Cited by 77Eating Disorders and BehaviorsNeurotransmitter Receptor Influence on BehaviorRegulation of Appetite and Obesity

A DRD4/BDNF gene–gene interaction associated with maximum BMI in women with bulimia nervosa

Kaplan, Allan S., Levitan, Robert D., Yilmaz, Zeynep, Davis, Caroline, Tharmalingam, Subi, Kennedy, James L.·2008·International Journal of Eating Disorders

Abstract

Objective: The goals of the current study were threefold: 1) to examine whether the hypofunctional 7R allele of the DRD4 gene contributes to maximal lifetime body mass in women with BN; 2) to determine whether the BDNF gene contributes to maximal BMI on its own, and 3) to explore possible BDNF/DRD4 gene‐gene interactions in mediating maximum lifetime BMIs in BN. Method: We tested two General Linear Models predicting maximum lifetime BMI with the exon 3 VNTR polymorphism of the dopamine‐4 receptor gene (DRD4) and either the Val66Met or the ‐270C/T polymorphism of BDNF respectively in 163 female probands with BN, purging subtype. Results: In these bulimic subjects, the hypofunctional 7R allele of DRD4 predicted maximal BMI (p < .01). There was also a significant interaction between the DRD4 gene and the BDNF gene in predicting maximal BMI. The Val66Met rather than the 270C/T polymorphism of BDNF interacting with DRD4 predicted maximum BMI in this BN sample (p < .01). Probands carrying both the hypofunctional 7R allele of DRD4 and the Met66 allele of BDNF had significantly higher maximal BMI than did probands in the other gene‐gene interaction groups. Conclusion: These results provide further evidence that the hypofunctional 7R allele of DRD4 contributes to weight gain in women with BN and that the BDNF gene interacts with DRD4 to influence weight regulation in these subjects. © 2007 by Wiley Periodicals, Inc. Int J Eat Disord 2008

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Crossref · 10.1002/eat.20474

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Authors
Kaplan, A. S., Levitan, R. D., Yilmaz, Z., Davis, C., Tharmalingam, S., & Kennedy, J. L.
Affiliations
  • Centre for Addiction and Mental Health (CA)
  • York University (CA)
Venue
International Journal of Eating Disorders
Publisher
Wiley
Published
2007-10-05
Volume
41
Issue
1
Pages
22-28
ISSN
  • 0276-3478 (ISSN-L)
  • 1098-108X
OpenAlex
W1973957647
Cited by
77
References
43
Citations by year
2026: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 3 · 2019: 3 · 2018: 1 · 2017: 3 · 2016: 3 · 2015: 11 · 2014: 5 · 2013: 7 · 2012: 7
FWCI
7.25
Type
journal article
Language
en
Open access
closed
Locations
  • International Journal of Eating Disorders (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Eating Disorders and Behaviors
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
bulimia nervosa, DRD4, brain-derived neurotrophic factor, gene-gene interaction, body mass index, BDNF Val66Met polymorphism, dopamine receptors, body weight regulation, women, genetic susceptibility
MeSH terms
Adult, Alleles, Female, Genotype, Humans, Obesity, Polymorphism, Genetic, Body Mass Index, Brain-Derived Neurotrophic Factor, Receptors, Dopamine D4, Bulimia Nervosa

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