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Cited by 97Neuroinflammation and Neurodegeneration MechanismsCytokine Signaling Pathways and InteractionsImmune cells in cancer

Interkeukin‐34, a cytokine crucial for the differentiation and maintenance of tissue resident macrophages and L angerhans cells

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Wang, Yaming, Colonna, Marco·2014·European Journal of Immunology
DOI 10.1002/eji.201344365PMC PMC4137395
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Abstract

IL‐34 is a recently discovered cytokine that acts on tissue resident macrophages and L angerhans cells upon binding the receptor for CSF‐1, CSF‐1 R. The existence of two ligands for CSF‐1 R, IL‐34, and CSF‐1, raises several intriguing questions. Are IL‐34 and CSF‐1 redundant or does each perform temporally and spatially distinct functions? Is IL‐34 involved in human pathology? Would therapeutic strategies based on selective inhibition or administration of either IL‐34 or CSF‐1 be advantageous for preventing human pathology? Recent in vivo studies indicate that IL‐34 promotes the development, survival, and function of microglia and L angerhans cells; therefore, this cytokine may predominately function in brain and skin biology. Here, we review the evidence for IL‐34 as a key cytokine in the development and function of these two diverse cell types and discuss its potential role in pathological conditions.

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  • Although IL-34 and CD207 do not directly interact, this result is highly consistent with the crucial role of IL-34 in the development and survival of Langerhans cells.

    “Although IL-34 and CD207 do not directly interact, this result is highly consistent with the crucial role of IL-34 in the development and survival of Langerhans cells 39”

    From Plasma proteomic associations with genetics and health in the UK Biobank (2023) · cites this paper as [39]

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Authors
Wang, Y., & Colonna, M.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Colonna, Marco
ORCID
Colonna, Marco
Venue
European Journal of Immunology
Publisher
Wiley
Published
2014-05-22
Volume
44
Issue
6
Pages
1575-1581
ISSN
  • 0014-2980 (ISSN-L)
  • 1521-4141
DOI
10.1002/eji.201344365
PMC
PMC4137395
OpenAlex
W2043894488
Cited by
97
References
11
Citations by year
2026: 5 · 2025: 8 · 2024: 4 · 2023: 7 · 2022: 10 · 2021: 12 · 2020: 9 · 2019: 8 · 2018: 7 · 2017: 9 · 2016: 7 · 2015: 8 · 2014: 3
FWCI
0.73
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • European Journal of Immunology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Institutes of Health
  • National Institute of Allergy and Infectious Diseases (R21AI105728)
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
  • Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords
IL-34, CSF-1, CSF-1 receptor, tissue-resident macrophages, Langerhans cells, microglia, macrophage differentiation, cytokine redundancy, neuroinflammation, skin immunity
MeSH terms
Animals, Cell Differentiation, Humans, Interleukins, Langerhans Cells, Macrophages, Macrophage Colony-Stimulating Factor, Receptor, Macrophage Colony-Stimulating Factor, Microglia

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