer patients with depression w…”
BackgroundFerretti, M., Lowery Walker, K., Bires, J., & BrintzenhofeSzoc, K. (2024) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2023.2238263 · Cited by 3 · see citing works
Proportion and Correlates of Psychiatric Morbidity Among Psychiatry-Assessed Oncology Inpatients
Pâslaru, A., Bounegru, I., Pleșea-Condratovici, C., Marius, M., & Ciubara, A. (2025) · Diseases · doi:10.3390/diseases13110350 · Cited by 4 · see citing works
“…large claims-based analysis shows significantly higher annual costs in cancer patients with anxiety/depression; meta-analytic work also associates depression/anxiety with increased cancer-specific and all-cause mortality, underscoring the importance of early identification and intervention [38–40].”
Ehlers, S. L., Gudenkauf, L. M., Kacel, E. L., Hanna, S. M., Sinicrope, P. S., Patten, C. A., Morrison, E. J. P., Snuggerud, J. R., Bevis, D., Kirsch, J. L., et al. (2023) · Journal of the National Comprehensive Cancer Network · doi:10.6004/jnccn.2023.7009 · Cited by 3 · see citing works
McIntyre, R., & Ferretti, M. (2026) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2025.2531106 · Cited by 2 · see citing works
you, S., Gu, X., Sui, J., Xiang, Z., & Gao, F. (2025) · PLoS ONE · doi:10.1371/journal.pone.0328491 · Cited by 2 · see citing works
Bitēna, D. K., Salmane-Kuļikovska, I., Duhovská, J., Znotiņa, I., Lejniece, S., & Mārtinsone, K. (2026) · Journal of Religion and Health · doi:10.1007/s10943-025-02550-w · Cited by 2 · see citing works
“These unmet psychosocial needs can negatively impact QoL, reduce adherence to medical recommendations, and increase health care costs for both patients and the health care system across the cancer trajectory despite advances in treatment and supportive care (Mausbach et al., 2020).”
Liel, F. A., Salameh, B. S., Ayed, A., & Aqtam, I. F. (2026) · SAGE Open Nursing · doi:10.1177/23779608261418588 · Cited by 2 · see citing works
“The clinical environment, combined with treatment-related side effects and uncertainty about outcomes, frequently exacerbates anxiety and stress responses (Gustafson, 2017; Mausbach et al., 2020).”
Yan, K., Kim, E., Small, B., Wang, H.-L., Elliott, A., & Loerzel, V. W. (2026) · Journal of Affective Disorders · doi:10.1016/j.jad.2026.121900 · Cited by 2 · see citing works
Mitchell, R. J., Delaney, G. P., Arnolda, G., Liauw, W., Lystad, R. P., & Braithwaite, J. (2024) · Cancer Epidemiology · doi:10.1016/j.canep.2024.102676 · Cited by 2 · see citing works
Mitchell, R. J., Delaney, G. P., Arnolda, G., Liauw, W., Lystad, R. P., & Braithwaite, J. (2024) · Cancer Epidemiology · doi:10.1016/j.canep.2024.102584 · Cited by 2 · see citing works
Psycho-Social Prehabilitation Before Surgery in Oncology
Datta, S. S., & Mukherjee, A. (2022) · Springer eBooks · doi:10.1007/978-981-16-6494-6_9 · Cited by 1 · see citing works
Xu, W., Zhao, N., Li, W., Qiu, L., Luo, X., Lin, Y., Wang, W., Garg, S., Sun, H., & Yang, Y. (2024) · Contemporary Clinical Trials Communications · doi:10.1016/j.conctc.2024.101299 · Cited by 1 · see citing works
“Brent et al. found that cancer patients with more emotional distress were at a greater risk for Emergency Department visits and hospitalizations, experienced longer hospital stays, and accrued higher health-care costs [10].”
BackgroundPrevalence and Associated Factors for Depression Among Patients With Sarcoma
Robinson, M. J., Nguyen, S. M., Friedman, D. L., Schremp, E. A., Wang, L. L., Borinstein, S. C., Davis, E. J., Pal, T., Park, B. H., & Shu, X. (2025) · JCO Oncology Practice · doi:10.1200/op.24.00163 · Cited by 2 · see citing works
Yedigün, T., & İnan, F. Ş. (2025) · Psychology Health & Medicine · doi:10.1080/13548506.2025.2496997 · Cited by 1 · see citing works
“Patients with cancer suffering from anxiety and depression are admitted to emergency departments and hospitals more frequently, have longer hospitalization periods and have to bear higher healthcare costs (Mausbach et al., 2020).”
Effect of a Novel Antidepressant and Anticancer Nuc01 on Depression in Cancer Survivors
Yuan, C.-C., Shi, X., Wang, Z.-Q., Li, Y.-Q., Ma, W.-B., & Fu, K. (2025) · Current Issues in Molecular Biology · doi:10.3390/cimb47080587 · Cited by 1 · see citing works
Irwin, S. A., Oppenheim, S., Hallum, A. D., Wolcott, D. L., Danovitch, I., & Figlin, R. A. (2026) · Journal of Psychosocial Oncology · doi:10.1080/07347332.2026.2613157 · Cited by 1 · see citing works
Self-citationCenobamate’s effect on mood and seizure frequency
Karatas, M., Yavuz, A., Newman, B. J., Peters, A. Y., Johnson, B., Richards, S. V., Rawal, P., Rothenfluh, A., & Arain, A. M. (2026) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2026.110913 · Cited by 1 · see citing works
“[22] This comorbidity is reported to be linked to worse outcomes and a marked reduction in health-related quality of life.”
Association between generalized anxiety disorder and health-related quality of life
Kim, J., Lee, Y., & Park, S. (2026) · Annals of General Psychiatry · doi:10.1186/s12991-026-00682-1 · Cited by 1 · see citing works
“Individuals suffering from GAD are more likely to visit emergency medical services, experience prolonged hospitalizations, and incur significantly higher annual medical costs [3].”
Borda, J. P., Shapiro, G. K., Rosa, W. E., Bergerot, C. D., Gonzalez, L. F., LAM, W. C. H., Mehnert-Theuerkauf, A., Jackson, M. J., Maués, J., Veeraiah, S., et al. (2026) · EClinicalMedicine · doi:10.1016/j.eclinm.2026.104047 · Cited by 1 · see citing works
Walsan, R., Harrison, R., Ng, H. S., Koh, E.-S., Sabesan, S., Chauhan, A., Vandyke, A., Taylor, N. J., Manias, E., Badgery‐Parker, T., et al. (2026) · Australian & New Zealand Journal of Psychiatry · doi:10.1177/00048674261470996 · Cited by 1 · see citing works
“One study from the United States reported higher rates of all ED visits and hospitalisations among cancer patients with anxiety and depression (Mausbach et al., 2020).”
Liu, C., Liu, C., Wang, J., & Chang, K. (2023) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.5889 · Cited by 1 · see citing works
Remission rates after complex treatment of depression using general magnetic therapy
Bakhmutsky, I. N., Kosenko, V. G., Guba, S., & Георгиевич, Б. Н. (2024) · Vestnik nevrologii psihiatrii i nejrohirurgii (Bulletin of Neurology Psychiatry and Neurosurgery) · doi:10.33920/med-01-2405-01 · Cited by 1 · see citing works
Torralvo, F. J. S., Bolívar, V. C., Vico, M. R., Fernández, J. A., Almendros, I., Barrios, M., & Olveira, G. (2021) · Research Square · doi:10.21203/rs.3.rs-427122/v1
“Cancer patients with anxiety and depression were at greater risk for emergency department visits and hospitalizations, experienced longer hospital stays, and accrued higher healthcare costs [9].”
BackgroundKwon, J., Moynihan, M., Wolff, A. C., Irlbacher, G., Joseph, A. L., Wilson, L., Horlock, H., Hung, L., Lambert, L. K., & Sawatzky, R. G. (2023) · Research Square · doi:10.21203/rs.3.rs-3438434/v1 · Cited by 1 · see citing works
Psychosocial Dimension in Older Adults with Cancer and Frailty
Bjerre-Real, C., Shah, N., & Alici, Y. (2022) · Springer eBooks · doi:10.1007/978-3-030-89162-6_5
Oncology, C. (2012) · Current Oncology · doi:10.3747/co.19.1329
Andreou, D. (2022) · Clinical Orthopaedics and Related Research · doi:10.1097/corr.0000000000002356
ANXIETY AND DEPRESSION IN GYNECOLOGICAL CANCER
Bugaeva, M. N., & Azhymamatova, Z. T. (2022) · Научное обозрение Медицинские науки (Scientific Review Medical Sciences) · doi:10.17513/srms.1277
Kao, Y., Lin, Y.-J., Weng, S., Wang, J.-J., Lee, I., & Huang, C. (2024) · Supportive Care in Cancer · doi:10.1007/s00520-024-08658-1
“Mausbach's (2020) study showed that cancer patients with comorbid depression had longer hospitalization days than those with cancer alone [25].”
Hill, C., Shah, S., Crowe, A. L., & McKnight, A. J. (2024) · Research Square · doi:10.21203/rs.3.rs-4616507/v1
Effect of depression on health care expenditure in middle-aged and older patients with heart diseasePreprint
you, S., Gu, X., Sui, J., Xiang, Z., & Gao, F. (2024) · Research Square · doi:10.21203/rs.3.rs-4668838/v1
Schlatter, M. C. (2024) · Springer eBooks · doi:10.1007/978-981-99-6794-0_17
Tercyak, S., Vyas, I., Kaplan, D. M., Palmer, P. K., Shelton, M., Raison, C. L., Grant, G. H., Idler, E. L., & Mascaro, J. S. (2025) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/10499091251320410
Lan, A., Li, H., Shen, M., Li, D., Shu, D., Liu, Y., Tang, H., Li, K., Peng, Y., & Liu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26729752
Lan, A., Li, H., Shen, M., Li, D., Shu, D., Liu, Y., Tang, H., Li, K., Peng, Y., & Liu, S. (2024) · Figshare · doi:10.6084/m9.figshare.25971794
Lan, A., Li, H., Shen, M., Li, D., Shu, D., Liu, Y., Tang, H., Li, K., Peng, Y., & Liu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26729740
Lan, A., Li, H., Shen, M., Li, D., Shu, D., Liu, Y., Tang, H., Li, K., Peng, Y., & Liu, S. (2024) · Figshare · doi:10.6084/m9.figshare.25971715
Lan, A., Li, H., Shen, M., Li, D., Shu, D., Liu, Y., Tang, H., Li, K., Peng, Y., & Liu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26729743
Lan, A., Li, H., Shen, M., Li, D., Shu, D., Liu, Y., Tang, H., Li, K., Peng, Y., & Liu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26729749
Lan, A., Li, H., Shen, M., Li, D., Shu, D., Liu, Y., Tang, H., Li, K., Peng, Y., & Liu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26729746
Lan, A., Li, H., Shen, M., Li, D., Shu, D., Liu, Y., Tang, H., Li, K., Peng, Y., & Liu, S. (2024) · Figshare · doi:10.6084/m9.figshare.26729737
Yang, J., Yin, Y., Yu, G., & Yu, F. (2026) · Frontiers in Psychology · doi:10.3389/fpsyg.2025.1718034 · Cited by 1 · see citing works
Integrative approaches to anxiety
Addington, E. L. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-30194-0.00034-5
Kang, T., Moon, E., Kim, K., Lim, H. J., Suh, H., Kim, K.-E., & Park, H. (2026) · Journal of Korean Medical Science · doi:10.3346/jkms.2026.41.e211
“13 These psychological issues can also lead to decreased treatment adherence and may adversely affect survival rates.”
The Experience of Depression in Older Adults With Cancer: A Qualitative Descriptive Analysis
Hardt, M. M., Gilliland, J. L., Rubi, L., Dolma, R., Saracino, R. M., Sirey, J. A., & McConnell, K. M. (2026) · Psycho-Oncology · doi:10.1002/pon.70512
“In patients with cancer, depression is associated with more physical symptoms [6]; poor quality of life [7]; longer hospitalizations [8]; increased risk of 30‐day readmission [9]; and worse survival [10].”
Farokhzad, S., & Navidian, A. (2026) · Iranian Journal of Breast Diseases · doi:10.66224/ijbd.19.1.12
Ferretti, M., BrinzenhofeSzoc, K., Taylor, T., Grant, T. D., Varikkodan, S., Sedaghatshoar, S., O'Neil, K., Raja, N., Miller, M. F., Acquati, C., et al. (2026) · Psycho-Oncology · doi:10.1002/pon.70523
“Unmet psychosocial needs can lead to lower quality of life, poorer adherence to medical treatments, increased healthcare costs [1, 9, 10] and reduced survival [11].”
He, Y., & Tong, L.-Y. (2026) · Psycho-Oncologie · doi:10.18282/po5742
The Essential Role of Mental Health Professionals in Integrative Oncology Teams
Ferretti, M., Christie, A. J., & Zimmaro, L. A. (2026) · Journal of Integrative and Complementary Medicine · doi:10.1177/27683605261463084
Dwijayanti, A., Tantri, A. R., Muktiarti, D., Sianipar, I. R., Sari, U. N., Raharjanti, N. W., Hidayati, R. M., & Ma, M. (2026) · Depression and Anxiety · doi:10.1155/da/3317133
“In addition to the emergence of physical disorders, it also causes psychological problems such as anxiety disorders and depression [6].”
Matthews, E., Webber, K., Parker, C., Feola, C., Gencarelli, T., Koe-Leong, P., & Wiley, J. F. (2026) · Psycho-Oncology · doi:10.1002/pon.70584
Delivering online communication skills training for radiation therapists
Halkett, G. K. B., Berg, M. N., York, D., Naehrig, D. N., Arnold, B., Hilder, B., Oultram, S., Harrison, J., & Dhillon, H. M. (2026) · Technical Innovations & Patient Support in Radiation Oncology · doi:10.1016/j.tipsro.2026.100435
“This can worsen outcomes and increase healthcare use [10,11].”
Anxiety in patients with cancer and emergency department use: a systematic review
Chung, H.-Y., Nagaratnam, K., Walsh, C., Thompson, C., Borgundvaag, B., McLeod, S. L., & Grewal, K. (2026) · Supportive Care in Cancer · doi:10.1007/s00520-026-11325-2
“Three studies reported a significant positive association between anxiety and increased ED use in multivariable analysis [17, 18, 20].”
Influential
- Authors
- Mausbach, B. T., Decastro, G., Schwab, R. B., Tiamson‐Kassab, M., & Irwin, S. A.
- Affiliations
- University of California San Diego (US)
- San Diego State University (US)
- Cedars-Sinai Medical Center (US)
- Corresponding author
- Mausbach, Brent T.
- Venue
- Depression and Anxiety
- Publisher
- Wiley
- Published
- 2020-06-02
- Volume
- 37
- Issue
- 9
- Pages
- 908-915
- ISSN
- 1091-4269 (ISSN-L)
- 1520-6394
- PMC
- PMC7484454
- OpenAlex
- W3032392427
- Cited by
- 95
- References
- 35
- Citations by year
- 2026: 20 · 2025: 12 · 2024: 23 · 2023: 17 · 2022: 15 · 2021: 6 · 2020: 1 · 2012: 1
- FWCI
- 3.52
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Depression and Anxiety (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Foundation for the National Institutes of Health (UL1TR001442)
- Topics
- Health Sciences › Medicine › Oncology › Cancer survivorship and care
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Economic and Financial Impacts of Cancer
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Keywords
- cancer, anxiety, depression, comorbid depression and anxiety, health care utilization, health care costs, emergency department visits, hospitalization, length of hospital stay
- MeSH terms
- Adolescent, Adult, Anxiety, Anxiety Disorders, Depression, Emergency Service, Hospital, Humans, Neoplasms, Retrospective Studies, Health Care Costs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
