Student or educator? Sign up with your school email and get 6 months of Pro free.
CoChat
Sign Up
Cited by 24

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Adolescent TBI-induced hypopituitarism causes sexual dysfunction in adult male rats

Greco, Tiffany, Hovda, David A., Prins, Mayumi L.·2015·Developmental Neurobiology
DOI 10.1002/dneu.22218
Open this paper in CoChat — free account

Abstract

Adolescents are at greatest risk for traumatic brain injury (TBI) and repeat TBI (RTBI). TBI‐induced hypopituitarism has been documented in both adults and juveniles and despite the necessity of pituitary function for normal physical and brain development, it is still unrecognized and untreated in adolescents following TBI. TBI induced hormonal dysfunction during a critical developmental window has the potential to cause long‐term cognitive and behavioral deficits and the topic currently remains unaddressed. The purpose of this study was to determine if four mild TBIs delivered to adolescent male rats disrupts testosterone production and adult behavioral outcomes. Plasma testosterone was quantified from 72 hrs preinjury to 3 months postinjury and pubertal onset, reproductive organ growth, erectile function and reproductive behaviors were assessed at 1 and 2 months postinjury. RTBI resulted in both acute and chronic decreases in testosterone production and delayed onset of puberty. Significant deficits were observed in reproductive organ growth, erectile function and reproductive behaviors in adult rats at both 1 and 2 months postinjury. These data suggest adolescent RTBI‐induced hypopituitarism underlies abnormal behavioral changes observed during adulthood. The impact of undiagnosed hypopituitarism following RTBI in adolescence has significance not only for growth and puberty, but also for brain development and neurobehavioral function as adults. © 2014 Wiley Periodicals, Inc. Develop Neurobiol 75: 193–202, 2015

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1002/dneu.22218

Cites

12 of 12 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 12 references

Research works printed but not linked: 39

  1. 10.1111/j.1365-2265.2006.02517.x · DOI · Paper page
  2. 10.1212/WNL.30.9.912 · DOI · Paper page
  3. 10.1023/A:1022542221535 · DOI
  4. 10.1007/BF01638061 · DOI
  5. 10.1016/j.neuroscience.2007.09.038 · DOI
  6. 10.1016/j.brainres.2012.04.035 · DOI
  7. Dyer K, 2013, Talking about sex after traumatic brain injury: Perceptions and experiences of multidisciplinary rehabilitation professionals, Disabil Rehabil, 29, 29
  8. 10.1016/j.yhbeh.2011.05.007 · DOI
  9. 10.1038/13158 · DOI · Paper page
  10. Gilchrist J, 2011, Nonfatal traumatic brain injuries related to sports and recreation acitivities among persons aged ≤ 19 years – united states, 2001–2009, MMRW, 60, 1337
  11. 10.1016/S0149-7634(00)00020-8 · DOI
  12. 10.1001/jama.290.19.2549 · DOI · Paper page
  13. 10.1016/0018-506X(83)90026-0 · DOI
  14. Hibbard MR, 2000, Sexual dysfunction after traumatic brain injury, NeuroRehabilitation, 15, 107, 10.3233/NRE-2000-15204 · DOI
  15. 10.7326/0003-4819-61-2-255 · DOI
  16. 10.1016/j.yhbeh.2007.03.030 · DOI · Paper page
  17. Insel TR, 1990, The ontogeny of excitatory amino acid receptors in rat forebrain–I, N‐methyl‐d‐aspartate and quisqualate receptors. Neuroscience, 35, 31
  18. 10.1111/j.1365-2265.2010.03857.x · DOI · Paper page
  19. 10.1111/j.1600-0404.1981.tb00769.x · DOI
  20. 10.1186/cc10906 · DOI
  21. Lewis VG, 1977, Idiopathic pubertal delay beyond age fifteen: Psychologic study of twelve boys, Adolescence, 12, 1
  22. 10.1136/adc.2008.145235 · DOI
  23. Moreno JA, 2013, Sexuality after traumatic brain injury: a critical review, NeuroRehabilitation, 32, 69, 10.3233/NRE-130824 · DOI
  24. Moreno JA, 2012, Sexuality following traumatic brain injury, Neuropsychol Int J Psychol, 47, 574
  25. Moreno JA, 2012, Unraveling the complexity of sexuality after traumatic brain injury, Sex Int J Psychol, 47, 684
  26. 10.3109/01485018008986974 · doi:10.3109/01485018008986974
  27. 10.1111/j.1749-6632.1999.tb09271.x · DOI · Paper page
  28. 10.1002/dev.420220608 · DOI · Paper page
  29. 10.1016/j.ijdevneu.2011.05.009 · DOI
  30. 10.1159/000316800 · DOI
  31. 10.1007/s11102-011-0360-x · DOI · Paper page
  32. 10.1016/j.yhbeh.2003.12.007 · DOI · Paper page
  33. Sizonenko PC, 1987, Normal sexual maturation, Pediatrician, 14, 191
  34. 10.1016/j.bandc.2009.07.003 · DOI · Paper page
  35. 10.1016/S0149-7634(00)00014-2 · DOI · Paper page
  36. 10.1007/s00701-009-0444-9 · DOI
  37. Eden CG, 1990, The development of the rat prefrontal cortex, Its size and development of connections with thalamus, spinal cord and other cortical areas. Prog Brain Res, 85, 169
  38. 10.1002/dev.20610 · DOI
  39. 10.3109/02699052.2012.672786 · DOI

Cited by

Metadata

Authors
Greco, T., Hovda, D. A., & Prins, M. L.
Affiliations
Department of Neurosurgery Semel Institute Los Angeles California 90095
Venue
Developmental Neurobiology
Publisher
Wiley
Published
2014-08
Volume
75
Issue
2
Pages
193-202
ISSN
  • 1932-8451
  • 1932-846X
DOI
10.1002/dneu.22218
Cited by
24
References
12
Language
en
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Funders
NFL Charities

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.