Tubulin polymerization promoting protein (TPPP/p25) as a marker for oligodendroglial changes in multiple sclerosis
Abstract
Multiple sclerosis (MS) is an idiopathic chronic inflammatory demyelinating disease of the central nervous system with variable extent of remyelination. Remyelination originates from oligodendrocyte (OG) precursor cells, which migrate and differentiate into mature OG. Tubulin polymerization promoting protein (TPPP/p25) is located in mature OG and aggregates in oligodendroglial cytoplasmic inclusions in multiple system atrophy. We developed a novel monoclonal anti-TPPP/p25 antibody to quantify OG in different subtypes and disease stages of MS, and possible degenerative changes in OG. We evaluated autopsy material from 25 MS cases, including acute, primary progressive, secondary progressive, relapsing remitting MS, and five controls. Demyelinated lesions revealed loss of TPPP/p25-positive OG within the plaques. In remyelination, TPPP/p25 was first expressed in OG cytoplasms and later became positive in myelin sheaths. We observed increased numbers of TPPP/p25 immunoreactive OG in the normal appearing white matter (NAWM) in MS patients. In MS cases, the cytoplasmic area of TPPP/p25 immunoreactivity in the OG was higher in the periplaque area when compared with NAWM and the plaque, and TPPP/p25 immunoreactive OG cytoplasmic area inversely correlated with the disease duration. There was a lack of phospho-TDP-43, phospho-tau, α-synuclein, and ubiquitin immunoreactivity in OG with enlarged cytoplasm. Our data suggest impaired differentiation, migration, and activation capacity of OG…
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Increased densities of TPPP/p25 myelin-maintaining oligodendrocytes have previously been demonstrated in normal-appearing white matter in autopsy tissue of patients with chronic MS.
“increased densities of TPPP/p25 myelin-maintaining oligodendrocytes have previously been demonstrated in the normal-appearing white matter in autopsy tissue of patients with chronic MS.69”
From BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis (2025) · cites this paper as [69]
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302 · see citing works
Continuous cultures of fused cells secreting antibody of predefined specificity
Köhler, G., & Milstein, C. (1975) · Nature · doi:10.1038/256495a0 · Cited by 17,200 · see citing works
McDonald, W. I., Compston, A., Edan, G., Goodkin, D., Hartung, H., Lublin, F. D., McFarland, H. F., Paty, D. W., Polman, C. H., Reingold, S. C., et al. (2001) · Annals of Neurology · doi:10.1002/ana.1032 · Cited by 6,969 · see citing works
Cahoy, J. D., Emery, B., Kaushal, A., Foo, L. C., Zamanian, J. L., Christopherson, K. S., Xing, Y., Lubischer, J. L., Krieg, P. A., Krupenko, S. A., et al. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.4178-07.2008 · Cited by 3,129 · see citing works
Biology of Oligodendrocyte and Myelin in the Mammalian Central Nervous System
Baumann, N., & Pham-Dinh, D. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.871 · Cited by 1,828 · see citing works
The Immunopathology of Multiple Sclerosis: An Overview
Lassmann, H., Brück, W., & Lucchinetti, C. F. (2007) · Brain Pathology · doi:10.1111/j.1750-3639.2007.00064.x · Cited by 1,182 · see citing works
Self-citationPremyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis
Chang, A., Tourtellotte, W. W., Rudick, R., & Trapp, B. D. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa010994 · Cited by 991 · see citing works
Kuhlmann, T., Miron, V., Cuo, Q., Wegner, C., Antel, J., & Bruck, W. (2008) · Brain · doi:10.1093/brain/awn096 · Cited by 864 · see citing works
Remyelination is extensive in a subset of multiple sclerosis patients
Patrikios, P., Stadelmann, C., Kutzelnigg, A., Rauschka, H., Schmidbauer, M., Laursen, H., Sorensen, P. S., Bruck, W., Lucchinetti, C., & Lassmann, H. (2006) · Brain · doi:10.1093/brain/awl217 · Cited by 807 · see citing works
Self-citationXu, J., Kao, S., Lee, F. J. S., Song, W., Jin, L., & Yankner, B. A. (2002) · Nature Medicine · doi:10.1038/nm0602-600 · Cited by 757 · see citing works
Multiple sclerosis: Remyelination of nascent lesions: Remyelination of nascent lesions
Prineas, J. W., Barnard, R. O., Kwon, E. E., Sharer, L. R., & Cho, E. ‐. (1993) · Annals of Neurology · doi:10.1002/ana.410330203 · Cited by 574 · see citing works
Monocyte/macrophage differentiation in early multiple sclerosis lesions
Brück, W., Porada, P., Poser, S., Rieckmann, P., Hanefeld, F., Kretzschmarch, H. A., & Lassmann, H. (1995) · Annals of Neurology · doi:10.1002/ana.410380514 · Cited by 521 · see citing works
Self-citationRemyelination capacity of the MS brain decreases with disease chronicity
Goldschmidt, T., Antel, J., König, F. B., Brück, W., & Kuhlmann, T. (2009) · Neurology · doi:10.1212/wnl.0b013e3181a8260a · Cited by 411 · see citing works
Multiple system atrophy: A primary oligodendrogliopathy
Wenning, G. K., Stefanova, N., Jellinger, K. A., Poewe, W. H., & Schlossmacher, M. G. (2008) · Annals of Neurology · doi:10.1002/ana.21465 · Cited by 320 · see citing works
Multiple Sclerosis: Remyelination in Acute Lesions
Raine, C. S., & WU, E. (1993) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/00005072-199305000-00003 · Cited by 285 · see citing works
Multiple sclerosis. Oligodendrocyte proliferation and differentiation in fresh lesions.
Prineas, J. W., Kwon, E. E., Goldenberg, P. Z., Ilyas, A. A., Quarles, R. H., Benjamins, J. A., & Sprinkle, T. J. (1989) · PubMed · Cited by 265 · see citing works
Oligodendrocyte survival, loss and birth in lesions of chronic-stage multiple sclerosis
Wolswijk, G. (2000) · Brain · doi:10.1093/brain/123.1.105 · Cited by 238 · see citing works
Höftberger, R., Aboul‐Enein, F., Brück, W., Lucchinetti, C. F., Rodriguez, M., Schmidbauer, M., Jellinger, K. A., & Lassmann, H. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00496.x · Cited by 229 · see citing works
Self-citationp25α Relocalizes in Oligodendroglia from Myelin to Cytoplasmic Inclusions in Multiple System Atrophy
Song, Y. J. C., Lundvig, D. M. S., Huang, Y. M., Gai, W., Blumbergs, P. C., Højrup, P., Otzen, D. E., Halliday, G. M., & Jensen, P. H. (2007) · American Journal Of Pathology · doi:10.2353/ajpath.2007.070201 · Cited by 201 · see citing works
Lindersson, E., Lundvig, D. M. S., Petersen, C. E. L., Madsen, P., Nyengaard, J. R., Højrup, P., Moos, T., Otzen, D. E., Gai, W.-P., Blumbergs, P. C., et al. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m410409200 · Cited by 196 · see citing works
Pattern of remyelination in the CNS
BLAKEMORE, W. F. (1974) · Nature · doi:10.1038/249577a0 · Cited by 182 · see citing works
di Bello, I. C., Dawson, M. R. L., Levine, J. M., & Reynolds, R. (1999) · Journal of Neurocytology · doi:10.1023/a:1007069815302 · Cited by 178 · see citing works
Lindner, M., Heine, S., Haastert, K., Garde, N., Fokuhl, J., Linsmeier, F., Grothe, C., Baumgärtner, W., & Stangel, M. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2007.00879.x · Cited by 169 · see citing works
Kovács, G. G., László, L., Kovács, J., Jensen, P. H., Lindersson, E., Botond, G., Molnár, T., Perczel, A., Hudecz, F., Mező, G., et al. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2004.06.006 · Cited by 159 · see citing works
Self-citationAnderson, J. M., Hampton, D. W., Patani, R., Pryce, G., Crowther, R. A., Reynolds, R., Franklin, R. J. M., Giovannoni, G., Compston, D. A. S., Baker, D., et al. (2008) · Brain · doi:10.1093/brain/awn119 · Cited by 141 · see citing works
Hlavanda, E., Kovács, J., Oláh, J., Orosz, F., Medzihradszky, K. F., & Ovádi, J. (2002) · Biochemistry · doi:10.1021/bi020140g · Cited by 136 · see citing works
Tubulin polymerization‐promoting protein (TPPP/p25) is critical for oligodendrocyte differentiation
Lehotzky, A., Lau, P., Tőkési, N., Muja, N., Hudson, L. D., & Ovádi, J. (2009) · Glia · doi:10.1002/glia.20909 · Cited by 132 · see citing works
Zhou, W., Schaack, J. B., Zawada, W. M., & Freed, C. R. (2002) · Brain Research · doi:10.1016/s0006-8993(01)03292-9 · Cited by 129 · see citing works
?Minimal change? multiple system atrophy
Wenning, G. K., Quinn, N. P., es, M. M., Mathias, C. J., & Daniel, S. E. (1994) · Movement Disorders · doi:10.1002/mds.870090206 · Cited by 100 · see citing works
Kuhlmann, T., Remington, L. T., Maruschak, B., Owens, T., & Brück, W. (2007) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/01.jnen.0000248559.83573.71 · Cited by 98 · see citing works
Dynamic targeting of microtubules by TPPP/p25 affects cell survival
Lehotzky, A., Tirián, L., Tőkési, N., Lénárt, P., Szabó, B., Kovács, J., & Ovádi, J. (2004) · Journal of Cell Science · doi:10.1242/jcs.01550 · Cited by 84 · see citing works
Dubois-Dalcq, M. E., Williams, A., Stadelmann, C., Stankoff, B., Zalc, B., & Lubetzki, C. (2008) · Brain · doi:10.1093/brain/awn076 · Cited by 72 · see citing works
Höftberger, R., Kunze, M., Weinhofer, I., Aboul-Enein, F., Voigtländer, T., Oezen, I., Amann, G., Bernheimer, H., Budka, H., & Berger, J. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.07.007 · Cited by 69 · cited 2× · see citing works
“The DAKO EnVision detection kit, peroxidase/DAB, rabbit/mouse (Dako, Glostrup, Denmark) was used for visualization of the antibody reaction (Hoftberger et al., 2007).”
MethodSelf-citationThe brain-specific protein TPPP/p25 in pathological protein deposits of neurodegenerative diseases
Kovács, G. G., Gelpí, E., Lehotzky, A., Höftberger, R., Erdei, A., Budka, H., & Ovádi, J. (2006) · Acta Neuropathologica · doi:10.1007/s00401-006-0167-4 · Cited by 68 · see citing works
Self-citationSkjørringe, T., Lundvig, D. M. S., Jensen, P. H., & Moos, T. (2006) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2006.04073.x · Cited by 54 · see citing works
Winkler, M. K., & Benveniste, E. N. (1998) · Glia · doi:10.1002/(sici)1098-1136(199802)22:2 · Cited by 50 · see citing works
Nakamura, S., Kawamoto, Y., Nakano, S., Akiguchi, I., & Kimura, J. (1998) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-199807000-00006 · Cited by 48 · see citing works
Oláh, J., Tőkési, N., Vincze, O., Horváth, I., Lehotzky, A., Erdei, A., Szájli, E., Medzihradszky, K. F., Orosz, F., Kovács, G. G., et al. (2006) · FEBS Letters · doi:10.1016/j.febslet.2006.09.037 · Cited by 41 · see citing works
Evidence for abnormal tau phosphorylation in early aggressive multiple sclerosis
Anderson, J. M., Patani, R., Reynolds, R., Nicholas, R. S., Compston, A., Spillantini, M. G., & Chandran, S. (2009) · Acta Neuropathologica · doi:10.1007/s00401-009-0515-2 · Cited by 38 · see citing works
Lu, J.-Q., Fan, Y., Mitha, A., Bell, R., Metz, L., Moore, G. R. W., & Yong, W. V. (2009) · Journal of Neuropathology and Experimental Neurology · doi:10.1097/nen.0b013e318196e905 · Cited by 31 · see citing works
Gender differences in the histopathology of MS?
Kuhlmann, T., Goldschmidt, T., Antel, J., Wegner, C., König, F., Metz, I., & Brück, W. (2009) · Journal of Neurological Sciences · doi:10.1016/j.jns.2009.07.014 · Cited by 31 · see citing works
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Myelination of the Nervous System: Mechanisms and Functions
Nave, K., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 1,000 · see citing works
Oxidative damage in multiple sclerosis lesions
Haider, L., Fischer, M. T., Frischer, J., Bauer, J., Höftberger, R., Botond, G., Esterbauer, H., Binder, C., Witztum, J., & Lassmann, H. (2011) · Brain : a journal of neurology · doi:10.1093/brain/awr128 · Cited by 754 · see citing works
Self-citationAn updated histological classification system for multiple sclerosis lesions
Kuhlmann, T., Ludwin, S., Prat, A., Antel, J., Brück, W., & Lassmann, H. (2017) · Acta Neuropathologica · doi:10.1007/s00401-016-1653-y · Cited by 692 · see citing works
Self-citationTracking iron in multiple sclerosis: a combined imaging and histopathological study at 7 Tesla
Bagnato, F., Hametner, S., Yao, B., van Gelderen, P., Merkle, H., Cantor, F. K., Lassmann, H., & Duyn, J. H. (2011) · Brain · doi:10.1093/brain/awr278 · Cited by 351 · see citing works
Self-citationDisease-specific molecular events in cortical multiple sclerosis lesions
Fischer, M. T., Wimmer, I., Höftberger, R., Gerlach, S., Haider, L., Zrzavy, T., Hametner, S., Mahad, D., Binder, C. J., Krumbholz, M., et al. (2013) · Brain · doi:10.1093/brain/awt110 · Cited by 311 · see citing works
Self-citationMisu, T., Höftberger, R., Fujihara, K., Wimmer, I., Takai, Y., Nishiyama, S., Nakashima, I., Konno, H., Bradl, M., Garzuly, F., et al. (2013) · Acta Neuropathologica · doi:10.1007/s00401-013-1116-7 · Cited by 233 · see citing works
Self-citationInflammatory demyelinating diseases of the central nervous system
Höftberger, R., & Lassmann, H. (2017) · Handbook of clinical neurology · doi:10.1016/b978-0-12-802395-2.00019-5 · Cited by 193 · see citing works
Self-citationInteractions of Pathological Hallmark Proteins
Oláh, J., Vincze, O., Virok, D. P., Simon, D., Bozsó, Z., Tőkési, N., Horváth, I., Hlavanda, E., Kovács, J., Magyar, A., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.243907 · Cited by 156 · see citing works
The Golgi Outpost Protein TPPP Nucleates Microtubules and Is Critical for Myelination
Fu, M., McAlear, T. S., Nguyen, H., Osés-Prieto, J. A., Valenzuela, A., Shi, R., Perrino, J. J., Huang, T., Burlingame, A. L., Bechstedt, S., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.025 · Cited by 147 · see citing works
Lesion stage-dependent causes for impaired remyelination in MS
Heß, K., Starost, L. J., Kieran, N. W., Thomas, C., Vincenten, M. C. J., Antel, J. P., Martino, G., Huitinga, I., Healy, L. M., & Kuhlmann, T. (2020) · Acta Neuropathologica · doi:10.1007/s00401-020-02189-9 · Cited by 137 · see citing works
Distinct Patterns of Sirtuin Expression During Progression of Alzheimer’s Disease
Lutz, M. I., Milenković, I., Regelsberger, G., & Kovács, G. G. (2014) · NeuroMolecular Medicine · doi:10.1007/s12017-014-8288-8 · Cited by 131 · see citing works
Duffy, S. S., Lees, J. G., & Moalem‐Taylor, G. (2014) · Multiple Sclerosis International · doi:10.1155/2014/285245 · Cited by 115 · see citing works
Schuh, C., Wimmer, I., Hametner, S., Haider, L., van Dam, A., Liblau, R., Smith, K. J., Probert, L., Binder, C., Bauer, J., et al. (2014) · Acta Neuropathologica · doi:10.1007/s00401-014-1263-5 · Cited by 123 · see citing works
Self-citationChanges in the Oligodendrocyte Progenitor Cell Proteome with Ageing
de la Fuente, A. G., Queiroz, R. M. L., Ghosh, T., McMurran, C. E., Cubillos, J. F., Bergles, D. E., Fitzgerald, D. C., Jones, C. A., Lilley, K. S., Glover, C. P. J., et al. (2020) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra120.002102 · Cited by 99 · see citing works
Cell type-specific Nrf2 expression in multiple sclerosis lesions
Licht‐Mayer, S., Wimmer, I., Traffehn, S., Metz, I., Brück, W., Bauer, J., Bradl, M., & Lassmann, H. (2015) · Acta Neuropathologica · doi:10.1007/s00401-015-1452-x · Cited by 86 · see citing works
Self-citationZarruk, J. G., Berard, J. L., dos Santos, R. P., Kroner, A., Lee, J., Arosio, P., & David, S. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.02.001 · Cited by 81 · see citing works
Scholl, T. O., Mühlebner, A., Ricken, G., Gruber, V., Fabing, A., Samueli, S., Gröppel, G., Dorfer, C., Czech, T., Hainfellner, J. A., et al. (2016) · Brain Pathology · doi:10.1111/bpa.12452 · Cited by 72 · see citing works
Golgi Outposts Nucleate Microtubules in Cells with Specialized Shapes
Valenzuela, A., Meservey, L. M., Nguyen, H., & Fu, M. (2020) · Trends in Cell Biology · doi:10.1016/j.tcb.2020.07.004 · Cited by 63 · see citing works
Girolamo, F., Ferrara, G., Strippoli, M., Rizzi, M., Errede, M., Trojano, M., Perris, R., Roncali, L., Svelto, M., Mennini, T., et al. (2011) · Neurobiology of Disease · doi:10.1016/j.nbd.2011.05.021 · Cited by 60 · see citing works
Microtubule organization and dynamics in oligodendrocytes, astrocytes, and microglia
Weigel, M. K., Wang, L., & Fu, M. (2020) · Developmental Neurobiology · doi:10.1002/dneu.22753 · Cited by 52 · see citing works
Paling, D., Tozer, D. J., Wheeler‐Kingshott, C. A. M. G., Kapoor, R., Miller, D. H., & Golay, X. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2012-302541 · Cited by 45 · see citing works
Shared and Distinct Patterns of Oligodendroglial Response in α-Synucleinopathies and Tauopathies
Rohan, Z., Milenković, I., Lutz, M. I., Matěj, R., & Kovács, G. G. (2016) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nlw087 · Cited by 45 · see citing works
Ota, K., Obayashi, M., Ozaki, K., Ichinose, S., Kakita, A., Tada, M., Takahashi, H., Ando, N., Eishi, Y., Mizusawa, H., et al. (2014) · Acta Neuropathologica Communications · doi:10.1186/s40478-014-0136-4 · Cited by 49 · see citing works
Non‐neuronal cell responses differ between normal and Down syndrome developing brains
Kanaumi, T., Milenković, I., Adle‐Biassette, H., Aronica, E., & Kovács, G. G. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.09.011 · Cited by 39 · see citing works
Grigoletto, J., Pukaß, K., Gamliel, A., Davidi, D., Katz‐Brull, R., Richter‐Landsberg, C., & Sharon, R. (2017) · Acta Neuropathologica Communications · doi:10.1186/s40478-017-0439-3 · Cited by 38 · see citing works
Kovács, G. G., van der Zee, J., Hort, J., Kristoferitsch, W., Leitha, T., Höftberger, R., Ströbel, T., Broeckhoven, C. V., & Matěj, R. (2015) · Neuropathology · doi:10.1111/neup.12233 · Cited by 34 · see citing works
Self-citationMicrotubule-Associated Proteins with Regulatory Functions by Day and Pathological Potency at Night
Oláh, J., Lehotzky, A., Szunyogh, S., Szénási, T., Orosz, F., & Ovádi, J. (2020) · Cells · doi:10.3390/cells9020357 · Cited by 32 · see citing works
Hajdarevic, R., Lande, A., Mehlsen, J., Rydland, A., Sosa, D. D., Strand, E. B., Mella, O., Pociot, F., Fluge, Ø., Lie, B. A., et al. (2022) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2022.03.010 · Cited by 29 · see citing works
Identification of motives mediating alternative functions of the neomorphic moonlighting TPPP/p25
Tőkési, N., Oláh, J., Hlavanda, E., Szunyogh, S., Szabó, A., Babos, F., Magyar, A., Lehotzky, A., Vass, E., & Ovádi, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.01.009 · Cited by 28 · see citing works
Oligodendroglial Response in the Spinal Cord in TDP-43 Proteinopathy with Motor Neuron Involvement
Rohan, Z., Matěj, R., Rusina, R., & Kovács, G. G. (2014) · Neurodegenerative Diseases · doi:10.1159/000362929 · Cited by 27 · see citing works
Vincze, O., Oláh, J., Zádori, D., Klivènyi, P., Vécsei, L., & Ovádi, J. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.04.130 · Cited by 26 · see citing works
Szénási, T., Oláh, J., Szabó, A., Szunyogh, S., Láng, A., Perczel, A., Lehotzky, A., Uversky, V. N., & Ovádi, J. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.09.017 · Cited by 26 · see citing works
Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling
Kramann, N., Menken, L., Hayardeny, L., Hanisch, U., & Brück, W. (2016) · Neurology Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000233 · Cited by 22 · see citing works
Myelin Proteome Analysis: Methods and Implications for the Myelin Cytoskeleton
Jahn, O., Tenzer, S., Bartsch, N., Patzig, J., & Werner, H. B. (2012) · Neuromethods · doi:10.1007/978-1-62703-266-7_15 · Cited by 21 · see citing works
Oláh, J., Bertrand, P., & Ovádi, J. (2017) · Expert Review of Proteomics · doi:10.1080/14789450.2017.1304216 · Cited by 20 · see citing works
Practical approach to diagnosis
Kovács, G. G. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781107588660.005 · Cited by 21 · see citing works
Dysfunction of the oligodendrocytes in amyotrophic lateral sclerosis
Gong, Z., Ba, L., & Zhang, M. (2022) · Journal of Biomedical Research · doi:10.7555/jbr.36.20220009 · Cited by 19 · see citing works
Szalárdy, L., Molnar, M. F., Maszlag-Török, R., Zádori, D., Vécsei, L., Klivènyi, P., Liberski, P. P., & Kovács, G. G. (2016) · Folia Neuropathologica · doi:10.5114/fn.2016.58911 · Cited by 19 · see citing works
Puska, G., Lutz, M. I., Molnár, K., Regelsberger, G., Ricken, G., Pirker, W., László, L., & Kovács, G. G. (2018) · Neurobiology of Disease · doi:10.1016/j.nbd.2018.02.019 · Cited by 19 · see citing works
Further evidence for microtubule-independent dimerization of TPPP/p25
Oláh, J., Szénási, T., Szunyogh, S., Szabó, A., Lehotzky, A., & Ovádi, J. (2017) · Scientific Reports · doi:10.1038/srep40594 · Cited by 19 · see citing works
Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors
Sanjuan, V. M., Oláh, J., González‐Álvarez, I., Lehotzky, A., Tőkési, N., Bermejo, M., & Ovádi, J. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12946 · Cited by 18 · see citing works
Marín‐Prida, J., Fuentes, N. P., Lagumersindez-Denis, N., Camacho, H., García-Soca, A. M., Sarduy-Chávez, R. D. L. C., Vieira, É. L. M., Tavares, J. C., Falcón‐Cama, V., Fernández, J. R., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1036200 · Cited by 18 · see citing works
Szabó, A., Oláh, J., Szunyogh, S., Lehotzky, A., Szénási, T., Mezősi-Csaplár, M., Schiedel, M., Lőw, P., Jung, M., & Ovádi, J. (2017) · Scientific Reports · doi:10.1038/s41598-017-17381-3 · Cited by 18 · see citing works
Epigenetic regulation of myelination in health and disease
Lu, G., Zhang, M., Wang, J., Zhang, K., Wu, S., & Zhao, X. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14337 · Cited by 16 · see citing works
BCAS1-positive oligodendrocytes enable efficient cortical remyelination in multiple sclerosis
Bergner, C. G., van der Meer, F., Franz, J., Vakrakou, A., Würfel, T., Nessler, S., Schäfer, L., Nau-Gietz, C., Winkler, A., Lagumersindez-Denis, N., et al. (2025) · Brain · doi:10.1093/brain/awae293 · Cited by 16 · see citing works
“…oligodendrocytes have previously been demonstrated in the normal-appearing white matter in autopsy tissue of patients with chronic MS. 69 Of note, in previous work we found evidence of higher g-ratios of cortical myelinated fibres in MS, suggesting that part of the microscopically…”
InfluentialKessler, W., Thomas, C., & Kuhlmann, T. (2023) · Acta Neuropathologica · doi:10.1007/s00401-023-02645-2 · Cited by 16 · see citing works
Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model
Takase, E. O., Yamasaki, R., Nagata, S., Watanabe, M., Masaki, K., Yamaguchi, H., Kira, J., Takeuchi, H., & Isobe, N. (2024) · Scientific Reports · doi:10.1038/s41598-024-61508-2 · Cited by 16 · see citing works
Oláh, J., & Ovádi, J. (2019) · FEBS Letters · doi:10.1002/1873-3468.13464 · Cited by 14 · see citing works
Modulatory Role of TPPP3 in Microtubule Organization and Its Impact on Alpha-Synuclein Pathology
Oláh, J., Lehotzky, A., Szénási, T., Berki, T., & Ovádi, J. (2022) · Cells · doi:10.3390/cells11193025 · Cited by 14 · see citing works
Self-citationKon, T., Forrest, S. L., Lee, S., Li, J., Chasiotis, H., Nassir, N., Uddin, M. J., Lang, A. E., & Kovács, G. G. (2024) · Neurobiology of Disease · doi:10.1016/j.nbd.2024.106551 · Cited by 14 · see citing works
Lehotzky, A., Oláh, J., Szunyogh, S., Szabó, A., Berki, T., & Ovádi, J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.10.015 · Cited by 14 · see citing works
Self-citationNørregaard, A., Jensen, S. S., Kolenda, J., Aaberg-Jessen, C., Christensen, K. G., Jensen, P. H., Schrøder, H. D., & Kristensen, B. W. (2011) · Neurotoxicity Research · doi:10.1007/s12640-011-9300-9 · Cited by 14 · see citing works
Dual life of TPPP/p25 evolved in physiological and pathological conditions
Oláh, J., & Ovádi, J. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140257 · Cited by 12 · see citing works
Schwaiger, C., Haider, T. T., Endmayr, V., Zrzavy, T., Gruber, V., Ricken, G., Simonovska, A., Hametner, S., Schwab, J. M., & Höftberger, R. (2022) · Brain Pathology · doi:10.1111/bpa.13098 · Cited by 10 · see citing works
Self-citationKim, A., Yoshida, K., Kovács, G. G., & Forrest, S. L. (2024) · Modern Pathology · doi:10.1016/j.modpat.2024.100533 · Cited by 8 · see citing works
Novel crystalloid oligodendrogliopathy in hereditary spastic paraplegia
Wöehrer, A., László, L., Finsterer, J., Stöllberger, C., Furtner, J., Rinner, W., Molnár, K., Budka, H., & Kovács, G. G. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0965-9 · Cited by 7 · see citing works
Self-citationTakatori, R., VU, P. L., Iwamoto, T., Satsu, H., Totsuka, M., Chida, K., & Shimizu, M. (2013) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.130318 · Cited by 6 · see citing works
Overlaps between multiple system atrophy and multiple sclerosis: A novel perspective
Jellinger, K. A., & Wenning, G. K. (2016) · Movement Disorders · doi:10.1002/mds.26870 · Cited by 6 · see citing works
Oláh, J., Szunyogh, S., Szénási, T., Szaniszló, T., Szabó, A., Lehotzky, A., Berki, T., Nyitray, L., & Ovádi, J. (2019) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2019.118556 · Cited by 6 · see citing works
Self-citationA global map for introgressed structural variation and selection in humans
Hsieh, P., Soisangwan, N., Gordon, D., Javidh, A., Harvey, W. T., Porubskỳ, D., Hoekzema, K., Baker, C. A., Munson, K. M., Kinipi, C., et al. (2026) · Science · doi:10.1126/science.adz7518 · Cited by 6 · see citing works
Pathological and Molecular Insights into the Early Stage of Multiple System Atrophy
Tanaka, M. T., Miki, Y., Kon, T., Mori, F., & Wakabayashi, K. (2025) · Cells · doi:10.3390/cells14241966 · Cited by 5 · see citing works
Diaz, P. J., Shi, Q., McNeish, P. Y., & Banerjee, S. (2025) · Journal of Neuroscience Research · doi:10.1002/jnr.70044 · Cited by 5 · see citing works
Zhang, L., Sun, J.-H., Liu, S., Zhang, W., & Zou, J. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114322 · Cited by 4 · see citing works
Roll, W., Bauer, J., Dik, A., Mueller, C., Backhaus, P., Räuber, S. J., Zinnhardt, B., Gallus, M., Wimberley, C., Körtvelyessy, P., et al. (2024) · Journal of Neurology · doi:10.1007/s00415-024-12302-7 · Cited by 4 · see citing works
MAPT gene rs1052553 variant is not associated with the risk for multiple sclerosis
Agúndez, J. A. G., García‐Martín, E., Martínez, C., Benito‐León, J., Millán‐Pascual, J., Calleja, P., Díaz-Sánchez, M., Pisa, D., Turpín‐Fenoll, L., Alonso‐Navarro, H., et al. (2013) · Human Immunology · doi:10.1016/j.humimm.2013.07.008 · Cited by 4 · see citing works
Kostyushev, D. S., Tsarev, I., Gnatenko, D., Paltsev, M. A., & Suchkov, S. V. (2011) · Open Journal of Immunology · doi:10.4236/oji.2011.13010 · Cited by 3 · see citing works
Perspective Strategies for Interventions in Parkinsonism: Remedying the Neglected Role of TPPP
Oláh, J., Norris, V., Lehotzky, A., & Ovádi, J. (2024) · Cells · doi:10.3390/cells13040338 · Cited by 2 · see citing works
Oláh, J., Lehotzky, A., Szénási, T., & Ovádi, J. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.97271 · Cited by 2 · see citing works
Szalárdy, L. (2016) · doi:10.14232/phd.3120 · Cited by 1 · see citing works
Cyclical partial remyelination provokes demyelination in multiple sclerosis
Agius, L. M. (2011) · Revista Española de Patología · doi:10.1016/j.patol.2011.02.009
Interactions of the disordered TPPP/p25 with physiological and pathological partners
Szunyogh, S. (2017) · Eötvös Loránd Tudományegyetem · doi:10.15476/elte.2016.188
Engstler, M., & Morriswood, B. (2019) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.736596149.793568010
A human-induced pluripotent stem cell-derived spheroid model to investigate myelin injury and repair
Ramesan, S., Mason, J., Kumar, S. S., Swanson, M. E. V., Korneev, D., Mills, S. A., Mathangasinghe, Y., Andres, A., Loh, L. J., Fraser, T. D., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02457-z
- Authors
- Höftberger, R., Fink, S., Aboul‐Enein, F., Botond, G., Olah, J., Berki, T., Ovadi, J., Lassmann, H., Budka, H., & Kovacs, G. G.
- Affiliations
- Medical University of Vienna (AT)
- Donauspital (AT)
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2010-08-24
- Volume
- 58
- Issue
- 15
- Pages
- 1847-1857
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W2112703333
- Cited by
- 79
- References
- 41
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 2 · 2020: 5 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 9 · 2015: 3 · 2014: 14 · 2013: 5 · 2012: 3
- FWCI
- 3.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- multiple sclerosis, oligodendrocytes, remyelination, demyelination, oligodendrocyte precursor cells, disease duration, prognostic factors, monoclonal antibodies
- MeSH terms
- Adult, Aged, Aged, 80 and over, Animals, Cell Movement, DNA-Binding Proteins, Myelin Basic Protein, Enzyme-Linked Immunosorbent Assay, Female, Glial Fibrillary Acidic Protein, Humans, Male, Mice, Inbred C57BL, Middle Aged, Multiple Sclerosis, Myelin Sheath, Nerve Tissue Proteins, Oligodendroglia, Severity of Illness Index, Biomarkers, tau Proteins, Myelin Proteolipid Protein, Mice, alpha-Synuclein
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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