The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
The Toll‐like receptor 7 (TLR7)‐specific stimulus loxoribine uncovers a strong relationship within the TLR7, 8 and 9 subfamily
Open accessAbstract
Loxoribine (7‐allyl‐7,8‐dihydro‐8‐oxo‐guanosine) acts as synthetic adjuvant in anti‐tumor responses. Here we first demonstrate that loxoribine activates cells of the innate immune system selectively via the Toll‐like receptor (TLR) 7/MyD88‐dependent signaling pathway. TLR7‐ and MyD88‐deficient immune cells fail to proliferate or produce cytokines in response to loxoribine, and genetic complementation of TLR7‐deficient cells with murine or human TLR7 confers responsiveness. Subsequently we show that cellular activation by loxoribine and resiquimod (R‐848), a stimulus for TLR7 and TLR8, depends on acidification and maturation of endosomes and targets MyD88 to vesicular structures with lysosomal characteristics. This mode of TLR7 and TLR8 action resembles CpG‐DNA‐driven TLR9 activation. We thus conclude that TLR7, 8 and 9 form a functional subgroup within the TLR family that recognizes pathogen‐associated molecular patterns in endosomal/lysosomal compartments.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
A Toll-like receptor recognizes bacterial DNA
Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491
Self-citationRecognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129
Toll-like receptors: critical proteins linking innate and acquired immunity
Akira, S., Takeda, K., & Kaisho, T. (2001) · Nature Immunology · doi:10.1038/90609 · Cited by 4,777
Self-citation
Cited by
Akira, S., & Takeda, K. (2004) · Nature reviews. Immunology · doi:10.1038/nri1391 · Cited by 8,312
Self-citationSpecies-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G., Wagner, H., & Bauer, S. (2004) · Science · doi:10.1126/science.1093620 · Cited by 3,947
Self-citationInnate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S., & Reis e Sousa, C. (2004) · Science · doi:10.1126/science.1093616 · Cited by 3,444
Toll-like receptors in innate immunity
Takeda, K. (2004) · International Immunology · doi:10.1093/intimm/dxh186 · Cited by 3,328
Self-citationCell Type-Specific Involvement of RIG-I in Antiviral Response
Kato, H., Sato, S., Yoneyama, M., Yamamoto, M., Uematsu, S., Matsui, K., Tsujimura, T., Takeda, K., Fujita, T., Takeuchi, O., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.04.010 · Cited by 1,368
Self-citationPlasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases
Gilliet, M., Cao, W., & Liu, Y.-J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2358 · Cited by 1,190
An unconventional role for miRNA: let-7 activates toll-like receptor 7 and causes neurodegeneration
Lehmann, S. M., Krüger, C., Park, B., Derkow, K., Rosenberger, K., Baumgart, J., Trimbuch, T., Eom, G., Hinz, M., Kaul, D., et al. (2012) · Nature Neuroscience · doi:10.1038/nn.3113 · Cited by 786
Toll‐like receptors control autophagy
Delgado, M. A., Elmaoued, R. A., Davis, A. S., Kyei, G., & Deretic, V. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.31 · Cited by 744
Tabeta, K., Hoebe, K., Janssen, E. M., Du, X., Georgel, P., Crozat, K., Mudd, S., Mann, N., Sovath, S., Goode, J., et al. (2006) · Nature Immunology · doi:10.1038/ni1297 · Cited by 600
Toll-like receptors — taking an evolutionary approach
Leulier, F., & Lemaitre, B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2303 · Cited by 581
Zhang, Z., Ohto, U., Shibata, T., Krayukhina, E., Taoka, M., Yamauchi, Y., Tanji, H., Isobe, T., Uchiyama, S., Miyake, K., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.09.011 · Cited by 461
Identification of RNA Sequence Motifs Stimulating Sequence-Specific TLR8-Dependent Immune Responses
Forsbach, A., Nemorin, J.-G., Montino, C., Müller, C., Samulowitz, U., Vicari, A. P., Jurk, M., Mutwiri, G. K., Krieg, A. M., Lipford, G. B., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.6.3729 · Cited by 281
Self-citationMa, Y., Li, J., Chiu, I., Wang, Y., Sloane, J. A., Lü, J., Kosaras, B., Sidman, R. L., Volpe, J. J., & Vartanian, T. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200606016 · Cited by 237
de Bouteiller, O., Merck, E., Hasan, U. A., Hubac, S., Benguigui, B., Trinchieri, G., Bates, E. E. M., & Caux, C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m507163200 · Cited by 220
Targeting the TLR9–MyD88 pathway in the regulation of adaptive immune responses
Huang, X., & Yang, Y. (2010) · Expert Opinion on Therapeutic Targets · doi:10.1517/14728222.2010.501333 · Cited by 121
Nucleic acid‐sensing TLR s and autoimmunity: novel insights from structural and cell biology
Pelka, K., Shibata, T., Miyake, K., & Latz, E. (2016) · Immunological Reviews · doi:10.1111/imr.12375 · Cited by 110
Toll like receptors and viruses
Finberg, R. W., Wang, J. P., & Kurt‐Jones, E. A. (2007) · Reviews in Medical Virology · doi:10.1002/rmv.525 · Cited by 90
SARM1, Not MyD88, Mediates TLR7/TLR9-Induced Apoptosis in Neurons
Mukherjee, P., Winkler, C. W., Taylor, K. G., Woods, T. A., Nair, V., Khan, B. A., & Peterson, K. E. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500953 · Cited by 64
Extracellularly Delivered Single-Stranded Viral RNA Causes Neurodegeneration Dependent on TLR7
Lehmann, S. M., Rosenberger, K., Krüger, C., Habbel, P., Derkow, K., Kaul, D., Rybak, A., Brandt, C., Schott, E., Wulczyn, F. G., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201078 · Cited by 64
Wallach, T., Wetzel, M., Dembny, P., Staszewski, O., Krüger, C., Buonfiglioli, A., Prinz, M., & Lehnardt, S. (2020) · Cells · doi:10.3390/cells9010186 · Cited by 26
Metadata
- Authors
- Heil, F., Ahmad‐Nejad, P., Hemmi, H., Hochrein, H., Ampenberger, F., Gellert, T., Dietrich, H., Lipford, G., Takeda, K., Akira, S., Wagner, H., & Bauer, S.
- Venue
- European Journal of Immunology
- Publisher
- Wiley
- Published
- 2003-09-29
- Volume
- 33
- Issue
- 11
- Pages
- 2987-2997
- ISSN
- 0014-2980 (ISSN-L)
- 1521-4141
- OpenAlex
- W2116692899
- Cited by
- 518
- References
- 3
- FWCI
- 13.94
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
