Mitogen-activated protein kinase-signaling regulates the ability of Müller glia to proliferate and protect retinal neurons against excitotoxicity
Open accessAbstract
The purpose of this study was to investigate whether insulin, fibroblast growth factor (FGF), and mitogen‐activated protein kinase (MAPK) pathways protect retinal neurons against excitotoxicity and regulate the proliferation of Müller glia. We found that intraocular injections of insulin or FGF2 had variable effects upon the phosphorylation of ERK1/2, p38 MAPK, and CREB, and the expression of immediate early genes, cFos and Egr1. Accumulations of pERK1/2, p38 MAPK, pCREB, cFos and Egr1 in response to insulin or FGF2 were confined to Müller glia, whereas retinal neurons did not seem to respond to growth factors. Unlike FGF2, insulin stimulated microglia‐like cells to upregulate the intermediate filament transitin and lysosomal membrane glycoprotein (LMG). With microglia‐like cells and Müller glia stimulated by insulin or FGF2 there were profound effects upon numbers of dying neurons in response to excitotoxic damage. Although FGF2 significantly reduced numbers of dying neurons, insulin significantly increased numbers of dying neurons. In addition to neuroprotective affects, FGF2 also “primed” the Müller glia to proliferate following retinal damage, whereas insulin had no effect upon glial proliferation. Further, we found that FGF receptor isoform 1 (FGFR1) and FGFR3 were prominently expressed in the retina, whereas the insulin receptor and FGFR2 are not expressed, or are expressed at very low levels. We conclude that MAPK‐signaling through FGF receptors stimulates Müller glia to become more neuroprotective and progenitor‐like, whereas insulin acting on Müller and microglia‐like cells through unidentified receptors had the opposite effect. © 2009 Wiley‐Liss, Inc.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
MG are primarily responsive to intra-ocular insulin with increased phosphorylation of ERK1/2 and p38.
“Additionally, MG are primarily responsive to intra-ocular insulin with increased phosphorylation of ERK1/2 and p38 [ 77 ].”
From MAPK Pathways in Ocular Pathophysiology: Potential Therapeutic Drugs and Challenges (2023) · cites this paper as [77]
The Results section on insulin and MAPK signaling reports increased pERK1/2 in Müller glia after intraocular insulin. It also reports no increase in p38 MAPK after insulin treatment; the Discussion distinguishes this response from the p38 response to FGF2. Thus the ERK1/2 part is supported, but the attributed p38 increase is contradicted. (LLM, conf=0.88)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Müller glia are a potential source of neural regeneration in the postnatal chicken retina
Fischer, A. J., & Reh, T. A. (2001) · Nature Neuroscience · doi:10.1038/85090 · Cited by 579 · see citing works
Self-citationThe transcriptome of retinal Müller glial cells
Roesch, K., Jadhav, A. P., Trimarchi, J. M., Stadler, M. B., Roska, B., Sun, B. B., & Cepko, C. L. (2008) · The Journal of Comparative Neurology · doi:10.1002/cne.21730 · Cited by 409 · see citing works
Stimulation of neural regeneration in the mouse retina
Karl, M. O., Hayes, S., Nelson, B. R., Tan, K., Buckingham, B., & Reh, T. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0807453105 · Cited by 368 · see citing works
Harada, T., Harada, C., Kohsaka, S., Wada, E., Yoshida, K., Ohno, S., Mamada, H., Tanaka, K., Parada, L. F., & Wada, K. (2002) · The Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09228.2002 · Cited by 325 · see citing works
Wnt signaling promotes regeneration in the retina of adult mammals
Osakada, F., Ooto, S., Akagi, T., Mandai, M., Akaike, A., & Takahashi, M. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4193-06.2007 · Cited by 322 · see citing works
Expression and characterization of a functional human insulin-like growth factor I receptor.
Steele-Perkins, G., Turner, J. D., Edman, J. C., Hari, J., Pierce, S. B., Stover, C., Rutter, W. J., & Roth, R. A. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)37983-3 · Cited by 314 · see citing works
Peterson, W. M., Wang, Q., Tzekova, R., & Wiegand, S. J. (2000) · The Journal of Neuroscience · doi:10.1523/jneurosci.20-11-04081.2000 · Cited by 267 · see citing works
Potential of Müller glia to become neurogenic retinal progenitor cells
Fischer, A. J., & Reh, T. A. (2003) · Glia · doi:10.1002/glia.10218 · Cited by 248 · see citing works
Self-citationSteininger, T. L., Gong, H., McGinty, D., & Szymusiak, R. S. (2000) · The Journal of Comparative Neurology · doi:10.1002/1096-9861(20010122)429:4 · Cited by 240 · see citing works
Harada, T., Harada, C., Nakayama, N., Okuyama, S., Yoshida, K., Kohsaka, S., Matsuda, H., & Wada, K. (2000) · Neuron · doi:10.1016/s0896-6273(00)81185-x · Cited by 221 · see citing works
Fischer, A. J., McGuire, C. R., Dierks, B. D., & Reh, T. A. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-21-09387.2002 · Cited by 210 · see citing works
Self-citationSignalling pathways: Jack of all cascades
Cahill, M. A., Janknecht, R., & Nordheim, A. (1996) · Current Biology · doi:10.1016/s0960-9822(02)00410-4 · Cited by 186 · see citing works
Neural Regeneration and Cell Replacement: A View from the Eye
Lamba, D. A., Karl, M., & Reh, T. A. (2008) · Cell stem cell · doi:10.1016/j.stem.2008.05.002 · Cited by 167 · see citing works
Liang, F.-Q., Dejneka, N. S., Cohen, D. R., Krasnoperova, N. V., Lem, J., Maguire, A. M., Dudus, L., Fisher, K. J., & Bennett, J. (2001) · Molecular Therapy · doi:10.1006/mthe.2000.0252 · Cited by 167 · see citing works
Notch signaling regulates regeneration in the avian retina
Hayes, S., Nelson, B. R., Buckingham, B., & Reh, T. A. (2007) · Developmental Biology · doi:10.1016/j.ydbio.2007.09.046 · Cited by 141 · see citing works
Lu, J. W., McMurtry, J. P., & Coon, C. N. (2007) · Poultry Science · doi:10.1093/ps/86.4.673 · Cited by 135 · see citing works
Neural regeneration in the chick retina
Fischer, A. J. (2004) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2004.07.003 · Cited by 124 · see citing works
Self-citationRetinal neuroprotection by growth factors: A mechanistic perspective
Chaum, E. (2002) · Journal of Cellular Biochemistry · doi:10.1002/jcb.10354 · Cited by 124 · see citing works
Epidermal growth factor receptor expression regulates proliferation in the postnatal rat retina
Close, J., Liu, J., Gümüşçü, B., & Reh, T. A. (2006) · Glia · doi:10.1002/glia.20361 · Cited by 121 · see citing works
Chong, V. N., Alexander, R., Waters, L., Barnett, K. C., Bird, A. C., & Luthert, P. J. (1999) · PubMed · Cited by 120 · see citing works
Cao, W., Li, F., Steinberg, R. H., & LaVail, M. M. (2001) · Experimental Eye Research · doi:10.1006/exer.2001.0990 · Cited by 119 · see citing works
Exogenous growth factors induce the production of ganglion cells at the retinal margin
Fischer, A. J., Dierks, B. D., & Reh, T. A. (2002) · Development · doi:10.1242/dev.129.9.2283 · Cited by 118 · see citing works
Self-citationHarada, C., Harada, T., Quah, H.-M. A., Maekawa, F., Yoshida, K., Ohno, S., Wada, K., Parada, L. F., & Tanaka, K. (2003) · Neuroscience · doi:10.1016/s0306-4522(03)00599-2 · Cited by 113 · see citing works
Fischer, A. J., Scott, M. A., & Tuten, W. (2009) · Glia · doi:10.1002/glia.20743 · Cited by 105 · see citing works
Self-citationStem Cells in the Vertebrate Retina
Reh, T. A., & Fischer, A. J. (2001) · Brain Behavior and Evolution · doi:10.1159/000057571 · Cited by 101 · see citing works
Self-citationSurvival and axonal regeneration of retinal ganglion cells in adult cats
Watanabe, M., & Fukuda, Y. (2002) · Progress in Retinal and Eye Research · doi:10.1016/s1350-9462(02)00037-x · Cited by 89 · see citing works
Fischer, A. J., Schmidt, M., Omar, G., & Reh, T. A. (2004) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2004.08.007 · Cited by 81 · see citing works
Self-citationFischer, A. J., Omar, G., Eubanks, J., McGuire, C. R., Dierks, B. D., & Reh, T. A. (2004) · PubMed · Cited by 63 · see citing works
Self-citationFischer, A. J., & Omar, G. (2005) · The Journal of Comparative Neurology · doi:10.1002/cne.20406 · Cited by 56 · see citing works
Self-citationJoly, S., Pernet, V., Chemtob, S., Polo, A. D., & Lachapelle, P. (2007) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.06-1205 · Cited by 56 · see citing works
Waldbillig, R. J., Arnold, D. R., Fletcher, R. T., & Chader, G. J. (1991) · Experimental Eye Research · doi:10.1016/0014-4835(91)90139-6 · Cited by 46 · see citing works
ERK1 plays a critical protective role against N‐methyl‐ D ‐aspartate‐induced retinal injury
Nakazawa, T., Shimura, M., Ryu, M., Nishida, K., Pagès, G., Pouysségur, J., & Endo, S. (2007) · Journal of Neuroscience Research · doi:10.1002/jnr.21472 · Cited by 43 · see citing works
Patterning of the circumferential marginal zone of progenitors in the chicken retina
Ghai, K., Stanke, J. J., & Fischer, A. J. (2007) · Brain Research · doi:10.1016/j.brainres.2007.01.105 · Cited by 40 · see citing works
Self-citationNeuronal stem/progenitor cells in the vertebrate eye
Ohta, K., Ito, A., & Tanaka, H. (2008) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2008.01006.x · Cited by 38 · see citing works
The roles of Hedgehogs and Fibroblast Growth Factors in eye development and retinal cell rescue
Russell, C. (2003) · Vision Research · doi:10.1016/s0042-6989(02)00416-9 · Cited by 36 · see citing works
Layton, C. J., Becker, S., & Osborne, N. N. (2006) · PubMed · Cited by 30 · see citing works
Shape diversity among chick retina Müller cells and their postnatal differentiation
Anezary, L., Medina, J. I., Sánchez‐Nogueiro, J., López‐Gallardo, M., & Prada, C. (2001) · The Journal of Comparative Neurology · doi:10.1002/cne.1300 · Cited by 27 · see citing works
MOONEY, R. D., Crnko-Hoppenjans, T. A., Ke, M., Bennett‐Clarke, C. A., Lane, R. D., Chiaia, N. L., & Rhoades, R. W. (1998) · The Journal of Comparative Neurology · doi:10.1002/(sici)1096-9861(19980330)393:1 · Cited by 20 · see citing works
Signal transduction pathways activated by ciliary neurotrophic factor and related cytokines.
Da, F., & Greenberg, M. E. (1996) · PubMed · Cited by 19 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Fischer AJ 2005 Neural regeneration in the chick retina Prog Retin Eye Res 24 2 161 82 15610972
Cited by
Sorted by citations
Pollen, A. A., Nowakowski, T. J., Shuga, J., Wang, X., Leyrat, A. A., Lui, J. H., Li, N., Szpankowski, L., Fowler, B., Chen, P., et al. (2014) · Nature Biotechnology · doi:10.1038/nbt.2967 · Cited by 920 · see citing works
Reichenbach, A., & Bringmann, A. (2013) · Glia · doi:10.1002/glia.22477 · Cited by 720 · see citing works
Müller glial cell reprogramming and retina regeneration
Goldman, D. J. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3723 · Cited by 629 · see citing works
Govetto, A., Lalane, R. A., Sarraf, D., Figueroa, M. S., & Hubschman, J. (2016) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2016.12.006 · Cited by 538 · see citing works
Menon, M., Mohammadi, S., Davila-Velderrain, J., Goods, B. A., Cadwell, T. D., Xing, Y., Stemmer-Rachamimov, A., Shalek, A. K., Love, J. C., Kellis, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12780-8 · Cited by 331 · see citing works
HB-EGF is Necessary and Sufficient for Müller Glia Dedifferentiation and Retina Regeneration
Wan, J., Ramachandran, R., & Goldman, D. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.020 · Cited by 262 · see citing works
“MAPK signaling was previously reported to be required for proliferation of MG-derived progenitors in the postnatal chick retina (Fischer et al., 2009a; Fischer et al., 2009b) and likely mediates the effects of EGF on MG proliferation in the injured mouse retina (Karl et al., 2008).”
BackgroundRamachandran, R., Zhao, X.-F., & Goldman, D. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1107220108 · Cited by 206 · see citing works
Berner, A., Brouwers, O., Pringle, R., Klaassen, I., Colhoun, L. M., McVicar, C. M., Brockbank, S., Curry, J., Miyata, T., Brownlee, M., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2393-0 · Cited by 153 · see citing works
Hamon, A., Roger, J. E., Yang, X.-J., & Perron, M. (2015) · Developmental Dynamics · doi:10.1002/dvdy.24375 · Cited by 139 · see citing works
Turning Müller Glia into Neural Progenitors in the Retina
Fischer, A. J., & Bongini, R. E. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8152-2 · Cited by 111 · see citing works
Self-citationNotch signaling influences neuroprotective and proliferative properties of mature Müller glia
Ghai, K., Zelinka, C., & Fischer, A. J. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4919-09.2010 · Cited by 111 · see citing works
Self-citationEffect of inhibition of the FGFR–MAPK signaling pathway on the development of ocular toxicities
van der Noll, R., Leijen, S., Neuteboom, G. H. G., Beijnen, J. H., & Schellens, J. H. M. (2013) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2013.01.003 · Cited by 106 · see citing works
Fischer, A. J., Zelinka, C. P., Gallina, D., Scott, M. A., & Todd, L. J. (2014) · Glia · doi:10.1002/glia.22703 · Cited by 100 · see citing works
Self-citationThe ciliary marginal zone (CMZ) in development and regeneration of the vertebrate eye
Fischer, A. J., Bosse, J. L., & El‐Hodiri, H. M. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.08.018 · Cited by 96 · see citing works
Self-citationThe chick eye in vision research: An excellent model for the study of ocular disease
Wisely, C. E., Sayed, J. A., Tamez, H. M., Zelinka, C. P., Abdel‐Rahman, M. H., Fischer, A. J., & Cebulla, C. M. (2017) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2017.06.004 · Cited by 94 · see citing works
Self-citationLens and retina regeneration: new perspectives from model organisms
Barbosa-Sabanero, K., Hoffmann, A., Judge, C. J., Lightcap, N., Tsonis, P. A., & Rio‐Tsonis, K. D. (2012) · Biochemical Journal · doi:10.1042/bj20120813 · Cited by 92 · see citing works
Todd, L. J., Squires, N. A., Suarez, L., & Fischer, A. J. (2016) · Scientific Reports · doi:10.1038/srep35703 · Cited by 87 · see citing works
Self-citationA comparative analysis of Müller glia-mediated regeneration in the vertebrate retina
Gallina, D., Todd, L. J., & Fischer, A. J. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.06.019 · Cited by 84 · see citing works
Self-citationPalazzo, I., Todd, L. J., Hoang, T. V., Reh, T. A., Blackshaw, S., & Fischer, A. J. (2022) · Glia · doi:10.1002/glia.24181 · Cited by 82 · see citing works
Self-citationMüller Glia-Mediated Retinal Regeneration
Gao, H., Luodan, A., Huang, X., Chen, X., & Xu, H. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02274-w · Cited by 83 · see citing works
Gallina, D., Zelinka, C. P., & Fischer, A. J. (2014) · Development · doi:10.1242/dev.109835 · Cited by 77 · see citing works
Self-citationStanke, J. J., Moose, H. E., El‐Hodiri, H. M., & Fischer, A. J. (2010) · The Journal of Comparative Neurology · doi:10.1002/cne.22335 · Cited by 74 · see citing works
Self-citationThe combination of IGF1 and FGF2 and the induction of excessive ocular growth and extreme myopia
Ritchey, E. R., Zelinka, C. P., Tang, J., Liu, J., & Fischer, A. J. (2012) · Experimental Eye Research · doi:10.1016/j.exer.2012.03.019 · Cited by 71 · see citing works
Self-citationHeterogeneity of Glia in the Retina and Optic Nerve of Birds and Mammals
Fischer, A. J., Zelinka, C. P., & Scott, M. A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010774 · Cited by 69 · see citing works
Self-citationZelinka, C. P., Volkov, L. I., Goodman, Z. A., Todd, L. J., Palazzo, I., Bishop, W. A., & Fischer, A. J. (2016) · Development · doi:10.1242/dev.133215 · Cited by 62 · see citing works
Self-citationMAPK Pathways in Ocular Pathophysiology: Potential Therapeutic Drugs and Challenges
Moustardas, P., Aberdam, D., & Lagali, N. (2023) · Cells · doi:10.3390/cells12040617 · Cited by 63 · see citing works
“Additionally, MG are primarily responsive to intra-ocular insulin with increased phosphorylation of ERK1/2 and p38 [77].”
BackgroundReactive retinal microglia, neuronal survival, and the formation of retinal folds and detachments
Fischer, A. J., Zelinka, C. P., & Milani‐Nejad, N. (2014) · Glia · doi:10.1002/glia.22752 · Cited by 60 · see citing works
Self-citationFischer, A. J., Scott, M. A., Zelinka, C. P., & Sherwood, P. (2009) · Glia · doi:10.1002/glia.20950 · Cited by 61 · see citing works
Self-citationPalazzo, I., Deistler, K., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2020) · Development · doi:10.1242/dev.183418 · Cited by 60 · see citing works
Self-citationTodd, L. J., & Fischer, A. J. (2015) · Development · doi:10.1242/dev.121616 · Cited by 57 · see citing works
Self-citationTodd, L. J., Palazzo, I., Squires, N. A., Mendonca, N., & Fischer, A. J. (2017) · Glia · doi:10.1002/glia.23185 · Cited by 56 · see citing works
Self-citationCampbell, W. A., Fritsch‐Kelleher, A., Palazzo, I., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2021) · Glia · doi:10.1002/glia.23976 · Cited by 51 · see citing works
Self-citationTodd, L. J., Suarez, L., Quinn, C. H., & Fischer, A. J. (2017) · Stem Cells · doi:10.1002/stem.2742 · Cited by 54 · see citing works
Self-citationTodd, L. J., Volkov, L. I., Zelinka, C. P., Squires, N. A., & Fischer, A. J. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.10.004 · Cited by 52 · see citing works
Self-citationZelinka, C. P., Scott, M. A., Volkov, L. I., & Fischer, A. J. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044477 · Cited by 50 · see citing works
Self-citationMatteucci, A., Gaddini, L., Villa, M., Varano, M., Parravano, M., Monteleone, V., Cavallo, F., Leo, L., Mallozzi, C., Malchiodi‐Albedi, F., et al. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.05.011 · Cited by 45 · see citing works
W nt/β‐catenin‐signaling and the formation of M üller glia‐derived progenitors in the chick retina
Gallina, D., Palazzo, I., Steffenson, L. N., Todd, L. J., & Fischer, A. J. (2015) · Developmental Neurobiology · doi:10.1002/dneu.22370 · Cited by 42 · see citing works
Self-citationGallina, D., Zelinka, C. P., Cebulla, C. M., & Fischer, A. J. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.08.007 · Cited by 41 · see citing works
Self-citationChuang, J., Huang, J.-Y., Tsai, S., Sun, H. S., Yang, S., Chuang, P., Huang, B., & Ching, C. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.08.011 · Cited by 43 · see citing works
Retinal cell death dependent reactive proliferative gliosis in the mouse retina
Pasha, S. P. B. S., Münch, R., Schäfer, P., Oertel, P., Sykes, A. M., Zhu, Y., & Karl, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-09743-8 · Cited by 40 · see citing works
Purinergic signaling in the retina: From development to disease
Ventura, A. L. M., dos Santos‐Rodrigues, A., Mitchell, C. H., & Faillace, M. P. (2018) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2018.10.016 · Cited by 42 · see citing works
Focused ultrasound as a novel strategy for noninvasive gene delivery to retinal Müller glia
Touahri, Y., Dixit, R., Kofoed, R. H., Miloska, K., Park, E., Raeisossadati, R., Markham-Coultes, K., David, L. A., Rijal, H., Zhao, J., et al. (2020) · Theranostics · doi:10.7150/thno.42611 · Cited by 39 · see citing works
Beach, K. M., Wang, J., & Otteson, D. C. (2017) · Stem Cells International · doi:10.1155/2017/1610691 · Cited by 37 · see citing works
Qian, C., Dong, B. C., Wang, X., & Zhou, F. (2020) · FEBS Journal · doi:10.1111/febs.15681 · Cited by 36 · see citing works
Campbell, W. A., Blum, S. A., Reske, A., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2021) · Glia · doi:10.1002/glia.24056 · Cited by 35 · see citing works
Self-citationTNFα activates MAPK and Jak-Stat pathways to promote mouse Müller cell proliferation.
Niu, L., Fang, Y., Yao, X., Zhang, Y., Wu, J., Chen, D. F., & Sun, X. (2021) · Experimental Eye Research · doi:10.1016/j.exer.2020.108353 · Cited by 32 · see citing works
Campbell, W. A., Deshmukh, A. A., Blum, S. A., Todd, L. J., Mendonca, N., Weist, J. L., Zent, J. M., Hoang, T. V., Blackshaw, S., Leight, J. L., et al. (2019) · Experimental Neurology · doi:10.1016/j.expneurol.2019.112984 · Cited by 31 · see citing works
Self-citationEl‐Hodiri, H. M., Campbell, W. A., Kelly, L. E., Hawthorn, E. C., Schwartz, M., Jalligampala, A., McCall, M. A., Meyer, K., & Fischer, A. J. (2021) · The Journal of Comparative Neurology · doi:10.1002/cne.25270 · Cited by 31 · see citing works
Self-citationCampbell, W. A., Tangeman, A., El‐Hodiri, H. M., Hawthorn, E. C., Hathoot, M., Blum, S., Hoang, T. V., Blackshaw, S., & Fischer, A. J. (2022) · Development · doi:10.1242/dev.200127 · Cited by 28 · see citing works
Self-citationRebuilding the Retina: Prospects for Müller Glial-mediated Self-repair
Langhe, R., & Pearson, R. A. (2019) · Current Eye Research · doi:10.1080/02713683.2019.1669665 · Cited by 26 · see citing works
Mdzomba, J. B., Joly, S., Rodriguez, L., Dirani, A., Lassiaz, P., Béhar‐Cohen, F., & Pernet, V. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-2302-x · Cited by 27 · see citing works
Reprint of: The ciliary marginal zone (CMZ) in development and regeneration of the vertebrate eye
Fischer, A. J., Bosse, J. L., & El‐Hodiri, H. M. (2014) · Experimental Eye Research · doi:10.1016/j.exer.2014.04.019 · Cited by 25 · see citing works
Self-citationMüller cells trophism and pathology as the next therapeutic targets for retinal diseases
Arrigo, A., Cremona, O., Aragona, E., Casoni, F., Consalez, G., Dogru, R. M., Hauck, S. M., Antropoli, A., Bianco, L., Parodi, M. B., et al. (2025) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2025.101357 · Cited by 25 · see citing works
MIF Inhibitor ISO-1 Protects Photoreceptors and Reduces Gliosis in Experimental Retinal Detachment
Kim, B., Kusibati, R., Heisler‐Taylor, T., Mantopoulos, D., Ding, J., Abdel‐Rahman, M. H., Satoskar, A. R., Godbout, J. P., Bhattacharya, S. K., & Cebulla, C. M. (2017) · Scientific Reports · doi:10.1038/s41598-017-14298-9 · Cited by 23 · see citing works
Müller glia express rhodopsin in a mouse model of inherited retinal degeneration
Goel, M., & Dhingra, N. K. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.066 · Cited by 23 · see citing works
El‐Hodiri, H. M., Bentley, J. R., Reske, A., Taylor, O. B., Palazzo, I., Campbell, W. A., Halloy, N. R., & Fischer, A. J. (2023) · Development · doi:10.1242/dev.202070 · Cited by 23 · see citing works
Self-citationLiu, Y., Wang, C., & Su, G. (2019) · Journal of Ophthalmology · doi:10.1155/2019/5743109 · Cited by 26 · see citing works
Elevated serum IGF-1 level enhances retinal and choroidal thickness in untreated acromegaly patients
Zhang, X., Ma, J., Wang, Y., Li, L., Gao, L., Guo, X., Xing, B., & Zhong, Y. (2018) · Endocrine · doi:10.1007/s12020-017-1511-2 · Cited by 21 · see citing works
Fleming, T., Balderas-Márquez, J. E., Epardo, D., Ávila-Mendoza, J., Carranza, M., Luna, M., Harvey, S., Arámburo, C., & Martínez-Moreno, C. G. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27473 · Cited by 21 · see citing works
Hoang, T. V., Wang, J., Boyd, P., Wang, F., Santiago, C. P., Jiang, L., Lahne, M., Yoo, S., Todd, L. J., Gonzalez, C. S., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/717876 · Cited by 23 · see citing works
Self-citationThe Effects of Sonic Hedgehog on Retinal Müller Cells Under High-Glucose Stress
Zhao, X., Li, Y., Lin, S., Cai, Y. L., Zhang, J., Yu, X., Yang, H., Yang, L., Chen, X. N., Luo, Y., et al. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-16104 · Cited by 20 · see citing works
Yu, Y., Bao, Z., Wang, X., Gong, W., Chen, H., Guan, H., Le, Y., Su, S., Chen, K., & Wang, J. M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01852 · Cited by 19 · see citing works
Chromatin access regulates the formation of Müller glia‐derived progenitor cells in the retina
Campbell, W. A., El‐Hodiri, H. M., Torres, D., Hawthorn, E. C., Kelly, L. E., Volkov, L. I., Akanonu, D., & Fischer, A. J. (2023) · Glia · doi:10.1002/glia.24366 · Cited by 19 · see citing works
Self-citationCorradetti, G., Au, A. C., Borrelli, E., Xu, X., Freund, K. B., & Sarraf, D. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.19-27476 · Cited by 19 · see citing works
Harun‐Or‐Rashid, M., Lindqvist, N., & Hallböök, F. (2014) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.13-13823 · Cited by 18 · see citing works
Reichenbach, A., & Bringmann, A. (2015) · Colloquium Series on Neuroglia in Biology and Medicine From Physiology to Disease · doi:10.4199/c00122ed1v01y201412ngl003 · Cited by 17 · see citing works
Controlled microenvironments to evaluate chemotactic properties of cultured Müller glia
Peña, J. S., Dulger, N., Singh, T., Zhou, J., Majeska, R. J., Redenti, S., & Vázquez, M. (2018) · Experimental Eye Research · doi:10.1016/j.exer.2018.05.005 · Cited by 17 · see citing works
Jacques, F. J., Silva, T. M., da Silva, F. E., Ornelas, I. M., & Ventura, A. L. M. (2017) · Cellular Signalling · doi:10.1016/j.cellsig.2017.03.019 · Cited by 16 · see citing works
Regulating the formation of Müller glia‐derived progenitor cells in the retina
Taylor, O. B., El‐Hodiri, H. M., Palazzo, I., Todd, L. J., & Fischer, A. J. (2024) · Glia · doi:10.1002/glia.24635 · Cited by 14 · see citing works
Self-citationGalán, A., Jmaeff, S., Barcelona, P. F., Brahimi, F., Šarunic, M. V., & Saragovi, H. U. (2017) · Cell Death and Disease · doi:10.1038/s41419-017-0074-8 · Cited by 15 · see citing works
Coorey, N. J., Shen, W., Zhu, L., & Gillies, M. C. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.14-15695 · Cited by 14 · see citing works
Fard, S. S., All‐Ericsson, C., & Hallböök, F. (2013) · Cell Cycle · doi:10.4161/cc.27200 · Cited by 13 · see citing works
Reactive Muller Glia as Potential Retinal Progenitors
Teri, L. L., Ellen, C. W., Muñoz-Cabrera, J., & Dharmaraj, S. (2013) · InTech eBooks · doi:10.5772/55150 · Cited by 14 · see citing works
Müller glia activation by VEGF-antagonizing drugs: An in vitro study on rat primary retinal cultures
Gaddini, L., Varano, M., Matteucci, A., Mallozzi, C., Villa, M., Pricci, F., & Malchiodi‐Albedi, F. (2015) · Experimental Eye Research · doi:10.1016/j.exer.2015.11.010 · Cited by 12 · see citing works
Harun‐Or‐Rashid, M., Konjusha, D., Galindo‐Romero, C., & Hallböök, F. (2016) · PLoS ONE · doi:10.1371/journal.pone.0167778 · Cited by 12 · see citing works
Taylor, O. B., Patel, S. P., Hawthorn, E. C., El‐Hodiri, H. M., & Fischer, A. J. (2024) · Glia · doi:10.1002/glia.24523 · Cited by 10 · see citing works
Self-citationMarkitantova, Y. V., Авдонин, П. П., & Grigoryan, E. N. (2014) · Biology Bulletin · doi:10.1134/s1062359014040074 · Cited by 12 · see citing works
Mafi, M., Govetto, A., Mahmoudinezhad, G., Prasad, P. S., Bousquet, E., Voichanski, S., Feo, A., & Sarraf, D. (2025) · Retina · doi:10.1097/iae.0000000000004418 · Cited by 11 · see citing works
Induction of a proliferative response in the zebrafish retina by injection of extracellular vesicles
Didiano, D., Abner, J. J., Hinger, S. A., Flickinger, Z., Kent, M. R., Clement, M. A., Balaiya, S., Liu, Q., Dai, X., Levine, E. M., et al. (2020) · Experimental Eye Research · doi:10.1016/j.exer.2020.108254 · Cited by 11 · see citing works
Epigenetic mechanisms of Müller glial reprogramming mediating retinal regeneration
Si, T., Li, Z., Zhang, J., Su, S., Liu, Y., Chen, S., Peng, G.-H., Cao, J., & Zang, W. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1157893 · Cited by 9 · see citing works
bFGF and insulin lead to migration of Müller glia to photoreceptor layer in rd1 mouse retina
Goel, M., & Dhingra, N. K. (2021) · Neuroscience Letters · doi:10.1016/j.neulet.2021.135936 · Cited by 8 · see citing works
Guo, Q., Huang, S.-D., Zou, T., & Yin, Z. (2023) · International Journal of Ophthalmology · doi:10.18240/ijo.2023.04.01 · Cited by 8 · see citing works
Cebulla, C. M., Kim, B., George, V., Heisler‐Taylor, T., Hamadmad, S., Reese, A. Y., Kothari, S. S., Kusibati, R., Wilson, H., & Abdel‐Rahman, M. H. (2019) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.18-25405 · Cited by 8 · see citing works
Harun‐Or‐Rashid, M., Diaz‐delCastillo, M., Galindo‐Romero, C., & Hallböök, F. (2015) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.15-16816 · Cited by 8 · see citing works
MAPK signaling during Müller glial cell development in retina explant cultures
Zhang, S. S.-M., Li, H., Huang, P., Lou, L. X., Fu, X.-Y., & Barnstable, C. J. (2010) · Journal of Ocular Biology, Diseases, and Informatics · doi:10.1007/s12177-011-9064-8 · Cited by 7 · see citing works
Retinal transcriptome of neonatal mice after optic nerve injury
Yao, S., Wang, M., Liang, J., Ng, T. K., & Cen, L. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286344 · Cited by 7 · see citing works
Müller Glia, Vision-Guided Ocular Growth, Retinal Stem Cells, and a Little Serendipity
Fischer, A. J. (2011) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.11-8330 · Cited by 7 · see citing works
Self-citationNomura-Komoike, K., Nishino, R., & Fujieda, H. (2024) · Scientific Reports · doi:10.1038/s41598-023-50485-7 · Cited by 6 · see citing works
Comprehensive analysis of transcription factors involved in odontoblast differentiation mechanism
Nakazato, H., Onodera, S., Aida, N., Furusawa, M., & Azuma, T. (2024) · Medical Molecular Morphology · doi:10.1007/s00795-024-00389-w · Cited by 6 · see citing works
ERK1/2 pathway is activated in degenerated Rpe65-deficient mice
Métrailler, S., Emery, M., Schorderet, D. F., Cottet, S., & Roduit, R. (2013) · Experimental Eye Research · doi:10.1016/j.exer.2013.08.015 · Cited by 5 · see citing works
BAC-Dkk3-EGFPTransgenic Mouse: AnIn VivoAnalytical Tool forDkk3Expression
Muranishi, Y., & Furukawa, T. (2012) · BioMed Research International · doi:10.1155/2012/973140 · Cited by 5 · see citing works
Zhang, M., Deng, X., Jiang, Z., & Ge, Z. (2022) · Medicine · doi:10.1097/md.0000000000029569 · Cited by 4 · see citing works
Kelly, L. E., El‐Hodiri, H. M., Crider, A., & Fischer, A. J. (2024) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2024.103932 · Cited by 4 · see citing works
Self-citationSükösd, A. K. (2020) · International Journal of Ophthalmology · doi:10.18240/ijo.2020.06.11 · Cited by 3 · see citing works
Palazzo, I., Todd, L. J., Hoang, T. V., Reh, T. A., Blackshaw, S., & Fischer, A. J. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.10.05.463152 · Cited by 3 · see citing works
Self-citationFormation of Müller glia-derived progenitor cells in retinas depleted of microgliaPreprint
El‐Hodiri, H. M., Bentley, J. R., Reske, A., Palazzo, I., Campbell, W. A., Halloy, N. R., & Fischer, A. J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.06.08.544205 · Cited by 3 · see citing works
Self-citationAdvancements in Müller Glia Reprogramming: Pioneering Approaches for Retinal Neuron Regeneration
Zhou, Y., Qin, S., & Wu, J. (2025) · Neuroglia · doi:10.3390/neuroglia6020020 · Cited by 2 · see citing works
Hyperreflective Foci in the Ectopic Inner Foveal Layer of Advanced Idiopathic Epiretinal Membranes
Valsecchi, N., Mete, M., Rapezzi, G., Elifani, M., Folgaria, G., Finzi, A., Moramarco, A., & Fontana, L. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.9.14 · Cited by 2 · see citing works
İçöz, M., YORGUN, M. A., Taşçı, Y. Y., & TOKLU, Y. (2024) · Turkiye Klinikleri Journal of Ophthalmology · doi:10.5336/ophthal.2023-98823 · Cited by 2 · see citing works
Zheng, D., Wang, Y., Guan, Y., Xu, P., Xie, B., Gao, G., Yu, X., Peng, F., Xiang, M., & Zhong, X. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04700-z · Cited by 1 · see citing works
- Authors
- Fischer, A. J., Scott, M. A., Ritchey, E. R., & Sherwood, P.
- Affiliations
- The Ohio State University (US)
- Corresponding author
- Fischer, Andy J.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2009-03-20
- Volume
- 57
- Issue
- 14
- Pages
- 1538-1552
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- PMC
- PMC2775435
- OpenAlex
- W1998523437
- Cited by
- 111
- References
- 39
- Citations by year
- 2026: 3 · 2025: 5 · 2024: 6 · 2023: 7 · 2022: 3 · 2021: 8 · 2020: 8 · 2019: 8 · 2018: 4 · 2017: 9 · 2016: 5 · 2015: 12 · 2014: 10 · 2013: 7 · 2012: 6
- FWCI
- 2.15
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Eye Institute (R01EY016043, EY016043)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Keywords
- Müller cells, retinal neurons, excitotoxicity, neuroprotection, MAPK signaling, insulin, fibroblast growth factor 2, FGF receptor 1, FGF receptor 3, ERK1/2, p38 MAPK, CREB, c-fos, EGR1, microglia-like cells, lysosomal membrane glycoprotein, glial cell proliferation, retinal damage
- MeSH terms
- Animals, Chickens, Fibroblast Growth Factors, Insulin, Intermediate Filament Proteins, Nerve Tissue Proteins, Neuroglia, Neurotoxins, Phosphorylation, Retina, Signal Transduction, Proto-Oncogene Proteins c-fos, Cell Death, Cyclic AMP Response Element-Binding Protein, Receptors, Fibroblast Growth Factor, MAP Kinase Signaling System, p38 Mitogen-Activated Protein Kinases, Mitogen-Activated Protein Kinase 3, Cell Proliferation, Early Growth Response Protein 1, Lysosomal Membrane Proteins, Retinal Neurons, Nestin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
