Effects of tea or tea extract on metabolic profiles in patients with type 2 diabetes mellitus: a meta‐analysis of ten randomized controlled trials

Li, Yanchuan; Wang, Cheng; Huai, Qingjie; Guo, Fuchuan; Liu, Liyan; Feng, Rennan; Sun, Changhao

doi:10.1002/dmrr.2641

Cited by 80Tea Polyphenols and EffectsNatural Antidiabetic Agents StudiesCoffee research and impacts

Effects of tea or tea extract on metabolic profiles in patients with type 2 diabetes mellitus: a meta‐analysis of ten randomized controlled trials

Li, Yanchuan, Wang, Cheng, Huai, Qingjie, Guo, Fuchuan, Liu, Liyan, Feng, Rennan, Sun, Changhao·2016·Diabetes/Metabolism Research and Reviews

DOI 10.1002/dmrr.2641

Open this paper in CoChat — free account

Abstract

Summary: As consumption of tea has been confirmed as a protective factor for type 2 diabetes mellitus (T2DM), it would be interesting to know if T2DM patients could benefit from tea. Because of small sample sizes and inconsistent results of previous studies, we performed this meta‐analysis to reevaluate the effects of tea or tea extract on all available outcomes in patients with T2DM. We systematically searched electronic databases of PubMed, Cochrane Library and EMBASE to identify randomized controlled trials of tea in T2DM patients up to January 2015. Weight mean differences for the changes in all outcomes were pooled by Review Manager 5.2 (Cochrane Collaboration, Oxford, England). A total of ten trials including 608 subjects were identified. The meta‐analysis found that tea could alleviate the decrease of fasting blood insulin [1.30 U/L, 95% CI (0.36, 2.24)], and reduced waist circumference only in more than 8‐week intervention [−2.70 cm, 95% CI (−4.72, −0.69)], whereas there were no statistically significant differences with regard to homeostasis model of insulin resistance 0.38 (−0.18, 0.95), fasting blood glucose −0.05 mmol/L (−0.51, 0.40), low density lipoprotein‐cholesterol 0.07 mmol/L (−0.15, 0.29), high density lipoprotein‐cholesterol 0.01 mmol/L (−0.08, 0.09), body mass index −0.15 kg/m 2 (−0.50, 0.21), SBP 0.35 mmHg (−3.54, 4.24), DBP −1.02 mmHg (−3.53, 1.48), triglycerides −0.11 mmol/L (−0.28, 0.05) and fasting cholesterol −0.05 mmol/L (−0.20, 0.11) in patients with T2DM, and leptin, ADPN, CRE and UA were also non‐significant. The intervention of tea or tea extraction could maintain a stable fasting blood insulin and reduce waist circumference in the T2DM patients; however, the effects on other outcomes were not significant. Copyright © 2015 John Wiley & Sons, Ltd.

Integrity signals

Registry

Crossref · 10.1002/dmrr.2641

Cites

43 of 43 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Global Prevalence of Diabetes
Wild, S., Roglic, G., Green, A., Sicree, R., & King, H. (2004) · Diabetes Care · doi:10.2337/diacare.27.5.1047 · Cited by 15,297 · see citing works
Global Burden of Diabetes, 1995–2025: Prevalence, numerical estimates, and projections
King, H. O. M., Aubert, R. E., & Herman, W. H. (1998) · Diabetes Care · doi:10.2337/diacare.21.9.1414 · Cited by 6,267 · see citing works
Global estimates of diabetes prevalence for 2013 and projections for 2035
Guariguata, L., Whiting, D. R., Hambleton, I., Beagley, J., Linnenkamp, U., & Shaw, J. E. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2013.11.002 · Cited by 4,642 · see citing works
Tea catechins and polyphenols: Health effects, metabolism, and antioxidant functions
Higdon, J. V., & Frei, B. (2003) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690390826464 · Cited by 1,854 · cited 1× · see citing works
“EGCG as the most abundant compound of catechin in green tea is known with beneficial effects on human health [28].”
Background
Is Oxidative Stress the Pathogenic Mechanism Underlying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited
Ceriello, A., & Motz, E. (2004) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000122852.22604.78 · Cited by 1,378 · see citing works
The chemistry of tea flavonoids
Balentine, D. A., Wiseman, S. A., & Bouwens, L. C. M. (1997) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399709527797 · Cited by 1,130 · see citing works
Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans
Dulloo, A. G., Duret, C., Rohrer, D., Girardier, L., Mensi, N., Fathi, M., Chantre, P., & Vandermander, J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.6.1040 · Cited by 925 · see citing works
The Role of Tea in Human Health: An Update
McKay, D. L., & Blumberg, J. B. (2002) · Journal of the American College of Nutrition · doi:10.1080/07315724.2002.10719187 · Cited by 772 · see citing works
An official ATS statement: Grading the quality of evidence and strength of recommendations in ATS guidelines and recommendations.
Schünemann, H. J., Jaeschke, R., Cook, D. J., Bria, W. F., El-Solh, A. A., Ernst, A., Fahy, B. F., Gould, M. K., Horan, K. L., Krishnan, J. A., et al. (2006) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200602-197st · Cited by 577 · see citing works
Oxidative stress in type 2 diabetes: the role of fasting and postprandial glycaemia
Wright, E., Scism-Bacon, J. L., & Glass, L. C. (2006) · International Journal of Clinical Practice · doi:10.1111/j.1368-5031.2006.00825.x · Cited by 517 · see citing works
Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation
Klaus, S., Pültz, S., Thöne‐Reineke, C., & Wolfram, S. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802926 · Cited by 423 · see citing works
Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes
Sabu, M. C., Smitha, K., & Kuttan, R. (2002) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(02)00217-9 · Cited by 418 · see citing works
The effects of green tea on weight loss and weight maintenance: a meta-analysis
Hursel, R., Viechtbauer, W., & Westerterp‐Plantenga, M. S. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.135 · Cited by 323 · see citing works
A Catechin‐rich Beverage Improves Obesity and Blood Glucose Control in Patients With Type 2 Diabetes
Nagao, T., Meguro, S., Hase, T., Otsuka, K., Komikado, M., Tokimitsu, I., Yamamoto, T., & Yamamoto, K. (2008) · Obesity · doi:10.1038/oby.2008.505 · Cited by 287 · see citing works
Effect of green tea extract on obese women: A randomized, double-blind, placebo-controlled clinical trial
Hsu, C.-H., Tsai, T., Kao, Y.-H., Hwang, K., Tseng, T.-Y., & Chou, P. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.03.007 · Cited by 266 · see citing works
Green and Black Tea Consumption and Risk of Stroke: A Meta-Analysis
Arab, L., Liu, W., & Elashoff, D. (2009) · Stroke · doi:10.1161/strokeaha.108.538470 · Cited by 264 · see citing works
Insulin promoter DNA methylation correlates negatively with insulin gene expression and positively with HbA1c levels in human pancreatic islets
Yang, B. T., Dayeh, T. A., Kirkpatrick, C. L., Taneera, J., Kumar, R., Groop, L., Wollheim, C. B., Nitert, M. D., & Ling, C. (2011) · Diabetologia · doi:10.1007/s00125-010-1967-6 · Cited by 251 · see citing works
Tea Catechin Suppresses Adipocyte Differentiation Accompanied by Down-regulation of PPARγ2 and C/EBPα in 3T3-L1 Cells
Furuyashiki, T., Nagayasu, H., Yukiko, A. O. K. I., Bessho, H., Hashimoto, T., Kanazawa, K., & Ashida, H. (2004) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.68.2353 · Cited by 237 · see citing works
Chronic oxidative stress as a mechanism for glucose toxicity of the beta cell in type 2 diabetes
Robertson, R. P., Zhou, H., Zhang, T., & Harmon, J. S. (2007) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-007-0026-5 · Cited by 222 · see citing works
Green tea intake lowers fasting serum total and LDL cholesterol in adults: a meta-analysis of 14 randomized controlled trials
Zheng, X., Xu, Y.-L., Li, S., Liu, X., Hui, R., & Huang, X. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010926 · Cited by 212 · see citing works
Green tea supplementation ameliorates insulin resistance and increases glucose transporter IV content in a fructose-fed rat model
Wu, L.-Y., Juan, C., Hwang, L. S., Hsu, Y.-P., Ho, P., & Ho, L. (2004) · European Journal of Nutrition · doi:10.1007/s00394-004-0450-x · Cited by 204 · see citing works
Effects of encapsulated green tea and Guarana extracts containing a mixture of epigallocatechin-3-gallate and caffeine on 24 h energy expenditure and fat oxidation in men
Bérubé-Parent, S., Pelletier, C., Doré, J., & Tremblay, A. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20051502 · Cited by 202 · see citing works
Randomized controlled trial for an effect of green tea-extract powder supplementation on glucose abnormalities
Fukino, Y., Ikeda, A., Maruyama, K., Aoki, N., Okubo, T., & Iso, H. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602806 · Cited by 179 · see citing works
Effects of green tea consumption on inflammation, insulin resistance and pulse wave velocity in type 2 diabetes patients
Ryu, O. H., Lee, J., Lee, K. W., Kim, H. Y., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.08.001 · Cited by 166 · see citing works
Antihyperglycemic Effect of Oolong Tea in Type 2 Diabetes
Hosoda, K., Wang, M.-F., Liao, M.-L., Chuang, C.-K., Iha, M., Clevidence, B. A., & Yamamoto, S. (2003) · Diabetes Care · doi:10.2337/diacare.26.6.1714 · Cited by 163 · see citing works
The phytochemical, EGCG , extends lifespan by reducing liver and kidney function damage and improving age‐associated inflammation and oxidative stress in healthy rats
Niu, Y., Na, L., Feng, R., Gong, L., Zhao, Y., Li, Q., Li, Y., & Sun, C. (2013) · Aging Cell · doi:10.1111/acel.12133 · Cited by 162 · see citing works
Self-citation
Effects of Green Tea Extract on Insulin Resistance and Glucagon-Like Peptide 1 in Patients with Type 2 Diabetes and Lipid Abnormalities: A Randomized, Double-Blinded, and Placebo-Controlled Trial
Liu, C.-Y., Huang, C.-J., Huang, L.-H., Chen, I.-J., Chiu, J.-P., & Hsu, C.-H. (2014) · PLoS ONE · doi:10.1371/journal.pone.0091163 · Cited by 157 · see citing works
Black and green tea consumption and the risk of coronary artery disease: a meta-analysis
Wang, Z., Zhou, B., Wang, Y., Gong, Q.-Y., Wang, Q., Yan, J.-J., Gao, W., & Wang, L. (2011) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.005363 · Cited by 152 · see citing works
Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials
Zheng, X.-X., Xu, Y.-L., Li, S.-H., Hui, R., Wu, Y.-J., & Huang, X.-H. (2013) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.111.032573 · Cited by 146 · see citing works
The effect of an extract of green and black tea on glucose control in adults with type 2 diabetes mellitus: double-blind randomized study
MacKenzie, T. A., Leary, L., & Brooks, W. B. (2007) · Metabolism · doi:10.1016/j.metabol.2007.05.018 · Cited by 141 · see citing works
Does supplementation with green tea extract improve insulin resistance in obese type 2 diabetics? A randomized, double-blind, and placebo-controlled clinical trial.
Hsu, C.-H., Liao, Y.-L., Lin, S.-C., Tsai, T., Huang, C.-J., & Chou, P. (2011) · PubMed · Cited by 140 · see citing works
Daily Consumption of an Aqueous Green Tea Extract Supplement Does Not Impair Liver Function or Alter Cardiovascular Disease Risk Biomarkers in Healthy Men
Frank, J., George, T. W., Lodge, J. K., Rodriguez‐Mateos, A., Spencer, J. P. E., Minihane, A. M., & Rimbach, G. H. (2008) · Journal of Nutrition · doi:10.3945/jn.108.096412 · Cited by 133 · see citing works
Consumption of coffee, green tea, oolong tea, black tea, chocolate snacks and the caffeine content in relation to risk of diabetes in Japanese men and women
Oba, S., Nagata, C., Nakamura, K., Fujii, K., Kawachi, T., Takatsuka, N., & Shimizu, H. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509991966 · Cited by 132 · see citing works
Effects of Chinese Green Tea on Weight, and Hormonal and Biochemical Profiles in Obese Patients With Polycystic Ovary Syndrome—A Randomized Placebo-Controlled Trial
Chan, C. C. W., Koo, M. W. L., Ng, E. H. Y., Tang, O., Yeung, W. S. B., & Ho, P. (2005) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2005.10.006 · Cited by 124 · see citing works
Effect of green tea consumption on blood pressure: A meta-analysis of 13 randomized controlled trials
Peng, X., Zhou, R., Wang, B., Yu, X., Yang, X., Liu, K., & Mi, M. (2014) · Scientific Reports · doi:10.1038/srep06251 · Cited by 119 · see citing works
Epigallocatechin gallate, a constituent of green tea, suppresses cytokine-induced pancreatic β-cell damage
Han, M. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.19 · Cited by 119 · see citing works
Standardized capsule of Camellia sinensis lowers cardiovascular risk factors in a randomized, double-blind, placebo-controlled study
Nantz, M. P., Rowe, C. A., Bukowski, J. F., & Percival, S. S. (2008) · Nutrition · doi:10.1016/j.nut.2008.07.018 · Cited by 116 · see citing works
Tea consumption and risk of type 2 diabetes: a dose–response meta-analysis of cohort studies
Yang, W.-S., Wang, W.-Y., Fan, W.-Y., Deng, Q., & Wang, X. (2014) · British Journal of Nutrition · doi:10.1017/s0007114513003887 · Cited by 103 · see citing works
Potential Health Benefits of Green Tea (Camellia sinensis): A Narrative Review
Pastore, R. L., & Fratellone, P. M. (2006) · EXPLORE · doi:10.1016/j.explore.2006.08.008 · Cited by 87 · see citing works
Regular Daily Intake of Black Tea Improves Oxidative Stress Biomarkers and Decreases Serum C-Reactive Protein Levels in Type 2 Diabetic Patients
Neyestani, T. R., Shariatzade, N., Kalayi, A., Gharavi, A., Khalaji, N., Dadkhah-Piraghaj, M., Zowghi, T., Haidari, H., & Shab‐Bidar, S. (2010) · Annals of Nutrition and Metabolism · doi:10.1159/000312666 · Cited by 53 · see citing works
The effects of green tea consumption on metabolic and anthropometric indices in patients with Type 2 diabetes.
Mousavi, A., Vafa, M., Neyestani, T. R., Khamseh, M., & Hoseini, F. S. (2013) · Europe PMC (PubMed Central) · Cited by 44 · see citing works
High oolong tea consumption predicts future risk of diabetes among Japanese male workers: a prospective cohort study
Hayashino, Y., Fukuhara, S., Okamura, T., Tanaka, T., & Ueshima, H. (2011) · Diabetic Medicine · doi:10.1111/j.1464-5491.2011.03239.x · Cited by 42 · see citing works

Flagged first, then by citations

Sorted by citations

Dietary and Policy Priorities for Cardiovascular Disease, Diabetes, and Obesity: A Comprehensive Review
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
The effects of ginger intake on weight loss and metabolic profiles among overweight and obese subjects: A systematic review and meta-analysis of randomized controlled trials
Maharlouei, N., Tabrizi, R., Lankarani, K. B., Rezaianzadeh, A., Akbari, M., Kolahdooz, F., Rahimi, M., Keneshlou, F., & Asemi, Z. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1427044 · Cited by 99 · see citing works

Authors: Li, Y., Wang, C., Huai, Q., Guo, F., Liu, L., Feng, R., & Sun, C.
Affiliations: Harbin Medical University (CN)
Department of Virus Harbin Center for Disease Control and Prevention Harbin China
Corresponding author: Feng, Rennan
Sun, Changhao
ORCID: Li, Yanchuan
Wang, Cheng
Guo, Fuchuan
Liu, Liyan
Feng, Rennan
Sun, Changhao
Venue: Diabetes/Metabolism Research and Reviews
Publisher: Wiley
Published: 2015-04-21
Volume: 32
Issue: 1
Pages: 2-10
ISSN: 1520-7552 (ISSN-L)
1520-7560
DOI: 10.1002/dmrr.2641
OpenAlex: W2115775125
Cited by: 80
References: 43
Citations by year: 2026: 1 · 2025: 3 · 2024: 12 · 2023: 8 · 2022: 8 · 2021: 11 · 2020: 8 · 2019: 8 · 2018: 8 · 2017: 10 · 2016: 3
FWCI: 1.03
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Diabetes/Metabolism Research and Reviews (publishedVersion)
PubMed (publishedVersion)
Funders: General Financial Grant from China Postdoctoral Science Foundation (2013M531076)
National 12th Five-Year Scientific and Technical Support Program of China (2012BAI02B02)
National Natural Science Fund of China (81202184)
Topics: Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
Health Sciences › Medicine › Pharmacology › Coffee research and impacts
Keywords: tea, tea extract, type 2 diabetes, fasting insulin, insulin resistance, waist circumference, body mass index, serum lipids, blood glucose, blood pressure, leptin, adiponectin, creatinine, uric acid, metabolic profile, lifestyle intervention, diabetes prevention and management, cardiovascular risk factors, glycemic control, dyslipidemia
MeSH terms: Appetite Depressants, Appetite Regulation, Diabetes Mellitus, Type 2, Diet, Diabetic, Diet, Reducing, Glycated Hemoglobin, Humans, Hyperglycemia, Hyperlipidemias, Hypoglycemic Agents, Insulin Resistance, Plant Extracts, Tea, Weight Loss, Randomized Controlled Trials as Topic, Plant Leaves, Dietary Supplements, Camellia sinensis, Overweight, Waist Circumference

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Effects of tea or tea extract on metabolic profiles in patients with type 2 diabetes mellitus: a meta‐analysis of ten randomized controlled trials

Abstract

Integrity signals

Claims the paper makes

Cites

Cited by

Related

Record

About these checks