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Stressin’ Sestrins take an aging fight
Open accessAbstract
Sestrins (Sesns) are a family of highly conserved stress-responsive proteins, transcriptionally regulated by p53 and forkhead transcription factor that exhibit oxidoreductase activity in vitro and can protect cells from oxidative stress. However, their major biochemical and physiological function does not appear to depend on their redox (reduction and oxidation) activity. Sesns promote activation of adenosine-5'-monophosphate (AMP)-dependent protein kinase in both mammals and flies. Stress-induced Sesn expression results in inhibition of the target of rapamycin complex 1 (TORC1) and the physiological and pathological implications of disrupting the Sesns-TORC1 crosstalk are now being unravelled. Detailing their mechanism of action and exploring their roles in human physiology point to exciting new insights to topics as diverse as stress, cancer, metabolism and aging.
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“Sestrins are a family of stress-inducible proteins involved in the negative regulation of the AMPK/TORC1 axis [227] and in ROS detoxifying by restoration of the activity of oxidized peroxiredoxins [227,228].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [227]
In the citing paper
“UCP-1 expression in BAT seems to be regulated by oxidative stress.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [227]
In the citing paper
“In line with this theory, the use of antioxidant molecules (butylated hydroxyanisole or N-acetylcysteine) decreases UCP-1 expression (both at mRNA and protein levels) in mouse BAT [227].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [227]
In the citing paper
“In accordance with its role, Sestrin2 defective mice are characterized by a decrease in BAT UCP-1 expression [227].”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [227]
In the citing paper
“Mechanistically, the effect seems to be dependent on Sestrin2.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [227]
In the citing paper
“Moreover, in the same mouse strain, cold does not upregulate UCP-1 abundance.”
From Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases (2019) · cites this paper as [227]
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Metadata
- Authors
- Budanov, A. V., Lee, J. H., & Karin, M.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Karin, Michael
- Venue
- EMBO Molecular Medicine
- Published
- 2010-09-28
- Volume
- 2
- Issue
- 10
- Pages
- 388-400
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- PMC
- PMC3166214
- OpenAlex
- W1891170558
- Cited by
- 208
- References
- 117
- Citations by year
- 2026: 5 · 2025: 8 · 2024: 15 · 2023: 15 · 2022: 14 · 2021: 18 · 2020: 22 · 2019: 14 · 2018: 11 · 2017: 19 · 2016: 15 · 2015: 10 · 2014: 16 · 2013: 10 · 2012: 10
- FWCI
- 0.73
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- EMBO Molecular Medicine (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
- Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
- Funders
- National Institutes of Health (ES010337)
- National Cancer Institute (R01CA118165, CA118165)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK082080, K99DK082080)
- National Institute of Environmental Health Sciences (P42ES010337, ES-006376, R01ES006376)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Keywords
- sestrins, aging, oxidative stress, AMPK, TORC1, p53, forkhead transcription factor, redox activity, stress response, cancer, metabolism
- MeSH terms
- Sestrins, Aging, Heat-Shock Proteins, Humans, Neoplasms, Nuclear Proteins, Oxidoreductases, Stress, Physiological, Transcription Factors
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