Cited by 60Nutritional Studies and DietHeart Failure Treatment and ManagementCardiovascular Health and Risk Factors

Adherence to Mediterranean Diet and All-Cause Mortality After an Episode of Acute Heart Failure

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Miró, Òscar, Estruch, Ramon, Martín-Sánchez, Francisco J., Gil, Víctor, Jacob, Javier, Herrero-Puente, Pablo, Herrera Mateo, Sergio, Aguirre, Alfons +47 more·2018·JACC: Heart Failure

Abstract

Objectives The authors sought to evaluate clinical outcomes of patients after an episode of acute heart failure (AHF) according to their adherence to the Mediterranean diet (MedDiet).Background It has been proved that MedDiet is a useful tool in primary prevention of cardiovascular diseases. However, it is unknown whether adherence to MedDiet is associated with better outcomes in patients who have already experienced an episode of AHF.Methods We designed a prospective study that included consecutive patients diagnosed with AHF in 7 Spanish emergency departments (EDs). Patients were included if they or their relatives were able to answer a 14-point score of adherence to the MedDiet, which classified patients as adherents (≥9 points) or nonadherents (≤8 points). The primary endpoint was all-cause mortality at the end of follow-up, and secondary endpoints were 1-year ED revisit without hospitalization, rehospitalization, death, and a combined endpoint of all these variables for patients discharged after the index episode. Unadjusted and adjusted hazard ratios (HRs) were calculated.Results We included 991 patients (mean age of 80 ± 10 years, 57.8% women); 523 (52.9%) of whom were adherent to the MedDiet. After a mean follow-up period of 2.1 ± 1.3 years, no differences were observed in survival between adherent and nonadherent patients (HR of adherents [HR adh] = 0.86; 95% confidence interval [CI]: 0.73 to 1.02). The 1-year cumulative ED revisit for the whole cohort was 24.5% (HR adh = 1.10; 95% CI: 0.84 to 1.42), hospitalization 43.7% (HR adh = 0.74; 95% CI: 0.61 to 0.90), death 22.7% (HR adh = 1.05; 95% CI: 0.8 to 1.38), and combined endpoint 66.8% (HR adh = 0.89; 95% CI: 0.76 to 1.04). Adjustment by age, hypertension, peripheral arterial disease, previous episodes of AHF, treatment with statins, air-room pulsioxymetry, and need for ventilation support in the ED rendered similar results, with no statistically significant differences in mortality (HR adh = 0.94; 95% CI: 0.80 to 1.13) and persistence of lower 1-year hospitalization for adherents (HR adh = 0.76; 95% CI: 0.62 to 0.93).Conclusions Adherence to the MedDiet did not influence long-term mortality after an episode of AHF, but it was associated with decreased rates of rehospitalization during the next year.

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Crossref · 10.1016/j.jchf.2017.09.020

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Authors
Miró, Ò., Estruch, R., Martín-Sánchez, F. J., Gil, V., Jacob, J., Herrero-Puente, P., Herrera Mateo, S., Aguirre, A., Andueza, J. A., Llorens, P., Alonso, H., Fuentes, M., Gil, C., Pérez-Durá, M. J., Salvo, E., Escoda, R., Xipell, C., Sánchez, C., Gaytan, J. M., Noval, A., Torres, J. M., López-Grima, M. L., Juan, M. A., Valero, A., Pedragosa, M. À., Alonso, M. I., Ruiz, F., Romero, R., Calvache, R., Morante, C., Lorca, M. T., Mecina, A. B., Tost, J., de la Fuente Penco, B., López Sánchez, A., Sánchez, S., Piñera, P., Garate, R. T., Alquézar, A., Rizzi, M. A., Richard, F., Álvarez Pérez, J. M., López Diez, M. P., Lucas, J., Roset, Á., Rodríguez-Adrada, E., Llopis García, G., Garrido, J. M., Fernández-Cañadas, J. M., Marquina, V., Jiménez, I., Javaloyes, P., Vázquez Alvarez, J., Alonso Morilla, A., & Irimia, A.
Affiliations
  • Hospital Clínic de Barcelona (ES)
  • Bellvitge University Hospital (ES)
  • Hospital Del Mar (ES)
  • Hospital General Universitario Gregorio Marañón (ES)
  • Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (ES)
  • Hospital Universitario Insular de Gran Canaria (ES)
Corresponding author
Miró, Òscar
Venue
JACC: Heart Failure
Publisher
Elsevier BV
Published
2018-01
Volume
6
Issue
1
Pages
52-62
ISSN
2213-1779 (ISSN-L)
OpenAlex
W2774631978
Cited by
60
References
29
Citations by year
2026: 5 · 2025: 6 · 2024: 6 · 2023: 4 · 2022: 6 · 2021: 5 · 2020: 11 · 2019: 9 · 2018: 7 · 2017: 1
FWCI
7.18
Type
journal article
Language
en
Open access
Locations
  • JACC Heart Failure (publishedVersion)
  • PubMed (publishedVersion)
  • Repositori digital de la UPF (Universitat Pompeu Fabra) (acceptedVersion)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Nutritional Studies and Diet
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Failure Treatment and Management
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Health and Risk Factors
Keywords
Mediterranean diet, dietary adherence, acute heart failure, all-cause mortality, hospital readmission, emergency department revisits, cardiovascular risk factors, statins, primary prevention of cardiovascular disease, older adults, secondary prevention, quality of life
MeSH terms
Acute Disease, Aged, 80 and over, Cause of Death, Female, Follow-Up Studies, Heart Failure, Humans, Male, Patient Compliance, Patient Readmission, Primary Prevention, Prognosis, Prospective Studies, Spain, Survival Rate, Diet, Mediterranean

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