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Cited by 169Sexual Differentiation and DisordersHypothalamic control of reproductive hormonesNeuroendocrine regulation and behavior

Gonadal hormones masculinize and defeminize reproductive behaviors during puberty in the male Syrian hamster

Schulz, Kalynn M, Richardson, Heather N, Zehr, Julia L, Osetek, Andrew J, Menard, Tami A, Sisk, Cheryl L·2004·Hormones and Behavior
DOI 10.1016/j.yhbeh.2003.12.007
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Abstract

Three experiments were conducted to test whether testicular hormones secreted during puberty masculinize and defeminize the expression of adult reproductive behavior. Experiment 1 tested the hypothesis that gonadal hormones during puberty masculinize behavioral responses to testosterone (T) in adulthood. Male hamsters were castrated either before puberty (noTduringP) or after puberty (TduringP). All males were implanted with a 2.5-mg T pellet 6 weeks following castration and tested once for masculine reproductive behavior 7 days after the onset of T replacement. TduringP males displayed significantly more mounts, intromissions, and ejaculations than noTduringP males. Experiment 2 tested the hypothesis that gonadal hormones during puberty defeminize behavioral responses to estrogen (EB) and progesterone (P). Eight weeks following castration, noTduringP and TduringP males were primed with EB and P and tested for lordosis behavior with a stud male. Behavioral responses of males were compared to that of ovariectomized (OVX) and hormone primed females. NoTduringP males and OVX females displayed significantly shorter lordosis latencies than TduringP males. Experiment 3 investigated whether prolonged T treatment or sexual experience could reverse the deficits in masculine behavior caused by the absence of T during puberty. Extending the T treatment from 7 to 17 days did not ameliorate the deficits in masculine behavior caused by absence of T during puberty. Similarly, when the level of sexual experience was increased from one to three tests, the deficits in masculine behavior persisted. These studies demonstrate that gonadal hormones during puberty further masculinize and defeminize neural circuits and behavioral responsiveness to steroid hormones in adulthood.

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  • Recent studies demonstrate that organizational changes occur during adolescence and may be critical for activational changes to take place.

    “recent studies have demonstrated that there are organizational changes occurring during adolescence as well, and, moreover, that these organizational changes may be critical for activational changes to take place”

    From Impact of socio-emotional context, brain development, and pubertal maturation on adolescent risk-taking (2013) · cites this paper as Schulz et al., 2004

  • The juvenile to adolescent transition is a sensitive period for steroid-induced organization of hypothalamic and limbic circuitry that regulates basic motivated behaviors, including sex and aggression.

    “Sisk and colleagues have demonstrated that the juvenile to adolescent transition is a sensitive period for steroid-induced organization of hypothalamic and limbic circuitry that regulates basic motivated behaviors, including sex and aggression (Schulz-Wilson et al., 2002; Schulz et al., 2004; Schulz et al., 2009a).”

    From Does puberty mark a transition in sensitive periods for plasticity in the associative neocortex? (2017) · cites this paper as Schulz et al., 2004

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Authors
Schulz, K. M., Richardson, H. N., Zehr, J. L., Osetek, A. J., Menard, T. A., & Sisk, C. L.
Affiliations
Michigan State University (US)
Corresponding author
Sisk, Cheryl L
ORCID
Venue
Hormones and Behavior
Publisher
Elsevier BV
Published
2004-04
Volume
45
Issue
4
Pages
242-249
ISSN
0018-506X (ISSN-L)
DOI
10.1016/j.yhbeh.2003.12.007
OpenAlex
W1991689970
Cited by
169
References
34
Citations by year
2026: 1 · 2025: 5 · 2024: 1 · 2023: 5 · 2022: 4 · 2021: 9 · 2020: 13 · 2019: 14 · 2018: 4 · 2017: 4 · 2016: 15 · 2015: 6 · 2014: 11 · 2013: 10 · 2012: 11
FWCI
2.13
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Hormones and Behavior (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Science Foundation
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Keywords
gonadal hormones, puberty, masculinization, defeminization, male reproductive behavior, testosterone, estrogen, progesterone, castration, lordosis, sexual experience, golden hamster, neural circuits
MeSH terms
Animals, Castration, Estradiol, Female, Cricetinae, Male, Mesocricetus, Progesterone, Reproduction, Sexual Behavior, Animal, Sex Characteristics, Sex Differentiation, Gonadal Steroid Hormones, Sexual Maturation, Testis, Testosterone

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