The DOI matches its Crossref record; 18 of the 18 references it cites were found in a registry or an index.
Resolution of inflammation: an integrated view
Open accessAbstract
Resolution of inflammation is a coordinated and active process aimed at restoration of tissue integrity and function. This review integrates the key molecular and cellular mechanisms of resolution. We describe how abrogation of chemokine signalling blocks continued neutrophil tissue infiltration and how apoptotic neutrophils attract monocytes and macrophages to induce their clearance. Uptake of apoptotic neutrophils by macrophages reprograms macrophages towards a resolving phenotype, a key event to restore tissue homeostasis. Finally, we highlight the therapeutic potential that derives from understanding the mechanisms of resolution.
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Cites
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“In addition, resolution-phase macrophages express TIM4 and TGF-b , key molecules in the clearance of inflammatory cells and the return to tissue homeostasis.”
InfluentialResolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators
Serhan, C. N., Chiang, N., & Van Dyke, T. E. (2008) · Nature Reviews Immunology · doi:10.1038/nri2294 · Cited by 2,932
Differential Roles of Macrophages in Diverse Phases of Skin Repair
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“Recent work points towards a critical role of alternatively activated macrophages (Lucas et al, 2010; Saclier et al, 2013; Sindrilaru et al, 2011), which secrete anti-inflammatory and reparative mediators including IL1 receptor antagonist, IL10, TGF-b and VEGF.”
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“Recent work points towards a critical role of alternatively activated macrophages (Lucas et al, 2010; Saclier et al, 2013; Sindrilaru et al, 2011), which secrete anti-inflammatory and reparative mediators including IL1 receptor antagonist, IL10, TGF-b and VEGF.”
Phagocyte partnership during the onset and resolution of inflammation
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Self-citation
Cited by
Microglial M1/M2 polarization and metabolic states
Orihuela, R., McPherson, C. A., & Harry, G. J. (2016) · British Journal of Pharmacology · doi:10.1111/bph.13139 · Cited by 2,070
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900
Low-grade inflammation, diet composition and health: current research evidence and its translation
Minihane, A. M., Vinoy, S., Russell, W. R., Baka, A., Roche, H. M., Tuohy, K. M., Teeling, J. L., Blaak, E. E., Fenech, M., Vauzour, D., et al. (2015) · British Journal of Nutrition · doi:10.1017/s0007114515002093 · Cited by 916
Resolution of Inflammation: What Controls Its Onset?
Sugimoto, M. A., Sousa, L. P., Pinho, V., Perretti, M., & Teixeira, M. M. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00160 · Cited by 638
Self-citationBlevins, H. M., Xu, Y., Biby, S., & Zhang, S. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.879021 · Cited by 587
Metadata
- Authors
- Ortega‐Gómez, A., Perretti, M., & Soehnlein, O.
- Venue
- EMBO Molecular Medicine
- Published
- 2013-04-17
- Volume
- 5
- Issue
- 5
- Pages
- 661-674
- ISSN
- 1757-4676 (ISSN-L)
- 1757-4684
- OpenAlex
- W2133496985
- Cited by
- 733
- References
- 18
- FWCI
- 24.70
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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