A high-fat diet is associated with endotoxemia that originates from the gut
Open accessAbstract
Endotoxemia, characterized by an excess of circulating bacterial wall lipopolysaccharide, is associated with systemic inflammation and the metabolic syndrome. Placing 8 healthy subjects on a Western-style diet for 1 month induced a 71% increase in plasma levels of endotoxin activity (endotoxemia), whereas a prudent-style diet reduced levels by 31%. The Western-style diet might, therefore, contribute to endotoxemia by causing changes in gastrointestinal barrier function or the composition of the microbiota. Endotoxemia might also develop in individuals with gastrointestinal barrier impairment. Therapeutic reagents that reduce endotoxemia might reduce systemic inflammation in patients with gastrointestinal diseases or metabolic syndrome.
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Changes in gut microbiota composition may occur after dietary interventions.
“Recent research indicates that changes in gut microbiota composition may occur after dietary interventions [13–15].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [13]
Dietary interventions can induce quick changes in microbiota composition.
“dietary interventions can induce quick changes in composition [13, 15].”
From Intestinal Microbiota Is Influenced by Gender and Body Mass Index (2016) · cites this paper as [13]
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Cites
The gut microbiota as an environmental factor that regulates fat storage
Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407076101 · Cited by 6,245 · see citing works
Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works
Inflammation, stress, and diabetes
Wellen, K. E., & Hotamisligil, G. S. (2005) · Journal of Clinical Investigation · doi:10.1172/jci25102 · Cited by 4,143 · see citing works
Turnbaugh, P. J., Bäckhed, F., Fulton, L., & Gordon, J. I. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.02.015 · Cited by 2,915 · see citing works
Cani, P. D., Possemiers, S., Van de Wiele, T., Guiot, Y., Everard, A., Rottier, O., Geurts, L., Naslain, D., Neyrinck, A., Lambert, D. M., et al. (2009) · Gut · doi:10.1136/gut.2008.165886 · Cited by 2,518 · see citing works
Cani, P. D., Neyrinck, A. M., Fava, F., Knauf, C., Burcelin, R., Tuohy, K. M., Gibson, G. R., & Delzenne, N. M. (2007) · Diabetologia · doi:10.1007/s00125-007-0791-0 · Cited by 1,776 · see citing works
Detection of circulating tumor necrosis factor after endotoxin administration
Michie, H. R., Manogue, K. R., Spriggs, D. R., Revhaug, A., O'Dwyer, S., Dinarello, C. A., Cerami, A., Wolff, S. M., & Wilmore, D. W. (1988) · New England Journal of Medicine · doi:10.1056/nejm198806093182301 · Cited by 1,677 · see citing works
Brun, P., Castagliuolo, I., di Leo, V., Buda, A., Pinzani, M., Palù, G., & Martines, D. (2007) · American Journal of Physiology - Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00024.2006 · Cited by 877 · see citing works
Erridge, C., Attina, T., Spickett, C. M., & Webb, D. J. (2007) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/86.5.1286 · Cited by 776 · see citing works
Energy intake is associated with endotoxemia in apparently healthy men
Amar, J., Burcelin, R., Ruidavets, J. B., Cani, P. D., Fauvel, J., Alessi, M., Chamontin, B., & Ferrières, J. (2008) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/87.5.1219 · Cited by 594 · see citing works
Ghanim, H., Abuaysheh, S., Sia, C. L., Korzeniewski, K., Chaudhuri, A., Fernandez-Real, J. M., & Dandona, P. (2009) · Diabetes Care · doi:10.2337/dc09-0979 · Cited by 494 · see citing works
Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans
Mehta, N. N., McGillicuddy, F. C., Anderson, P. D., Hinkle, C. C., Shah, R. D., Pruscino, L., Tabita‐Martinez, J., Sellers, K. F., Rickels, M. R., & Reilly, M. P. (2009) · Diabetes · doi:10.2337/db09-0367 · Cited by 347 · see citing works
Significance of systemic endotoxaemia in inflammatory bowel disease.
Gardiner, K. R., HALLIDAY, M. I., Barclay, G. R., Milne, L., Brown, D. J., Stephens, S., Maxwell, R., & Rowlands, B. J. (1995) · Gut · doi:10.1136/gut.36.6.897 · Cited by 226 · see citing works
A rapid assay of endotoxin in whole blood using autologous neutrophil dependent chemiluminescence
Romaschin, A. D., Harris, D. M., Ribeiro, M. B., PAICE, J. C., Foster, D., Walker, P. M., & Marshall, J. C. (1998) · Journal of Immunological Methods · doi:10.1016/s0022-1759(98)00003-9 · Cited by 165 · see citing works
Diet-induced weight loss reduces colorectal inflammation: implications for colorectal carcinogenesis
Pendyala, S., Neff, L. M., Suárez‐Fariñas, M., & Holt, P. R. (2010) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.002683 · Cited by 153 · see citing works
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Flagged first, then by citations
Cited by
Sorted by citations
Intestinal permeability – a new target for disease prevention and therapy
Bischoff, S. C., Barbara, G., Buurman, W., Ockhuizen, T., Schulzke, J.-D., Serino, M., Tilg, H., Watson, A., & Wells, J. M. (2014) · BMC Gastroenterology · doi:10.1186/s12876-014-0189-7 · Cited by 1,755 · see citing works
The gut-liver axis and the intersection with the microbiome
Tripathi, A., Debelius, J., Brenner, D. A., Karin, M., Loomba, R., Schnabl, B., & Knight, R. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0011-z · Cited by 1,480 · see citing works
The intestinal microbiota fuelling metabolic inflammation
Tilg, H., Zmora, N., Adolph, T. E., & Elinav, E. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0198-4 · Cited by 1,089 · see citing works
Hemarajata, P., & Versalovic, J. (2013) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12459294 · Cited by 1,083 · see citing works
Obesity, inflammation, and the gut microbiota
Cox, A. J., West, N. P., & Cripps, A. W. (2015) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(14)70134-2 · Cited by 869 · see citing works
Lipotoxicity and the gut-liver axis in NASH pathogenesis
Marra, F., & Svegliati-Baroni, G. (2018) · Journal of Hepatology · doi:10.1016/j.jhep.2017.11.014 · Cited by 847 · see citing works
The Western Diet–Microbiome-Host Interaction and Its Role in Metabolic Disease
Zinöcker, M. K., & Lindseth, I. A. (2018) · doi:10.20944/preprints201803.0064.v1 · Cited by 776 · see citing works
Intestinal Microbiota Is Influenced by Gender and Body Mass Index
Haro, C., Rangel-Zúñiga, O. A., Alcalá-Díaz, J. F., Gómez-Delgado, F., Pérez-Martínez, P., Delgado-Lista, J., Quintana-Navarro, G. M., Landa, B. B., Navas-Cortés, J. A., Tena-Sempere, M., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154090 · Cited by 671 · see citing works
“Although the microbiota is generally highly stable over an extended period of time in the absence of significant perturbations [45], dietary interventions can induce quick changes in composition [13, 15].”
BackgroundRole of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions
Mohammad, S., & Thiemermann, C. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.594150 · Cited by 585 · see citing works
Gut barrier disruption and chronic disease
Martel, J., Chang, S.-H., Ko, Y.-F., Hwang, T.-L., Young, J. D., & Ojcius, D. M. (2022) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2022.01.002 · Cited by 514 · see citing works
Role of Insulin Resistance in MAFLD
Sakurai, Y., Kubota, N., Yamauchi, T., & Kadowaki, T. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22084156 · Cited by 448 · see citing works
Metabolic endotoxemia with obesity: Is it real and is it relevant?
Boutagy, N. E., McMillan, R. P., Frisard, M. I., & Hulver, M. W. (2016) · Biochimie · doi:10.1016/j.biochi.2015.06.020 · Cited by 413 · see citing works
Role of gut microbiota and Toll-like receptors in nonalcoholic fatty liver disease
Miura, K. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i23.7381 · Cited by 355 · see citing works
Noble, E. E., Hsu, T. M., & Kanoski, S. E. (2017) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2017.00009 · Cited by 333 · see citing works
Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability
de Punder, K., & Pruimboom, L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00223 · Cited by 321 · see citing works
Risk of cardiomyopathy and cardiac arrhythmias in patients with nonalcoholic fatty liver disease
Anstee, Q. M., Mantovani, A., Tilg, H., & Targher, G. (2018) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-018-0010-0 · Cited by 310 · see citing works
Food, immunity, and the microbiome
Tilg, H., & Moschen, A. R. (2015) · Gastroenterology · doi:10.1053/j.gastro.2014.12.036 · Cited by 292 · see citing works
Peripheral mechanisms in irritable bowel syndrome
Camilleri, M. (2012) · New England Journal of Medicine · doi:10.1056/nejmra1207068 · Cited by 300 · see citing works
Fermented foods, microbiota, and mental health: ancient practice meets nutritional psychiatry
Selhub, E. M., Logan, A. C., & Bested, A. C. (2014) · Journal of Physiological Anthropology · doi:10.1186/1880-6805-33-2 · Cited by 280 · see citing works
The “psychomicrobiotic”: targeting microbiota in major psychiatric disorders: a systematic review
Fond, G., Boukouaci, W., Chevalier, G., Regnault, A., Eberl, G., Hamdani, N., Dickerson, F., Macgregor, A., Boyer, L., Dargel, A., et al. (2015) · Pathologie Biologie · doi:10.1016/j.patbio.2014.10.003 · Cited by 219 · see citing works
Kim, M., Hwang, S., Park, E., & Bae, J. (2013) · Environmental Microbiology Reports · doi:10.1111/1758-2229.12079 · Cited by 220 · see citing works
Diet, inflammation and the gut microbiome: mechanisms for obesity-associated cognitive impairment
Leigh, S.-J., & Morris, M. J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2020.165767 · Cited by 221 · see citing works
High fat diet, gut microbiome and gastrointestinal cancer
Tong, Y., Gao, H., Qi, Q., Liu, X., Li, J., Gao, J., Li, P., Wang, Y., Du, L., & Wang, C. (2021) · Theranostics · doi:10.7150/thno.56157 · Cited by 205 · see citing works
Damms-Machado, A., Louis, S., Schnitzer, A., Volynets, V., Rings, A., Basrai, M., & Bischoff, S. C. (2017) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.116.131110 · Cited by 195 · see citing works
Qu, W., Yuan, X., Zhao, J., Zhang, Y., Hu, J., Wang, J., & Li, J. (2017) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201700118 · Cited by 195 · see citing works
Sharpton, S. R., Schnabl, B., Knight, R., & Loomba, R. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.11.010 · Cited by 194 · see citing works
Dietary fiber and its associations with depression and inflammation
Swann, O. G., Kilpatrick, M., Breslin, M., & Oddy, W. H. (2020) · Nutrition Reviews · doi:10.1093/nutrit/nuz072 · Cited by 185 · see citing works
Stenman, L. K., Lehtinen, M. J., Meland, N., Christensen, J. E., Yeung, N., Saarinen, M. T., Courtney, M., Burcelin, R., Lähdeaho, M.-L., Linros, J., et al. (2016) · EBioMedicine · doi:10.1016/j.ebiom.2016.10.036 · Cited by 177 · see citing works
Dietary Factors: Major Regulators of the Gut's Microbiota
Moschen, A. R., Wieser, V., & Tilg, H. (2012) · Gut and Liver · doi:10.5009/gnl.2012.6.4.411 · Cited by 173 · see citing works
Vors, C., Pineau, G., Drai, J., Meugnier, E., Pesenti, S., Laville, M., Laugerette, F., Malpuech-Brugère, C., Vidal, H., & Michalski, M.-C. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2015-2518 · Cited by 159 · see citing works
Mechanistic links between gut microbial community dynamics, microbial functions and metabolic health
Ha, C. W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i44.16498 · Cited by 137 · see citing works
Endotoxemia, nutrition, and cardiometabolic disorders
Kallio, K. A. E., Hätönen, K. A., Lehto, M., Salomaa, V., Männistö, S., & Pussinen, P. J. (2015) · Acta Diabetologica · doi:10.1007/s00592-014-0662-3 · Cited by 125 · see citing works
Bested, A. C., Logan, A. C., & Selhub, E. M. (2013) · Gut Pathogens · doi:10.1186/1757-4749-5-3 · Cited by 121 · see citing works
Diet-induced gut dysbiosis and inflammation: Key drivers of obesity-driven NASH
Kang, G. G., Trevaskis, N. L., Murphy, A. J., & Febbraio, M. A. (2023) · iScience · doi:10.1016/j.isci.2022.105905 · Cited by 94 · see citing works
Mastrocola, R., Ferrocino, I., Liberto, E., Chiazza, F., Cento, A. S., Collotta, D., Querio, G., Nigro, D., Bitonto, V., Cutrin, J. C., et al. (2018) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2018.02.003 · Cited by 68 · see citing works
Nutrient excess and autophagic deficiency: explaining metabolic diseases in obesity
van Niekerk, G., du Toit, A., Loos, B., & Engelbrecht, A.-M. (2018) · Metabolism · doi:10.1016/j.metabol.2017.12.007 · Cited by 34 · see citing works
- Authors
- Pendyala, S., Walker, J. M., & Holt, P. R.
- Affiliations
- Rockefeller University (US)
- Corresponding author
- Holt, Peter R.
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 142
- Issue
- 5
- Pages
- 1100-1101.e2
- ISSN
- 0016-5085 (ISSN-L)
- PMC
- PMC3978718
- OpenAlex
- W2035885128
- Cited by
- 546
- References
- 15
- Citations by year
- 2026: 18 · 2025: 46 · 2024: 40 · 2023: 47 · 2022: 46 · 2021: 51 · 2020: 49 · 2019: 43 · 2018: 36 · 2017: 43 · 2016: 31 · 2015: 34 · 2014: 25 · 2013: 27 · 2012: 10
- FWCI
- 12.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Clinical and Translational Science Collaborative of Cleveland, School of Medicine, Case Western Reserve University (5UL1 RR024143-5)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- endotoxemia, high-fat diet, Western diet, prudent diet, lipopolysaccharide, intestinal barrier, gut microbiota, systemic inflammation, metabolic syndrome, dietary intervention
- MeSH terms
- Aged, Female, Humans, Male, Middle Aged, Permeability, Endotoxemia, Gastrointestinal Tract, Diet, High-Fat
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