Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial
Open accessAbstract
AIMS: The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre-specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition-intervention prevention trial. METHODS AND RESULTS: Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra-virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low-fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41-1.13, and HR 0.92; 95% CI 0.56-1.49, respectively]. CONCLUSION: In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre-specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk. TRIAL REGISTRATION: ISRCTN35739639.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The text we found for this paper looks like another document, so the self-check wasn’t run.
Cites
2 retracted
RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet
Estruch, R., Ros, E., Salas-Salvadó, J., Covas, M.-I., Corella, D., Arós, F., Gómez-Gracia, E., Ruiz-Gutiérrez, V., Fiol, M., Lapetra, J., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1200303 · Cited by 4,257 · see citing works
RetractedEstruch, R., Martínez‐González, M. Á., Corella, D., Salas‐Salvadó, J., Fitó, M., Chiva‐Blanch, G., Fiol, M., Gómez‐Gracia, E., Arós, F., Lapetra, J., et al. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)30085-7 · Cited by 195 · see citing works
Retractedde Lorgeril, M., Salen, P., Martin, J.-L., Monjaud, I., Delaye, J., & Mamelle, N. (1999) · Circulation · doi:10.1161/01.cir.99.6.779 · Cited by 2,910 · see citing works
Cardiovascular effects of intensive lifestyle intervention in type 2 diabetes
The Look AHEAD Research Group (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1212914 · Cited by 2,908 · see citing works
Forecasting the Impact of Heart Failure in the United States
Heidenreich, P. A., Albert, N. M., Allen, L. A., Bluemke, D. A., Butler, J., Fonarow, G. C., Ikonomidis, J. S., Khavjou, O., Konstam, M. A., Maddox, T. M., et al. (2013) · Circulation Heart Failure · doi:10.1161/hhf.0b013e318291329a · Cited by 2,802 · see citing works
Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005)
Swedberg, K. B., Cleland, J. G. F., Dargie, H., Drexler, H., Folláth, F., Michel Komajda, N., Tavazzi, L., Smiseth, O. A., Gavazzi, A., Haverich, A., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi204 · Cited by 2,243 · see citing works
Effects of a Mediterranean-Style Diet on Cardiovascular Risk Factors: A Randomized Trial
Estruch, R., Martínez-González, M. Á., Corella, D., Salas-Salvadó, J., Ruiz-Gutiérrez, V., Covas, M. I., Fiol, M., Gómez-Gracia, E., López-Sabater, M. C., Vinyoles, E., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-1-200607040-00004 · Cited by 1,704 · see citing works
Schröder, H., Fitó, M., Estruch, R., Martínez-González, M. A., Corella, D., Salas-Salvadó, J., Lamuela-Raventós, R., Ros, E., Salaverría, I., Fiol, M., et al. (2011) · The Journal of Nutrition · doi:10.3945/jn.110.135566 · Cited by 1,624 · see citing works
Oxidative stress and heart failure
Tsutsui, H., Kinugawa, S., & Matsushima, S. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00554.2011 · Cited by 1,246 · see citing works
Executive summary of the guidelines on the diagnosis and treatment of acute heart failure
Nieminen, M. S., Böhm, M., Cowie, M., Drexler, H., Filippatos, G. S., Jondeau, G., Hasin, Y., Lopez-Sendon, J., Mebazaa, A., Metra, M., et al. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi044 · Cited by 1,174 · see citing works
Reduction in the Incidence of Type 2 Diabetes With the Mediterranean Diet
Salas-Salvadó, J., Bulló, M., Babio, N., Martínez-González, M. Á., Ibarrola-Jurado, N., Basora, J., Estruch, R., Covas, M. I., Corella, D., Arós, F., et al. (2011) · Diabetes Care · doi:10.2337/dc10-1288 · Cited by 901 · see citing works
Fernández-Ballart, J. D., Piñol, J. L., Zazpe, I., Corella, D., Carrasco, P., Toledo, E., Perez-Bauer, M., Martínez-González, M. Á., Salas-Salvadó, J., & Martín-Moreno, J. M. (2010) · British Journal of Nutrition · doi:10.1017/s0007114509993837 · Cited by 898 · see citing works
Cohort Profile: Design and methods of the PREDIMED study
Martinez-Gonzalez, M. A., Corella, D., Salas-Salvado, J., Ros, E., Covas, M. I., Fiol, M., Warnberg, J., Aros, F., Ruiz-Gutierrez, V., Lamuela-Raventos, R. M., et al. (2012) · International Journal of Epidemiology · doi:10.1093/ije/dyq250 · Cited by 671 · see citing works
2014 ACC/AHA Key Data Elements and Definitions for Cardiovascular Endpoint Events in Clinical Trials
Hicks, K. A., Tcheng, J. E., Bozkurt, B., CHAITMAN, B. R., Cutlip, D. E., Farb, A. A., Fonarow, G. C., Jacobs, J. P., Jaff, M. R., Lichtman, J. H., et al. (2014) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2014.12.018 · Cited by 608 · see citing works
Prevention of Atrial Fibrillation
Benjamin, E. J., Chen, P., Bild, D. E., Mascette, A. M., Albert, C. M., Alonso, Á., Calkins, H. G., Connolly, S. J., Curtis, A. B., Darbar, D., et al. (2009) · Circulation · doi:10.1161/circulationaha.108.825380 · Cited by 471 · see citing works
Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil
Cicerale, S., Lucas, L., & Keast, R. (2011) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2011.09.006 · Cited by 467 · see citing works
Anti-inflammatory effects of the Mediterranean diet: the experience of the PREDIMED study
Estruch, R. (2010) · Proceedings of The Nutrition Society · doi:10.1017/s0029665110001539 · Cited by 347 · see citing works
Toledo, E., Hu, F. B., Estruch, R., Buil-Cosiales, P., Corella, D., Salas-Salvadó, J., Covas, M. I., Arós, F., Gómez-Gracia, E., Fiol, M., et al. (2013) · BMC Medicine · doi:10.1186/1741-7015-11-207 · Cited by 289 · see citing works
Association between adherence to the Mediterranean diet and oxidative stress
Dai, J., Jones, D. P., Goldberg, J., Ziegler, T. R., Bostick, R. M., Wilson, P. W., Manatunga, A. K., Shallenberger, L., Jones, L., & Vaccarino, V. (2008) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2008.26528 · Cited by 256 · see citing works
Multimorbidity in Heart Failure: A Community Perspective
Chamberlain, A. M., Sauver, J. L. S., Gerber, Y., Manemann, S. M., Boyd, C. M., Dunlay, S. M., Rocca, W. A., Rutten, L. J. F., Jiang, R., Weston, S. A., et al. (2014) · The American Journal of Medicine · doi:10.1016/j.amjmed.2014.08.024 · Cited by 231 · see citing works
Tektonidis, T. G., Åkesson, A., Gigante, B., Wolk, A., & Larsson, S. C. (2015) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2015.08.039 · Cited by 216 · see citing works
Hospitalization for congestive heart failure: United States, 2000-2010.
Hall, M. J., Levant, S., & DeFrances, C. J. (2012) · PubMed · Cited by 166 · see citing works
Fitó, M., Estruch, R., Salas‐Salvadó, J., Martínez‐González, M. Á., Arós, F., Vila, J., Corella, D., Díaz, Ó., Sáez, G. T., de la Torre, R., et al. (2014) · European Journal of Heart Failure · doi:10.1002/ejhf.61 · Cited by 164 · see citing works
Adherence to a Mediterranean Diet is Associated With Reduced Risk of Heart Failure in Men
Tektonidis, T. G., Åkesson, A., Gigante, B., Wolk, A., & Larsson, S. C. (2016) · European Journal of Heart Failure · doi:10.1002/ejhf.481 · Cited by 110 · see citing works
The Population Burden of Heart Failure Attributable to Modifiable Risk Factors
Avery, C. L., Loehr, L. R., Baggett, C. D., Chang, P. P., Kucharska‐Newton, A., Matsushita, K., Rosamond, W. D., & HEISS, G. M. (2012) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2012.07.022 · Cited by 105 · see citing works
Healthy Lifestyle and Risk of Heart Failure
Larsson, S. C., Tektonidis, T. G., Gigante, B., Åkesson, A., & Wolk, A. (2016) · Circulation Heart Failure · doi:10.1161/circheartfailure.115.002855 · Cited by 72 · see citing works
Chrysohoou, C. A., Pitsavos, C., Barbetseas, J. D., Kotroyiannis, I., Brili, S. V., Vasiliadou, K., Papadimitriou, L., & Stefanadis, C. (2009) · Heart and Vessels · doi:10.1007/s00380-008-1080-7 · Cited by 62 · see citing works
Lifestyle and Dietary Risk Factors for Peripheral Artery Disease
Ruiz‐Canela, M., & Martínez‐González, M. Á. (2014) · Circulation Journal · doi:10.1253/circj.cj-14-0062 · Cited by 54 · see citing works
Wirth, J., di Giuseppe, R., Boeing, H., & Weikert, C. (2016) · European Journal of Clinical Nutrition · doi:10.1038/ejcn.2016.140 · Cited by 49 · see citing works
Larsson, S. C., Drca, N., Jensen‐Urstad, M., & Wolk, A. (2015) · International Journal of Cardiology · doi:10.1016/j.ijcard.2015.10.106 · Cited by 28 · see citing works
Chrysohoou, C. A., Kastorini, C.-M., Panagiotakos, D. B., Aggelopoulos, P., Tsiachris, D., Pitsavos, C. S., & Stefanadis, C. (2009) · Annals of Nutrition and Metabolism · doi:10.1159/000261898 · Cited by 13 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Dietary metabolism, the gut microbiome, and heart failure
Tang, W. H. W., Li, D. Y., & Hazen, S. L. (2019) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0108-7 · Cited by 789 · see citing works
Health Benefits of the Mediterranean Diet: Metabolic and Molecular Mechanisms
Tosti, V., Bertozzi, B., & Fontana, L. (2018) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glx227 · Cited by 762 · see citing works
Global Public Health Burden of Heart Failure: An Updated Review
Shahim, B., Kapelios, C., Savarese, G., & Lund, L. (2023) · Cardiac failure review · doi:10.15420/cfr.2023.05 · Cited by 655 · see citing works
Metabolic and Vascular Effect of the Mediterranean Diet
Tuttolomondo, A., Simonetta, I., Daidone, M., Mogavero, A., Ortello, A., & Pinto, A. V. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20194716 · Cited by 269 · see citing works
Papadaki, A., Nolen‐Doerr, E., & Mantzoros, C. S. (2020) · Nutrients · doi:10.3390/nu12113342 · Cited by 266 · see citing works
Benefits of the Mediterranean diet: Epidemiological and molecular aspects
Serra‐Majem, L., Román‐Viñas, B., Sánchez‐Villegas, A., Guasch‐Ferré, M., Corella, D., & Vecchia, C. L. (2019) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2019.06.001 · Cited by 240 · see citing works
Vest, A. R., Chan, M. C. Y., Deswal, A. M., Givertz, M. M., Lekavich, C. L., Lennie, T. A., Litwin, S. E., Parsly, L., Rodgers, J. E., Rich, M. W., et al. (2019) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2019.03.007 · Cited by 233 · see citing works
Mediterranean Diet and Cardiovascular Disease Prevention: What Do We Know?
Salas‐Salvadó, J., Becerra‐Tomás, N., García-Gavilán, J. F., Bulló, M., & Barrubés, L. (2018) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2018.04.006 · Cited by 199 · see citing works
The gut microbiota and its interactions with cardiovascular disease
Xu, H., Wang, X., Feng, W., Liu, Q., Zhou, S., Liu, Q., & Cai, L. (2020) · Microbial Biotechnology · doi:10.1111/1751-7915.13524 · Cited by 192 · see citing works
Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease
Abdelhamid, A. S., Martin, N., Bridges, C., Brainard, J. S., Wang, X., Brown, T. J., Hanson, S., Jimoh, F. O., Ajabnoor, S. M., Deane, K. H., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012345.pub2 · Cited by 187 · see citing works
Lean Mass Abnormalities in Heart Failure: The Role of Sarcopenia, Sarcopenic Obesity, and Cachexia
Carbone, S., Billingsley, H., Rodriguez‐Miguelez, P., Kirkman, D. L., Garten, R. S., Franco, R. L., Lee, D.-C., & Lavie, C. J. (2019) · Current Problems in Cardiology · doi:10.1016/j.cpcardiol.2019.03.006 · Cited by 169 · see citing works
Lifestyle modifications for preventing and treating heart failure
Aggarwal, M., Bozkurt, B., Panjrath, G., Aggarwal, B., Ostfeld, R. J., Barnard, N. D., Gaggin, H., Freeman, A. M., Allen, K., Madan, S., et al. (2018) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.08.2160 · Cited by 162 · see citing works
Sanches Machado d’Almeida, K., Ronchi Spillere, S., Zuchinali, P., & Corrêa Souza, G. (2018) · Nutrients · doi:10.3390/nu10010058 · Cited by 157 · see citing works
Polyunsaturated fatty acids for the primary and secondary prevention of cardiovascular disease
Abdelhamid, A. S., Martin, N., Bridges, C., Brainard, J. S., Wang, X., Brown, T. J., Hanson, S., Jimoh, F. O., Ajabnoor, S. M., Deane, K. H., et al. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012345.pub3 · Cited by 147 · see citing works
Sánchez-Sánchez, M. L., García-Vigara, A., Hidalgo-Mora, J. J., García-Pérez, M.-Á., Tarín, J., & Cano, A. (2020) · Maturitas · doi:10.1016/j.maturitas.2020.03.008 · Cited by 137 · see citing works
Nuts: Natural Pleiotropic Nutraceuticals
Ros, E., Singh, A., & O’Keefe, J. H. (2021) · Nutrients · doi:10.3390/nu13093269 · Cited by 135 · see citing works
Role of the intestinal microbiome and its therapeutic intervention in cardiovascular disorder
Luqman, A., Hassan, A., Ullah, M., Naseem, S., Ullah, M., Zhang, L., Din, A. U., Ullah, K., Ahmad, W., & Wang, G. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1321395 · Cited by 138 · see citing works
Dietary Patterns and Incident Heart Failure in U.S. Adults Without Known Coronary Disease
Lara, K. M., Levitan, E. B., Gutiérrez, O. M., Shikany, J. M., Safford, M. M., Judd, S. E., & Rosenson, R. S. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2019.01.067 · Cited by 115 · see citing works
Dietary Fats and Chronic Noncommunicable Diseases
Billingsley, H., Carbone, S., & Lavie, C. J. (2018) · Nutrients · doi:10.3390/nu10101385 · Cited by 110 · see citing works
Dietary Management of Heart Failure: DASH Diet and Precision Nutrition Perspectives
Wickman, B. E., Enkhmaa, B., Ridberg, R. A., Romero, E., Cadeiras, M., Meyers, F., & Steinberg, F. M. (2021) · Nutrients · doi:10.3390/nu13124424 · Cited by 113 · see citing works
The role of diet and nutrition in heart failure: A state-of-the-art narrative review
Billingsley, H. E., Hummel, S. L., & Carbone, S. (2020) · Progress in Cardiovascular Diseases · doi:10.1016/j.pcad.2020.08.004 · Cited by 106 · see citing works
Molecular Mechanisms of SGLT2 Inhibitor on Cardiorenal Protection
Hou, Y., Zheng, C., Yen, T., & Lu, K. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21217833 · Cited by 108 · see citing works
Lipid Profiles and Heart Failure Risk
Wittenbecher, C., Eichelmann, F., Toledo, E., Guasch‐Ferré, M., Ruiz‐Canela, M., Li, J., Arós, F., Lee, C., Liang, L., Salas‐Salvadó, J., et al. (2020) · Circulation Research · doi:10.1161/circresaha.120.317883 · Cited by 98 · see citing works
Barteková, M., Adameová, A., Görbe, A., Ferenczyová, K., Pecháňová, O., Lazou, A., Dhalla, N. S., Ferdinandy, P., & Giricz, Z. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.045 · Cited by 98 · see citing works
Milton-Laskibar, I., Martínez, J. A., & Portillo, M. P. (2021) · Foods · doi:10.3390/foods10061314 · Cited by 77 · see citing works
Choline Metabolism and Risk of Atrial Fibrillation and Heart Failure in the PREDIMED Study
Papandreou, C., Bulló, M., Hernández‐Alonso, P., Ruiz‐Canela, M., Li, J., Guasch‐Ferré, M., Toledo, E., Clish, C. B., Corella, D., Estruch, R., et al. (2020) · Clinical Chemistry · doi:10.1093/clinchem/hvaa224 · Cited by 72 · see citing works
Mediterranean diet impact on cardiovascular diseases
Mattioli, A. V., Palmiero, P., Manfrini, O., Puddu, P. E., Nodari, S., Dei, A., Mercuro, G. G., Scrutinio, D., Palermo, P., Sciomer, S., et al. (2017) · Journal of Cardiovascular Medicine · doi:10.2459/jcm.0000000000000573 · Cited by 67 · see citing works
Tricarboxylic acid cycle related-metabolites and risk of atrial fibrillation and heart failure
Bulló, M., Papandreou, C., García-Gavilán, J. F., Ruiz‐Canela, M., Li, J., Guasch‐Ferré, M., Toledo, E., Clish, C. B., Corella, D., Estruch, R., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154915 · Cited by 63 · see citing works
Mukherjee, M. S., Han, C. Y., Sukumaran, S., Delaney, C. L., & Miller, M. (2022) · Nutrition Reviews · doi:10.1093/nutrit/nuac045 · Cited by 62 · see citing works
Diagnosis and management of malnutrition in patients with heart failure
Esteban-Fernández, A., Villar-Taibo, R., Alejo, M., Arroyo, D., Bonilla Palomas, J. L., Cachero, M., Joaquin, C., Méndez Bailón, M., Pérez-Rivera, J. Á., Romero-Vigara, J. C., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12093320 · Cited by 61 · see citing works
Adherence to Mediterranean Diet and All-Cause Mortality After an Episode of Acute Heart Failure
Miró, Ò., Estruch, R., Martín-Sánchez, F. J., Gil, V., Jacob, J., Herrero-Puente, P., Herrera Mateo, S., Aguirre, A., Andueza, J. A., Llorens, P., et al. (2018) · JACC: Heart Failure · doi:10.1016/j.jchf.2017.09.020 · Cited by 60 · see citing works
Gut Microbiota Modulation as a Novel Therapeutic Strategy in Cardiometabolic Diseases
Mutalub, Y. B., Abdulwahab, M., Mohammed, A., Yahkub, A. M., Al-Mhanna, S. B., Yusof, W., Tang, S. P., Rasool, A. H. G., & Mokhtar, S. S. (2022) · Foods · doi:10.3390/foods11172575 · Cited by 60 · see citing works
Regulation of miRNAs by Natural Antioxidants in Cardiovascular Diseases: Focus on SIRT1 and eNOS
Lee, Y., & Im, E. (2021) · Antioxidants · doi:10.3390/antiox10030377 · Cited by 59 · see citing works
2026 ESC Guidelines for the management of heart failure
Køber, L., Adamo, M., Ruwald, A., Tomasoni, D., Anderson, L., Andersson, C., Brugts, J. J., Chioncel, O. D., Donal, E., Ferdinandy, P., et al. (2026) · European Heart Journal · doi:10.1093/eurheartj/ehag100 · Cited by 91 · see citing works
A Review of Plant-based Diets to Prevent and Treat Heart Failure
Kerley, C. P. (2018) · Cardiac failure review · doi:10.15420/cfr.2018:1:1 · Cited by 51 · see citing works
Kerley, C. P. (2018) · Nutrition Research Reviews · doi:10.1017/s0954422418000148 · Cited by 51 · see citing works
Gut microbiota in heart failure and related interventions
Chen, A., Zhang, J., & Zhang, Y. (2023) · iMeta · doi:10.1002/imt2.125 · Cited by 47 · see citing works
Nutrition in chronic heart failure patients: a systematic review
Bianchi, V. E. (2019) · Heart Failure Reviews · doi:10.1007/s10741-019-09891-1 · Cited by 43 · see citing works
Karğın, D., Tomaino, L., & Serra‐Majem, L. (2019) · Nutrients · doi:10.3390/nu11122991 · Cited by 41 · see citing works
Papandreou, C., Hernández‐Alonso, P., Bulló, M., Ruiz‐Canela, M., Li, J., Guasch‐Ferré, M., Toledo, E., Clish, C. B., Corella, D., Estruch, R., et al. (2020) · Journal of Nutrition · doi:10.1093/jn/nxaa273 · Cited by 40 · see citing works
Is There More to Olive Oil than Healthy Lipids?
Isaakidis, A., Maghariki, J. E., Carvalho-Barros, S., Gomes, A., & Correia, M. (2023) · Nutrients · doi:10.3390/nu15163625 · Cited by 43 · see citing works
Nut consumption and incidence of seven cardiovascular diseases
Larsson, S. C., Drca, N., Björck, M., Bäck, M., & Wolk, A. (2018) · Heart · doi:10.1136/heartjnl-2017-312819 · Cited by 40 · see citing works
Henríquez‐Hernández, L. A., Luzardo, O. P., Zumbado, M. L., Serra‐Majem, L., Valerón, P. F., Camacho, M., Álvarez-Pérez, J., Salas‐Salvadó, J., & Boada, L. D. (2017) · Environmental Research · doi:10.1016/j.envres.2017.03.053 · Cited by 38 · see citing works
The Mediterranean Diet And Cardioprotection: Historical Overview And Current Research
Minelli, P., & Montinari, M. R. (2019) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s219875 · Cited by 35 · see citing works
Role of gut microbiota and derived metabolites in cardiovascular diseases
Yu, J., Yang, Y., Chen, W., Hu, J., Jin, Z., Wu, C., & Li, Y. (2025) · iScience · doi:10.1016/j.isci.2025.113247 · Cited by 33 · see citing works
Gut macrobiotic and its metabolic pathways modulate cardiovascular disease
Zhu, J., Lyu, J., Zhao, R., Liu, G., & Wang, S. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1272479 · Cited by 30 · see citing works
Furbatto, M., Lelli, D., Incalzi, R. A., & Pedone, C. (2024) · Nutrients · doi:10.3390/nu16223947 · Cited by 29 · see citing works
Cardiovascular, kidney, and metabolic health: an actionable vision for heart failure prevention
Ostrominski, J. W., CHENG, A. Y. Y., Nelson, A. J., Neuen, B. L., Sattar, N. A., Tuttle, K. R., & Vaduganathan, M. (2025) · The Lancet · doi:10.1016/s0140-6736(25)01384-4 · Cited by 27 · see citing works
Tuttolomondo, A., Raimondo, D. D., Casuccio, A., Velardo, M., Salamone, G., Cataldi, M., Corpora, F., Restivo, V., Pecoraro, R., Corte, V. D., et al. (2019) · Nutrition · doi:10.1016/j.nut.2019.110584 · Cited by 27 · see citing works
Chang, C.-Y., Lee, C.-L., Liu, W.-J., & Wang, J. (2022) · Nutrients · doi:10.3390/nu14040842 · Cited by 25 · see citing works
Effects of dietary interventions on cardiovascular outcomes: a network meta-analysis
Doundoulakis, I., Farmakis, I. T., Theodoridis, X., Konstantelos, A., Christoglou, M., Kotzakioulafi, E., Chrysoula, L., Siargkas, A., Karligkiotis, A., Kyprianou, G., et al. (2023) · Nutrition Reviews · doi:10.1093/nutrit/nuad080 · Cited by 28 · see citing works
Yang, Y., Karampoor, S., Mirzaei, R., Бороздкин, Л. Л., & Zhu, P. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110546 · Cited by 24 · see citing works
The association of the Mediterranean diet with heart failure risk in a Dutch population
Strengers, J. G., den Ruijter, H. M., Boer, J. M. A., Asselbergs, F. W., Verschuren, W. M. M., van der Schouw, Y. T., & Sluijs, I. (2020) · Nutrition Metabolism and Cardiovascular Diseases · doi:10.1016/j.numecd.2020.08.003 · Cited by 21 · see citing works
Grammatikopoulou, M. G., Nigdelis, M. P., Theodoridis, X., Gkiouras, K., Tranidou, A., Papamitsou, T., Bogdanos, D. P., & Goulis, D. G. (2021) · BMJ Nutrition Prevention & Health · doi:10.1136/bmjnph-2020-000188 · Cited by 19 · see citing works
Veronese, N., Ragusa, F. S., Maggi, S., Witard, O. C., Smith, L., Dominguez, L. J., Barbagallo, M., Isanejad, M., & Prokopidis, K. (2024) · European Journal of Clinical Nutrition · doi:10.1038/s41430-024-01519-4 · Cited by 19 · see citing works
Gut Microbiota and Cardiovascular System: An Intricate Balance of Health and the Diseased State
Bhat, M. A., Mishra, A. K., Tantray, J. A., Alatawi, H. A., Saeed, M., Rahman, S., & Jan, A. T. (2022) · Life · doi:10.3390/life12121986 · Cited by 19 · see citing works
Gut Microbiome and Precision Nutrition in Heart Failure: Hype or Hope?
Chaikijurajai, T., & Tang, W. H. W. (2021) · Current Heart Failure Reports · doi:10.1007/s11897-021-00503-4 · Cited by 16 · see citing works
Barrea, L., Verde, L., Annunziata, G., Chedraui, P. A., Petraglia, F., Cucalón, G., Camajani, E., Caprio, M., Gorini, S., Iorio, G. G., et al. (2025) · Current Obesity Reports · doi:10.1007/s13679-025-00662-8 · Cited by 15 · see citing works
Frías-Toral, E., Chapela, S. P., Carignano, M. D. L. A., Moretti, D., Martinuzzi, A. L. N., Veintimilla, D. R., Guerrero, M., Pugliese, G., Muscogiuri, G., & Barrea, L. (2021) · Endocrines · doi:10.3390/endocrines2040034 · Cited by 15 · see citing works
Bansal, B., Lajeunesse‐Trempe, F., Keshvani, N., Lavie, C. J., & Pandey, A. (2025) · Canadian Journal of Cardiology · doi:10.1016/j.cjca.2025.04.012 · Cited by 15 · see citing works
Deep dive to the secrets of the PREDIMED trial
Fernandez-Lazaro, C. I., Ruiz‐Canela, M., & Martínez‐González, M. Á. (2020) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000000731 · Cited by 12 · see citing works
Song, P. S., Kim, M., Seong, S.-W., Park, J., Choi, S. W., Hahn, J., Gwon, H., Hur, S., Rha, S., Yoon, C., et al. (2021) · Heart and Vessels · doi:10.1007/s00380-021-01876-1 · Cited by 12 · see citing works
Mehmood, K., Moin, A., Hussain, T., Rizvi, S. M. D., Gowda, D., Shakil, S., & Kamal, M. (2021) · Folia Microbiologica · doi:10.1007/s12223-021-00926-5 · Cited by 11 · see citing works
Goñi, L., Razquín, C., Toledo, E., Guasch‐Ferré, M., Clish, C. B., Babió, N., Wittenbecher, C., Atzeni, A., Li, J., Liang, L., et al. (2022) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqac139 · Cited by 11 · see citing works
Caloric restriction in heart failure: A systematic review
Bianchi, V. E. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.04.009 · Cited by 10 · see citing works
Yu, L., Wang, J., Gong, Q., An, Y., Chen, F., Chen, Y., Chen, X., He, S., Qian, X., Chen, B., et al. (2024) · Diabetes Obesity and Metabolism · doi:10.1111/dom.15413 · Cited by 9 · see citing works
Papadaki, A., Martínez‐González, M. Á., Alonso‐Gómez, Á. M., Rekondo, J., Salas‐Salvadó, J., Corella, D., Ros, E., Fitó, M., Estruch, R., Lapetra, J., et al. (2019) · European Journal of Heart Failure · doi:10.1002/ejhf.1346 · Cited by 8 · see citing works
Arayıcı, M. E., Kılıç, M. E., & Yılmaz, M. B. (2025) · Life · doi:10.3390/life15010063 · Cited by 8 · see citing works
de Rojas, J. P., Toledo, E., Estruch, R., Guasch‐Ferré, M., Salas‐Salvadó, J., Gómez‐Gracia, E., Ros, E., Fitó, M., Arós, F., Fiol, M., et al. (2025) · American Heart Journal · doi:10.1016/j.ahj.2025.08.021 · Cited by 6 · see citing works
Kwant, C. T., de Man, F. S., van der Horst, F. A. L., Bogaard, H. J., & Noordegraaf, A. V. (2023) · Pulmonary Circulation · doi:10.1002/pul2.12243 · Cited by 6 · see citing works
The association between olive oil consumption and primary prevention of cardiovascular diseases
Al-Ghamdi, S. H. (2018) · Journal of Family Medicine and Primary Care · doi:10.4103/jfmpc.jfmpc_191_18 · Cited by 5 · see citing works
Satogami, K., Katayama, Y., Ozaki, Y., Taruya, A., Taniguchi, M., Ota, S., Kuroi, A., Shiono, Y., Tanimoto, T., Yamano, T., et al. (2023) · ESC Heart Failure · doi:10.1002/ehf2.14325 · Cited by 4 · see citing works
Lee, H. S., Han, G. I., Kim, K., Kang, S., Jang, J.-H., Jo, Y., Son, J. M., Lee, M. S., Kwon, J., & Oh, B. (2025) · International Journal of Medical Informatics · doi:10.1016/j.ijmedinf.2025.105843 · Cited by 4 · see citing works
Heart-healthy effect of extra virgin olive oil: a bibliographic review
García, R. G., & Claros, C. F. G. (2023) · Enfermería Cuidándote · doi:10.51326/ec.6.4987133 · Cited by 3 · see citing works
A Focus on Heart Failure Management through Diet and Nutrition: A Comprehensive Review
Liao, L. P., Pant, A., Marschner, S. L., Talbot, P. L., & Zaman, S. J. (2024) · Hearts · doi:10.3390/hearts5030022 · Cited by 4 · see citing works
Intestinal microbiota in the pathogenesis of chronic heart failure
Ivashkin, V. T., Fadeeva, M. V., Схиртладзе, М. Р., & Zolnikova, O. Y. (2020) · Italian Journal of Medicine · doi:10.4081/itjm.2020.1185 · Cited by 3 · see citing works
Volpe, R., Ciccone, M. M., Pala, B., Barbarano, F., Camastra, S., Caprio, M., Casirati, A., Ferrera, A., Galletti, F., Greatti, A., et al. (2025) · Nutrition · doi:10.1016/j.nut.2025.113038 · Cited by 2 · see citing works
Ma, T.-C., Gao, F., Liu, X., Wang, C., Liu, Q., & Zhou, J. (2024) · PLoS ONE · doi:10.1371/journal.pone.0304289 · Cited by 2 · see citing works
Predictive Modeling of Heart Failure Risk Based on Dietary Antioxidants: A Machine Learning Approach
Zhao, H., Shen, G., Zhang, W., Zhang, Y., Wang, X., Chen, X., Chen, Y., Ye, L., Liu, J., Jiang, J., et al. (2025) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.70249 · Cited by 1 · see citing works
Martín‐Conty, J. L., Rodríguez, F. M., Criado‐Álvarez, J. J., Castillo, C. A., Maestre-Miquel, C., Mohedano‐Moriano, A., López, B. P., Durantez‐Fernández, C., Villamor, M. Á. C., & Viñuela, A. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17176374 · Cited by 1 · see citing works
Franco, A. D., Morfino, P., & Aimo, A. (2022) · Revista Española de Cardiología · doi:10.1016/j.recesp.2022.01.020 · Cited by 1 · see citing works
Nature of intestinal microflora disorders in cardiovascular diseases
Stepanov, Y. М., & Budzak, I. Y. (2023) · GASTROENTEROLOGY · doi:10.22141/2308-2097.57.2.2023.541 · Cited by 1 · see citing works
Efecto de la Dieta Mediterránea en la prevención de la preeclampsia
García, Á. L. (2023) · MLS Health & Nutrition Research · doi:10.60134/mlshn.v2i1.1999 · Cited by 1 · see citing works
A mikrobiom és a kardiovaszkuláris egészség
Péterfi, Z. (2024) · Cardiologia Hungarica · doi:10.26430/chungarica.2024.54.1.32 · Cited by 1 · see citing works
Association of Dietary Fats with Ischemic Heart Disease (IHD): A Sustainable Decision
Alhouei, B., Ajami, M., Abdollahi, M., & Doaei, S. (2024) · Food Science and Nutrition Cases · doi:10.1079/fsncases.2024.0016 · Cited by 1 · see citing works
Metra, M. (2017) · European Journal of Heart Failure · doi:10.1002/ejhf.947 · Cited by 1 · see citing works
The Mediterranean diet and cardiovascular disease: An overview
Magriplis, E., & Zampelas, A. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-818649-7.00004-7 · Cited by 1 · see citing works
Gut Microbiota as a Potential Treatment Target in Patient with Chronic Heart Failure
Henrina, J., Cahyadi, I., Gunawan, H. F. H., & Suciadi, L. P. (2020) · SN Comprehensive Clinical Medicine · doi:10.1007/s42399-020-00436-4 · Cited by 1 · see citing works
BALANCE Dietary Index in Patients with Heart Failure, and Its Adherence in Sergipe, Brazil
Costa, J. O., Aidar, F. J., Barbosa, J. S., Alves, L. V. S., Oliveira, V. B., de Oliveira, L. M. S. M., Rocha, R. M. S., Vieira, D. A. D. S., Costa, I. M. N. B. D. C., de Souza, M. F. C., et al. (2022) · Clinics and Practice · doi:10.3390/clinpract12030043 · Cited by 1 · see citing works
Bala, C. G. (2019) · Updates in hypertension and cardiovascular protection · doi:10.1007/978-3-319-93320-7_17 · Cited by 1 · see citing works
Gut Microbial Dysbiosis and Cardiovascular Diseases
Gasmi, A., Noor, S., Piscopo, S., & Berthouze, S. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-819265-8.00050-4
Franco, A. D., Morfino, P., & Aimo, A. (2022) · Revista Española de Cardiología (English Edition) · doi:10.1016/j.rec.2022.01.008
Fatty Acids and Cardiometabolic Health
Wu, J. H. Y., & Marklund, M. (2019) · MDPI eBooks · doi:10.3390/books978-3-03897-891-6
Lewis, S. A., Britt, W. M., Koch, R. L., Razavi, A. C., Patel, P., Sperling, L. S., & Souza, M. S. D. (2023) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2023.1
Progress in Dietary Quality and Cardiovascular and Cerebrovascular Diseases
古丽洁合热, ·. (2023) · Advances in Clinical Medicine · doi:10.12677/acm.2023.133660
Effects of High-Sugar Dietary Patterns on Adolescents
Yan, S. (2023) · Highlights in Science Engineering and Technology · doi:10.54097/wmagnh55
Cardiometabolic-Based Chronic Disease
Hernández-Sevillano, J., Babagoli, M. A., Mellacheruvu, P., & Mechanick, J. I. (2025) · Springer eBooks · doi:10.1007/978-3-031-82888-1_6
Maharana, K. C., Adsule, M., Rajkumar, M., Vishwas, G., & Singh, S. (2025) · Next research. · doi:10.1016/j.nexres.2025.101133
Lahiani, S., Boushaki, S. I., Terniche, M., Ketfi, A., & Sahir-Halouane, F. (2026) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-026-04549-7
The Mediterranean diet: nutritional insights and sustainability
Chira, A., & Saleem, F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45513-1.00033-4
- Authors
- Papadaki, A., Martínez-González, M. Á., Alonso-Gómez, A., Rekondo, J., Salas-Salvadó, J., Corella, D., Ros, E., Fitó, M., Estruch, R., Lapetra, J., García-Rodriguez, A., Fiol, M., Serra-Majem, L., Pintó, X., Ruiz-Canela, M., Bulló, M., Serra-Mir, M., Sorlí, J. V., & Arós, F.
- Affiliations
- University of Bristol (GB)
- University of Navarra, Department of Preventive Medicine and Public Health, Faculty of Medicine , IdiSNA, Pamplona ,
- CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), Instituto de Salud Carlos III (ISCIII) , Madrid ,
- Instituto de Salud Carlos III (ES)
- Universitat de València (ES)
- Department of Preventive Medicine, University of Malaga , Malaga ,
- Corresponding author
- Arós, Fernando
- ORCID
- Venue
- European Journal of Heart Failure
- Publisher
- Oxford University Press (OUP)
- Published
- 2017-01-30
- Volume
- 19
- Issue
- 9
- Pages
- 1179-1185
- ISSN
- 1388-9842 (ISSN-L)
- 1879-0844
- OpenAlex
- W2580402140
- Cited by
- 104
- References
- 31
- Citations by year
- 2026: 7 · 2025: 11 · 2024: 8 · 2023: 15 · 2022: 8 · 2021: 12 · 2020: 15 · 2019: 12 · 2018: 11 · 2017: 5
- FWCI
- 11.00
- Type
- journal article
- Language
- en
- Update notices
- erratum (2019-01-30)
- Open access
- Locations
- European Journal of Heart Failure (publishedVersion)
- PubMed (publishedVersion)
- Bristol Research (University of Bristol) (publishedVersion, other-oa)
- RECERCAT (Consorci de Serveis Universitaris de Catalunya) (acceptedVersion)
- Rovira & Virgili repository (submittedVersion, cc-by)
- RISalud Institutional Health Repository of Andalucía (submittedVersion, other-oa)
- Dipòsit Digital de la Universitat de Barcelona (Universitat de Barcelona) (submittedVersion, public-domain)
- Docusalut (Conselleria de Salut i Consum del Govern de les Illes Balears) (submittedVersion, cc-by-nc-nd)
- Hispana (submittedVersion, cc-by-nc-nd)
- Repositori digital de la UPF (Universitat Pompeu Fabra) (submittedVersion)
- Explore Bristol Research (submittedVersion, other-oa)
- Funders
- Biomedical Research of the Spanish government (RTIC G03/140, RTIC RD 06/0045)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
- Health Sciences › Nursing › Nutrition and Dietetics › Fatty Acid Research and Health
- Keywords
- Mediterranean diet, heart failure, PREDIMED trial, extra virgin olive oil, nuts, cardiovascular disease prevention, dietary supplementation, incident heart failure, high cardiovascular risk
- MeSH terms
- Olive Oil, Aged, Cardiovascular Diseases, Female, Heart Failure, Humans, Male, Middle Aged, Nuts, Outcome and Process Assessment, Health Care, Statistics as Topic, Incidence, Risk Assessment, Dietary Supplements, Diet, Mediterranean
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
