Effects of green tea catechins with or without caffeine on glycemic control in adults: a meta-analysis of randomized controlled trials
Open accessAbstract
Background The effect of green tea catechins (GTCs) with or without caffeine on glycemic control is controversial.Objective We aimed to identify and quantify the effects of GTCs or GTC-caffeine mixtures on glucose metabolism in adults.Design A comprehensive literature search was conducted to identify relevant trials of GTCs with or without caffeine on markers of glycemic control [fasting blood glucose (FBG), fasting blood insulin (FBI), glycated hemoglobin (Hb A1c), and homeostatic model assessment of insulin resistance (HOMA-IR)]. Weighted mean differences were calculated for net changes by using fixed-effects models. Prespecified subgroup analyses were performed to explore the influence of covariates on net changes in FBG and FBI concentrations.Results Twenty-two eligible randomized controlled trials with 1584 subjects were identified. Pooled analyses showed that FBG (-1.48 mg/dL; 95% CI: -2.57, -0.40 mg/dL) decreased significantly with GTCs with or without caffeine, whereas FBI (0.04 μU/mL; 95% CI: -0.36, 0.45 μU/mL), Hb A1c (-0.04%; 95% CI: -0.15, 0.08%), and HOMA-IR (-0.05; 95% CI: -0.37, 0.26) did not. Subgroup analyses indicated that the glucose-lowering effect was apparent when the duration of follow-up was over a median of 12 wk. Overall, no significant heterogeneity was detected for FBG, FBI, Hb A1c, or HOMA-IR.Conclusions The meta-analysis showed that the administration of GTCs with or without caffeine resulted in a significant reduction in FBG. The limited data available on GTCs did not support a positive effect on FBI, Hb A1c, or HOMA-IR. Thus, more large and well-designed trials are needed in the future. This trial was registered at http://www.crd.york.ac.uk/prospero as CRD42012002139.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Others have found cardiometabolic improvement effects of anthocyanin, catechin, curcumin, flavanol, genistein, and quercetin.
“Others have also found cardiometabolic improvement effects of anthocyanin,32 catechin,33,34 curcumin,35 flavanol,36 genistein,37 and quercetin.38,39”
From Micronutrient Supplementation to Reduce Cardiovascular Risk (2022) · cites this paper as [33]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139 · see citing works
Meta-analysis in clinical trials
DerSimonian, R., & Laird, N. (1986) · Controlled Clinical Trials · doi:10.1016/0197-2456(86)90046-2 · Cited by 39,552 · see citing works
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048 · see citing works
Moher, D., Pham, B., Jones, A., Cook, D. J., Jadad, A. R., Moher, M., Tugwell, P., & Klassen, T. P. (1998) · The Lancet · doi:10.1016/s0140-6736(98)01085-x · Cited by 3,560 · see citing works
Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes
Malik, V. S., Popkin, B. M., Bray, G. A., Després, J.-P., Willett, W. C., & Hu, F. B. (2010) · Diabetes Care · doi:10.2337/dc10-1079 · Cited by 2,116 · see citing works
The chemistry of tea flavonoids
Balentine, D. A., Wiseman, S. A., & Bouwens, L. C. M. (1997) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408399709527797 · Cited by 1,130 · see citing works
American Diabetes Association (2003) · Diabetes Care · doi:10.2337/diacare.26.2007.s106 · Cited by 1,034 · see citing works
Dulloo, A. G., Duret, C., Rohrer, D., Girardier, L., Mensi, N., Fathi, M., Chantre, P., & Vandermander, J. (1999) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/70.6.1040 · Cited by 925 · see citing works
Goldstein, D. E., Little, R. R., Lorenz, R. A., Malone, J. I., Nathan, D., Peterson, C. M., & Sacks, D. B. (2004) · Diabetes Care · doi:10.2337/diacare.27.7.1761 · Cited by 625 · see citing works
Bonora, E., Formentini, G., Calcaterra, F., Lombardi, S., Marini, F., Zenari, L., Saggiani, F., Poli, M., Perbellini, S., Raffaelli, A., et al. (2002) · Diabetes Care · doi:10.2337/diacare.25.7.1135 · Cited by 604 · see citing works
A Green Tea Extract High in Catechins Reduces Body Fat and Cardiovascular Risks in Humans
Nagao, T., Hase, T., & Tokimitsu, I. (2007) · Obesity · doi:10.1038/oby.2007.176 · Cited by 524 · see citing works
Modulation of Endocrine Systems and Food Intake by Green Tea Epigallocatechin Gallate*
Kao, Y.-H., Hiipakka, R. A., & Liao, S. (2000) · Endocrinology · doi:10.1210/endo.141.3.7368 · Cited by 510 · see citing works
Coffee, Decaffeinated Coffee, and Tea Consumption in Relation to Incident Type 2 Diabetes Mellitus
Huxley, R. (2009) · Archives of Internal Medicine · doi:10.1001/archinternmed.2009.439 · Cited by 471 · see citing works
Nagao, T., Komine, Y., Soga, S., Meguro, S., Hase, T., Tanaka, Y., & Tokimitsu, I. (2005) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/81.1.122 · Cited by 467 · see citing works
Iso, H., Date, C., Wakai, K., Fukui, M., Tamakoshi, A., & and the JACC Study Group* (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-144-8-200604180-00005 · Cited by 462 · see citing works
Insulin-like Biological Activity of Culinary and Medicinal Plant Aqueous Extracts in Vitro
Broadhurst, C. L., Polansky, M. M., & Anderson, R. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9904517 · Cited by 429 · see citing works
Klaus, S., Pültz, S., Thöne‐Reineke, C., & Wolfram, S. (2005) · International Journal of Obesity · doi:10.1038/sj.ijo.0802926 · Cited by 423 · see citing works
Chow, H.-H. S., Hakim, I. A., Vining, D. R., Crowell, J. A., Ranger-Moore, J., Chew, W. M., Celaya, C. A., Rodney, S. R., Hara, Y., & Alberts, D. S. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-04-2549 · Cited by 400 · see citing works
Cellular and in vivo hepatotoxicity caused by green tea phenolic acids and catechins
Galati, G., Lin, A. L., Sultan, A. M., & O'Brien, P. J. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.09.014 · Cited by 383 · see citing works
Anderson, R. A., & Polansky, M. M. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020514c · Cited by 366 · see citing works
Basu, A., Sanchez, K., Leyva, M. J., Wu, M., Betts, N. M., Aston, C. E., & Lyons, T. J. (2010) · Journal of the American College of Nutrition · doi:10.1080/07315724.2010.10719814 · Cited by 341 · see citing works
Collins, Q. F., Liu, H.-Y., Pi, J., Liu, Z., Quon, M. J., & Cao, W. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m702390200 · Cited by 333 · see citing works
Westerterp‐Plantenga, M. S., Lejeune, M. P. G. M., & Kovacs, E. M. R. (2005) · Obesity Research · doi:10.1038/oby.2005.142 · Cited by 328 · see citing works
The effects of green tea on weight loss and weight maintenance: a meta-analysis
Hursel, R., Viechtbauer, W., & Westerterp‐Plantenga, M. S. (2009) · International Journal of Obesity · doi:10.1038/ijo.2009.135 · Cited by 323 · see citing works
A Catechin‐rich Beverage Improves Obesity and Blood Glucose Control in Patients With Type 2 Diabetes
Nagao, T., Meguro, S., Hase, T., Otsuka, K., Komikado, M., Tokimitsu, I., Yamamoto, T., & Yamamoto, K. (2008) · Obesity · doi:10.1038/oby.2008.505 · Cited by 287 · see citing works
Green tea extract ingestion, fat oxidation, and glucose tolerance in healthy humans
Venables, M., Hulston, C. J., Cox, H. R., & Jeukendrup, A. E. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.3.778 · Cited by 281 · see citing works
Hsu, C.-H., Tsai, T., Kao, Y.-H., Hwang, K., Tseng, T.-Y., & Chou, P. (2008) · Clinical Nutrition · doi:10.1016/j.clnu.2008.03.007 · Cited by 266 · see citing works
Brown, A. L., Lane, J., Coverly, J., Stocks, J., Jackson, S. J., Stephen, A. M., Bluck, L. J. C., Coward, A. W., & Hendrickx, H. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508047727 · Cited by 257 · see citing works
Effects of green tea on weight maintenance after body-weight loss
Kovacs, E. M. R., Lejeune, M. P. G. M., Nijs, I. M. T., & Westerterp‐Plantenga, M. S. (2004) · British Journal Of Nutrition · doi:10.1079/bjn20041061 · Cited by 235 · see citing works
Wolfram, S., Raederstorff, D., Wang, Y., Teixeira, S. R., Elste, V., & Weber, P. (2005) · Annals of Nutrition and Metabolism · doi:10.1159/000084178 · Cited by 202 · see citing works
Phung, O. J., Baker, W. L., Matthews, L. J., Lanosa, M., Thorne, A. M., & Coleman, C. I. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28157 · Cited by 197 · see citing works
Green tea minimally affects biomarkers of inflammation in obese subjects with metabolic syndrome
Basu, A., Du, M., Sanchez, K., Leyva, M. J., Betts, N. M., Blevins, S., Wu, M., Aston, C. E., & Lyons, T. J. (2011) · Nutrition · doi:10.1016/j.nut.2010.01.015 · Cited by 194 · see citing works
Effects of Catechin Enriched Green Tea on Body Composition
Wang, H., Wen, Y., Du, Y., Yan, X., Guo, H., Rycroft, J. A., Boon, N., Kovacs, E. M. R., & Mela, D. J. (2010) · Obesity · doi:10.1038/oby.2009.256 · Cited by 185 · see citing works
Fukino, Y., Ikeda, A., Maruyama, K., Aoki, N., Okubo, T., & Iso, H. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602806 · Cited by 179 · see citing works
Fukino, Y., Shimbo, M., Aoki, N., Okubo, T., & Iso, H. (2005) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.51.335 · Cited by 168 · see citing works
Ryu, O. H., Lee, J., Lee, K. W., Kim, H. Y., Seo, J. A., Kim, S. G., Kim, N. H., Baik, S. H., Choi, D. S., & Choi, K. M. (2006) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2005.08.001 · Cited by 166 · see citing works
Sano, M., Tabata, M., Suzuki, M., Degawa, M., Miyase, T., & Maeda‐Yamamoto, M. (2001) · The Analyst · doi:10.1039/b102541b · Cited by 163 · see citing works
Global complication rates of type 2 diabetes in Indigenous peoples: A comprehensive review
Naqshbandi, M., Harris, S. B., Esler, J. G., & Antwi-Nsiah, F. (2008) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2008.07.017 · Cited by 161 · see citing works
Brown, A. L., Lane, J., Holyoak, C. D., Nicol, B., Mayes, A. E., & Dadd, T. (2011) · British Journal Of Nutrition · doi:10.1017/s0007114511002376 · Cited by 145 · see citing works
MacKenzie, T. A., Leary, L., & Brooks, W. B. (2007) · Metabolism · doi:10.1016/j.metabol.2007.05.018 · Cited by 141 · see citing works
Hsu, C.-H., Liao, Y.-L., Lin, S.-C., Tsai, T., Huang, C.-J., & Chou, P. (2011) · PubMed · Cited by 140 · see citing works
Can EGCG Reduce Abdominal Fat in Obese Subjects?
Hill, A. M., Coates, A. M., Buckley, J. D., Ross, R., Thielecke, F., & Howe, P. R. C. (2007) · Journal of the American College of Nutrition · doi:10.1080/07315724.2007.10719628 · Cited by 139 · see citing works
Frank, J., George, T. W., Lodge, J. K., Rodriguez‐Mateos, A., Spencer, J. P. E., Minihane, A. M., & Rimbach, G. H. (2008) · Journal of Nutrition · doi:10.3945/jn.108.096412 · Cited by 133 · see citing works
Unanticipated Benefits of CAM Therapies for Back Pain: An Exploration of Patient Experiences
Hsu, C. W., BlueSpruce, J., Sherman, K. J., & Cherkin, D. C. (2010) · The Journal of Alternative and Complementary Medicine · doi:10.1089/acm.2009.0188 · Cited by 128 · see citing works
Chan, C. C. W., Koo, M. W. L., Ng, E. H. Y., Tang, O., Yeung, W. S. B., & Ho, P. (2005) · Journal of the Society for Gynecologic Investigation · doi:10.1016/j.jsgi.2005.10.006 · Cited by 124 · see citing works
LeRoith, D., Novosyadlyy, R., Gallagher, E. J., Lann, D. E., Vijayakumar, A., & Yakar, S. (2008) · Experimental and Clinical Endocrinology & Diabetes · doi:10.1055/s-2008-1081488 · Cited by 120 · see citing works
Metabolic effects of green tea and of phases of weight loss
DIEPVENS, K., KOVACS, E., VOGELS, N., & WESTERTERPPLANTENGA, M. (2006) · Physiology & Behavior · doi:10.1016/j.physbeh.2005.09.013 · Cited by 113 · see citing works
Josic, J., Olsson, A. T., Wickeberg, J., Lindstedt, S., & Hlebowicz, J. (2010) · Nutrition Journal · doi:10.1186/1475-2891-9-63 · Cited by 104 · see citing works
Roghani, M., & Baluchnejadmojarad, T. (2009) · Pathophysiology · doi:10.1016/j.pathophys.2009.07.004 · Cited by 98 · see citing works
Di Pierro, F., Menghi, A. B., Barreca, A., Lucarelli, M., & Calandrelli, A. (2009) · PubMed · Cited by 91 · see citing works
Anti-obesity Effects of Tea Catechins in Humans.
Hase, T., KOMINE, Y., Meguro, S., TAKEDA, Y., Takahashi, H., Matsui, Y., INAOKA, S., Katsuragi, Y., Tokimitsu, I., Shimasaki, H., et al. (2001) · Journal of Oleo Science · doi:10.5650/jos.50.599 · Cited by 84 · see citing works
Hursel, R., & Westerterp‐Plantenga, M. S. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.27043 · Cited by 81 · see citing works
Stendell-Hollis, N. R., Thomson, C. A., Thompson, P. A., Bea, J. W., CUSSLER, E. C., & Hakim, I. A. (2010) · Journal of Human Nutrition and Dietetics · doi:10.1111/j.1365-277x.2010.01078.x · Cited by 76 · see citing works
Mann, J. I. (2006) · Nutrition Reviews · doi:10.1111/j.1753-4887.2006.tb00227.x · Cited by 71 · see citing works
Sone, T., Kuriyama, S., Nakaya, N., Hozawa, A., Shimazu, T., Nomura, K., Rikimaru, S., & Tsuji, I. (2011) · Food & Nutrition Research · doi:10.3402/fnr.v55i0.8326 · Cited by 60 · see citing works
Eichenberger, P. A., Colombani, P. C., & Mettler, S. (2009) · International Journal for Vitamin and Nutrition Research · doi:10.1024/0300-9831.79.1.24 · Cited by 58 · see citing works
The Effects of EGCG on Fat Oxidation and Endurance Performance in Male Cyclists
Dean, S., Braakhuis, A. J., & Paton, C. D. (2009) · International Journal of Sport Nutrition and Exercise Metabolism · doi:10.1123/ijsnem.19.6.624 · Cited by 58 · see citing works
Sakurai, N., Mochizuki, K., Kameji, H., Shimada, M., & Goda, T. (2009) · Nutrition · doi:10.1016/j.nut.2009.02.012 · Cited by 55 · see citing works
Rondanelli, M., Opizzi, A., Solerte, S. B., Trotti, R., Klersy, C., & Cazzola, R. (2008) · British Journal Of Nutrition · doi:10.1017/s0007114508024008 · Cited by 44 · see citing works
Panagiotakos, D. B., Lionis, C. D., Zeimbekis, A., Gelastopoulou, K., Papairakleous, N., Das, U. N., & Polychronopoulos, E. (2009) · Yonsei Medical Journal · doi:10.3349/ymj.2009.50.1.31 · Cited by 44 · see citing works
Takabayashi, F., Tahara, S., Kaneko, T., & Harada, N. (2004) · BioFactors · doi:10.1002/biof.552210165 · Cited by 36 · see citing works
The Association between Concentrations of Green Tea and Blood Glucose Levels
Maruyama, K., Iso, H., Sasaki, S., & Fukino, Y. (2009) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.08-13 · Cited by 32 · see citing works
Effect of Green Tea Flavonoid Supplementation on Features of Metabolic Syndrome (MeS)
Penugonda, K., Sanchez, K., Leyva, M. J., Aston, C. E., Lyons, T. J., & Basu, A. (2009) · The FASEB Journal · doi:10.1096/fasebj.23.1_supplement.lb446 · Cited by 4 · see citing works
Flagged first, then by citations
6 of the 69 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- Hase T, Komine Y, Meguro S, Takeda Y, Takahashi H, Matsui Y, Inaoka S, Katsuragi Y, Tokimitsu I, Shimasaki H, et al. Antiobesity effects of tea catechins in humans. J Oleo Sci 2001;50:599-605.
- Mirzaei K, Hossein-Nezhad A, Karimi M, Hosseinzadeh-Attar MJ, Jafari N, Najmafshar A, Larijani B. Effect of green tea extract on bone turnover markers in type 2 diabetic patients; a double-blind, placebo- controlled clinical trial study. Daru 2009;17:38-44.
- Tsuchida T, Itakura H, Nakamura H. Reduction of body fat in humans by long-term ingestion of catechins. Prog Med 2002;22:2189-203.
- Higgins JPT, Green S, eds. Cochrane handbook for systematic reviews of interventions. Version 5.0.2. New York, NY: Wiley, 2009.
- Mohammadi S, Hosseinzadeh Attar MJ, Karimi M, Hosseinnezhad A, Eshraghian MR, Hosseini SH, Rahmani M, Karimi F, Jafari N. The effects of green tea extract on serum adiponectin concentration and insulin resistance in patients with type 2 diabetes mellitus. J Zanjan University of Medical Sciences and Health Services 2010;18:44-57.
- Kozuma K, Chikama A, Hishino E, Kataoka K, Mori K, Hase T, Katsuragi Y, Tokimitsu I, Nakamura H. Effect of intake of a beverage containing 540mg catechins on the body composition of obese women and men. Prog Med 2005;25:1945-57.
Cited by
Sorted by citations
Mozaffarian, D. (2016) · Circulation · doi:10.1161/circulationaha.115.018585 · Cited by 2,216 · see citing works
The effects of polyphenols and other bioactives on human health
Fraga, C. G., Croft, K. D., Kennedy, D. O., & Tomás-Barberán, F. A. (2019) · Food & Function · doi:10.1039/c8fo01997e · Cited by 1,150 · see citing works
Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes
Kolb, H., & Martin, S. (2017) · BMC Medicine · doi:10.1186/s12916-017-0901-x · Cited by 735 · see citing works
Dietary factors affecting polyphenol bioavailability
Bohn, T. (2014) · Nutrition Reviews · doi:10.1111/nure.12114 · Cited by 577 · see citing works
Polyphenols and Glycemic Control
Kim, Y., Keogh, J. B., & Clifton, P. M. (2016) · Nutrients · doi:10.3390/nu8010017 · Cited by 557 · see citing works
Functional Foods and Lifestyle Approaches for Diabetes Prevention and Management
Alkhatib, A., Tsang, C., Tiss, A., Bahorun, T., Arefanian, H., Barake, R., Khadir, A., & Tuomilehto, J. (2017) · Nutrients · doi:10.3390/nu9121310 · Cited by 376 · see citing works
Guasch-Ferré, M., Merino, J., Sun, Q., Fitó, M., & Salas-Salvadó, J. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6723931 · Cited by 297 · see citing works
Dietary polyphenols and type 2 diabetes: Human Study and Clinical Trial
Cao, H., Ou, J., Chen, L., Zhang, Y., Szkudelski, T., Delmas, D., Daglia, M., & Xiao, J. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1492900 · Cited by 293 · see citing works
Peluso, I., & Serafini, M. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13649 · Cited by 240 · see citing works
Functional foods and dietary supplements for the management of dyslipidaemia
Hunter, P. M., & Hegele, R. A. (2017) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2016.210 · Cited by 226 · see citing works
Micronutrient Supplementation to Reduce Cardiovascular Risk
An, P., Wan, S., Luo, Y., Luo, J., Zhang, X., Zhou, S., Xu, T., He, J., Mechanick, J. I., Wu, W.-C., et al. (2022) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2022.09.048 · Cited by 189 · see citing works
Hussain, T., Tan, B., Murtaza, G., Liu, G., Rahu, N., Kalhoro, M. S., Kalhoro, D. H., Adebowale, T. O., Mazhar, M. U., Rehman, Z. U., et al. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104629 · Cited by 202 · see citing works
Chrononutrition in the management of diabetes
Henry, C. J., Kaur, B., & Quek, R. Y. C. (2020) · Nutrition & Diabetes · doi:10.1038/s41387-020-0109-6 · Cited by 174 · see citing works
Grosso, G., Stepaniak, U., Micek, A., Stefler, D., Bobák, M., & Pająk, A. (2016) · European Journal of Nutrition · doi:10.1007/s00394-016-1187-z · Cited by 153 · see citing works
Dietary and policy priorities to reduce the global crises of obesity and diabetes
Mozaffarian, D. (2020) · Nature Food · doi:10.1038/s43016-019-0013-1 · Cited by 133 · see citing works
Tabrizi, R., Saneei, P., Lankarani, K. B., Akbari, M., Kolahdooz, F., Esmaillzadeh, A., Nadi-Ravandi, S., Mazoochi, M., & Asemi, Z. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1507996 · Cited by 121 · see citing works
Herbal Medications in Cardiovascular Medicine
Liperoti, R., Vetrano, D. L., Bernabei, R., & Onder, G. (2017) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2016.11.078 · Cited by 120 · see citing works
Effects of Polyphenols on Insulin Resistance
Williamson, G., & Sheedy, K. (2020) · Nutrients · doi:10.3390/nu12103135 · Cited by 118 · see citing works
The role of nutraceuticals in the prevention of cardiovascular disease
Sosnowska, B., Penson, P. E., & Banach, M. (2017) · Cardiovascular Diagnosis and Therapy · doi:10.21037/cdt.2017.03.20 · Cited by 113 · see citing works
Krawczyk, M., Burzyńska-Pędziwiatr, I., Woźniak, L. A., & Bukowiecka‐Matusiak, M. (2023) · Biomolecules · doi:10.3390/biom13091402 · Cited by 114 · see citing works
Tea consumption and risk of type 2 diabetes: a dose–response meta-analysis of cohort studies
Yang, W.-S., Wang, W.-Y., Fan, W.-Y., Deng, Q., & Wang, X. (2014) · British Journal of Nutrition · doi:10.1017/s0007114513003887 · Cited by 103 · see citing works
Flavonoids and Insulin-Resistance: From Molecular Evidences to Clinical Trials
Russo, B., Picconi, F., Malandrucco, I., & Frontoni, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092061 · Cited by 99 · see citing works
The hypoglycemic potential of phenolics from functional foods and their mechanisms
Головинская, О., & Wang, C. (2022) · Food Science and Human Wellness · doi:10.1016/j.fshw.2022.10.020 · Cited by 99 · see citing works
Coffee, Tea, and Cocoa and Risk of Stroke
Larsson, S. C. (2013) · Stroke · doi:10.1161/strokeaha.113.003131 · Cited by 97 · see citing works
Qiao, C., Xu, B., Han, Y., Wang, J., Wang, X., Liu, L., Liu, W., Wan, S., Tan, H., Liu, Y., et al. (2018) · Agronomy for Sustainable Development · doi:10.1007/s13593-017-0485-z · Cited by 96 · see citing works
Systems biology of personalized nutrition
van Ommen, B., van den Broek, T., de Hoogh, I. M., van Erk, M., van Someren, E. P., Rankouhi, T. R., Anthony, J. C., Hogenelst, K., Pasman, W. J., Boorsma, A., et al. (2017) · Nutrition Reviews · doi:10.1093/nutrit/nux029 · Cited by 95 · see citing works
Vascular and Metabolic Actions of the Green Tea Polyphenol Epigallocatechin Gallate
Keske, M. A., Ng, H., Premilovac, D., Rattigan, S., Kim, J., Munir, K. M., Yang, P., & Quon, M. J. (2014) · Current Medicinal Chemistry · doi:10.2174/0929867321666141012174553 · Cited by 92 · see citing works
Grosso, G., Stepaniak, U., Micek, A., Kozela, M., Stefler, D., Bobák, M., & Pająk, A. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517001805 · Cited by 91 · see citing works
Trends of tea in cardiovascular health and disease: A critical review
Fang, J., Sureda, A., Sanches-Silva, A. T., Khan, F., Xu, S., & Nabavi, S. M. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.04.001 · Cited by 91 · see citing works
Effects of tea intake on blood pressure: a meta-analysis of randomised controlled trials
Liu, G., Mi, X.-N., Zheng, X.-X., Xu, Y.-L., Lu, J., & Huang, X.-H. (2014) · British Journal of Nutrition · doi:10.1017/s0007114514001731 · Cited by 85 · see citing works
Self-citationSaito, E., Inoue, M., Sawada, N., Shimazu, T., Yamaji, T., Iwasaki, M., Sasazuki, S., Noda, M., Iso, H., Tsugane, S., et al. (2015) · Annals of Epidemiology · doi:10.1016/j.annepidem.2015.03.007 · Cited by 85 · see citing works
Green tea and cancer and cardiometabolic diseases: a review of the current epidemiological evidence
Abe, S. K., & Inoue, M. (2020) · European Journal of Clinical Nutrition · doi:10.1038/s41430-020-00710-7 · Cited by 84 · see citing works
Li, Y., Wang, C., Huai, Q., Guo, F., Liu, L., Feng, R., & Sun, C. (2016) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.2641 · Cited by 80 · see citing works
Gentile, D., Fornai, M., Pellegrini, C., Colucci, R., Blandizzi, C., & Antonioli, L. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422418000082 · Cited by 80 · see citing works
Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate
Ortega, Á., Berná, G., Rojas, A., Martı́n, F., & Soria, B. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18061188 · Cited by 82 · see citing works
The Benefits of Flavonoids in Diabetic Retinopathy
Matos, A. L., Bruno, D. F., Ambrósio, A. F., & Santos, P. F. (2020) · Nutrients · doi:10.3390/nu12103169 · Cited by 71 · see citing works
Mechanisms Underlying the Antidiabetic Activities of Polyphenolic Compounds: A Review
Nie, T., & Cooper, G. J. S. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.798329 · Cited by 70 · see citing works
Bhatti, S. K., O’Keefe, J. H., & Lavie, C. J. (2013) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e328365b9a0 · Cited by 70 · see citing works
Kellogg, J. J., Graf, T. N., Paine, M. F., McCune, J. S., Kvalheim, O. M., Oberlies, N. H., & Cech, N. B. (2017) · Journal of Natural Products · doi:10.1021/acs.jnatprod.6b01156 · Cited by 67 · see citing works
Fu, J., Zhang, L., Li, W., Zhang, Y., Zhang, Y., Liu, F., & Zou, L. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.130697 · Cited by 66 · see citing works
Palma-Duran, S. A., Vlassopoulos, A., Lean, M. E. J., Govan, L., & Combet, E. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.973932 · Cited by 66 · see citing works
Păun, G., Neagu, E., Albu, C., Savin, S., & Radu, G. L. (2020) · ACS Omega · doi:10.1021/acsomega.0c00929 · Cited by 65 · see citing works
Hibi, M., Takase, H., Iwasaki, M., Osaki, N., & Katsuragi, Y. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.03.012 · Cited by 64 · see citing works
Wan, C. C., Ouyang, J., Li, M., Rengasamy, K. R. R., & Liu, Z. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2157372 · Cited by 64 · see citing works
Takahashi, M., Miyashita, M., Suzuki, K., Bae, S.-R., Kim, H., Wakisaka, T., Matsui, Y., Takeshita, M., & Yasunaga, K. (2014) · British Journal Of Nutrition · doi:10.1017/s0007114514002530 · Cited by 63 · see citing works
Coffee and green tea consumption is associated with insulin resistance in Japanese adults
Pham, N. M., Nanri, A., Kochi, T., Kuwahara, K., Tsuruoka, H., Kurotani, K., Akter, S., Kabe, I., Sato, M., Hayabuchi, H., et al. (2013) · Metabolism · doi:10.1016/j.metabol.2013.11.008 · Cited by 62 · see citing works
Green tea changes serum and liver metabolomic profiles in mice with high‐fat diet‐induced obesity
Lee, L., Choi, J. H., Sung, M. J., Hur, J., Hur, H. J., Park, J. D., Kim, Y., Gu, E., Min, B., & Kim, H. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201400470 · Cited by 60 · see citing works
Diabetes and Alzheimer’s Disease: Can Tea Phytochemicals Play a Role in Prevention?
Fernando, W. M. A. D. B., Somaratne, G., Goozee, K. G., Williams, S., Singh, H., & Martins, R. N. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161200 · Cited by 55 · see citing works
Melino, S., Leo, S., & Papajani, V. T. (2019) · Nutrients · doi:10.3390/nu11071581 · Cited by 56 · see citing works
Yadav, R., Kumar, D., Kumari, A., & Yadav, S. K. (2014) · Europe PMC (PubMed Central) · Cited by 55 · see citing works
Raimundo, A., Félix, F. I. B., Andrade, R., García‐Conesa, M., González‐Sarrías, A., Gilsa-Lopes, J., Ó, D. D., Raimundo, A., Ribeiro, R. T., Rodriguez‐Mateos, A., et al. (2020) · European Journal of Nutrition · doi:10.1007/s00394-020-02189-1 · Cited by 55 · see citing works
Xu, R., Bai, Y., Yang, K., & Chen, G. (2020) · Nutrition & Metabolism · doi:10.1186/s12986-020-00469-5 · Cited by 52 · see citing works
The therapeutic potential of matcha tea: A critical review on human and animal studies
Sokary, S., Al‐Asmakh, M., Zakaria, Z. Z., & Bawadi, H. A. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.11.015 · Cited by 62 · see citing works
Mental Performance and Sport: Caffeine and Co-Consumed Bioactive Ingredients
Kennedy, D. O., & Wightman, E. L. (2022) · Sports Medicine · doi:10.1007/s40279-022-01796-8 · Cited by 50 · see citing works
Abe, S. K., Saito, E., Sawada, N., Tsugane, S., Ito, H. M., Lin, Y., Tamakoshi, A., Sado, J., Kitamura, Y., Sugawara, Y., et al. (2019) · European Journal of Epidemiology · doi:10.1007/s10654-019-00545-y · Cited by 50 · see citing works
Peluso, I., Romanelli, L., & Palmery, M. (2014) · International Journal of Food Sciences and Nutrition · doi:10.3109/09637486.2014.880670 · Cited by 48 · see citing works
The Challenge of Reproducibility and Accuracy in Nutrition Research: Resources and Pitfalls
Sorkin, B. C., Kuszak, A. J., Williamson, J. S., Hopp, D. C., & Betz, J. M. (2016) · Advances in Nutrition · doi:10.3945/an.115.010595 · Cited by 49 · see citing works
Murphy, K. J., Walker, K. M., Dyer, K. A., & Bryan, J. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.10.006 · Cited by 48 · see citing works
Pleiotropic effects of polyphenols on glucose and lipid metabolism: Focus on clinical trials
Matacchione, G., Gurău, F., Baldoni, S., Prattichizzo, F., Silvestrini, A., Giuliani, A., Pugnaloni, A., Espinosa, E., Amenta, F., Bonafè, M., et al. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101074 · Cited by 48 · see citing works
García‐Conesa, M. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2014.980499 · Cited by 47 · see citing works
Cerbin‐Koczorowska, M., Waszyk-Nowaczyk, M., Bakun, P., Gośliński, T. A., & Koczorowski, T. (2021) · Applied Sciences · doi:10.3390/app11114905 · Cited by 46 · see citing works
Tawab, M. A. (2017) · Planta Medica · doi:10.1055/s-0043-123764 · Cited by 47 · see citing works
Giacco, R., Costabile, G., Fatati, G., Frittitta, L., Maiorino, M. I., Marelli, G., Parillo, M., Pistis, D., Tubili, C., Vetrani, C., et al. (2019) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2019.11.015 · Cited by 45 · see citing works
Potenza, M. A., Iacobazzi, D., Sgarra, L., & Montagnani, M. (2020) · Molecules · doi:10.3390/molecules25133061 · Cited by 41 · see citing works
Nutritional characteristics and health effects of regional cuisines in China
Zhang, N., & Ma, G. (2020) · Journal of Ethnic Foods · doi:10.1186/s42779-020-0045-z · Cited by 39 · see citing works
Takahashi, M., Ozaki, M., Miyashita, M., Fukazawa, M., Nakaoka, T., Wakisaka, T., Matsui, Y., Hibi, M., Osaki, N., & Shibata, S. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.108221 · Cited by 39 · see citing works
Apaya, M. K., Kuo, T., Yang, M.-T., Yang, G. L., Hsiao, C.-L., Chang, S., Lin, Y., & Yang, W. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.104754 · Cited by 38 · see citing works
Wan, S., Luo, J., Zhu, Y., An, P., Luo, Y., & Xing, Q. (2024) · Nutrients · doi:10.3390/nu16234206 · Cited by 37 · see citing works
Yuan, F., Dong, H., Fang, K., Gong, J., & Lu, F.-E. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201601122 · Cited by 37 · see citing works
Olcha, P., Winiarska‐Mieczan, A., Kwiecień, M., Nowakowski, Ł., Miturski, A., Semczuk, A., Kiczorowska, B., & Gałczyński, K. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23126703 · Cited by 38 · see citing works
de Bie, T. H., Witkamp, R. F., Balvers, M. G. J., & Jongsma, M. A. (2023) · American Journal of Clinical Nutrition · doi:10.1016/j.ajcnut.2023.07.017 · Cited by 36 · see citing works
Mahboob, A., Senevirathne, D. K. L., Paul, P., Nabi, F., Khan, R. H., & Châari, A. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.11.038 · Cited by 34 · see citing works
Setozaki, S., Minakata, K., Masumoto, H., Hirao, S., Yamazaki, K., Kuwahara, K., Ikeda, T., & Sakata, R. (2016) · Journal of Vascular Surgery · doi:10.1016/j.jvs.2016.06.003 · Cited by 35 · see citing works
Sohrab, G., Ebrahimof, S., Hosseinpour‐Niazi, S., Yuzbashian, E., Mirmiran, P., & Azizi, F. (2018) · Metabolic Syndrome and Related Disorders · doi:10.1089/met.2017.0140 · Cited by 31 · see citing works
Mah, E., Chen, O., Liska, D. J., & Blumberg, J. B. (2022) · Nutrients · doi:10.3390/nu14091787 · Cited by 31 · see citing works
de Santana, A. A., Santamarina, A. B., Souza, G., Mennitti, L. V., Okuda, M. H., Venâncio, D. P., Seelaender, M. C. L., do Nascimento, C. O., Ribeiro, E., Lira, F. S., et al. (2015) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2015.03.001 · Cited by 31 · see citing works
Chen, Y., Li, W., Qiu, S., Carvalho, V., Xu, X., Wang, X., Xin, N., Chen, Q., Wang, Q., Tu, P., et al. (2019) · British Journal Of Nutrition · doi:10.1017/s000711451900299x · Cited by 30 · see citing works
Do flavanols-rich natural products relieve obesity-related insulin resistance?
Engin, A. B., Tsatsakis, A. M., Tsoukalas, D., & Engin, A. (2017) · Food and Chemical Toxicology · doi:10.1016/j.fct.2017.12.055 · Cited by 30 · see citing works
Jafarnejad, S., Tsang, C., Taghizadeh, M., Asemi, Z., & Keshavarz, S. A. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2018.03.026 · Cited by 29 · see citing works
Hansel, B., Roussel, R., Diguet, V., Deplaude, A., Chapman, M. J., & Bruckert, É. (2013) · European Journal of Preventive Cardiology · doi:10.1177/2047487313506829 · Cited by 29 · see citing works
Targeting the Gut Microbiota for Prevention and Management of Type 2 Diabetes
Zeppa, S. D., Gervasi, M., Bartolacci, A., Ferrini, F., Patti, A., Sestili, P., Stocchi, V., & Agostini, D. (2024) · Nutrients · doi:10.3390/nu16223951 · Cited by 28 · see citing works
Wei, Y., Shao, J., Pang, Y., Wen, C., Wei, K., Peng, L., Wang, Y., & Wei, X. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c08492 · Cited by 28 · see citing works
Autophagy-associated signal pathways of functional foods for chronic diseases
Xie, J., Liang, J., & Chen, N. (2019) · Food Science and Human Wellness · doi:10.1016/j.fshw.2019.03.002 · Cited by 25 · see citing works
Fulminant liver failure and transplantation after use of dietary supplements
Smith, R. J., Bertilone, C., & Robertson, A. G. (2016) · The Medical Journal of Australia · doi:10.5694/mja15.00816 · Cited by 24 · see citing works
Dietary Polyphenols and Type 2 Diabetes: Human Study and Clinical Trial
Cao, H., Wang, Y., & Xiao, J. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.10.243 · Cited by 24 · see citing works
Takahashi, M., Ozaki, M., Tsubosaka, M., Kim, H., Sasaki, H., Matsui, Y., Hibi, M., Osaki, N., Miyashita, M., & Shibata, S. (2020) · Nutrients · doi:10.3390/nu12020565 · Cited by 24 · see citing works
Özyurt, V. H., Luna, C., & Estévez, M. (2016) · Food & Function · doi:10.1039/c5fo01525a · Cited by 22 · see citing works
Review and Perspective on the Composition and Safety of Green Tea Extracts
Blumberg, J. B., Bolling, B. W., Chen, C., & Xiao, H. (2014) · European Journal of Nutrition & Food Safety · doi:10.9734/ejnfs/2015/12712 · Cited by 22 · see citing works
Beneficial effects of polyphenols on chronic diseases and ageing
Cvejić, J., Russo, G. I., Godos, J., Neda, M.-D., Simin, N. Đ., Bjelica, A., & Giuseppe, G. (2018) · Elsevier eBooks · doi:10.1016/b978-0-12-813572-3.00003-8 · Cited by 21 · see citing works
The Possible Role of Nutraceuticals in the Prevention of Cardiovascular Disease
Rivellese, A. A., Ciciola, P., Costabile, G., Vetrani, C., & Vitale, M. (2019) · High Blood Pressure & Cardiovascular Prevention · doi:10.1007/s40292-019-00309-5 · Cited by 22 · see citing works
Unveiling the role of polyphenols in diabetic retinopathy
Behl, T., Kumar, K., Singh, S., Sehgal, A., Sachdeva, M., Bhatia, S., Al‐Harrasi, A., Buhaș, C. L., Pusta, C. T. J., Negruţ, N., et al. (2021) · Journal of Functional Foods · doi:10.1016/j.jff.2021.104608 · Cited by 19 · see citing works
Neyestani, T. R., & Nikooyeh, B. (2022) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2022.05.021 · Cited by 19 · see citing works
Alkhatib, A., & Tuomilehto, J. (2019) · Encyclopedia of Endocrine Diseases · doi:10.1016/b978-0-12-801238-3.64358-1 · Cited by 26 · see citing works
Martin, B. J., MacInnis, M. J., Gillen, J. B., Skelly, L. E., & Gibala, M. J. (2016) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/apnm-2016-0169 · Cited by 16 · see citing works
Vasconcelos, M. D. S., de Oliveira, L. M. N., Mota, É. F., Oliveira, L. D. S., Gomes-Rochette, N. F., Nunes‐Pinheiro, D. C. S., Nabavi, S. M., & de Melo, D. F. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-815354-3.00006-x · Cited by 12 · see citing works
The Hypoglycaemic Potential of Antioxidant-Rich Food Extracts
Chepulis, L. M., Al-Aubaidy, H. A., & Page, R. A. (2016) · Functional Foods in Health and Disease · doi:10.31989/ffhd.v6i8.271 · Cited by 10 · see citing works
Atazadegan, M. A., Bagherniya, M., Fakheran, O., Sathyapalan, T., & Sahebkar, A. (2021) · Advances in Experimental Medicine and Biology · doi:10.1007/978-3-030-73234-9_4 · Cited by 6 · see citing works
Timing of caffeine ingestion alters postprandial metabolism in rats
Jarrar, S. F., & Obeid, O. (2013) · Nutrition · doi:10.1016/j.nut.2013.07.015 · Cited by 10 · see citing works
Kour, N., Bhagat, G., Singh, S., Bhatti, S. S., Arora, S., Singh, B., & Bhatia, A. (2023) · Journal of Diabetes & Metabolic Disorders · doi:10.1007/s40200-023-01326-x · Cited by 9 · see citing works
Ritu, R., Goyal, R. K., Narwal, S., Bhatt, A., Sehrawat, R., Devi, P., Gulati, M., & Singla, R. K. (2024) · Current Medicinal Chemistry · doi:10.2174/0109298673316493240527113707 · Cited by 9 · see citing works
- Authors
- Zheng, X.-X., Xu, Y.-L., Li, S.-H., Hui, R., Wu, Y.-J., & Huang, X.-H.
- Affiliations
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- ORCID
- Hui, Rutai
- Venue
- The American Journal of Clinical Nutrition
- Publisher
- Elsevier BV
- Published
- 2013-04
- Volume
- 97
- Issue
- 4
- Pages
- 750-762
- ISSN
- 0002-9165 (ISSN-L)
- OpenAlex
- W2137040425
- Cited by
- 146
- References
- 69
- Citations by year
- 2026: 7 · 2025: 3 · 2024: 11 · 2023: 7 · 2022: 11 · 2021: 10 · 2020: 21 · 2019: 13 · 2018: 11 · 2017: 15 · 2016: 13 · 2015: 7 · 2014: 9 · 2013: 8
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- American Journal of Clinical Nutrition (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Tea Polyphenols and Effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Natural Antidiabetic Agents Studies
- Health Sciences › Medicine › Pharmacology › Coffee research and impacts
- Keywords
- green tea catechins, caffeine, glycemic control, fasting blood glucose, fasting insulin, HbA1c, insulin resistance, glucose metabolism, type 2 diabetes
- MeSH terms
- Adult, Blood Glucose, Caffeine, Catechin, Glycated Hemoglobin, Humans, Hyperglycemia, Hypoglycemic Agents, Insulin, Insulin Resistance, Phytotherapy, Metabolic Diseases, Plant Extracts, Camellia sinensis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review