Cited by 208Genetics, Aging, and Longevity in Model OrganismsPI3K/AKT/mTOR signaling in cancerMetabolism, Diabetes, and Cancer

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Stressin’ Sestrins take an aging fight

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Budanov, Andrei V., Lee, Jun Hee, Karin, Michael·2010·EMBO Molecular Medicine

DOI 10.1002/emmm.201000097PMC PMC3166214

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Abstract

Sestrins (Sesns) are a family of highly conserved stress-responsive proteins, transcriptionally regulated by p53 and forkhead transcription factor that exhibit oxidoreductase activity in vitro and can protect cells from oxidative stress. However, their major biochemical and physiological function does not appear to depend on their redox (reduction and oxidation) activity. Sesns promote activation of adenosine-5'-monophosphate (AMP)-dependent protein kinase in both mammals and flies. Stress-induced Sesn expression results in inhibition of the target of rapamycin complex 1 (TORC1) and the physiological and pathological implications of disrupting the Sesns-TORC1 crosstalk are now being unravelled. Detailing their mechanism of action and exploring their roles in human physiology point to exciting new insights to topics as diverse as stress, cancer, metabolism and aging.

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Authors: Budanov, A. V., Lee, J. H., & Karin, M.
Affiliations: University of California San Diego (US)
Corresponding author: Karin, Michael
ORCID: Budanov, Andrei V.
Lee, Jun Hee
Karin, Michael
Venue: EMBO Molecular Medicine
Publisher: Springer Science and Business Media LLC
Published: 2010-09-28
Volume: 2
Issue: 10
Pages: 388-400
ISSN: 1757-4676 (ISSN-L)
1757-4684
DOI: 10.1002/emmm.201000097
PMC: PMC3166214
OpenAlex: W1891170558
Cited by: 208
References: 117
Citations by year: 2026: 5 · 2025: 8 · 2024: 15 · 2023: 15 · 2022: 14 · 2021: 18 · 2020: 22 · 2019: 14 · 2018: 11 · 2017: 19 · 2016: 15 · 2015: 10 · 2014: 16 · 2013: 10 · 2012: 10
FWCI: 0.73
Type: journal article
Language: en
Open access: gold
doi.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: EMBO Molecular Medicine (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Arrow@dit (Dublin Institute of Technology) (submittedVersion, cc-by-nc-sa)
Trinity's Access to Research Output (TARA) (Trinity College Dublin) (submittedVersion)
Funders: National Institutes of Health (ES010337)
National Cancer Institute (R01CA118165, CA118165)
National Institute of Diabetes and Digestive and Kidney Diseases (DK082080, K99DK082080)
National Institute of Environmental Health Sciences (P42ES010337, ES-006376, R01ES006376)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Keywords: sestrins, aging, oxidative stress, AMPK, TORC1, p53, forkhead transcription factor, redox activity, stress response, cancer, metabolism
MeSH terms: Sestrins, Aging, Heat-Shock Proteins, Humans, Neoplasms, Nuclear Proteins, Oxidoreductases, Stress, Physiological, Transcription Factors

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Stressin’ Sestrins take an aging fight

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