Depressive Symptoms and the Cost of Health Services in HMO Patients Aged 65 Years and Older: A 4-Year Prospective Study
Abstract
OBJECTIVE: To examine whether depressive symptoms in older adults contribute to increased cost of general medical services. DESIGN: A 4-year prospective cohort study. SETTING: Four primary care clinics of a large staff-model health maintenance organization (HMO) in Seattle, Wash. PATIENTS: A total of 5012 Medicare enrollees older than 65 years were invited to participate in the study; 2558 subjects (51%) were successfully enrolled. Non-participants were somewhat older and had a higher level of chronic medical illness. MAIN OUTCOME MEASURES: Depressive symptoms as measured by the Center for Epidemiological Studies Depression scale, which was administered as part of a mail survey at baseline, at 2 years, and at 4 years; and total cost of medical services from the perspective of the HMO. Data were obtained from the cost accounting system of the HMO. RESULTS: In this cohort of older adults, depressive symptoms were common, persistent, and associated with a significant increase in the cost of general medical services. This increase was seen for every component of health care costs and was not accounted for by an increase in specialty mental health care. The increase in health care costs remained significant after adjusting for differences in age, sex, and chronic medical illness. CONCLUSIONS: Depressive symptoms in older adults are associated with a significant increase in the cost of medical services, even after adjusting for the severity of chronic medical illness.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Depressed patients with a chronic medical illness are usually sicker than their counterparts.
“Depressed patients with a chronic medical illness are usually sicker than their counterparts37–46 and have lower treatment adherence.37,47–51”
From Anxiety and Depression in COPD (2008) · cites this paper as [40]
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267 · see citing works
Maximum Likelihood Estimation of Misspecified Models
White, H. (1983) · Econometrica · doi:10.2307/1912004 · Cited by 3,702 · see citing works
Assessing depressive symptoms in five psychiatric populations: a validation study.
Weissman, M., Sholomskas, D., Pottenger, M., Prusoff, B., & Locke, B. Z. (1977) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a112455 · Cited by 2,232 · see citing works
Depression Following Myocardial Infarction
Frasure‐Smith, N. (1993) · JAMA · doi:10.1001/jama.1993.03510150053029 · Cited by 2,028 · see citing works
Greenberg, P. E., Stiglin, L. E., Finkelstein, S. N., & Berndt, E. R. (1994) · PharmacoResources · doi:10.1007/bf03289581 · Cited by 974 · see citing works
A chronic disease score from automated pharmacy data
Korff, M. V., Wagner, E. H., & Saunders, K. W. (1992) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(92)90016-g · Cited by 962 · see citing works
Hays, R. D. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950130011002 · Cited by 835 · see citing works
Utilization of Health and Mental Health Services
Shapiro, S. (1984) · Archives of General Psychiatry · doi:10.1001/archpsyc.1984.01790210053007 · Cited by 816 · see citing works
Use of a self-report symptom scale to detect depression in a community sample
Myers, J. K., & Weissman, M. M. (1980) · American Journal of Psychiatry · doi:10.1176/ajp.137.9.1081 · Cited by 777 · see citing works
Service utilization and social morbidity associated with depressive symptoms in the community
Johnson, J. (1992) · JAMA: The Journal of the American Medical Association · doi:10.1001/jama.1992.03480110054033 · Cited by 726 · see citing works
The Epidemiology of Depression in an Elderly Community Population
Blazer, D. G., Hughes, D. C., & George, L. K. (1987) · The Gerontologist · doi:10.1093/geront/27.3.281 · Cited by 690 · see citing works
The Prognosis of Depression in Old Age
Murphy, E. (1983) · The British Journal of Psychiatry · doi:10.1192/bjp.142.2.111 · Cited by 621 · see citing works
Model Robust Confidence Intervals Using Maximum Likelihood Estimators
Royall, R. M. (1986) · International Statistical Review · doi:10.2307/1403146 · Cited by 579 · see citing works
Screening for Depression in Primary Care Clinics: The CES-D and the BDI
Zich, J. M., Attkisson, C. C., & Greenfield, T. K. (1990) · The International Journal of Psychiatry in Medicine · doi:10.2190/lykr-7vhp-yjem-mkm2 · Cited by 570 · see citing works
Health care costs associated with depressive and anxiety disorders in primary care
(1995) · American Journal of Psychiatry · doi:10.1176/ajp.152.3.352 · Cited by 555 · see citing works
BRUCE, M. L., Seeman, T. E., Merrill, S. S., & Blazer, D. G. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.11.1796 · Cited by 554 · see citing works
Health Care Costs of Primary Care Patients With Recognized Depression
Simon, G. E. (1995) · Archives of General Psychiatry · doi:10.1001/archpsyc.1995.03950220060012 · Cited by 520 · see citing works
Distressed high utilizers of medical care
Katon, W., Von Korff, M., Lin, E., Lipscomb, P., Russo, J., Wagner, E., & Polk, E. (1990) · General Hospital Psychiatry · doi:10.1016/0163-8343(90)90002-t · Cited by 512 · see citing works
The Prevalence of Psychiatric Disorders in a Primary Care Practice
Barrett, J. E. (1988) · Archives of General Psychiatry · doi:10.1001/archpsyc.1988.01800360048007 · Cited by 490 · see citing works
The economic burden of depression
Stoudemire, A., Frank, R. W., Hedemark, N., Kamlet, M. S., & Blazer, D. G. (1986) · General Hospital Psychiatry · doi:10.1016/0163-8343(86)90018-6 · Cited by 480 · see citing works
The Course of Depression in Adult Outpatients: Results From the Medical Outcomes Study
Wells, K. B. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820100032007 · Cited by 475 · see citing works
Depressive Symptoms as Relative and Attributable Risk Factors for First-Onset Major Depression
Horwath, E. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820100061011 · Cited by 456 · see citing works
Sartorius, N., & Ban, T. A. (1986) · Springer eBooks · doi:10.1007/978-3-642-70486-4 · Cited by 436 · see citing works
Self-Efficacy and Health Behavior Among Older Adults
Grembowski, D. E., Patrick, D. L., Diehr, P. K., Durham, M., Beresford, S. A. A., Kay, E., & Hecht, J. A. (1993) · Journal of Health and Social Behavior · doi:10.2307/2137237 · Cited by 408 · see citing works
A new look at evidence about reduced cost of medical utilization following mental health treatment
Mumford, E., Schlesinger, H. J., Glass, G. V., Patrick, C., & Cuerdon, T. T. (1984) · American Journal of Psychiatry · doi:10.1176/ajp.141.10.1145 · Cited by 404 · see citing works
Subsyndromal symptomatic depression: a new mood disorder?
Judd, L. L., Rapaport, M. H., Paulus, M. P., & Brown, J. L. (1994) · PubMed · Cited by 402 · see citing works
Age Differences in the Symptoms of Depression: A Latent Trait Analysis
Gallo, J. J., Anthony, J. C., & Muthén, B. (1994) · Journal of Gerontology · doi:10.1093/geronj/49.6.p251 · Cited by 391 · see citing works
Longitudinal Study of Depression and Health Services Use Among Elderly Primary Care Patients
Callahan, C. M., Hui, S. L., Nienaber, N. A., Musick, B. S., & Tierney, W. M. (1994) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1994.tb06554.x · Cited by 295 · see citing works
Depression in rural communities: Validating the CES-D scale
Husaini, B. A., Neff, J. A., Harrington, J. B., Hughes, M. D., & Stone, R. H. (1980) · Journal of Community Psychology · doi:10.1002/1520-6629(198001)8:1 · Cited by 284 · see citing works
Disability in geriatric depression
Alexopoulos, G. S., Vrontou, C., Kakuma, T., Meyers, B. S., Young, R. C., Klausner, E. J., & Clarkin, J. F. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.7.877 · Cited by 268 · see citing works
The deliberate misdiagnosis of major depression in primary care
ROST, K. M. (1994) · Archives of Family Medicine · doi:10.1001/archfami.3.4.333 · Cited by 265 · see citing works
Kennedy, G. J., Kelman, H. R., & Thomas, C. (1990) · Journal of Community Health · doi:10.1007/bf01321314 · Cited by 264 · see citing works
How can care for depression become more cost-effective?
Sturm, R. (1995) · JAMA · doi:10.1001/jama.273.1.51 · Cited by 239 · see citing works
Newmann, J. P. (1989) · Psychology and Aging · doi:10.1037//0882-7974.4.2.150 · Cited by 236 · see citing works
Persistence and remission of depressive symptoms in late life.
Kennedy, G. J., Kelman, H. R., & Thomas, C. (1991) · PubMed · doi:10.1176/ajp.148.2.174 · Cited by 206 · see citing works
Depression and disability in the elderly: Reciprocal relations and changes with age
Gurland, B. J., Wilder, D. E., & Berkman, C. (1988) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.930030304 · Cited by 183 · see citing works
Relation of psychopathology in general medical inpatients to use and cost of services
Levenson, J. L., Hamer, R. M., & Rossiter, L. F. (1990) · American Journal of Psychiatry · doi:10.1176/ajp.147.11.1498 · Cited by 173 · see citing works
The Effects of Psychological Distress and Psychological Well-Being on Use of Medical Services
Manning, W. G., & Wells, K. B. (1992) · Medical Care · doi:10.1097/00005650-199206000-00007 · Cited by 167 · see citing works
Kessler, L. G., Burns, B. J., Shapiro, S., Tischler, G. L., George, L. K., Hough, R. L., Bodison, D., & Miller, R. H. (1987) · American Journal of Public Health · doi:10.2105/ajph.77.1.18 · Cited by 166 · see citing works
Symptomatic Depression in Elderly Medical Outpatients
Soo Borson, B., Barnes, R. A., Kukull, W. A., Okimoto, J. T., Veith, R. C., Inui, T. S., Carter, W., & Raskind, M. A. (1986) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1986.tb04316.x · Cited by 162 · see citing works
Living Longer in the United States: Demographic Changes and Health Needs of the Elderly
Rice, D. P., & Feldman, J. J. (1983) · The Milbank Memorial Fund Quarterly Health and Society · doi:10.2307/3349863 · Cited by 162 · see citing works
Psychological status among elderly people with chronic diseases: Does type of disease play a part?
Penninx, B. W. J. H., Beekman, A. T. F., Ormel, J., Kriegsman, D. M. W., Boeke, A. J. P., van Eijk, J. T. M., & Deeg, D. J. H. (1996) · Journal of Psychosomatic Research · doi:10.1016/0022-3999(95)00620-6 · Cited by 160 · see citing works
The impact of major depression on chronic medical illness
Katon, W. J. (1996) · General Hospital Psychiatry · doi:10.1016/0163-8343(96)00065-5 · Cited by 134 · see citing works
McFarland, B. H., Freeborn, D. K., Mullooly, J. P., & Pope, C. R. (1985) · Medical Care · doi:10.1097/00005650-198511000-00001 · Cited by 112 · see citing works
Forsell, Y., Jorm, A. F., & Winblad, B. G. (1994) · American Journal of Psychiatry · doi:10.1176/ajp.151.11.1600 · Cited by 110 · see citing works
Psychiatric disorder and functional somatic symptoms as predictors of health care use.
Simon, G. (1992) · PubMed · Cited by 91 · see citing works
Somatic Complaints and the CES‐D
Foelker, G. A., & Shewchuk, R. M. (1992) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1992.tb02079.x · Cited by 84 · see citing works
Outcomes of Geriatric Depression
Alexopoulos, G. S., & Chester, J. G. (1992) · Clinics in Geriatric Medicine · doi:10.1016/s0749-0690(18)30487-7 · Cited by 82 · see citing works
Psychopathology and mortality in the general population
Kouzis, A. C., Eaton, W. W., & Leaf, P. J. (1995) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/bf00790655 · Cited by 82 · see citing works
Distress Syndromes, Illness Behavior, Access to Care and Medical Utilization in a Defined Population
Mechanic, D., Cleary, P. D., & Greenley, J. R. (1982) · Medical Care · doi:10.1097/00005650-198204000-00002 · Cited by 80 · see citing works
Depressive symptoms and mental health service utilization in a community sample
Olfson, M., & Klerman, G. L. (1992) · Social Psychiatry and Psychiatric Epidemiology · doi:10.1007/bf00789000 · Cited by 77 · see citing works
Depressive Symptoms and Associated Factors in a Rural Elderly Population: The MoVIES Project
Ganguli, M., Gilby, J. E., Seaberg, E. C., & Belle, S. H. (1995) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199500320-00006 · Cited by 76 · see citing works
Mental Health Services Use by Elderly Adults in a Primary Care Setting
Goldstrom, I. D., Burns, B. J., Kessler, L. G., Feuerberg, M., Larson, D. B., Miller, N. E., & Cromer, W. J. (1987) · Journal of Gerontology · doi:10.1093/geronj/42.2.147 · Cited by 76 · see citing works
Mental Dysfunction and Resource Use in Nursing Homes
Fries, B. E., Mehr, D. R., Schneider, D., Foley, W. J., & Burke, R. E. (1993) · Medical Care · doi:10.1097/00005650-199310000-00004 · Cited by 72 · see citing works
Disability and depressive symptoms in two communities
Craig, T., & Natta, P. A. V. (1983) · American Journal of Psychiatry · doi:10.1176/ajp.140.5.598 · Cited by 57 · see citing works
Somatization, psychiatric disorder, and stress in utilization of ambulatory medical services.
Miranda, J., Pérez‐Stable, E. J., Muñoz, R. F., Hargreaves, W. A., & al, E. (1991) · Health Psychology · doi:10.1037//0278-6133.10.1.46 · Cited by 53 · see citing works
Somatization, psychiatric disorder, and stress in utilization of ambulatory medical services.
Miranda, J., Perez-Stable, E. J., Muñoz, R. F., Hargreaves, W., & Henke, C. J. (1991) · Health Psychology · doi:10.1037/0278-6133.10.1.46 · Cited by 53 · see citing works
Durham, M. L., Beresford, S. A. A., Diehr, P. K., Grembowski, D. E., Hecht, J. A., & Patrick, D. L. (1991) · The Gerontologist · doi:10.1093/geront/31.5.603 · Cited by 48 · see citing works
Late-life depression in primary care
Banazak, D. A. (1996) · Journal of General Internal Medicine · doi:10.1007/bf02600269 · Cited by 47 · see citing works
Efficacy of risperidone on positive features of schizophrenia.
McEvoy, J. P. (1994) · PubMed · Cited by 39 · see citing works
Katz, I. R., Parmelee, P. A., & Streim, J. E. (1995) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199500320-00007 · Cited by 32 · see citing works
Blazer, D. G. (1989) · Current Opinion in Psychiatry · doi:10.1097/00001504-198908000-00011 · Cited by 31 · see citing works
Community mental health care for the elderly--a look at the obstacles.
Hm, W. (1986) · PubMed · Cited by 17 · see citing works
Methodology of Treatment Studies in Geriatric Depression
Alexopoulos, G. S. (1995) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-199503040-00002 · Cited by 16 · see citing works
The danger of reducing reimbursement for psychiatric disorders in late life
Blazer, D. G. (1996) · American Journal of Psychiatry · doi:10.1176/ajp.153.7.857 · Cited by 10 · see citing works
Depression and Survival Following Myocardial Infarction-Reply
Chesney, M. A. (1994) · JAMA · doi:10.1001/jama.1994.03510380036032 · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Unützer, J., Katon, W., Callahan, C. M., Williams, Jr., Hunkeler, E., Harpole, L., Hoffing, M., Della Penna, R. D., Noël, P. H., Lin, E. H. B., et al. (2002) · JAMA · doi:10.1001/jama.288.22.2836 · Cited by 2,405 · see citing works
Depression in Late Life: Review and Commentary
Blazer, D. G. (2003) · The Journals of Gerontology Series A · doi:10.1093/gerona/58.3.m249 · Cited by 2,363 · see citing works
Depression and Diabetes: Impact of Depressive Symptoms on Adherence, Function, and Costs
Ciechanowski, P. S., Katon, W. J., & Russo, J. E. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.21.3278 · Cited by 1,465 · see citing works
Risk Factors for Depression Among Elderly Community Subjects: A Systematic Review and Meta-Analysis
Cole, M. G., & Dendukuri, N. (2003) · American Journal of Psychiatry · doi:10.1176/appi.ajp.160.6.1147 · Cited by 1,368 · see citing works
Katon, W. J. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00273-7 · Cited by 1,216 · see citing works
Recurrent Concussion and Risk of Depression in Retired Professional Football Players
GUSKIEWICZ, K. M., MARSHALL, S. W., BAILES, J., MCCREA, M., HARDING, H. P., MATTHEWS, A., MIHALIK, J. R., & CANTU, R. C. (2007) · Medicine & Science in Sports & Exercise · doi:10.1249/mss.0b013e3180383da5 · Cited by 928 · see citing works
Health Literacy Among Medicare Enrollees in a Managed Care Organization
Gazmararian, J. A. (1999) · JAMA · doi:10.1001/jama.281.6.545 · Cited by 876 · see citing works
Epidemiology and treatment of depression in patients with chronic medical illness
J. Katon, W. (2011) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2011.13.1/wkaton · Cited by 820 · see citing works
Egede, L. E., Zheng, D., & Simpson, K. (2002) · Diabetes Care · doi:10.2337/diacare.25.3.464 · Cited by 816 · see citing works
Depressive Symptoms and Physical Decline in Community-Dwelling Older Persons
Penninx, B. W. J. H. (1998) · JAMA · doi:10.1001/jama.279.21.1720 · Cited by 809 · see citing works
Anxiety and Depression in COPD
Maurer, J., Rebbapragada, V., Borson, S., Goldstein, R., Kunik, M. E., Yohannes, A. M., & Hanania, N. A. (2008) · Chest · doi:10.1378/chest.08-0342 · Cited by 720 · see citing works
Reynolds III, C. F., Frank, E., Perel, J. M., Imber, S. D., Cornes, C., Miller, M. D., Mazumdar, S., Houck, P. R., Dew, M. A., Stack, J. A., et al. (1999) · JAMA · doi:10.1001/jama.281.1.39 · Cited by 659 · see citing works
Katon, W., Korff, M. V., Lin, E., Simon, G., Walker, E., Unützer, J., Bush, T., Russo, J., & Ludman, E. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.12.1109 · Cited by 697 · see citing works
Lin, E. H. B., Katon, W., Von Korff, M., Tang, L., Williams, Jr., Kroenke, K., Hunkeler, E., Harpole, L., Hegel, M., Arean, P., et al. (2003) · JAMA · doi:10.1001/jama.290.18.2428 · Cited by 590 · see citing works
Depressive Symptoms and Risks of Coronary Heart Disease and Mortality in Elderly Americans
Ariyo, A. A., Haan, M. N., Tangen, C. M., Rutledge, J. C., Cushman, M., Dobs, A. S., & Furberg, C. D. (2000) · Circulation · doi:10.1161/01.cir.102.15.1773 · Cited by 556 · see citing works
Mental Disorders and Use of Cardiovascular Procedures After Myocardial Infarction
Druss, B. G. (2000) · JAMA · doi:10.1001/jama.283.4.506 · Cited by 533 · see citing works
Minor and Major Depression and the Risk of Death in Older Persons
Penninx, B. W. J. H., Geerlings, S. W., Deeg, D. J. H., van Eijk, J. T. M., van Tilburg, W., & Beekman, A. T. F. (1999) · Archives of General Psychiatry · doi:10.1001/archpsyc.56.10.889 · Cited by 524 · see citing works
Exercise and the Treatment of Clinical Depression in Adults: Recent Findings and Future Directions
Brosse, A. L., Sheets, E. S., Lett, H. S., & Blumenthal, J. A. (2002) · Sports Medicine · doi:10.2165/00007256-200232120-00001 · Cited by 505 · see citing works
Increased Medical Costs of a Population-Based Sample of Depressed Elderly Patients
Katon, W. J., Lin, E. H. B., Russo, J. E., & Unützer, J. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.9.897 · Cited by 500 · see citing works
Maintenance Treatment of Major Depression in Old Age
Reynolds, C. F., Dew, M. A., Pollock, B. G., Mulsant, B. H., Frank, E., Miller, M. D., Houck, P. R., Mazumdar, S., Butters, M. A., Stack, J. A., et al. (2006) · New England Journal of Medicine · doi:10.1056/nejmoa052619 · Cited by 476 · see citing works
Awareness, diagnosis, and treatment of depression
the Council on Scientific Affairs, A. M. A., Goldman, L. S., Nielsen, N. H., & Champion, H. C. (1999) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1999.03478.x · Cited by 466 · see citing works
Charney, D., Reynolds, C., Lewis, L., Lebowitz, B., Sunderland, T., Alexopoulos, G., Blazer, D., Katz, I., Meyers, B., Areán, P., et al. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.7.664 · Cited by 485 · see citing works
Who is at risk of nondetection of mental health problems in primary care?
Borowsky, S. J., Rubenstein, L. V., Meredith, L. S., Camp, P., Jackson‐Triche, M., & Wells, K. B. (2000) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.2000.12088.x · Cited by 460 · see citing works
Social and economic burden of mood disorders
Simon, G. E. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00420-7 · Cited by 430 · see citing works
Bartels, S. J., Coakley, E. H., Zubritsky, C., Ware, J. H., Miles, K. M., Areán, P. A., Chen, H., Oslin, D. W., Llorente, M. D., Costantino, G., et al. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.8.1455 · Cited by 417 · see citing works
Katon, W. J., Sullivan, M. D., & Walker, E. A. (2001) · Annals of Internal Medicine · doi:10.7326/0003-4819-134-9_part_2-200105011-00017 · Cited by 416 · see citing works
Chronic diseases and risk for depression in old age: A meta-analysis of published literature
Huang, C.-Q., Dong, B., Lu, Z., Yue, J., & Liu, Q. (2009) · Ageing Research Reviews · doi:10.1016/j.arr.2009.05.005 · Cited by 411 · see citing works
Community-Integrated Home-Based Depression Treatment in Older Adults: A Randomized Controlled Trial
Ciechanowski, P., Wagner, E., Schmaling, K., Schwartz, S., Williams, B., Diehr, P., Kulzer, J., Gray, S., Collier, C., & LoGerfo, J. (2004) · JAMA · doi:10.1001/jama.291.13.1569 · Cited by 406 · see citing works
Inadequate Response to Treatment in Coronary Heart Disease
Denollet, J., Vaes, J., & Brutsaert, D. L. (2000) · Circulation · doi:10.1161/01.cir.102.6.630 · Cited by 388 · see citing works
Mittelman, M. S., Roth, D. L., Coon, D. W., & Haley, W. E. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.5.850 · Cited by 385 · see citing works
Long-term mortality and quality of life after prolonged mechanical ventilation*
Chelluri, L., Im, K. A., Belle, S. H., Schulz, R., Rotondi, A. J., Donahoe, M. P., Sirio, C., Mendelsohn, A. B., & Pinsky, M. R. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000098029.65347.f9 · Cited by 361 · see citing works
Cost-of-illness studies of depression
Luppa, M., Heinrich, S., Angermeyer, M. C., König, H., & Riedel-Heller, S. G. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.07.017 · Cited by 356 · see citing works
Cole, M. G., Bellavance, F., & Mansour, A. (1999) · American Journal of Psychiatry · doi:10.1176/ajp.156.8.1182 · Cited by 351 · see citing works
The Effects of Exercise on Mood in Older Adults: A Meta-Analytic Review
Arent, S. M., Landers, D. M., & Etnier, J. L. (2000) · Journal of Aging and Physical Activity · doi:10.1123/japa.8.4.407 · Cited by 338 · see citing works
Randomized Trial of a Depression Management Program in High Utilizers of Medical Care
Katzelnick, D. J. (2000) · Archives of Family Medicine · doi:10.1001/archfami.9.4.345 · Cited by 331 · see citing works
Cost-effectiveness of Practice-Initiated Quality Improvement for Depression
Schoenbaum, M., Unützer, J., Sherbourne, C. D., Duan, N., Rubenstein, L. V., Miranda, J. M., Meredith, L. S., Carney, M. F., & Wells, K. B. (2001) · JAMA · doi:10.1001/jama.286.11.1325 · Cited by 330 · see citing works
Osório, F. D. L., Mendes, A. V., Crippa, J. A. S., & Loureiro, S. R. (2009) · Perspectives In Psychiatric Care · doi:10.1111/j.1744-6163.2009.00224.x · Cited by 321 · see citing works
Depression Among Older Adults: A 20-Year Update on Five Common Myths and Misconceptions
Haigh, E. A. P., Bogucki, O. E., Sigmon, S. T., & Blazer, D. G. (2017) · American Journal of Geriatric Psychiatry · doi:10.1016/j.jagp.2017.06.011 · Cited by 318 · see citing works
Provisional Diagnostic Criteria for Depression of Alzheimer Disease: Rationale and Background
Olin, J. T., Katz, I. R., Meyers, B. S., Schneider, L. S. S., & Lebowitz, B. D. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200203000-00004 · Cited by 315 · see citing works
Functional impairment in COPD patients: the impact of anxiety and depression
Kim, H. F. S., Kunik, M. E., Molinari, V. A., Hillman, S. L., Lalani, S., Orengo, C. A., Petersen, N. J., Nahas, Z., & Goodnight-White, S. (2000) · Psychosomatics · doi:10.1176/appi.psy.41.6.465 · Cited by 310 · see citing works
Arnow, B. A. (2004) · PubMed · Cited by 313 · see citing works
Cost-effectiveness of Systematic Depression Treatment Among People With Diabetes Mellitus
Simon, G. E., Katon, W. J., Lin, E. H. B., Rutter, C. M., Manning, W. G., Korff, M. V., Ciechanowski, P. S., Ludman, E. J., & Young, B. A. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.1.65 · Cited by 312 · see citing works
Mental Disorders and the Use of Alternative Medicine: Results From a National Survey
Unützer, J., Klap, R. S., Sturm, R., Young, A. S., Marmon, T., Shatkin, J. P., & Wells, K. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.11.1851 · Cited by 288 · see citing works
Caring for Mental Illness in the United States: A Focus on Older Adults
Klap, R., Unroe, K. T., & Unützer, J. (2003) · The American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200309000-00006 · Cited by 292 · see citing works
(2008) · PubMed · Cited by 292 · see citing works
Improving Primary Care for Depression in Late Life: The Design of a Multicenter Randomized Trial
Unützer, J., Katon, W. J., Williams, J. W., Callahan, C. M., Harpole, L. H., Hunkeler, E. M., Hoffing, M., Areán, P. A., Hegel, M. T., Schoenbaum, M., et al. (2001) · Medical Care · doi:10.1097/00005650-200108000-00005 · Cited by 290 · see citing works
Health status and risk for depression among the elderly: a meta-analysis of published literature
Chang-Quan, H., Xue-Mei, Z., Bi-Rong, D., Lu, Z., Ji-Rong, Y., & Qing‐Xiu, L. (2009) · Age and Ageing · doi:10.1093/ageing/afp187 · Cited by 284 · see citing works
Kerr, Z. Y., Marshall, S. W., Harding, H. P., & Guskiewicz, K. M. (2012) · The American Journal of Sports Medicine · doi:10.1177/0363546512456193 · Cited by 282 · see citing works
Lyness, J. M., King, D. A., Cox, C., Yoediono, Z., & Caine, E. D. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb01584.x · Cited by 276 · see citing works
Comorbidity of late life depression: an opportunity for research on mechanisms and treatment
Alexopoulos, G. S., Buckwalter, K. C., Olin, J. T., Martínez, R. A., Wainscott, C., & Krishnan, K. (2002) · Biological Psychiatry · doi:10.1016/s0006-3223(02)01468-3 · Cited by 269 · see citing works
Association Between Depressive Symptoms and Mortality in Older Women
Whooley, M., & Browner, W. (1998) · Archives of Internal Medicine · doi:10.1001/archinte.158.19.2129 · Cited by 290 · see citing works
Recovery from depression, work productivity, and health care costs among primary care patients
Simon, G. E., Revicki, D. A., Heiligenstein, J. H., Grothaus, L. C., VonKorff, M., Katon, W. J., & Hylan, T. R. (2000) · General Hospital Psychiatry · doi:10.1016/s0163-8343(00)00072-4 · Cited by 267 · see citing works
Using Administrative Data to Measure Ambulatory Mental Health Service Provision in Primary Care
Steele, L. S., Glazier, R. H., Lin, E. H. B., & Evans, M. (2004) · Medical Care · doi:10.1097/00005650-200410000-00004 · Cited by 267 · see citing works
Long-term Risk for Depressive Symptoms After a Medical Diagnosis
Polsky, D. E., Doshi, J. A., Marcus, S. C., Oslin, D. W., Rothbard, A. B., Thomas, N., & Thompson, C. L. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.11.1260 · Cited by 263 · see citing works
Katon, W. J., Unützer, J., Fan, M.-Y., Williams, J. W., Schoenbaum, M., Lin, E. H. B., & Hunkeler, E. M. (2006) · Diabetes Care · doi:10.2337/diacare.29.02.06.dc05-1572 · Cited by 259 · see citing works
Evaluating the Older Patient with Cancer: Understanding Frailty and the Geriatric Assessment
Pal, S. K., Katheria, V., & Hurria, A. (2010) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.20059 · Cited by 258 · see citing works
Unützer, J., Schoenbaum, M., Druss, B. G., & Katon, W. J. (2006) · Psychiatric Services · doi:10.1176/appi.ps.57.1.37 · Cited by 247 · see citing works
Depression and Service Utilization in Elderly Primary Care Patients
Luber, M. P., Meyers, B. S., Williams-Russo, P. G., Hollenberg, J. P., DiDomenico, T. N., Charlson, M. E., & Alexopoulos, G. S. (2001) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200105000-00009 · Cited by 248 · see citing works
Cost-effectiveness of Improving Primary Care Treatment of Late-Life Depression
Katon, W. J. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.12.1313 · Cited by 245 · see citing works
Diabetes complications and depression as predictors of health service costs
Simon, G. E., Katon, W. J., Lin, E. H. B., Ludman, E. J., VonKorff, M., Ciechanowski, P. S., & Young, B. A. (2005) · General Hospital Psychiatry · doi:10.1016/j.genhosppsych.2005.04.008 · Cited by 243 · see citing works
The relationship between depression and frailty syndrome: a systematic review
Buigues, C., Padilla-Sánchez, C., Garrido, J. F., Navarro-Martínez, R., Ruiz-Ros, V., & Cauli, O. (2015) · Aging & Mental Health · doi:10.1080/13607863.2014.967174 · Cited by 235 · see citing works
Long-term medical conditions and major depression in a Canadian population study at waves 1 and 2
Patten, S. B. (2001) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00186-5 · Cited by 238 · see citing works
Health Care Costs Associated With Posttraumatic Stress Disorder Symptoms in Women
Walker, E. A., Katon, W. J., Russo, J. E., Ciechanowski, P. S., Newman, E., & Wagner, A. W. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.4.369 · Cited by 234 · see citing works
Depression Treatment in a Sample of 1,801 Depressed Older Adults in Primary Care
Unützer, J., Katon, W., Callahan, C. M., Williams, J. W., Hunkeler, E., Harpole, L., Hoffing, M., Della Penna, R. D., Noel, P. H., Lin, E. H. B., et al. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51159.x · Cited by 229 · see citing works
Crystal, S., Sambamoorthi, U., Walkup, J. T., & Akıncıgil, A. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51555.x · Cited by 233 · see citing works
Changes in depression and physical decline in older adults: a longitudinal perspective
Penninx, B. W. J. H., Deeg, D. J. H., van Eijk, J. T. M., Beekman, A. T. F., & Guralnik, J. M. (2000) · Journal of Affective Disorders · doi:10.1016/s0165-0327(00)00152-x · Cited by 230 · see citing works
Economic costs of minor depression: a population-based study
Cuijpers, P., Smit, F., Oostenbrink, J., De Graaf, R., Ten Have, M., & Beekman, A. (2007) · Acta Psychiatrica Scandinavica · doi:10.1111/j.1600-0447.2006.00851.x · Cited by 226 · see citing works
Coleman, E. A., Grothaus, L. C., Sandhu, N., & Wagner, E. H. (1999) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.1999.tb03832.x · Cited by 221 · see citing works
Donohue, J. M., & Pincus, H. A. (2007) · PharmacoEconomics · doi:10.2165/00019053-200725010-00003 · Cited by 214 · see citing works
Fruit, vegetable, and antioxidant intakes are lower in older adults with depression
Payne, M. E., Steck, S. E., George, R. R., & Steffens, D. C. (2012) · Journal of the Academy of Nutrition and Dietetics · doi:10.1016/j.jand.2012.08.026 · Cited by 211 · see citing works
Depression and health-care costs during the first year following myocardial infarction
Frasure‐Smith, N., Lespérance, F., Gravel, G., Masson, A., Juneau, M., Talajic, M. R., & Bourassa, M. G. (2000) · Journal of Psychosomatic Research · doi:10.1016/s0022-3999(99)00088-4 · Cited by 202 · see citing works
Opportunities for Cost-effective Prevention of Late-Life Depression
Smit, F., Ederveen-Grochowska, A., Cuijpers, P. J., Deeg, D. J. H., & Beekman, A. T. F. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.3.290 · Cited by 200 · see citing works
Strategies to Improve the Management of Depression in Primary Care
Unützer, J., & Park, M. (2012) · Primary Care Clinics in Office Practice · doi:10.1016/j.pop.2012.03.010 · Cited by 197 · see citing works
Cost-effectiveness of Systematic Depression Treatment for High Utilizers of General Medical Care
Simon, G. E., Manning, W. G., Katzelnick, D. J., Pearson, S. D., Henk, H. J., & Helstad, C. P. (2001) · Archives of General Psychiatry · doi:10.1001/archpsyc.58.2.181 · Cited by 198 · see citing works
Depression-related costs in heart failure care
Sullivan, M., Simon, G., Spertus, J., & Russo, J. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.16.1860 · Cited by 196 · see citing works
Healthcare Costs Associated with Depression in Medically Ill Fee‐for‐Service Medicare Participants
Unützer, J., Schoenbaum, M., Katon, W. J., Fan, M., Pincus, H. A., Hogan, D., & Taylor, J. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.02134.x · Cited by 197 · see citing works
Quality Adjusted Life Years in Older Adults With Depressive Symptoms and Chronic Medical Disorders
Unützer, J., Patrick, D. L., Diehr, P. H., Simon, G., Grembowski, D. E., & Katon, W. J. (2000) · International Psychogeriatrics · doi:10.1017/s1041610200006177 · Cited by 193 · see citing works
Insurance Coverage, Medical Conditions, and Visits to Alternative Medicine Providers
Wolsko, P. M., Eisenberg, D. M., Davis, R. B., Ettner, S. L., & Phillips, R. S. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.3.281 · Cited by 190 · see citing works
Schizophrenia, substance use disorders and medical co-morbidity
Dickey, B., Azeni, H., Weiss, R. D., & Sederer, L. I. (2000) · The Journal of Mental Health Policy and Economics · doi:10.1002/1099-176x(200003)3:1 · Cited by 41 · see citing works
Kumar, A., Thomas, A., Lavretsky, H., Yue, K. T. N., Huda, A., Curran, J. G., Venkatraman, T. N., Estanol, L., Mintz, J., Mega, M. S., et al. (2002) · American Journal of Psychiatry · doi:10.1176/appi.ajp.159.4.630 · Cited by 189 · see citing works
Incontinence Severity and Major Depression in Incontinent Women
Melville, J., Delaney, K. M., Newton, K. M., & Katon, W. J. (2005) · Obstetrics and Gynecology · doi:10.1097/01.aog.0000173985.39533.37 · Cited by 188 · see citing works
Psychiatric disorders in older primary care patients
Lyness, J. M., Caine, E. D., King, D. A., Cox, C., & Yoediono, Z. (1999) · Journal of General Internal Medicine · doi:10.1046/j.1525-1497.1999.00326.x · Cited by 186 · see citing works
Lacasse, Y., Rousseau, L., & Maltais, F. (2001) · Journal of Cardiopulmonary Rehabilitation · doi:10.1097/00008483-200103000-00004 · Cited by 184 · see citing works
Kim, K., & Frongillo, E. A. (2007) · Journal of Nutrition · doi:10.1093/jn/137.4.1005 · Cited by 184 · see citing works
Choi, N. G., Ransom, S., & Wyllie, R. J. (2008) · Aging & Mental Health · doi:10.1080/13607860802343001 · Cited by 176 · see citing works
Outcomes of recognized and unrecognized depression in an international primary care study
Simon, G. E., Goldberg, D. P., Tiemens, B. G., & Üstün, T. B. (1999) · General Hospital Psychiatry · doi:10.1016/s0163-8343(98)00072-3 · Cited by 176 · see citing works
Suicide in Later Life: A Review and Recommendations for Prevention
Conwell, Y. (2001) · Suicide and Life-Threatening Behavior · doi:10.1521/suli.31.1.5.32.24221 · Cited by 176 · see citing works
Preventing Depression in Age-Related Macular Degeneration
Rovner, B. W., Casten, R. J., Hegel, M. T., Leiby, B. E., & Tasman, W. S. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.8.886 · Cited by 176 · see citing works
A Multivariate Analysis of Factors Associated With Depression
Gazmararian, J. A., Baker, D., Parker, R. M., & Blazer, D. G. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.21.3307 · Cited by 173 · see citing works
Melville, J., Walker, E., Katon, W. J., Lentz, G. M., Miller, J. L., & Fenner, D. E. (2002) · American Journal of Obstetrics and Gynecology · doi:10.1067/mob.2002.124839 · Cited by 173 · see citing works
Depression in Japanese community-dwelling elderly?prevalence and association with ADL and QOL
Wada, T., Ishine, M., Sakagami, T., Okumiya, K., Fujisawa, M., Murakami, S., Otsuka, K., Yano, S., Kita, T., & Matsubayashi, K. (2004) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2003.12.003 · Cited by 173 · see citing works
The economic burden of depression in the US: societal and patient perspectives
Greenberg, P. E., & Birnbaum, H. G. (2005) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.6.3.369 · Cited by 166 · see citing works
Kelly, R. H., Russo, J. E., & Katon, W. J. (2001) · General Hospital Psychiatry · doi:10.1016/s0163-8343(01)00129-3 · Cited by 166 · see citing works
Unützer, J., Katon, W. J., Sullivan, M., & Miranda, J. (1999) · Milbank Quarterly · doi:10.1111/1468-0009.00132 · Cited by 163 · see citing works
Mehta, K. M., Simonsick, E. M., Penninx, B. W. J. H., Schulz, R., Rubin, S. M., Satterfield, S., & Yaffe, K. S. (2003) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2003.51158.x · Cited by 162 · see citing works
Maraldi, C., Volpato, S., Penninx, B. W. J. H., Yaffe, K. S., Simonsick, E. M., Strotmeyer, E. S., Cesari, M., Kritchevsky, S. B., Perry, S., Ayonayon, H. N., et al. (2007) · Archives of Internal Medicine · doi:10.1001/archinte.167.11.1137 · Cited by 163 · see citing works
Wada, T., Ishine, M., Sakagami, T., Kita, T., Okumiya, K., Mizuno, K., Rambo, A. T., & Matsubayashi, K. (2005) · Archives of Gerontology and Geriatrics · doi:10.1016/j.archger.2005.03.003 · Cited by 159 · see citing works
Wang, Y., Eliot, M., Koutrakis, P., Gryparis, A., Schwartz, J. D., Coull, B. A., Mittleman, M. A., Milberg, W., Lipsitz, L. A., & Wellenius, G. A. (2014) · Environmental Health Perspectives · doi:10.1289/ehp.1205909 · Cited by 154 · see citing works
Marital Status and Risk for Late Life Depression: A Meta-Analysis of the Published Literature
Yan, X.-Y., Sm, H., Huang, C.-Q., Wu, W.-H., & Qin, Y. (2011) · Journal of International Medical Research · doi:10.1177/147323001103900402 · Cited by 151 · see citing works
Giltay, E. J., Zitman, F. G., & Kromhout, D. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2005.12.027 · Cited by 150 · see citing works
- Authors
- Unützer, J.
- Affiliations
- University of Washington (US)
- Corresponding author
- Unützer, Jürgen
- ORCID
- Unützer, Jürgen
- Venue
- JAMA
- Publisher
- American Medical Association (AMA)
- Published
- 1997-05-28
- Volume
- 277
- Issue
- 20
- Pages
- 1618
- ISSN
- 0002-9955 (ISSN-L)
- 0098-7484
- OpenAlex
- W2153731374
- Cited by
- 697
- References
- 65
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 9 · 2021: 11 · 2020: 17 · 2019: 14 · 2018: 15 · 2017: 8 · 2016: 17 · 2015: 22 · 2014: 12 · 2013: 37 · 2012: 29
- FWCI
- 61.67
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- JAMA (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Mental Health Treatment and Access
- Social Sciences › Economics, Econometrics and Finance › Economics and Econometrics › Health Systems, Economic Evaluations, Quality of Life
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
- Keywords
- depressive symptoms, geriatric depression, health care costs, health maintenance organizations, Medicare enrollees, primary care, chronic disease, mental health service utilization, older adults
- MeSH terms
- Aged, Chronic Disease, Depression, Family Practice, Female, Health Maintenance Organizations, Health Services, Humans, Male, Mental Health Services, Prospective Studies, Regression Analysis, United States, Prevalence, Health Care Costs
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review