Stressin’ Sestrins take an aging fight

Oxidants, oxidative stress and the biology of ageing

Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413

p53, the cellular gatekeeper for growth and division

Levine, A. J. (1997) · Cell · doi:10.1016/s0092-8674(00)81871-1 · Cited by 7,693

Signal integration in the endoplasmic reticulum unfolded protein response

Ron, D., & Walter, P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2199 · Cited by 6,431

TOR signaling in growth and metabolism

Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649

Alzheimer’s disease

Querfurth, H. W., & LaFerla, F. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0909142 · Cited by 4,569

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975

TSC2 Mediates Cellular Energy Response to Control Cell Growth and Survival

Inoki, K., Zhu, T., & Guan, K.-L. (2003) · Cell · doi:10.1016/s0092-8674(03)00929-2 · Cited by 3,914

Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

Hara, T., Nakamura, K., Matsui, M., Yamamoto, A., Nakahara, Y., Suzuki-Migishima, R., Yokoyama, M., Mishima, K., Saito, I., Okano, H., et al. (2006) · Nature · doi:10.1038/nature04724 · Cited by 3,882

AMPK Phosphorylation of Raptor Mediates a Metabolic Checkpoint

Gwinn, D. M., Shackelford, D. B., Egan, D. F., Mihaylova, M. M., Mery, A., Vasquez, D. S., Turk, B. E., & Shaw, R. J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.03.003 · Cited by 3,849

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163

Defining the role of mTOR in cancer

Guertin, D. A., & Sabatini, D. M. (2007) · Cancer Cell · doi:10.1016/j.ccr.2007.05.008 · Cited by 2,833

A model for p53-induced apoptosis

Polyak, K., Xia, Y., Zweier, J. L., Kinzler, K. W., & Vogelstein, B. (1997) · Nature · doi:10.1038/38525 · Cited by 2,500

T antigen is bound to a host protein in SY40-transformed cells

Lane, D. P., & Crawford, L. V. (1979) · Nature · doi:10.1038/278261a0 · Cited by 2,456

p53 in health and disease

Vousden, K. H., & Lane, D. P. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2147 · Cited by 2,351

Inhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington disease

Ravikumar, B., Vacher, C., Berger, Z., Davies, J. E., Luo, S., Oroz, L. G., Scaravilli, F., Easton, D. F., Duden, R., O'Kane, C. J., et al. (2004) · Nature Genetics · doi:10.1038/ng1362 · Cited by 2,347

Cellular response to oxidative stress: Signaling for suicide and survival*

Martindale, J. L., & Holbrook, N. J. (2002) · Journal of Cellular Physiology · doi:10.1002/jcp.10119 · Cited by 2,314

mTOR signaling at a glance

Laplante, M., & Sabatini, D. M. (2009) · Journal of Cell Science · doi:10.1242/jcs.051011 · Cited by 2,284

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Colman, R. J., Anderson, R. M., Johnson, S. C., Kastman, E. K., Kosmatka, K. J., Beasley, T. M., Allison, D. B., Cruzen, C., Simmons, H. A., Kemnitz, J. W., et al. (2009) · Science · doi:10.1126/science.1173635 · Cited by 2,277

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

Klionsky, D. J., Abeliovich, H., Agostinis, P., Agrawal, D. K., Aliev, G., Askew, D. S., Baba, M., Baehrecke, E. H., Bahr, B. A., Ballabio, A., et al. (2008) · Autophagy · doi:10.4161/auto.5338 · Cited by 2,230

Nutrient-dependent mTORC1 Association with the ULK1–Atg13–FIP200 Complex Required for Autophagy

Hosokawa, N., Hara, T., Kaizuka, T., Kishi, C., Takamura, A., Miura, Y., Iemura, S.-I., Natsume, T., Takehana, K., Yamada, N., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1248 · Cited by 2,076

ULK-Atg13-FIP200 Complexes Mediate mTOR Signaling to the Autophagy Machinery

Jung, C. H., Jun, C. B., Ro, S.-H., Kim, Y.-M., Otto, N. M., Cao, J., Kundu, M., & Kim, D.-H. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e08-12-1249 · Cited by 2,025

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019

Regulation of the heat shock transcriptional response: cross talk between a family of heat shock factors, molecular chaperones, and negative regulatorsPreprint

Morimoto, R. I. (1998) · Genes & Development · doi:10.1101/gad.12.24.3788 · Cited by 1,898

Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin

Clark, I. E., Dodson, M. W., Jiang, C., Cao, J. H., Huh, J. R., Seol, J. H., Yoo, S. J., Hay, B. A., & Guo, M. (2006) · Nature · doi:10.1038/nature04779 · Cited by 1,788

Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin

Park, J., Lee, S. B., Lee, S., Kim, Y., Song, S., Kim, S., Bae, E., Kim, J., Shong, M., Kim, J.-M., et al. (2006) · Nature · doi:10.1038/nature04788 · Cited by 1,705

Mitogenic Signaling Mediated by Oxidants in Ras-Transformed Fibroblasts

Irani, K., Xia, Y., Zweier, J. L., Sollott, S. J., Der, C. J., Fearon, E. R., Sundaresan, M., Finkel, T., & Goldschmidt-Clermont, P. J. (1997) · Science · doi:10.1126/science.275.5306.1649 · Cited by 1,588

Oxidant signals and oxidative stress

Finkel, T. (2003) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(03)00002-4 · Cited by 1,393

Intrinsic tumour suppression

Lowe, S. W., Cepero, E., & Evan, G. I. (2004) · Nature · doi:10.1038/nature03098 · Cited by 1,374

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326

Diversity of gene expression in adenocarcinoma of the lung

Garber, M. E., Troyanskaya, O. G., Schlüns, K., Petersen, S., Thäsler, Z., Pacyna-Gengelbach, M., van de Rijn, M., Rosen, G., Perou, C. M., Whyte, R. I., et al. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241500798 · Cited by 1,301

Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway

Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293

Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients

Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293

The coordinate regulation of the p53 and mTOR pathways in cells

Feng, Z., Zhang, H., Levine, A. J., & Jin, S. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0502857102 · Cited by 1,235

Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants

Greene, J. C., Whitworth, A. J., Kuo, I., Andrews, L. A., Feany, M. B., & Pallanck, L. J. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0737556100 · Cited by 1,203

The antioxidant function of the p53 tumor suppressor

Sablina, A. A., Budanov, A. V., Ilyinskaya, G. V., Agapova, L. S., Kravchenko, J. E., & Chumakov, P. M. (2005) · Nature Medicine · doi:10.1038/nm1320 · Cited by 1,137

Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span

Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · cited 1×

Tumor suppressors and cell metabolism: a recipe for cancer growth

Jones, R. G., & Thompson, C. B. (2009) · Genes & Development · doi:10.1101/gad.1756509 · Cited by 1,085

Current development of mTOR inhibitors as anticancer agents

Faivre, S. J., Kroemer, G., & Raymond, É. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd2062 · Cited by 1,012

ATP-dependent reduction of cysteine–sulphinic acid by S. cerevisiae sulphiredoxin

Biteau, B., Labarre, J., & Tolédano, M. B. (2003) · Nature · doi:10.1038/nature02075 · Cited by 970

Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function

Hu, W., Zhang, C., Wu, R., Sun, Y., Levine, A., & Feng, Z. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1001006107 · Cited by 862

DNA Repair Pathway Stimulated by the Forkhead Transcription Factor FOXO3a Through the Gadd45 Protein

Tran, H. G., Brunet, A., Grenier, J. M., Datta, S. R., Fornace, A. J., DiStefano, P. S., Chiang, L. W., & Greenberg, M. E. (2002) · Science · doi:10.1126/science.1068712 · Cited by 860

Akt Determines Replicative Senescence and Oxidative or Oncogenic Premature Senescence and Sensitizes Cells to Oxidative Apoptosis

Nogueira, V., Park, Y., Chen, C.-C., Xu, P.-Z., Chen, M.-L., Tonic, I., Unterman, T., & Hay, N. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.11.003 · Cited by 780

Autophagy regulates adipose mass and differentiation in mice

Singh, R., Xiang, Y., Wang, Y., Baikati, K., Cuervo, A. M., Luu, Y. K., Tang, Y., Pessin, J. E., Schwartz, G. J., & Czaja, M. J. (2009) · Journal of Clinical Investigation · doi:10.1172/jci39228 · Cited by 767

Regeneration of peroxiredoxins by p53-regulated sestrins, homologs of bacterial AhpD

Budanov, A. V., Sablina, A. A., Feinstein, E., Koonin, E. V., & Chumakov, P. M. (2004) · Science · doi:10.1126/science.1095569 · Cited by 731

ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS

Alexander, A., Cai, S.-L., Kim, J., Nanez, A., Sahin, M., MacLean, K. H., Inoki, K., Guan, K.-L., Shen, J., Person, M. D., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913860107 · Cited by 717

Intracellular messenger function of hydrogen peroxide and its regulation by peroxiredoxins

Rhee, S. G., Kang, S. W., Jeong, W., Chang, T.-S., Yang, K., & Woo, H. A. (2005) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2005.02.004 · Cited by 714

With TOR, Less Is More: A Key Role for the Conserved Nutrient-Sensing TOR Pathway in Aging

Kapahi, P., Chen, D., Rogers, A. N., Katewa, S. D., Li, P. W.-L., Thomas, E., & Kockel, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.05.001 · Cited by 678

LKB1 and AMP-activated protein kinase control of mTOR signalling and growth

Shaw, R. J. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01972.x · Cited by 644

An Emerging Role of mTOR in Lipid Biosynthesis

Laplante, M., & Sabatini, D. M. (2009) · Current Biology · doi:10.1016/j.cub.2009.09.058 · Cited by 642

Adipose-specific deletion of autophagy-related gene 7 ( atg7 ) in mice reveals a role in adipogenesis

Zhang, Y., Goldman, S., Baerga, R., Zhao, Y., Komatsu, M., & Jin, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0906048106 · Cited by 634

FoxO transcription factors in the maintenance of cellular homeostasis during aging

Salih, D. A., & Brunet, A. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.02.005 · Cited by 604

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570

JNK Extends Life Span and Limits Growth by Antagonizing Cellular and Organism-Wide Responses to Insulin Signaling

Wang, M. C., Bohmann, D., & Jasper, H. (2005) · Cell · doi:10.1016/j.cell.2005.02.030 · Cited by 546

Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses

Papadia, S., Soriano, F. X., Léveillé, F., Martel, M.-A., Dakin, K. A., Hansen, H. H., Kaindl, A., Sifringer, M., Fowler, J., Stefovska, V., et al. (2008) · Nature Neuroscience · doi:10.1038/nn2071 · Cited by 498

mTOR Complex1–S6K1 signaling: at the crossroads of obesity, diabetes and cancer

Dann, S. G., Selvaraj, A., & Thomas, G. (2007) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2007.04.002 · Cited by 481

Delayed ageing through damage protection by the Arf/p53 pathway

Matheu, A., Maraver, A., Klatt, P., Flores, I., Garcia-Cao, I., Borras, C., Flores, J. M., Viña, J., Blasco, M. A., & Serrano, M. (2007) · Nature · doi:10.1038/nature05949 · Cited by 466

Rapamycin Protects against Neuron Death inIn VitroandIn VivoModels of Parkinson's Disease

Malagelada, C., Jin, Z. H., Jackson-Lewis, V. R., Przedborski, S., & Greene, L. A. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.3944-09.2010 · Cited by 465

Metallothioneins: Proteins in search of function

Karin, M. (1985) · Cell · doi:10.1016/0092-8674(85)90051-0 · Cited by 442

Metabolic Enzymes of Mycobacteria Linked to Antioxidant Defense by a Thioredoxin-Like Protein

Bryk, R., Lima, C. D., Erdjument‐Bromage, H., Tempst, P., & Nathan, C. (2002) · Science · doi:10.1126/science.1067798 · Cited by 400

p53-Induced Up-Regulation of MnSOD and GPx but not Catalase Increases Oxidative Stress and Apoptosis

Hussain, S. P., Amstad, P., He, P., Robles, A. I., Lupold, S. E., Kaneko, I., Ichimiya, M., Sengupta, S., Mechanic, L. E., Okamura, S., et al. (2004) · Cancer Research · doi:10.1158/0008-5472.can-2287-2 · Cited by 394

AMPK alterations in cardiac physiology and pathology: enemy or ally?

Dyck, J. R. B., & Lopaschuk, G. D. (2006) · The Journal of Physiology · doi:10.1113/jphysiol.2006.109389 · Cited by 392

Characterization of Mammalian Sulfiredoxin and Its Reactivation of Hyperoxidized Peroxiredoxin through Reduction of Cysteine Sulfinic Acid in the Active Site to Cysteine

Chang, T.-S., Jeong, W., Woo, H. A., Lee, S. M., Park, S., & Rhee, S. G. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409482200 · Cited by 388

FoxOs Inhibit mTORC1 and Activate Akt by Inducing the Expression of Sestrin3 and Rictor

Chen, C.-C., Jeon, S., Bhaskar, P. T., Nogueira, V., Sundararajan, D., Tonic, I., Park, Y., & Hay, N. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.03.008 · Cited by 374

Identification of a novel stress-responsive gene Hi95 involved in regulation of cell viability

Budanov, A. V., Shoshani, T., Faerman, A., Zelin, E., Kamer, I., Kalinski, H., Gorodin, S., Fishman, A., Chajut, A., Einat, P., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205877 · Cited by 364

Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice

Singh, A. K., Riederer, B., Krabbenhöft, A., Rausch, B., Bonhagen, J., Lehmann, U., de Jonge, H. R., Donowitz, M., Yun, C. C., Weinman, E. J., et al. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35541 · Cited by 364

The TOR pathway comes of age

Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. R., & Kennedy, B. K. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.007 · Cited by 347

Aging: ROS or TOR

Blagosklonny, M. V. (2008) · Cell Cycle · doi:10.4161/cc.7.21.6965 · Cited by 332

Insulin regulation of heart function in aging fruit flies

Wessells, R. J., Fitzgerald, E., Cypser, J. R., Tatar, M., & Bodmer, R. (2004) · Nature Genetics · doi:10.1038/ng1476 · Cited by 325

Rapamycin activation of 4E-BP prevents parkinsonian dopaminergic neuron loss

Tain, L. S., Mortiboys, H., Tao, R. N., Ziviani, E., Bandmann, O., & Whitworth, A. J. (2009) · Nature Neuroscience · doi:10.1038/nn.2372 · Cited by 323

Stimulation of autophagy by the p53 target gene Sestrin2

Maiuri, M. C., Malik, S. A., Morselli, E., Kepp, O., Criollo, A., Mouchel, P., Carnuccio, R., & Kroemer, G. (2009) · Cell Cycle · doi:10.4161/cc.8.10.8498 · Cited by 278

Phosphoproteome Analysis of Drosophila melanogaster Embryos

Zhai, B., Villén, J., Beausoleil, S. A., Mintseris, J., & Gygi, S. P. (2008) · Journal of Proteome Research · doi:10.1021/pr700696a · Cited by 273

Declining p53 function in the aging process: A possible mechanism for the increased tumor incidence in older populations

Feng, Z., Hu, W., Teresky, A. K., Hernando, E., Cordon-Cardo, C., & Levine, A. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0708043104 · Cited by 264

Disruption of the gene encoding the latent transforming growth factor-β binding protein 4 (LTBP-4) causes abnormal lung development, cardiomyopathy, and colorectal cancerPreprint

Sterner‐Kock, A., Thorey, I. S., Koli, K. M., Wempe, F., Otte, J., Bangsow, T., Kuhlmeier, K., Kirchner, T., Jin, S., Keski‐Oja, J., et al. (2002) · Genes & Development · doi:10.1101/gad.229102 · Cited by 256

PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes

Velasco-Miguel, S., Buckbinder, L., Jean, P., Gelbert, L., Talbott, R. L., Laidlaw, J. L., Seizinger, B. R., & Kley, N. (1999) · Oncogene · doi:10.1038/sj.onc.1202274 · Cited by 252

Identification of ALDH4 as a p53-inducible gene and its protective role in cellular stresses

Yoon, K., Nakamura, Y., & Arakawa, H. (2004) · Journal of Human Genetics · doi:10.1007/s10038-003-0122-3 · Cited by 240

Hydrogen peroxide inhibits mTOR signaling by activation of AMPKα leading to apoptosis of neuronal cells

Chen, L., Xu, B., Liu, L., Luo, Y., Yin, J., Zhou, H., Chen, W., Shen, T., Han, X., & Huang, S. (2010) · Laboratory Investigation · doi:10.1038/labinvest.2010.36 · Cited by 236

A New Fork for Clinical Application: Targeting Forkhead Transcription Factors in Cancer

Yang, J.-Y., & Hung, M. (2009) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-08-0124 · Cited by 235

Autophagy in health and disease. 5. Mitophagy as a way of life

Gottlieb, R. A., & Carreira, R. (2010) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00097.2010 · Cited by 230

Huntington’s disease: degradation of mutant huntingtin by autophagy

Sarkar, S., & Rubinsztein, D. C. (2008) · FEBS Journal · doi:10.1111/j.1742-4658.2008.06562.x · Cited by 215

Molecular and clinical prodrome of Parkinson disease: implications for treatment

Schapira, A. H. V., & TOLOSA, E. S. (2010) · Nature Reviews Neurology · doi:10.1038/nrneurol.2010.52 · Cited by 210

Antioxidants protect PINK1 -dependent dopaminergic neurons in Drosophila

Wang, D., Li, Q., Xiong, H., Liu, J., Neckameyer, W. S., Oldham, S., Xia, K., Wang, J., Bodmer, R., & Zhang, Z. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604661103 · Cited by 203

Rapamycin confers preconditioning-like protection against ischemia–reperfusion injury in isolated mouse heart and cardiomyocytes

Khan, S. A., Salloum, F. N., Das, A., Xi, L., Vetrovec, G. W., & Kukreja, R. C. (2006) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2006.04.014 · Cited by 189

The mTOR pathway and its role in human genetic diseases

ROSNER, M., Hanneder, M., Siegel, N., Valli, A., Fuchs, C., & HENGSTSCHLAGER, M. (2008) · Mutation Research/Reviews in Mutation Research · doi:10.1016/j.mrrev.2008.06.001 · Cited by 185

Autophagy genes and ageing

Vellai, T. (2008) · Cell Death and Differentiation · doi:10.1038/cdd.2008.126 · Cited by 173

Converging Pathways in Lifespan Regulation

Narasimhan, S. D., Yen, K., & Tissenbaum, H. A. (2009) · Current Biology · doi:10.1016/j.cub.2009.06.013 · Cited by 169

AMP‐activated protein kinase and cancer

Wang, W., & Guan, K. (2009) · Acta Physiologica · doi:10.1111/j.1748-1716.2009.01980.x · Cited by 167

Loss of heterozygosity at chromosome 1p in different solid human tumours: association with survival

Ragnarsson, G., Eiriksdottir, G., Johannsdottir, J. T., Jonasson, J. G., Egilsson, V., & Ingvarsson, S. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690234 · Cited by 159

Tumor Protein 53–Induced Nuclear Protein 1 Is a Major Mediator of p53 Antioxidant Function

Cano, C. E., Gommeaux, J., Pietri, S., Culcasi, M., Garcia, S., Seux, M., Barelier, S., Vasseur, S., Spoto, R. P., Pébusque, M., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-2320 · Cited by 153

Repression of Sestrin Family Genes Contributes to Oncogenic Ras-Induced Reactive Oxygen Species Up-regulation and Genetic Instability

Kopnin, P., Agapova, L. S., Kopnin, B. P., & Chumakov, P. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2466 · Cited by 149

KSR2 Is an Essential Regulator of AMP Kinase, Energy Expenditure, and Insulin Sensitivity

Costanzo-Garvey, D. L., Pfluger, P. T., Dougherty, M. K., Stock, J. L., Boehm, M. B., Chaika, O. V., Fernandez, M. R., Fisher, K. W., Kortum, R. L., Hong, E., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.09.010 · Cited by 148

Rapamycin Protects Against High Fat Diet–Induced Obesity in C57BL/6J Mice

Chang, G., Chiu, Y., Wu, Y., Chen, W., Liao, J., Chao, T., & Mao, F. C. (2009) · Journal of Pharmacological Sciences · doi:10.1254/jphs.08215fp · Cited by 148

Regulation of Protein Synthesis by Ionizing Radiation

Braunstein, S. E., Badura, M. L., Xi, Q., Formenti, S. C., & Schneider, R. J. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00711-09 · Cited by 141

Molecular cloning of a cDNA specific for the murine p53 cellular tumor antigen.

Oren, M., & Levine, A. J. (1983) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.80.1.56 · Cited by 130

PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse

Peeters, H., Debeer, P., Bairoch, A., Wilquet, V., Huysmans, C., Parthoens, E., Fryns, J. P., Gewillig, M. H. M. L., Nakamura, Y., Niikawa, N., et al. (2003) · Human Genetics · doi:10.1007/s00439-003-0917-5 · Cited by 117

Transforming Growth Factor-β Signaling across Ages: From Distorted Lung Development to Chronic Obstructive Pulmonary Disease

Morty, R. E., Königshoff, M., & Eickelberg, O. (2009) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200908-087rm · Cited by 115

Sestrin 2 Is Not a Reductase for Cysteine Sulfinic Acid of Peroxiredoxins

Woo, H. A., Bae, S. H., Park, S., & Rhee, S. G. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2360 · Cited by 101

Role of sestrin2 in peroxide signaling in macrophages

Essler, S., Dehne, N., & Brüne, B. (2009) · FEBS Letters · doi:10.1016/j.febslet.2009.10.017 · Cited by 90

d4eBP acts downstream of both dTOR and dFoxo to modulate cardiac functional aging in Drosophila

Wessells, R. J., Fitzgerald, E., Piazza, N., Ocorr, K. A., Morley, S., Davies, C. R., Lim, H., Elmeń, L., Hayes, M., Oldham, S., et al. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00504.x · Cited by 90

Cellular context‐dependent “colors” of transforming growth factor‐β signaling

Ikushima, H., & Miyazono, K. (2009) · Cancer Science · doi:10.1111/j.1349-7006.2009.01441.x · Cited by 82

Gene regulation by temperature-sensitive p53 mutants: identification of p53 response genes.

Buckbinder, L., Talbott, R. L., Seizinger, B. R., & Kley, N. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10640 · Cited by 81

Identification of amyloid β-peptide responsive genes by cDNA microarray technology: Involvement of RTP801 in amyloid β-peptide toxicity

Kim, J.-R., Lee, S.-R., Chung, H. J., Kim, S., Baek, S.-H., Kim, J. H., & Kim, Y.-S. (2003) · Experimental & Molecular Medicine · doi:10.1038/emm.2003.53 · Cited by 78

ROS up-regulation mediates Ras-induced changes of cell morphology and motility

Alexandrova, A. Y., Kopnin, P., Vasiliev, J. M., & Kopnin, B. P. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.03.004 · Cited by 77

Lifespan extension by suppression of autophagy genes in Caenorhabditis elegans

Hashimoto, Y., Ookuma, S., & Nishida, E. (2009) · Genes to Cells · doi:10.1111/j.1365-2443.2009.01306.x · Cited by 76

Rapamycin inhibits hepatic fibrosis in rats by attenuating multiple profibrogenic pathways

Bridle, K. R., Popa, C., Morgan, M. L., Sobbe, A. L., Clouston, A. D., Fletcher, L. M., & Crawford, D. H. (2009) · Liver Transplantation · doi:10.1002/lt.21804 · Cited by 75

A Novel Antioxidant Function for the Tumor-Suppressor Gene p53 in the Retinal Ganglion Cell

O'Connor, J. C., Wallace, D., O'Brien, C. J., & Cotter, T. G. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.08-1963 · Cited by 60

Electron Microscope Studies on Aging Drosophila melanogaster III. Flight Muscle

Takahashi, A., Philpott, D. E., & Miquel, J. (1970) · Journal of Gerontology · doi:10.1093/geronj/25.3.222 · Cited by 55

Inactivation of sestrin 2 induces TGF-β signaling and partially rescues pulmonary emphysema in a mouse model of COPD

Wempe, F., De-Zolt, S., Koli, K. M., Bangsow, T., Parajuli, N., Dumitrascu, R., Sterner‐Kock, A., Weißmann, N., Keski‐Oja, J., & von Melchner, H. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004234 · Cited by 50

Role of p53 in antioxidant defense of HPV-positive cervical carcinoma cells following H2O2 exposure

Ding, B., Chi, S., Kim, S. H., Kang, S., Cho, J., Kim, D. S., & Cho, N. H. (2007) · Journal of Cell Science · doi:10.1242/jcs.002345 · Cited by 42

Differential Methylation Hybridization Array of Endometrial Cancers Reveals Two Novel Cancer-Specific Methylation Markers

Zighelboim, I., Goodfellow, P. J., Schmidt, A. P., Walls, K. C., Mallon, M. A., Mutch, D. G., Yan, P. S., Huang, T. H. ‐., & Powell, M. A. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-2367 · Cited by 40

Rosiglitazone acts as a neuroprotectant in retinal cells via up‐regulation of sestrin‐1 and SOD‐2

Doonan, F., Wallace, D., O’Driscoll, C., & Cotter, T. G. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.05995.x · Cited by 38

Electron microscope studies on aging Drosophila melanogaster. I

Miquel, J., Philpott, D. E., & Takahashi, A. (1970) · NASA Technical Reports Server (NASA) · Cited by 19

Burn Out or Fade Away?

Topisirović, I., & Sonenberg, N. (2010) · Science · doi:10.1126/science.1187497 · Cited by 13

A Xenopus homolog of a human p53-activated gene, PA26, is specifically expressed in the notochord

Hikasa, H., & Taira, M. (2001) · Mechanisms of Development · doi:10.1016/s0925-4773(00)00519-0 · Cited by 12

[Isolation of a plasmid clone containing the mRNA sequence for mouse nonviral T-antigen].

Chumakov, P. M., Iotsova, V., & Georgiev, G. P. (1982) · PubMed · Cited by 10

Antioxidants put Parkinson flies back in the PINK

Bier, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606288103 · Cited by 4

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

Robida-Stubbs, S., Glover-Cutter, K., Lamming, D. W., Mizunuma, M., Narasimhan, S. D., Neumann-Haefelin, E., Sabatini, D. M., & Blackwell, T. K. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.007 · Cited by 648

Mitochondrial Uncoupling: A Key Controller of Biological Processes in Physiology and Diseases

Demine, S., Renard, P., & Arnould, T. (2019) · Cells · doi:10.3390/cells8080795 · Cited by 476

The Sestrins Interact with GATOR2 to Negatively Regulate the Amino-Acid-Sensing Pathway Upstream of mTORC1

Chantranupong, L., Wolfson, R. L., Orozco, J. M., Saxton, R. A., Scaria, S. M., Bar-Peled, L., Spooner, E., Isasa, M., Gygi, S. P., & Sabatini, D. M. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.09.014 · Cited by 466

Metabolic regulation by p53

Maddocks, O. D. K., & Vousden, K. H. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0735-5 · Cited by 370

Sestrins inhibit mTORC1 kinase activation through the GATOR complex

Parmigiani, A., Nourbakhsh, A., Ding, B., Wang, W., Kim, Y. C., Akopiants, K., Guan, K.-L., Karin, M., & Budanov, A. V. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.10.019 · Cited by 336

Study Advances in Stress-responsive Proteins Sestrins

Wang, X. (2013) · Medical Recapitulate

Sestrins at the crossroad between stress and aging Research Perspective

Lee, J. H., Bodmer, R., Bier, E., & Karin, M. (2013)

Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

Lee, J. H., Budanov, A. V., Park, E. J., Birse, R., Kim, T. E., Perkins, G. A., Ocorr, K., Ellisman, M. H., Bodmer, R., Bier, E., et al. (2010) · Science · doi:10.1126/science.1182228 · Cited by 570

Sestrins in Aging and Metabolism

Tang, D., & Tao, S. (2014) · Else Kröner-Fresenius Symposia · doi:10.1159/000366571

Sestrins at the crossroad between stress and aging

Lee, J. H., Bodmer, R., Bier, E., & Karin, M. (2010) · Aging · doi:10.18632/aging.100157 · Cited by 65