Polycarbonate and polystyrene nanoplastic particles act as stressors to the innate immune system of fathead minnow ( Pimephales promelas )
Abstract
Water pollution with large-scale and small-scale plastic litter is an area of growing concern. Macro-plastic litter is a well-known threat to aquatic wildlife; however, the effects of micro-sized and nano-sized plastic particles on the health of organisms are not well understood. Small-scale plastic particles can easily be ingested by various aquatic organisms and potentially interfere with their immune system; therefore, the authors used a freshwater fish species as a model organism for nanoplastic exposure. Characterization of polystyrene (41.0 nm) and polycarbonate (158.7 nm) nanoplastic particles (PSNPs and PCNPs, respectively) in plasma was performed, and the effects of PSNPs and PCNPs on the innate immune system of fathead minnow were investigated. In vitro effects of PSNPs and PCNPs on neutrophil function were determined using a battery of neutrophil function assays. Exposure of neutrophils to PSNPs or PCNPs caused significant increases in degranulation of primary granules and neutrophil extracellular trap release compared to a nontreated control, whereas oxidative burst was less affected. The present study outlines the stress response of the cellular component of fish innate immune system to polystyrene and polycarbonate nanoparticles/aggregates and indicates their potential to interfere with disease resistance in fish populations. Environ Toxicol Chem 2016;35:3093–3100. © 2016 SETAC
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Laboratory experiments using fish have found that microplastics can cause stress to the immune system.
“laboratory experiments using fish have found that microplastics can cause stress to the immune system,25”
From Microplastics and Anthropogenic Particles in Recreationally Caught Freshwater Fish from an Urbanized Region of the North American Great Lakes (2024) · cites this paper as [25]
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- Authors
- Greven, A.-C., Merk, T., Karagöz, F., Mohr, K., Klapper, M., Jovanović, B., & Palić, D.
- Affiliations
- Chair for Fish Diseases and Fisheries BiologyLudwig Maximilian University Munich Munich Germany
- Ludwig-Maximilians-Universität München (DE)
- Max Planck Institute for Polymer Research (DE)
- Corresponding author
- Palić, Dušan
- Venue
- Environmental Toxicology and Chemistry
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-05-21
- Volume
- 35
- Issue
- 12
- Pages
- 3093-3100
- ISSN
- 0730-7268 (ISSN-L)
- 1552-8618
- OpenAlex
- W2465050110
- Cited by
- 357
- References
- 30
- Citations by year
- 2026: 25 · 2025: 33 · 2024: 42 · 2023: 36 · 2022: 59 · 2021: 51 · 2020: 51 · 2019: 27 · 2018: 16 · 2017: 13 · 2016: 4
- FWCI
- 10.85
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Environmental Toxicology and Chemistry (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion)
- Funders
- CIG project of D. Palić (PCIG13-GA-2013-618152)
- LMU startup funding provided to Chair of Fish Diseases and Fisheries Biology
- Topics
- Physical Sciences › Environmental Science › Pollution › Microplastics and Plastic Pollution
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Environmental Toxicology and Ecotoxicology
- Life Sciences › Immunology and Microbiology › Immunology › Aquaculture disease management and microbiota
- Keywords
- polystyrene nanoparticles, fathead minnow, innate immunity, neutrophils, neutrophil degranulation, neutrophil extracellular traps, respiratory burst, plastic pollution, fish disease resistance, freshwater fish
- MeSH terms
- Dynamic Light Scattering, Animals, Cyprinidae, Immunity, Innate, Neutrophils, Particle Size, Phagocytosis, Polycarboxylate Cement, Polystyrenes, Respiratory Burst, Secretory Vesicles, Nanoparticles
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