The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Sepsis and the evolution of human increased sensitivity to lipopolysaccharide
Abstract
Among mammals, humans are exquisitely sensitive to lipopolysaccharide (LPS), an environmentally pervasive bacterial cell membrane component. Very small doses of LPS trigger powerful immune responses in humans and can even initiate symptoms of sepsis. Close evolutionary relatives such as African and Asian monkeys require doses that are an order of magnitude higher to do the same. Why humans have evolved such an energetically expensive antimicrobial strategy is a question that biological anthropologists are positioned to help address. Here we compare LPS sensitivity in primate/mammalian models and propose that human high sensitivity to LPS is adaptive, linked to multiple immune tactics against pathogens, and part of multi‐faceted anti‐microbial strategy that strongly overlaps with that of other mammals. We support a notion that LPS sensitivity in humans has been driven by microorganisms that constitutively live on us, and has been informed by human behavioral changes over our species' evolution (e.g., meat eating, agricultural practices, and smoking).
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“The most common causative pathogens are among the most common causes of adult and infant sepsis worldwide ‐ Klebsiella pneumoniae and S. aureus (Brinkworth & Valizadegan, 2021; Deorari et al., 2005; Wattal et al., 2020).”
From On race, human variation, and who gets and dies of sepsis (2022) · cites this paper as Brinkworth & Valizadegan, 2021
In the citing paper
“Proinflammatory cytokine release invariably kills many infecting microorganisms, at the cost of bystander tissue damage in the host (reviewed in Brinkworth & Valizadegan, 2021).”
From On race, human variation, and who gets and dies of sepsis (2022) · cites this paper as Brinkworth & Valizadegan, 2021
In the citing paper
“Sepsis has been a major cause of death for millennia and is, itself, a source of human variation via post‐sepsis syndrome (Brinkworth & Valizadegan, 2021).”
From On race, human variation, and who gets and dies of sepsis (2022) · cites this paper as Brinkworth & Valizadegan, 2021
Citations
Cites
Kleinnijenhuis, J., Quintin, J., Preijers, F., Joosten, L. A. B., Ifrim, D. C., Saeed, S., Jacobs, C., van Loenhout, J., de Jong, D., Stunnenberg, H. G., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1202870109 · Cited by 1,728
Convergent adaptation of human lactase persistence in Africa and Europe
Tishkoff, S. A., Reed, F. A., Ranciaro, A., Voight, B. F., Babbitt, C. C., Silverman, J. S., Powell, K., Mortensen, H. M., Hirbo, J. B., Osman, M., et al. (2007) · Nature Genetics · doi:10.1038/ng1946 · Cited by 1,615
A network-based analysis of systemic inflammation in humans
Program, I. A. H. R. T. I. L. S. C. R., Calvano, S. E., Xiao, W., Richards, D. R., Felciano, R. M., Baker, H. V., Cho, R. J., Chen, R. O., Brownstein, B. H., Cobb, J. P., et al. (2005) · Nature · doi:10.1038/nature03985 · Cited by 1,429
Signal transduction by the lipopolysaccharide receptor, Toll-like receptor-4
Pålsson‐McDermott, E. M., & O'Neill, L. A. J. (2004) · Immunology · doi:10.1111/j.1365-2567.2004.01976.x · Cited by 1,254
Respiratory risks from household air pollution in low and middle income countries
Gordon, S. B., Bruce, N. G., Grigg, J., Hibberd, P. L., Kurmi, O. P., Lam, K.-B. H., Mortimer, K., Asante, K. P., Balakrishnan, K., Balmes, J., et al. (2014) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(14)70168-7 · Cited by 953
The Complex Microbiota of Raw Milk
Quigley, L., O'Sullivan, O., Stanton, C., Beresford, T. P., Ross, R. P., Fitzgerald, G. F., & Cotter, P. D. (2013) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12030 · Cited by 919
Why have clinical trials in sepsis failed?
Marshall, J. C. (2014) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2014.01.007 · Cited by 805
A randomized, double-blind, placebo-controlled trial of TAK-242 for the treatment of severe sepsis*
Rice, T. W., Wheeler, A. P., Bernard, G. R., Vincent, J.-L., Angus, D. C., Aikawa, N., Demeyer, I., Sainati, S., Amlot, N., Cao, C., et al. (2010) · Critical Care Medicine · doi:10.1097/ccm.0b013e3181e7c5c9 · Cited by 512
Dellinger, R. P., Bagshaw, S. M., Antonelli, M., Foster, D. M., Klein, D. J., Marshall, J. C., Palevsky, P. M., Weisberg, L. S., Schorr, C. A., Trzeciak, S., et al. (2018) · JAMA · doi:10.1001/jama.2018.14618 · Cited by 502
Ghanim, H., Abuaysheh, S., Sia, C. L., Korzeniewski, K., Chaudhuri, A., Fernandez-Real, J. M., & Dandona, P. (2009) · Diabetes Care · doi:10.2337/dc09-0979 · Cited by 494
Flagged first, then by citations
Research works printed but not linked: 169
- 10.1016/j.ccc.2008.12.003 · DOI
- 10.1164/rccm.201504-0781OC · DOI · Paper page
- World Health Organization, 2011, Report on the burden of endemic health care‐associated infection worldwide
- 10.1097/00003246-200107001-00035 · DOI · Paper page
- 10.1159/000315915 · DOI
- 10.1186/cc7936 · DOI
- 10.1097/01.shk.0000090843.66556.74 · DOI
- Bulow GU, 1992, Interleukin‐1 from baboon peripheral blood monocytes: altered response to endotoxin (lipopolysaccharide) and Staphylococcus aureus stimulation compared with human monocytes, Eur J Cell Biol, 59, 458
- 10.1093/infdis/167.6.1464 · DOI
- 10.1139/y87-220 · DOI
- 10.1097/00000658-198107000-00009 · DOI
- Black RE, 2016, Reproductive, maternal, newborn, and child health: disease control priorities, 10.1596/978-1-4648-0348-2_ch1 · DOI
- 10.1136/bmj.i1585 · DOI
- CantwellR Clutton‐BrockT CooperG et al.2011.Saving Mothers' lives: reviewing maternal deaths to make motherhood safer: 2006‐2008. The eighth report of the confidential enquiries into maternal deaths in the United Kingdom. BJOG 118(Suppl 1):1–203. · DOI
- 10.1371/journal.pone.0164938 · DOI
- 10.1016/j.jtherbio.2010.12.004 · DOI
- 10.1242/jeb.079574 · DOI
- 10.1152/jappl.1992.73.3.1146 · DOI
- 10.1152/jappl.1993.74.4.1528 · DOI
- 10.3181/00379727-61-15291P · DOI
- 10.1186/cc13110 · DOI
- 10.1189/jlb.3MR0316-118RR · DOI
- 10.3390/toxins5122589 · DOI
- 10.1016/j.immuni.2014.04.001 · DOI
- 10.1001/jama.2016.0287 · DOI · Paper page
- 10.1007/s11908-016-0535-8 · DOI
- 10.1097/CCM.0000000000003342 · DOI · Paper page
- 10.15585/mmwr.mm6533e1 · DOI · Paper page
- 10.1038/nri2402 · DOI
- 10.1038/nri1943 · DOI
- 10.1097/01.CCM.0000282072.56245.91 · DOI
- 10.1186/cc7969 · DOI
- 10.4049/jimmunol.168.5.2493 · DOI
- 10.4049/jimmunol.174.8.5110 · DOI
- 10.1186/cc13049 · DOI
- 10.1002/ags3.12194 · DOI
- 10.1097/00003246-199907000-00031 · DOI
- 10.1097/01.CCM.0000189943.60945.77 · DOI
- Solomkin JS, 1981, Neutrophil dysfunction in sepsis. II. Evidence for the role of complement activation products in cellular deactivation, Surgery, 90, 319
- 10.1016/j.thromres.2016.11.007 · DOI
- 10.1016/j.suc.2014.08.001 · DOI
- 10.1007/s00134-006-0392-2 · DOI
- 10.1093/emboj/20.24.6937 · DOI
- 10.3390/md11093197 · DOI
- 10.1074/jbc.M701454200 · DOI
- 10.12688/f1000research.13977.1 · DOI
- 10.1016/j.it.2017.05.001 · DOI
- 10.1093/bja/77.1.110 · DOI
- Suffredini AF, 1995, Effects of recombinant dimeric TNF receptor on human inflammatory responses following intravenous endotoxin administration, J Immunol, 155, 5038, 10.4049/jimmunol.155.10.5038 · DOI
- 10.1378/chest.126.3.860 · DOI
- 10.1016/j.numecd.2014.03.010 · DOI
- 10.1016/j.jneuroim.2017.12.020 · DOI
- 10.1016/j.metabol.2014.12.007 · DOI
- 10.1007/s10753-013-9758-0 · DOI
- 10.1016/j.clim.2006.05.012 · DOI
- 10.1038/76048 · DOI · Paper page
- 10.1186/s12865-018-0270-z · DOI
- 10.3390/ijms20133260 · DOI
- 10.1016/j.exger.2016.02.016 · DOI
- 10.1016/S0140-6736(80)90189-0 · DOI
- Fischer E, 1991, Comparison between effects of interleukin‐1 alpha administration and sublethal endotoxemia in primates, Am J Physiol, 261, R442
- 10.1258/0023677054306926 · DOI
- Brackett DJ, 1985, Evaluation of cardiac output, total peripheral vascular resistance, and plasma concentrations of vasopressin in the conscious unrestrained rat during endotoxemia, Circ Shock, 17, 273
- Lindsey DC, 1991, Characterization of an endotoxemic baboon model of metabolic and organ dysfunction, Circ Shock, 34, 298
- Traber DL, 1988, Cardiopulmonary responses to continuous administration of endotoxin, Am J Physiol, 254, H833
- 10.1128/IAI.61.7.2741-2747.1993 · DOI
- 10.1111/j.1582-4934.2011.01454.x · DOI
- 10.1186/cc2871 · DOI
- 10.1097/00024382-199509000-00011 · DOI
- 10.1097/00003246-199705000-00018 · DOI
- 10.1128/JB.172.1.94-101.1990 · DOI
- 10.1002/ajp.1350250403 · DOI
- 10.1126/science.282.5396.2085 · DOI · Paper page
- 10.1038/nature13683 · DOI · Paper page
- 10.1126/scisignal.aac6250 · DOI
- 10.1126/science.1240248 · DOI
- 10.1042/BST0390989 · DOI
- Staab JF, 1999, Distinctive structural features are shared by human, lapine and murine acyloxyacyl hydrolases, Innate Immunity, 5, 205
- Cooper NR, 1978, Binding and activation of the first component of human complement by the lipid A region of lipopolysaccharides, J Immunol, 120, 1862, 10.4049/jimmunol.120.6.1862 · DOI
- 10.1002/jlb.64.1.14 · DOI
- 10.1042/BJ20041270 · DOI
- 10.1111/j.1440-1681.2009.05260.x · DOI
- 10.1182/blood.V76.12.2520.2520 · DOI
- 10.1016/j.bbrc.2003.10.019 · DOI
- 10.4049/jimmunol.0803350 · DOI
- 10.1084/jem.189.4.615 · DOI
- 10.1186/gb-2000-1-1-research002 · DOI
- 10.1073/pnas.1201193109 · DOI
- 10.1074/jbc.M109.075127 · DOI
- 10.1371/journal.pgen.1001249 · DOI
- 10.1038/nrmicro1126 · DOI
- 10.1111/jmp.12002 · DOI
- 10.1385/CBB:40:3:289 · DOI
- 10.1007/978-1-4614-7181-3_2 · DOI
- 10.1093/molbev/msq104 · DOI
- 10.1007/978-1-4939-1438-8_4 · DOI
- 10.1038/nprot.2009.97 · DOI
- 10.1093/nar/gkw377 · DOI · Paper page
- 10.1093/sysbio/syq054 · DOI · Paper page
- 10.1186/1471-2105-11-165 · DOI
- 10.1093/database/bar030 · DOI
- 10.1093/nar/gkx1098 · DOI · Paper page
- 10.1371/journal.pone.0058993 · DOI
- 10.1146/annurev.immunol.26.021607.090400 · DOI · Paper page
- Senaldi G, 1999, Protection against the mortality associated with disease models mediated by TNF and IFN‐gamma in mice lacking IFN regulatory factor‐1, J Immunol, 163, 6820, 10.4049/jimmunol.163.12.6820 · DOI
- 10.1371/journal.pone.0130317 · DOI
- 10.1074/jbc.M205544200 · DOI
- 10.4049/jimmunol.1001952 · DOI
- 10.1124/mol.111.076976 · DOI
- 10.1016/j.molimm.2009.05.004 · DOI
- 10.1093/nar/gks544 · DOI
- 10.1038/ni.2688 · DOI
- 10.1073/pnas.1317723111 · DOI
- 10.1086/301867 · DOI · Paper page
- 10.7554/eLife.12994 · DOI
- 10.1016/j.coi.2016.10.005 · DOI
- 10.1016/S1473-3099(18)30407-9 · DOI · Paper page
- 10.1001/journalofethics.2016.18.7.mhst1-1607 · DOI
- Sattar SBA, 2019, Bacterial pneumonia
- 10.1371/journal.ppat.0020067 · DOI
- 10.3389/fmicb.2016.01936 · DOI
- 10.1002/ajp.20851 · DOI
- 10.1538/expanim.46.47 · DOI
- 10.1186/s40168-018-0560-y · DOI
- 10.7861/clinmedicine.17-6-525 · DOI
- 10.1001/jama.2013.2194 · DOI · Paper page
- 10.1084/jem.168.1.95 · DOI
- 10.4049/jimmunol.166.8.5161 · DOI
- 10.1038/nature09248 · DOI
- 10.1007/s10764-011-9574-z · DOI
- 10.1159/000110679 · DOI
- 10.1371/journal.pone.0009419 · DOI
- 10.1006/anbe.1994.1285 · DOI
- 10.1645/0022-3395(2000)086[0089:APHFSO]2.0.CO;2 · DOI
- Martin LD, 2003, Emerging pathogens: archaeology, ecology and evolution of infectious disease, 13, 10.1093/oso/9780198509004.003.0002 · DOI
- 10.1016/j.foodcont.2006.04.012 · DOI
- 10.1111/j.1365-2672.1979.tb01196.x · DOI
- 10.1038/nature12820 · DOI · Paper page
- 10.1017/S0007114510003004 · DOI
- 10.1016/j.numecd.2018.07.006 · DOI
- 10.1039/C9FO01760G · DOI
- 10.1053/j.gastro.2012.01.034 · DOI · Paper page
- 10.1016/j.jnutbio.2009.11.011 · DOI
- 10.1007/BF02381950 · DOI
- 10.1002/ajp.23029 · DOI
- 10.1084/jem.180.5.1985 · DOI
- 10.1084/jem.179.4.1253 · DOI
- 10.1371/journal.pone.0131422 · DOI
- 10.1002/ajpa.22396 · DOI
- 10.1111/j.1753-4887.2011.00431.x · DOI
- 10.1002/ajpa.21301 · DOI
- 10.1161/ATVBAHA.106.138743 · DOI
- 10.1016/j.quaint.2006.01.004 · DOI
- 10.1111/j.1399-302X.2008.00479.x · DOI
- 10.1177/0022034513483142 · DOI
- 10.1016/S0022-3476(74)80713-4 · DOI
- Winter JC, 2000, Tobacco use by native North Americans: sacred smoke and silent killer, 305
- Goodspeed T, 1954, The genu Nicotiana: origin, relationships and evolution of its species in the light of their distribution, morphology and cytogenetics
- 10.1016/S0140-6736(80)90493-6 · DOI
- 10.1378/chest.115.3.829 · DOI
- 10.1104/pp.65.3.557 · DOI
- 10.1126/science.1095443 · DOI · Paper page
- 10.1016/j.jasrep.2018.08.008 · DOI
- 10.1016/S0168-8278(00)80242-1 · DOI · Paper page
- 10.1186/1471-2148-10-15 · DOI
- 10.1089/cell.2012.0036 · DOI
- 10.7554/eLife.07103 · DOI
- 10.1038/s41598-018-24074-y · DOI
- 10.3390/jcm7090247 · DOI
Cited by
Sorted by citations
Miao, Y., Wang, M., Cai, X., Zhu, Q., & Mao, L. (2022) · Bioengineered · doi:10.1080/21655979.2022.2048775 · Cited by 22
On race, human variation, and who gets and dies of sepsis
Brinkworth, J. F., & Shaw, J. G. (2022) · American Journal of Biological Anthropology · doi:10.1002/ajpa.24527 · Cited by 9
Self-citation
Metadata
- Authors
- Brinkworth, J. F., & Valizadegan, N.
- Affiliations
- Evolutionary Immunology and Genomics Laboratory, Department of Anthropology University of Illinois Urbana‐Champaign Urbana Illinois USA
- Venue
- Evolutionary Anthropology: Issues, News, and Reviews
- Publisher
- Wiley
- Published
- 2021-03
- Volume
- 30
- Issue
- 2
- Pages
- 141-157
- ISSN
- 1060-1538
- 1520-6505
- Cited by
- 28
- References
- 13
- Language
- en
- Licence
- Funders
- Division of Behavioral and Cognitive Sciences (1750675)
- Leakey Foundation (# 0888118, # 214236)
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
