A DRD4/BDNF gene–gene interaction associated with maximum BMI in women with bulimia nervosa
Abstract
Objective: The goals of the current study were threefold: 1) to examine whether the hypofunctional 7R allele of the DRD4 gene contributes to maximal lifetime body mass in women with BN; 2) to determine whether the BDNF gene contributes to maximal BMI on its own, and 3) to explore possible BDNF/DRD4 gene‐gene interactions in mediating maximum lifetime BMIs in BN. Method: We tested two General Linear Models predicting maximum lifetime BMI with the exon 3 VNTR polymorphism of the dopamine‐4 receptor gene (DRD4) and either the Val66Met or the ‐270C/T polymorphism of BDNF respectively in 163 female probands with BN, purging subtype. Results: In these bulimic subjects, the hypofunctional 7R allele of DRD4 predicted maximal BMI (p < .01). There was also a significant interaction between the DRD4 gene and the BDNF gene in predicting maximal BMI. The Val66Met rather than the 270C/T polymorphism of BDNF interacting with DRD4 predicted maximum BMI in this BN sample (p < .01). Probands carrying both the hypofunctional 7R allele of DRD4 and the Met66 allele of BDNF had significantly higher maximal BMI than did probands in the other gene‐gene interaction groups. Conclusion: These results provide further evidence that the hypofunctional 7R allele of DRD4 contributes to weight gain in women with BN and that the BDNF gene interacts with DRD4 to influence weight regulation in these subjects. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2008
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Candidate genetic behavior investigations in BN have reported altered allelic frequencies for the DAT gene and DA receptor genes in individuals with bulimia.
“These studies compliment candidate genetic behavior investigations in BN that have reported altered allelic frequencies for the DAT gene [328] and DA receptor genes [329,330] in individuals with bulimia.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [329]
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- Authors
- Kaplan, A. S., Levitan, R. D., Yilmaz, Z., Davis, C., Tharmalingam, S., & Kennedy, J. L.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- York University (CA)
- Venue
- International Journal of Eating Disorders
- Publisher
- Wiley
- Published
- 2007-10-05
- Volume
- 41
- Issue
- 1
- Pages
- 22-28
- ISSN
- 0276-3478 (ISSN-L)
- 1098-108X
- OpenAlex
- W1973957647
- Cited by
- 77
- References
- 43
- Citations by year
- 2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 11 · 2014: 5 · 2013: 7 · 2012: 7
- FWCI
- 7.25
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Eating Disorders (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Keywords
- bulimia nervosa, DRD4, brain-derived neurotrophic factor, gene-gene interaction, body mass index, BDNF Val66Met polymorphism, dopamine receptors, body weight regulation, women, genetic susceptibility
- MeSH terms
- Adult, Alleles, Female, Genotype, Humans, Obesity, Polymorphism, Genetic, Body Mass Index, Brain-Derived Neurotrophic Factor, Receptors, Dopamine D4, Bulimia Nervosa
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