Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial
Open accessAbstract
AIMS: We evaluated the impact of diabetes mellitus (DM) and diabetic therapy on outcomes in patients with reduced ejection fraction (EF) after hospitalization for heart failure (HF). DM is prevalent in patients hospitalized with HF, yet inconclusive data exist on the post-discharge outcomes of this patient population. METHODS AND RESULTS: Post-hoc analysis was performed on the EVEREST (Efficacy of Vasopressin Antagonism in Heart Failure Outcome Study with Tolvaptan) study, a randomized trial of patients hospitalized with HF (n = 4133) with median follow-up of 9.9 months. DM status was determined from intake questionnaires and cross-verified by medication history. Univariate relationships were examined using χ(2) test, t-test, and Wilcoxon tests. The two primary outcomes of (i) all-cause mortality (ACM) and (ii) cardiovascular mortality or HF hospitalization (CVM + HFH) were assessed for those with and without DM and by diabetic treatment strategy using log rank tests and multivariable Cox regression models. DM was present in 40% of participants. Patients with DM were more likely to have hypertension, coronary artery disease, and chronic kidney disease. Diabetes was associated with ACM and CVM + HFH (both P < 0.001). Following multivariate risk adjustment, DM was associated with ACM, but this estimate was imprecise [hazard ratio (HR) 1.16; 95% confidence interval (CI) 1.00-1.34] and remained associated with CVM or HFH (HR 1.17; 95% CI 1.04-1.31). Diabetic control strategy did not independently affect outcomes. CONCLUSION: Diabetes is common in patients hospitalized for heart failure with a reduced EF. These patients have a higher post-discharge CVM and higher HF hospitalizations compared with patients with no diabetes. Different diabetic treatment regimens did not appear to influence post-discharge outcomes.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the EVEREST trial, in which patients were followed for 9.9 months after a HF hospitalization, T2DM conferred a slightly higher mortality.
“For example, in the EVEREST trial in which patients were followed for 9.9 months after a HF hospitalization, T2DM conferred a slightly higher mortality.45”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [45]
With longer-term follow-up, an association between T2DM and worse outcomes in HF patients becomes evident.
“However, with longer-term follow-up, an association between T2DM and worse outcomes in HF patients becomes evident.”
From Type 2 diabetes mellitus and heart failure: A position statement from the Heart Failure Association of the European Society of Cardiology (2018) · cites this paper as [45]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Heart Disease and Stroke Statistics—2023 Update: A Report From the American Heart Association
Tsao, C. W., Aday, A. W., Almarzooq, Z. I., Anderson, C. A. M., Arora, P., Avery, C. L., Baker-Smith, C. M., Beaton, A. Z., Boehme, A. K., Buxton, A. E., et al. (2023) · Circulation · doi:10.1161/cir.0000000000001123 · Cited by 8,300 · see citing works
Heart Disease and Stroke Statistics—2012 Update: A Report From the American Heart Association
Writing Group Members, Roger, V. L., Go, A. S., Lloyd-Jones, D. M., Benjamin, E. J., Berry, J. D., Borden, W. B., Bravata, D. M., Dai, S., Ford, E. S., et al. (2012) · Circulation · doi:10.1161/cir.0b013e31823ac046 · Cited by 7,333 · see citing works
HEART DISEASE AND STROKE STATISTICS–2014 UPDATE: A REPORT FROM THE AMERICAN HEART ASSOCIATION
Tarver, T. (2014) · Journal of Consumer Health on the Internet · doi:10.1080/15398285.2014.902284 · Cited by 5,595 · see citing works
The epidemiology of heart failure: The Framingham Study
Ho, K. K. L., Pinsky, J. L., Kannel, W. B., & Levy, D. A. (1993) · Journal of the American College of Cardiology · doi:10.1016/0735-1097(93)90455-a · Cited by 2,230 · see citing works
Fonarow, G. C. (2005) · JAMA · doi:10.1001/jama.293.5.572 · Cited by 1,617 · see citing works
Trends in Heart Failure Incidence and Survival in a Community-Based Population
Roger, V. L. (2004) · JAMA · doi:10.1001/jama.292.3.344 · Cited by 1,591 · see citing works
Home, P. D., Pocock, S. J., Beck-Nielsen, H., Curtis, P. S., Gomis, R., Hanefeld, M., Jones, N. P., Komajda, M., & McMurray, J. J. (2009) · The Lancet · doi:10.1016/s0140-6736(09)60953-3 · Cited by 1,393 · see citing works
Nieminen, M. S., Brutsaert, D. L., Dickstein, K., Drexler, H., Folláth, F., Harjola, V., Hochadel, M., Michel Komajda, N., Lassus, J. P. E., Lopez-Sendon, J. L., et al. (2006) · European Heart Journal · doi:10.1093/eurheartj/ehl193 · Cited by 1,292 · see citing works
Thiazolidinedione Use, Fluid Retention, and Congestive Heart Failure
Nesto, R. W., Bell, D. S. H., Bonow, R. O., Fonseca, V. A., Grundy, S. M., Horton, E. S., Winter, M. L., Porte, D., Semenkovich, C. F., Smith, S. E., et al. (2003) · Circulation · doi:10.1161/01.cir.0000103683.99399.7e · Cited by 831 · see citing works
Chen, J., Normand, S. T., Wang, Y., & Krumholz, H. M. (2011) · JAMA · doi:10.1001/jama.2011.1474 · Cited by 742 · see citing works
MacDonald, M. R., Petrie, M. C., Varyani, F., Ostergren, J., Michelson, E. L., Young, J. B., Solomon, S. D., Granger, C. B., Swedberg, K., Yusuf, S., et al. (2008) · European Heart Journal · doi:10.1093/eurheartj/ehn153 · Cited by 694 · see citing works
Nissen, S. E., & Wolski, K. (2010) · Archives of Internal Medicine · doi:10.1001/archinternmed.2010.207 · Cited by 590 · see citing works
Adaptation and Maladaptation of the Heart in Diabetes: Part I
Taegtmeyer, H., McNulty, P. H., & Young, M. E. (2002) · Circulation · doi:10.1161/01.cir.0000012466.50373.e8 · Cited by 517 · see citing works
Masoudi, F. A., Inzucchi, S. E., Wang, Y., Havranek, E. P., Foody, J. M., & Krumholz, H. M. (2005) · Circulation · doi:10.1161/01.cir.0000154542.13412.b1 · Cited by 458 · see citing works
Diabetes Mellitus and Associated Hypertension, Vascular Disease, and Nephropathy
Sowers, J. R., & Epstein, M. (1995) · Hypertension · doi:10.1161/01.hyp.26.6.869 · Cited by 436 · see citing works
Schramm, T. K., Gislason, G. H., Vaag, A., Rasmussen, J. N., Folke, F., Hansen, M. L., Fosbøl, E. L., Køber, L., Norgaard, M. L., Madsen, M., et al. (2011) · European Heart Journal · doi:10.1093/eurheartj/ehr077 · Cited by 418 · see citing works
Rossing, K., Schjoedt, K. J., Smidt, U., Boomsma, F., & Parving, H. (2005) · Diabetes Care · doi:10.2337/diacare.28.9.2106 · Cited by 297 · see citing works
Diabetes in heart failure: prevalence and impact on outcome in the population
From, A. M., Leibson, C. L., Bursi, F., Redfield, M. M., Weston, S. A., Jacobsen, S. J., Rodeheffer, R. J., & Roger, V. L. (2006) · The American Journal of Medicine · doi:10.1016/j.amjmed.2006.05.024 · Cited by 295 · see citing works
Gustafsson, I., Brendorp, B., Seibæk, M., Burchardt, H., Hildebrandt, P., Køber, L., & Torp-Pedersen, C. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.11.024 · Cited by 258 · see citing works
Harjola, V., Folláth, F., Nieminen, M. S., Brutsaert, D. L., Dickstein, K., Drexler, H., Hochadel, M., Michel Komajda, N., Lopez-Sendon, J. L., Ponikowski, P. P., et al. (2010) · European Journal of Heart Failure · doi:10.1093/eurjhf/hfq002 · Cited by 242 · see citing works
The effect of diabetes on outcomes of patients with advanced heart failure in the BEST trial
Domanski, M., Krause-Steinrauf, H., Deedwania, P., Follmann, D., Ghali, J. K., Gilbert, E., Haffner, S., Katz, R., Lindenfeld, J., Lowes, B. D., et al. (2003) · Journal of the American College of Cardiology · doi:10.1016/s0735-1097(03)00856-8 · Cited by 215 · see citing works
Wang, N. C. (2008) · JAMA · doi:10.1001/jama.299.22.2656 · Cited by 202 · see citing works
Greenberg, B. H., Abraham, W. T., Albert, N. M., Chiswell, K., Clare, R., Stough, W. G., Gheorghiade, M., O'Connor, C. M., Sun, J. L., Yancy, C. W., et al. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.05.001 · Cited by 196 · see citing works
Smooke, S., Horwich, T. B., & Fonarow, G. C. (2005) · American Heart Journal · doi:10.1016/j.ahj.2004.07.005 · Cited by 196 · see citing works
Impact of diabetes mellitus on long-term survival in patients with congestive heart failure
de Groote, P. (2004) · European Heart Journal · doi:10.1016/j.ehj.2004.01.010 · Cited by 192 · see citing works
Gheorghiade, M., Orlandi, C., Burnett, J. C. J., DeMets, D. L., Grinfeld, L. R., Maggioni, A. P., Swedberg, K. B., Udelson, J. E., Zannad, F. M., Zimmer, C., et al. (2005) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2005.03.009 · Cited by 171 · see citing works
Murcia, A. M., Hennekens, C. H., Lamas, G. A., Jiménez-Navarro, M. F., Rouleau, J. L., Flaker, G. C., Goldman, S., Skali, H., D, E. B. M., & Pfeffer, M. A. (2004) · Archives of Internal Medicine · doi:10.1001/archinte.164.20.2273 · Cited by 154 · see citing works
Greenberg, B., Abraham, W. T., Albert, N. M., Chiswell, K., Clare, R., Stough, W. G., Gheorghiade, M., O’Connor, C. M., Sun, J. L., Yancy, C. W., et al. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.08.002 · Cited by 76 · see citing works
Inzucchi, S. E., Masoudi, F. A., & McGuire, D. K. (2007) · Diabetes Care · doi:10.2337/dc07-1686 · Cited by 64 · see citing works
Parissis, J. T., Rafouli-Stergiou, P., Mebazaa, A., Ikonomidis, I., Bistola, V., Nikolaou, M., Meas, T., Delgado, J., Vilas-Boas, F., Paraskevaidis, I., et al. (2012) · International Journal of Cardiology · doi:10.1016/j.ijcard.2011.11.098 · Cited by 58 · see citing works
Andersson, C., Gislason, G., Jørgensen, C. H., Hansen, P. R., Vaag, A. A., Sørensen, R., Mérie, C., Olesen, J. B., Weeke, P. E., Schmiegelow, M., et al. (2011) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2011.07.011 · Cited by 28 · see citing works
Prognostic Impact of Diabetes Mellitus in Patients With Acute Decompensated Heart Failure
Burger, A. J., Tsao, L., & Aronson, D. (2005) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2004.12.070 · Cited by 21 · see citing works
Eurich, D. T., Majumdar, S. R., McAlister, F. A., Tsuyuki, R. T., & Johnson, J. A. (2011) · Europe PMC (PubMed Central) · Cited by 6 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association
Benjamin, E. J., Blaha, M. J., Chiuve, S. E., Cushman, M., Das, S. R., Deo, R., de Ferranti, S. D., Floyd, J., Fornage, M., Gillespie, C., et al. (2017) · Circulation · doi:10.1161/cir.0000000000000485 · Cited by 12,591 · see citing works
Heart Disease and Stroke Statistics—2020 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Delling, F. N., et al. (2020) · Circulation · doi:10.1161/cir.0000000000000757 · Cited by 9,175 · see citing works
Heart Disease and Stroke Statistics—2019 Update: A Report From the American Heart Association
Benjamin, E. J., Muntner, P., Alonso, A., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Chang, A. R., Cheng, S., Das, S. R., et al. (2019) · Circulation · doi:10.1161/cir.0000000000000659 · Cited by 9,036 · see citing works
Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146 · see citing works
Heart Disease and Stroke Statistics—2016 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., Das, S. R., de Ferranti, S., Després, J.-P., Fullerton, H. J., et al. (2016) · Circulation · doi:10.1161/cir.0000000000000350 · Cited by 6,596 · see citing works
Heart Disease and Stroke Statistics—2015 Update: A Report From the American Heart Association
Mozaffarian, D., Benjamin, E. J., Go, A. S., Arnett, D. K., Blaha, M. J., Cushman, M., de Ferranti, S., Després, J.-P., Fullerton, H. J., Howard, V. J., et al. (2015) · Circulation · doi:10.1161/cir.0000000000000152 · Cited by 5,797 · see citing works
Heart Disease and Stroke Statistics—2021 Update: A Report From the American Heart Association
Virani, S. S., Alonso, A., Aparicio, H. J., Benjamin, E. J., Bittencourt, M. S., Callaway, C. W., Carson, A. P., Chamberlain, A. M., Cheng, S., Delling, F. N., et al. (2021) · Circulation · doi:10.1161/cir.0000000000000950 · Cited by 5,784 · see citing works
Heart Disease and Stroke Statistics—2014 Update
Go, A. S., Mozaffarian, D., Roger, V. L., Benjamin, E. J., Berry, J. D., Blaha, M. J., Dai, S., Ford, E. S., Fox, C. S., Franco, S., et al. (2013) · Circulation · doi:10.1161/01.cir.0000441139.02102.80 · Cited by 5,207 · see citing works
Clinical Update: Cardiovascular Disease in Diabetes Mellitus
Wang, C. C. L., Hess, C. N., Hiatt, W. R., & Goldfine, A. B. (2016) · Circulation · doi:10.1161/circulationaha.116.022194 · Cited by 1,183 · see citing works
Crespo-Leiro, M. G., Anker, S. D., Maggioni, A. P., Coats, A. J., Filippatos, G., Ruschitzka, F., Ferrari, R., Piepoli, M. F., Delgado Jimenez, J. F., Metra, M., et al. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.566 · Cited by 798 · see citing works
Seferović, P. M., Petrie, M. C., Filippatos, G. S., Anker, S. D., Rosano, G., Bauersachs, J., Paulus, W. J., Komajda, M., Cosentino, F., de Boer, R. A., et al. (2018) · European Journal of Heart Failure · doi:10.1002/ejhf.1170 · Cited by 708 · see citing works
Self-citationDiabetes, cardiovascular disease and the microcirculation
Strain, W. D., & Paldánius, P. M. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0703-2 · Cited by 609 · see citing works
Noncardiac comorbidities in heart failure with reduced versus preserved ejection fraction
Mentz, R. J., Kelly, J. P., von Lueder, T. G., Voors, A. A., Lam, C. S. P., Cowie, M. R., Kjeldsen, K., Jankowska, E. A., Atar, D., Butler, J., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.08.036 · Cited by 546 · see citing works
Pop‐Busui, R., Januzzi, J. L., Bruemmer, D., Butalia, S., Green, J. B., Horton, W. B., Knight, C. M., Levi, M., Rasouli, N., & Richardson, C. R. (2022) · Diabetes Care · doi:10.2337/dci22-0014 · Cited by 424 · see citing works
Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure
Dei Cas, A., Khan, S. S., Butler, J., Mentz, R. J., Bonow, R. O., Avogaro, A., Tschoepe, D., Doehner, W., Greene, S. J., Senni, M., et al. (2015) · JACC Heart Failure · doi:10.1016/j.jchf.2014.08.004 · Cited by 401 · see citing works
Gheorghiade, M., Böhm, M., Greene, S. J., Fonarow, G. C., Lewis, E. F., Zannad, F. M., Solomon, S. D., Baschiera, F., Botha, J., Hua, T. A., et al. (2013) · JAMA · doi:10.1001/jama.2013.1954 · Cited by 325 · see citing works
Maack, C., Lehrke, M., Backs, J., Heinzel, F. R., Hulot, J., Marx, N., Paulus, W. J., Rossignol, P., Taegtmeyer, H., Bauersachs, J. K., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehy596 · Cited by 250 · see citing works
Fitchett, D., Butler, J., van de Borne, P., Zinman, B., Lachin, J. M., Wanner, C., Woerle, H. J., Hantel, S., George, J. T., Johansen, O. E., et al. (2018) · European Heart Journal · doi:10.1093/eurheartj/ehx511 · Cited by 242 · see citing works
McMurray, J. J. V., DeMets, D. L., Inzucchi, S. E., Køber, L., Kosiborod, M. N., Langkilde, A. M., Martinez, F. A., Bengtsson, O., Ponikowski, P., Sabatine, M. S., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1548 · Cited by 222 · see citing works
Pathophysiology and Therapeutic Approaches to Acute Decompensated Heart Failure
Njoroge, J. N., & Teerlink, J. R. (2021) · Circulation Research · doi:10.1161/circresaha.121.318186 · Cited by 229 · see citing works
Targher, G., Dauriz, M., Laroche, C., Temporelli, P. L., Hassanein, M., Seferovic, P. M., Drozdz, J., Ferrari, R., Anker, S., Coats, A., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.679 · Cited by 169 · see citing works
Molecular Dysfunction and Phenotypic Derangement in Diabetic Cardiomyopathy
Evangelista, I., Nuti, R., Picchioni, T., Dotta, F., & Palazzuoli, A. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20133264 · Cited by 170 · see citing works
The Diabetic Cardiomyopathy: The Contributing Pathophysiological Mechanisms
Salvatore, T., Pafundi, P. C., Galiero, R., Albanese, G., Di Martino, A., Caturano, A., Vetrano, E., Rinaldi, L., & Sasso, F. C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.695792 · Cited by 165 · see citing works
Mitochondrial Mechanisms in Diabetic Cardiomyopathy
Gollmer, J., Zirlik, A., & Bugger, H. (2020) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2019.0185 · Cited by 137 · see citing works
Etiologies, Trends, and Predictors of 30-Day Readmission in Patients With Heart Failure
Arora, S., Patel, P., Lahewala, S., Patel, N., Patel, N., Thakore, K., Amin, A., Tripathi, B., Kumar, V. M., Shah, H., et al. (2016) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2016.11.022 · Cited by 127 · see citing works
Dauriz, M., Mantovani, A., Bonapace, S., Verlato, G., Zoppini, G., Bonora, E., & Targher, G. (2017) · Diabetes Care · doi:10.2337/dc17-0697 · Cited by 123 · see citing works
Lee, M. M. Y., McMurray, J. J. V., Lorenzo-Almorós, A., Kristensen, S. L., Sattar, N. A., Jhund, P. S., & Petrie, M. C. (2018) · Heart · doi:10.1136/heartjnl-2016-310342 · Cited by 119 · see citing works
Effects of Metformin in Heart Failure: From Pathophysiological Rationale to Clinical Evidence
Salvatore, T., Galiero, R., Caturano, A., Vetrano, E., Rinaldi, L., Coviello, F., Martino, A. D., Albanese, G., Marfella, R., Sardu, C., et al. (2021) · Biomolecules · doi:10.3390/biom11121834 · Cited by 97 · see citing works
Concomitant Diabetes Mellitus and Heart Failure
Dei, A., Fonarow, G. C., Gheorghiade, M., & Butler, J. (2014) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2014.09.002 · Cited by 92 · see citing works
Sato, N., Ajioka, M., Yamada, T., Kato, M. C., Myoishi, M., Yamada, T., Kim, S.-Y., Nowack, C., Kolkhof, P., Shiga, T., et al. (2016) · Circulation Journal · doi:10.1253/circj.cj-16-0122 · Cited by 77 · see citing works
Dunbar, S. B., Reilly, C. M., GARY, R. A., Higgins, M. K., Culler, S. D., Butts, B., & Butler, J. (2015) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.05.012 · Cited by 69 · see citing works
Lorenzo-Almorós, A., Cepeda-Rodrigo, J. M., & Lorenzo, Ó. (2020) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2019.10.012 · Cited by 71 · see citing works
Noncardiac Comorbidities and Acute Heart Failure Patients
Mentz, R. J., & Felker, G. M. (2013) · Heart Failure Clinics · doi:10.1016/j.hfc.2013.04.003 · Cited by 65 · see citing works
Sharma, A., Demissei, B. G., Tromp, J., Hillege, H. L., Cleland, J. G. F., O’Connor, C. M., Metra, M., Ponikowski, P. P., Teerlink, J. R., Davison, B. A., et al. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.912 · Cited by 64 · see citing works
Epidemiology of heart failure in diabetes: a disease in disguise
Hoek, A. G., Canto, E. D., Wenker, E., Bindraban, N. R., Handoko, M. L., Elders, P. J. M., & Beulens, J. W. J. (2024) · Diabetologia · doi:10.1007/s00125-023-06068-2 · Cited by 71 · see citing works
Kodama*, S., Fujihara, K., Horikawa, C., Sato, T., Iwanaga, M., Yamada, T., Kato, K., Watanabe, K., Shimano, H., Izumi, T., et al. (2020) · ESC Heart Failure · doi:10.1002/ehf2.12782 · Cited by 63 · see citing works
Carrasco-Sánchez, F. J., Gómez-Huelgas, R., Formiga, F., Martel, A. C., Trullàs, J. C., Bettencourt, P., Arévalo‐Lorido, J. C., & Montero-Pérez-Barquero, M. (2014) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2014.03.015 · Cited by 63 · see citing works
Comorbidities in Heart Failure
van der Wal, H. H., van Deursen, V. M., van der Meer, P., & Voors, A. A. (2017) · Handbook of experimental pharmacology · doi:10.1007/164_2017_27 · Cited by 62 · see citing works
Heart Failure: a Major Cardiovascular Complication of Diabetes Mellitus
Bahtiyar, G., Gutterman, D. D., & Lebovitz, H. E. (2016) · Current Diabetes Reports · doi:10.1007/s11892-016-0809-4 · Cited by 59 · see citing works
The heart failure burden of type 2 diabetes mellitus—a review of pathophysiology and interventions
Ofstad, A. P., Atar, D., Gullestad, L. L., Langslet, G., & Johansen, O. E. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9685-0 · Cited by 59 · see citing works
Banks, A. Z., Mentz, R. J., Stebbins, A., Mikus, C. R., Schulte, P. J., Fleg, J. L., Cooper, L. S., Leifer, E. S., Badenhop, D. T., Keteyian, S. J., et al. (2016) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2015.12.007 · Cited by 56 · see citing works
Maggioni, A. P., Greene, S. J., Fonarow, G. C., Böhm, M., Zannad, F. M., Solomon, S. D., Lewis, E. F., Baschiera, F., Hua, T., Gimpelewicz, C. R., et al. (2013) · European Heart Journal · doi:10.1093/eurheartj/eht342 · Cited by 55 · see citing works
The role of hyperglycaemia in the development of diabetic cardiomyopathy
Hayek, M. S. E., Ernande, L., Bénitah, J., Gomez, A. M., & Pereira, L. (2021) · Archives of cardiovascular diseases · doi:10.1016/j.acvd.2021.08.004 · Cited by 56 · see citing works
Eby, E. L., Hardwick, C., Yu, M. B., Gelwicks, S., Deschamps, K., Xie, J., & George, T. (2014) · Current Medical Research and Opinion · doi:10.1185/03007995.2014.981632 · Cited by 55 · see citing works
Johansson, I., Edner, M., Dahlström, U., Näsman, P., Rydén, L., & Norhammar, A. (2013) · European Journal of Heart Failure · doi:10.1002/ejhf.44 · Cited by 52 · see citing works
Su, A., Alaref, S. J., Beecy, A., Min, J. K., & Karas, M. G. (2019) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2019.01.017 · Cited by 50 · see citing works
Management of Comorbid Diabetes Mellitus and Worsening Heart Failure
Khan, S. S., Butler, J., & Gheorghiade, M. (2014) · JAMA · doi:10.1001/jama.2014.4115 · Cited by 49 · see citing works
Dunbar, S. B., Butts, B., Reilly, C. M., GARY, R. A., Higgins, M. K., Ferranti, E. P., Culler, S. D., & Butler, J. (2013) · Nursing Outlook · doi:10.1016/j.outlook.2013.09.003 · Cited by 48 · see citing works
Roberts, T. J., Burns, A., MacIsaac, R. J., MacIsaac, A. I., Prior, D., & Gerche, A. L. (2018) · Cardiovascular Diabetology · doi:10.1186/s12933-018-0688-x · Cited by 46 · see citing works
Becher, P. M., Schrage, B., Ferrannini, G., Benson, L., Butler, J., Carrero, J. J., Cosentino, F., Dahlström, U., Mellbin, L., Rosano, G. M. C., et al. (2021) · European Journal of Heart Failure · doi:10.1002/ejhf.2131 · Cited by 46 · see citing works
Targher, G., Dauriz, M., Tavazzi, L., Temporelli, P. L., Lucci, D., Urso, R., Lecchi, G., Bellanti, G., Merlo, M., Rossi, A., et al. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.10.207 · Cited by 45 · see citing works
Mehra, P., Guo, Y., Nong, Y., Lorkiewicz, P. K., Nasr, M., Li, Q., Muthusamy, S., Bradley, J. A., Bhatnagar, A., Wysoczynski, M., et al. (2018) · Basic Research in Cardiology · doi:10.1007/s00395-018-0703-0 · Cited by 44 · see citing works
Win, T. T., Davis, H. T., & Laskey, W. K. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.003023 · Cited by 43 · see citing works
Fumagalli, S., Said, S. A., Laroche, C., Gabbai, D., Boni, S., Marchionni, N., Boriani, G., Maggioni, A. P., Musialik-Lydka, A., Sokal, A., et al. (2017) · European Heart Journal - Cardiovascular Pharmacotherapy · doi:10.1093/ehjcvp/pvx037 · Cited by 42 · see citing works
Kong, M. G., Jang, S. Y., Jang, J., Cho, H., Lee, S., Lee, S. E., Kim, K. H., Yoo, B., Kang, S., Baek, S. H., et al. (2020) · Cardiovascular Diabetology · doi:10.1186/s12933-020-01026-3 · Cited by 43 · see citing works
Blumer, V. L., Mentz, R. J., Sun, J., Butler, J., Metra, M., Voors, A. A., Hernandez, A. F., O’Connor, C. M., & Greene, S. J. (2021) · Circulation Heart Failure · doi:10.1161/circheartfailure.120.007871 · Cited by 43 · see citing works
Pavlovic, A. S., Polovina, M. M., Ristić, A. D., Seferović, J. P., Veljić, I., Simeunović, D. S., Milinković, I., Krljanać, G., Ašanin, M., Ostric, I., et al. (2018) · European Journal of Preventive Cardiology · doi:10.1177/2047487318807767 · Cited by 36 · see citing works
Campbell, P. T., Krim, S. R., & Ventura, H. O. (2015) · Cardiac failure review · doi:10.15420/cfr.2015.01.01.8 · Cited by 35 · see citing works
Arnold, S. V., Echouffo-Tcheugui, J. B., Lam, C. S. P., Inzucchi, S. E., Tang, F., McGuire, D. K., Goyal, A., Maddox, T. M., Sperling, L. S., Fonarow, G. C., et al. (2018) · American Heart Journal · doi:10.1016/j.ahj.2018.05.016 · Cited by 35 · see citing works
Glucose-Lowering Therapies and Heart Failure in Type 2 Diabetes Mellitus
Vijayakumar, S., Vaduganathan, M., & Butler, J. (2018) · Circulation · doi:10.1161/circulationaha.117.032099 · Cited by 32 · see citing works
Chiang, C., Ueng, K.-C., Chao, T., Lin, T., Wu, Y.-J., Wang, K.-L., Sung, S., Yeh, H., Li, Y., Liu, P., et al. (2020) · Journal of the Chinese Medical Association · doi:10.1097/jcma.0000000000000359 · Cited by 30 · see citing works
Khalil, C. A., Sulaiman, K., Singh, R., Jayyousi, A., Asaad, N., AlHabib, K. F., Alsheikh-Ali, A. A. A., Al‐Jarallah, M., Bulbanat, B., Almahmeed, W. A., et al. (2017) · International Journal of Cardiology · doi:10.1016/j.ijcard.2017.02.119 · Cited by 28 · see citing works
Lorenzo-Almorós, A., Cepeda-Rodrigo, J. M., & Lorenzo, Ó. (2020) · Revista Clínica Española · doi:10.1016/j.rce.2019.10.013 · Cited by 28 · see citing works
Myocardial dysfunction and cardiovascular disease in type 2 diabetes
Ofstad, A. P. (2016) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2016.1155230 · Cited by 25 · see citing works
Go, Y. Y., Allen, J. C., Chia, S. Y., Sim, L. L., Jaufeerally, F. R., Yap, J. J. L., Ching, C. K., Sim, D., Kwok, B. W. K., & Liew, R. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.119 · Cited by 24 · see citing works
Heart failure with multiple comorbidities
Moe, G. W. P. L. (2016) · Current Opinion in Cardiology · doi:10.1097/hco.0000000000000257 · Cited by 24 · see citing works
Epidemiology of the diabetes-cardio-renal spectrum: a cross-sectional report of 1.4 million adults
Schechter, M., Cohen, C. M., Yanuv, I., Rozenberg, A., Chodick, G., Bodegård, J., Leiter, L. A., Verma, S., Heerspink, H. J. L., Karasik, A., et al. (2022) · Cardiovascular Diabetology · doi:10.1186/s12933-022-01521-9 · Cited by 23 · see citing works
van den Berge, J. C., Constantinescu, A. A., Boiten, H. J., van Domburg, R. T., Deckers, J. W., & Akkerhuis, K. M. (2017) · Diabetes Care · doi:10.2337/dc17-0544 · Cited by 23 · see citing works
Chiang, C., Lin, S.-Y., Lin, T., Wang, T., Yeh, H., Chen, J., Tsai, C., Hung, Y.-J., Li, Y., Liu, P., et al. (2018) · Journal of the Chinese Medical Association · doi:10.1016/j.jcma.2018.01.001 · Cited by 22 · see citing works
Oikonomou, E. K., Mourouzis, K., Fountoulakis, P. N., Papamikroulis, G.-A., Siasos, G., Antonopoulos, A. S., Vogiatzi, G., Tsalamadris, S., Vavuranakis, M., & Tousoulis, D. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9682-3 · Cited by 22 · see citing works
Diabetes Management in Patients with Heart Failure
Shen, J., & Greenberg, B. (2021) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2020.0296 · Cited by 21 · see citing works
Jorsal, A., Wiggers, H., & McMurray, J. J. V. (2017) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2017.10.007 · Cited by 20 · see citing works
Nielsen, R. R., Wiggers, H., Thomsen, H. H., Bovin, A., Refsgaard, J. C., Abrahamsen, J., Møller, N., Bøtker, H. E., & Nørrelund, H. (2016) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2016-000202 · Cited by 18 · see citing works
Wan, S., Pumerantz, A. S., Dong, F., Ochoa, C., & Chen, H. H. (2019) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2019.04.015 · Cited by 18 · see citing works
Glucose variability predicts 6-month mortality in patients hospitalized with acute heart failure
Cunha, F. M., Cidade-Rodrigues, C., Elias, C., Oliveira, D., Bettencourt, P., & Lourenço, P. (2021) · Internal and Emergency Medicine · doi:10.1007/s11739-021-02719-7 · Cited by 18 · see citing works
Prevalencia y significado pronóstico de la comorbilidad en la insuficiencia cardiaca
Martel, A. C., & Hernández‐Meneses, M. (2015) · Revista Clínica Española · doi:10.1016/j.rce.2015.08.005 · Cited by 17 · see citing works
FITCHETT, D. H. (2018) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2018.14.2.40 · Cited by 17 · see citing works
Tougaard, R. S., Jorsal, A., Tarnow, L., Hansson, N. H., Kistorp, C., Schou, M., Nielsen, R. R., Flyvbjerg, A., Videbæk, L. M., Mølgaard, H., et al. (2020) · Scandinavian Cardiovascular Journal · doi:10.1080/14017431.2020.1751873 · Cited by 17 · see citing works
Chen, M., Dong, S., Cai, N., Fan, M., Gu, S.-P., Zheng, J.-J., Yin, H., Zhou, X., Wang, L.-X., Li, C., et al. (2016) · BMC Cardiovascular Disorders · doi:10.1186/s12872-016-0198-2 · Cited by 16 · see citing works
Prevalence and prognostic meaning of comorbidity in heart failure
Martel, A. C., & Hernández‐Meneses, M. (2015) · Revista Clínica Española (English Edition) · doi:10.1016/j.rceng.2015.08.007 · Cited by 15 · see citing works
Liu, J., & Hu, X. (2022) · Diabetes and Vascular Disease Research · doi:10.1177/14791641221093175 · Cited by 15 · see citing works
Melgaard, L., Gorst‐Rasmussen, A., Søgaard, P., Rasmussen, L. H., Lip, G. Y. H., & Larsen, T. B. (2016) · International Journal of Cardiology · doi:10.1016/j.ijcard.2016.02.004 · Cited by 16 · see citing works
Age affects the prognostic impact of diabetes in chronic heart failure
Cunha, F. M., Pereira, J. C., Ribeiro, A., Amorim, M., Silva, S., Araújo, J. P., Leite-Moreira, A. F., Bettencourt, P., & Lourenço, P. (2018) · Acta Diabetologica · doi:10.1007/s00592-017-1092-9 · Cited by 15 · see citing works
Kittel‐Schneider, S., Kaspar, M., Berliner, D., Weber, H., Deckert, J., Ertl, G., Störk, S., Angermann, C. E., & Reif, A. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.04.002 · Cited by 13 · see citing works
Revisiting the Diabetes-Heart Failure Connection
Wallner, M., Eaton, D., von Lewinski, D., & Sourij, H. (2018) · Current Diabetes Reports · doi:10.1007/s11892-018-1116-z · Cited by 14 · see citing works
Ruocco, G. M., Evangelista, I., Franci, B., Lucani, B., Martini, S., Nuti, R., & Palazzuoli, A. (2018) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000741 · Cited by 14 · see citing works
Tomasik, A. R., Nabrdalik, K., Kwiendacz, H., Radzik, E., Pigoń, K., Młyńczak, T., Sawczyn, T., Gumprecht, J., Nowalany-Kozielska, E., & Lip, G. Y. H. (2020) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2020.10.051 · Cited by 14 · see citing works
Diabetic patients need higher furosemide doses: a report on acute and chronic heart failure patients
Cunha, F. M., Pereira, J. M., Marques, P. S., Ribeiro, A., Bettencourt, P., & Lourenço, P. (2019) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000896 · Cited by 13 · see citing works
Mukherjee, T., Robbins, T., Keung, S. N. L. C., Sankar, S., Randeva, H. S., & Arvanitis, T. N. (2020) · Journal of Diabetes and its Complications · doi:10.1016/j.jdiacomp.2020.107705 · Cited by 13 · see citing works
Huang, B., Yang, Y., Zhu, J., Liang, Y., Zhang, H., Li, T. X., Shao, X., & Wang, J. (2014) · Yonsei Medical Journal · doi:10.3349/ymj.2015.56.1.62 · Cited by 13 · see citing works
Asleh, R., Sheikh‐Ahmad, M., Briasoulis, Α., & Kushwaha, S. S. (2017) · Heart Failure Reviews · doi:10.1007/s10741-017-9666-8 · Cited by 12 · see citing works
Mahtani, K., Patel, B., Wang, B. Z., & Barron, A. (2022) · International Journal of Cardiology · doi:10.1016/j.ijcard.2022.08.015 · Cited by 12 · see citing works
Hu, Y., Zhang, Y., Han, P., Pan, Y., Liu, J., Li, Y., Pan, D., & Ren, J. (2025) · International Journal of Cardiology · doi:10.1016/j.ijcard.2025.133743 · Cited by 11 · see citing works
Johansson, I., & Norhammar, A. (2021) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2021.108822 · Cited by 11 · see citing works
Low stress hyperglycemia ratio predicts worse prognosis in diabetic acute heart failure patients
Cunha, F. M., Carreira, M., Ferreira, I., Bettencourt, P., & Lourenço, P. (2023) · Revista Portuguesa de Cardiologia · doi:10.1016/j.repc.2022.02.013 · Cited by 11 · see citing works
Clinical impact of oral antidiabetic medications in heart failure patients
Palazzuoli, A., Ceccarelli, E., Ruocco, G. M., & Nuti, R. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9669-0 · Cited by 11 · see citing works
Chen, Y.-Y., Chen, Y., Liang, S.-M., Su, Z.-Z., Shu, X., Zhang, H.-F., Wan, S., Wang, J.-F., & Xie, S.-L. (2018) · Chinese Medical Journal · doi:10.4103/0366-6999.239310 · Cited by 11 · see citing works
Arnold, S. V., Yap, J. J. L., Lam, C. S. P., Tang, F., Tay, W. T., Teng, T. K., McGuire, D. K., Januzzi, J. L., Fonarow, G. C., Masoudi, F. A., et al. (2018) · Diabetes Obesity and Metabolism · doi:10.1111/dom.13511 · Cited by 11 · see citing works
Mechanisms underlying diabetic cardiomyopathy: From pathophysiology to novel therapeutic targets.
Cong, S., Ramachandra, C. J. A., Ja, K. P. M. M., Yap, J., SHIM, W. S. N., Wei, L., & Hausenloy, D. J. (2020) · PubMed · Cited by 11 · see citing works
Masip, J., Povar-Echeverría, M., Peacock, W. F., Jacob, J., Gil, V., Herrero, P., Llorens, P., Alquézar‐Arbé, A., Sánchez, C., Martín‐Sánchez, F. J., et al. (2022) · Internal and Emergency Medicine · doi:10.1007/s11739-022-02965-3 · Cited by 11 · see citing works
- Authors
- Sarma, S., Mentz, R. J., Kwasny, M. J., Fought, A. J., Huffman, M., Subacius, H., Nodari, S., Konstam, M., Swedberg, K., Maggioni, A. P., Zannad, F., Bonow, R. O., & Gheorghiade, M.
- Affiliations
- Northwestern University (US)
- Duke University (US)
- University of Brescia (IT)
- Tufts University (US)
- University of Gothenburg (SE)
- Associazione Nazionale Medici Cardiologi Ospedalieri (IT)
- Department of Cardiology, Nancy University , Nancy ,
- Corresponding author
- Gheorghiade, Mihai
- ORCID
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2013-02-01
- Volume
- 15
- Issue
- 2
- Pages
- 194-202
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- PMC
- PMC4176083
- OpenAlex
- W2085741095
- Cited by
- 202
- References
- 33
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 27 · 2023: 11 · 2022: 11 · 2021: 16 · 2020: 23 · 2019: 8 · 2018: 29 · 2017: 17 · 2016: 18 · 2015: 15 · 2014: 11 · 2013: 8
- FWCI
- 6.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- European Journal of Heart Failure (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Institutional Research Information System (Università degli Studi di Brescia) (submittedVersion, public-domain)
- Funders
- Northwestern University
- Feinberg School of Medicine
- National Institute of General Medical Sciences (T32GM086330)
- Topics
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Keywords
- diabetes mellitus, heart failure, reduced ejection fraction, post-discharge outcomes, all-cause mortality, cardiovascular mortality, heart failure hospitalization, EVEREST trial, tolvaptan, vasopressin receptor antagonism, comorbidities
- MeSH terms
- Tolvaptan, Adult, Aged, Aged, 80 and over, Benzazepines, Cause of Death, Combined Modality Therapy, Cross-Sectional Studies, Diet, Diabetic, Female, Follow-Up Studies, Hospitalization, Humans, Hypoglycemic Agents, Insulin, Male, Middle Aged, Patient Discharge, Comorbidity, Proportional Hazards Models, Treatment Outcome, Disease Progression, Diabetes Complications, Heart Failure, Systolic, Antidiuretic Hormone Receptor Antagonists
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
