Cited by 396Neurogenesis and neuroplasticity mechanismsSexual Differentiation and DisordersHypothalamic control of reproductive hormones

Pubertal hormones modulate the addition of new cells to sexually dimorphic brain regions

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Ahmed, Eman I, Zehr, Julia L, Schulz, Kalynn M, Lorenz, Betty H, DonCarlos, Lydia L, Sisk, Cheryl L·2008·Nature Neuroscience

Abstract

New cells, including neurons, arise in several brain regions during puberty in rats. Sex differences in pubertal addition of cells coincide with adult sexual dimorphisms: for each region, the sex that gains more cells during puberty has a larger volume in adulthood. Removing gonadal hormones before puberty eliminates these sex differences, indicating that gonadal steroids direct the addition of new cells during puberty to maintain and accentuate sexual dimorphisms in the adult brain.

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Authors
Ahmed, E. I., Zehr, J. L., Schulz, K. M., Lorenz, B. H., DonCarlos, L. L., & Sisk, C. L.
Affiliations
  • Michigan State University (US)
  • Loyola University Chicago (US)
Corresponding author
Sisk, Cheryl L
Venue
Nature Neuroscience
Published
2008-08-17
Volume
11
Issue
9
Pages
995-997
ISSN
  • 1097-6256 (ISSN-L)
  • 1546-1726
OpenAlex
W1989826158
Cited by
396
References
17
Citations by year
2026: 5 · 2025: 11 · 2024: 20 · 2023: 18 · 2022: 17 · 2021: 16 · 2020: 75 · 2019: 14 · 2018: 21 · 2017: 20 · 2016: 25 · 2015: 17 · 2014: 21 · 2013: 32 · 2012: 28
FWCI
5.71
Type
journal article
Language
en
Open access
Locations
  • Nature Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (F31MH070125, R01MH068764, R01MH062588, F32MH068975)
Topics
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Keywords
sexual dimorphism, pubertal hormones, sex steroids, cell proliferation, postnatal brain development, gonadectomy, brain volume, sex differences in brain structure
MeSH terms
Age Factors, Aging, Animals, Animals, Newborn, Brain, Bromodeoxyuridine, Castration, Cell Count, Female, Glial Fibrillary Acidic Protein, Male, Phosphopyruvate Hydratase, Random Allocation, Sex Characteristics, Rats, Sprague-Dawley, Rats, Neurogenesis

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