Control of local protein synthesis and initial events in myelination by action potentials
Open accessAbstract
Formation of myelin, the electrical insulation on axons produced by oligodendrocytes, is controlled by complex cell-cell signaling that regulates oligodendrocyte development and myelin formation on appropriate axons. If electrical activity could stimulate myelin induction, then neurodevelopment and the speed of information transmission through circuits could be modified by neural activity. We find that release of glutamate from synaptic vesicles along axons of mouse dorsal root ganglion neurons in culture promotes myelin induction by stimulating formation of cholesterol-rich signaling domains between oligodendrocytes and axons, and increasing local synthesis of the major protein in the myelin sheath, myelin basic protein, through Fyn kinase-dependent signaling. This axon-oligodendrocyte signaling would promote myelination of electrically active axons to regulate neural development and function according to environmental experience.
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Both intrinsic and extrinsic factors influence myelination.
“Both intrinsic and extrinsic factors have been shown to influence myelination. For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are linked.”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Wake et al., 2011
The paper reports that axonal electrical activity promotes myelin induction in mouse neuron–oligodendrocyte cultures, supporting the electrical-activity example for which it is cited. It also says the mechanism must be confirmed in vivo, so the unqualified statement that electrical activity drives myelination extends beyond what this study establishes. (LLM, conf=0.83)
Experimental — accuracy not yet measuredElectrical activity drives myelination.
“For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are linked.”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Wake et al., 2011
The supplied paper text (labeled Abstract; page not provided) reports that electrical stimulation increased myelin induction in neuron–oligodendrocyte cultures, with increased myelination persisting after 16 days. It also says the mechanisms must be confirmed in vivo, so the unqualified claim that electrical activity drives myelination extends beyond the demonstrated culture setting. (LLM, conf=0.86)
Experimental — accuracy not yet measuredSynaptogenesis and myelination are linked.
“For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are linked.”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Wake et al., 2011
Neuronal activity-dependent myelination changes have been observed in cell culture and in vivo experiments.
“Neuronal activity-dependent changes in myelination have been observed in cell culture (Wake et al., 2011; Fields, 2010) as well as in recent in vivo experiments (Gibson et al., 2014).”
From Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise (2016) · cites this paper as Wake et al., 2011
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Cites
Visualizing secretion and synaptic transmission with pH-sensitive green fluorescent proteins
Miesenböck, G., Angelis, D. A. D., & Rothman, J. E. (1998) · Nature · doi:10.1038/28190 · Cited by 2,569 · see citing works
A Photoactivatable GFP for Selective Photolabeling of Proteins and Cells
Patterson, G. H., & Lippincott‐Schwartz, J. (2002) · Science · doi:10.1126/science.1074952 · Cited by 1,612 · see citing works
Training induces changes in white-matter architecture
Scholz, J., Klein, M. C., Behrens, T. E. J., & Johansen-Berg, H. (2009) · Nature Neuroscience · doi:10.1038/nn.2412 · Cited by 1,508 · see citing works
Myelination and support of axonal integrity by glia
Nave, K.-A. (2010) · Nature · doi:10.1038/nature09614 · Cited by 1,062 · see citing works
Astrocytes promote myelination in response to electrical impulses
Ishibashi, T., Dakin, K. A., Stevens, B., Lee, P. R., Kozlov, S. V., Stewart, C. L., & Fields, R. D. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.006 · Cited by 689 · see citing works
Self-citationInduction of myelination in the central nervous system by electrical activity
Demerens, C., Stankoff, B., Logak, M., Anglade, P., Allinquant, B., Couraud, F., Zalc, B., & Lubetzki, C. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.18.9887 · Cited by 678 · see citing works
Regulation of oligodendrocyte differentiation and myelination
Emery, B. (2010) · Science · doi:10.1126/science.1190927 · Cited by 653 · see citing works
Stevens (2002) · doi:10.1016/s0896-6273(02)01067-x · Cited by 543 · see citing works
Self-citationAinger, K. J., Avossa, D., Morgan, F., Hill, S. J., Barry, C. T., Barbarese, E., & Carson, J. H. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.123.2.431 · Cited by 482 · see citing works
Sensitivity of embryonic rat dorsal root ganglia neurons to Clostridium botulinum neurotoxins
Welch, M. J., Purkiss, J. R., & Foster, K. (2000) · Toxicon · doi:10.1016/s0041-0101(99)00153-1 · Cited by 481 · see citing works
Gallo, V., Jm, Z., McBain, C. J., Wright, P., Knutson, P. L., & Armstrong, R. (1996) · Journal of Neuroscience · doi:10.1523/jneurosci.16-08-02659.1996 · Cited by 406 · see citing works
Syntaxin-4 defines a domain for activity-dependent exocytosis in dendritic spines
Kennedy, M. J., Davison, I. G., Robinson, C. G., & Ehlers, M. D. (2010) · Cell · doi:10.1016/j.cell.2010.02.042 · Cited by 294 · see citing works
Simons, M., Krämer, E.-M., Thiele, C., Stoffel, W., & Trotter, J. (2000) · The Journal of Cell Biology · doi:10.1083/jcb.151.1.143 · Cited by 293 · see citing works
Excitability and synaptic communication within the oligodendrocyte lineage
De Biase, L. M., Nishiyama, A., & Bergles, D. E. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.6000-09.2010 · Cited by 286 · see citing works
Response of Schwann Cells to Action Potentials in Development
Stevens, B. A., & Fields, R. D. (2000) · Science · doi:10.1126/science.287.5461.2267 · Cited by 267 · see citing works
Self-citationChange in the Brain's White Matter
Fields, R. D. (2010) · Science · doi:10.1126/science.1199139 · Cited by 265 · see citing works
Self-citationKrämer, E., Klein, C., Koch, T., Boytinck, M., & Trotter, J. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.41.29042 · Cited by 232 · see citing works
Back, S. A., Luo, N. L., Borenstein, N. S., Volpe, J. J., & Kinney, H. C. (2002) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/61.2.197 · Cited by 196 · see citing works
White, R., Gonsior, C., Krämer-Albers, E.-M., Stöhr, N., Hüttelmaier, S., & Trotter, J. (2008) · Journal of Cell Biology · doi:10.1083/jcb.200706164 · Cited by 194 · see citing works
Kukley, M., Nishiyama, A., & Dietrich, D. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0854-10.2010 · Cited by 169 · see citing works
Nonsynaptic Communication Through ATP Release from Volume-Activated Anion Channels in Axons
Fields, R. D., & Ni, Y. (2010) · Science Signaling · doi:10.1126/scisignal.2001128 · Cited by 135 · see citing works
Self-citationLaursen, L. S., Chan, C. W., & ffrench‐Constant, C. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201007014 · Cited by 118 · see citing works
A green to red photoconvertible protein as an analyzing tool for early vertebrate development
Wacker, S., Oswald, F., Wiedenmann, J., & Knöchel, W. (2006) · Developmental Dynamics · doi:10.1002/dvdy.20955 · Cited by 53 · see citing works
Electrical signalling properties of oligodendrocyte precursor cells
Bakiri, Y., Attwell, D., & Káradóttir, R. T. (2009) · Neuron Glia Biology · doi:10.1017/s1740925x09990202 · Cited by 37 · see citing works
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- [13]Fields RD Yu C Neale EA Nelson PG Kentenmann H Grantyn R Practical Electrophysiological Methods: A Guide for In Vitro Studies in Vertebrate Neurobiology Wiley New York 1992 chap 2.9
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Sorted by citations
Plasticity in gray and white: neuroimaging changes in brain structure during learning
Zatorre, R. J., Fields, R. D., & Johansen-Berg, H. (2012) · Nature Neuroscience · doi:10.1038/nn.3045 · Cited by 1,685 · see citing works
Self-citationNeuronal activity promotes oligodendrogenesis and adaptive myelination in the mammalian brain
Gibson, E. M., Purger, D., Mount, C. W., Goldstein, A. K., Lin, G. L., Wood, L. S., Inema, I., Miller, S. E., Bieri, G., Zuchero, J. B., et al. (2014) · Science · doi:10.1126/science.1252304 · Cited by 1,472 · see citing works
Motor skill learning requires active central myelination
McKenzie, I. A., Ohayon, D., Li, H., Paes de Faria, J., Emery, B., Tohyama, K., & Richardson, W. D. (2014) · Science · doi:10.1126/science.1254960 · Cited by 1,177 · see citing works
Myelination of the Nervous System: Mechanisms and Functions
Nave, K., & Werner, H. B. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-100913-013101 · Cited by 1,000 · see citing works
Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain
Lake, B. B., Chen, S., Sos, B. C., Fan, J., Kaeser, G. E., Yung, Y. C., Duong, T. E., Gao, D., Chun, J., Kharchenko, P. V., et al. (2018) · Nature Biotechnology · doi:10.1038/nbt.4038 · Cited by 983 · see citing works
A critical period for social experience-dependent oligodendrocyte maturation and myelination
Makinodan, M., Rosen, K. M., Ito, S., & Corfas, G. (2012) · Science · doi:10.1126/science.1220845 · Cited by 922 · see citing works
Neurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001604 · Cited by 812 · see citing works
Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
Young, K. M., Psachoulia, K., Tripathi, R. B., Dunn, S.-J., Cossell, L., Attwell, D., Tohyama, K., & Richardson, W. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.01.006 · Cited by 872 · see citing works
“Ultimately, the biochemical pathways that control OL maturation, myelination, and morphology might be stimulated by electrical activity in axons (Wake et al., 2011).”
BackgroundOligodendrocytes: Myelination and Axonal SupportPreprint
Simons, M., & Nave, K. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020479 · Cited by 862 · see citing works
A new mechanism of nervous system plasticity: activity-dependent myelination
Fields, R. D. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4023 · Cited by 794 · see citing works
Self-citationThe cortical language circuit: from auditory perception to sentence comprehension
Friederici, A. D. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2012.04.001 · Cited by 748 · see citing works
Prolonged myelination in human neocortical evolution
Miller, D. J., Duka, T., Stimpson, C. D., Schapiro, S. J., Baze, W. B., McArthur, M. J., Fobbs, A. J., Sousa, A. M. M., Šestan, N., Wildman, D. E., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117943109 · Cited by 699 · see citing works
Myelin in the Central Nervous System: Structure, Function, and Pathology
Stadelmann, C., Timmler, S., Barrantes‐Freer, A., & Simons, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00031.2018 · Cited by 735 · see citing works
Friederici, A. D., & Gierhan, S. M. E. (2012) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2012.10.002 · Cited by 673 · see citing works
Wolff, J. J., Gu, H., Gerig, G., Elison, J. T., Styner, M., Gouttard, S., Botteron, K. N., Dager, S. R., Dawson, G., Estes, A. M., et al. (2012) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2011.11091447 · Cited by 671 · see citing works
Regulation of prefrontal cortex myelination by the microbiota
Hoban, A. E., Stilling, R. M., Ryan, F. J., Shanahan, F., Dinan, T. G., Claesson, M. J., Clarke, G., & Cryan, J. F. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.42 · Cited by 635 · see citing works
Distinct Profiles of Myelin Distribution Along Single Axons of Pyramidal Neurons in the Neocortex
Tomassy, G. S., Berger, D. R., Chen, H.-H., Kasthuri, N., Hayworth, K. J., Vercelli, A., Seung, H. S., Lichtman, J. W., & Arlotta, P. (2014) · Science · doi:10.1126/science.1249766 · Cited by 600 · see citing works
Oligodendroglial NMDA receptors regulate glucose import and axonal energy metabolism
Saab, A. S., Tzvetavona, I. D., Trevisiol, A., Baltan, S., Dibaj, P., Kusch, K., Möbius, W., Goetze, B., Jahn, H. M., Huang, W., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.05.016 · Cited by 590 · see citing works
Oligodendrocyte Development and PlasticityPreprint
Bergles, D. E., & Richardson, W. D. (2015) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020453 · Cited by 573 · see citing works
Dynamics of Oligodendrocyte Generation and Myelination in the Human Brain
Yeung, M. S. Y., Zdunek, S., Bergmann, O., Bernard, S., Salehpour, M., Alkass, K., Perl, S., Tisdale, J., Possnert, G., Brundin, L., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.011 · Cited by 541 · see citing works
The Role of NMDA Receptors in Alzheimer’s Disease
Liu, J., Chang, L., Song, Y., Li, H., & Wu, Y. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00043 · Cited by 535 · see citing works
Neuronal activity biases axon selection for myelination in vivo
Hines, J. H., Ravanelli, A. M., Schwindt, R. K., Scott, E. K., & Appel, B. (2015) · Nature Neuroscience · doi:10.1038/nn.3992 · Cited by 453 · see citing works
Myelin Membrane Wrapping of CNS Axons by PI(3,4,5)P3-Dependent Polarized Growth at the Inner Tongue
Snaidero, N., Möbius, W., Czopka, T., Hekking, L. H. P., Mathisen, C., Verkleij, D., Goebbels, S., Edgar, J. M., Merkler, D., Lyons, D. A., et al. (2014) · Cell · doi:10.1016/j.cell.2013.11.044 · Cited by 451 · see citing works
White matter and cognition: making the connection
Filley, C. M., & Fields, R. D. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00221.2016 · Cited by 445 · see citing works
Self-citationDisruption of oligodendrogenesis impairs memory consolidation in adult mice
Steadman, P. E., Xia, F., Ahmed, M., Mocle, A. J., Penning, A. R. A., Geraghty, A. C., Steenland, H. W., Monje, M., Josselyn, S. A., & Frankland, P. W. (2020) · Neuron · doi:10.1016/j.neuron.2019.10.013 · Cited by 426 · see citing works
White Matter Plasticity in the Adult Brain
Sampaio‐Baptista, C., & Johansen‐Berg, H. (2017) · Neuron · doi:10.1016/j.neuron.2017.11.026 · Cited by 414 · see citing works
Synaptic vesicle release regulates myelin sheath number of individual oligodendrocytes in vivo
Mensch, S., Baraban, M., Almeida, R., Czopka, T., Ausborn, J., El Manira, A., & Lyons, D. A. (2015) · Nature Neuroscience · doi:10.1038/nn.3991 · Cited by 398 · see citing works
Role of myelin plasticity in oscillations and synchrony of neuronal activity
Pajevic, S., Basser, P. J., & Fields, R. D. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2013.11.007 · Cited by 378 · see citing works
Self-citationRemyelination in multiple sclerosis: From basic science to clinical translation
Lubetzki, C., Zalc, B., Williams, A., Stadelmann, C., & Stankoff, B. (2020) · The Lancet Neurology · doi:10.1016/s1474-4422(20)30140-x · Cited by 350 · see citing works
Friederici, A. D., Chomsky, N., Berwick, R. C., Moro, A., & Bolhuis, J. J. (2017) · Nature Human Behaviour · doi:10.1038/s41562-017-0184-4 · Cited by 349 · see citing works
Individual Oligodendrocytes Have Only a Few Hours in which to Generate New Myelin Sheaths In Vivo
Czopka, T., ffrench‐Constant, C., & Lyons, D. A. (2013) · Developmental Cell · doi:10.1016/j.devcel.2013.05.013 · Cited by 332 · see citing works
Neuregulin and BDNF Induce a Switch to NMDA Receptor-Dependent Myelination by Oligodendrocytes
Lundgaard, I., Luzhynskaya, A., Stockley, J. H., Wang, Z., Evans, K. A., Swire, M., Volbracht, K., Gautier, H. O. B., Franklin, R. J. M., ffrench‐Constant, C., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001743 · Cited by 340 · see citing works
Dynamics and Mechanisms of CNS Myelination
Bercury, K. K., & Macklin, W. B. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.01.016 · Cited by 320 · see citing works
Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices
Tremblay, M., Zettel, M. L., Ison, J. R., Allen, P. D., & Majewska, A. K. (2012) · Glia · doi:10.1002/glia.22287 · Cited by 309 · see citing works
Neuronal activity regulates remyelination via glutamate signalling to oligodendrocyte progenitors
Gautier, H. O. B., Evans, K. A., Volbracht, K., James, R., Sitnikov, S., Lundgaard, I., James, F., Lao‐Peregrín, C., Reynolds, R., Franklin, R. J. M., et al. (2015) · Nature Communications · doi:10.1038/ncomms9518 · Cited by 305 · see citing works
Loss of adaptive myelination contributes to methotrexate chemotherapy-related cognitive impairment
Geraghty, A. C., Gibson, E. M., Ghanem, R. A., Greene, J. J., Ocampo, A., Goldstein, A. K., Ni, L., Yang, T., Marton, R. M., Paşca, S. P., et al. (2019) · Neuron · doi:10.1016/j.neuron.2019.04.032 · Cited by 288 · see citing works
White Matter Microstructure and Atypical Visual Orienting in 7-Month-Olds at Risk for Autism
Elison, J. T., Paterson, S. J., Wolff, J. J., Reznick, J. S., Sasson, N. J., Gu, H., Botteron, K. N., Dager, S. R., Estes, A. M., Evans, A. C., et al. (2013) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2012.12091150 · Cited by 277 · see citing works
“We initially chose to focus on radial diffusivity because there have been reports linking this metric to myelination (30), and the relative myelin content is thought to support rapid and efficient signal transmission (31) and therefore efficient information processing.”
BackgroundMyelin plasticity and nervous system function
Monje, M. (2018) · Annual Review of Neuroscience · doi:10.1146/annurev-neuro-080317-061853 · Cited by 274 · see citing works
Myelin dynamics: protecting and shaping neuronal functions
Saab, A. S., & Nave, K. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.09.013 · Cited by 259 · see citing works
Marton, R. M., & Pașca, S. (2019) · Trends in Cell Biology · doi:10.1016/j.tcb.2019.11.004 · Cited by 202 · see citing works
Wrapped to Adapt: Experience-Dependent Myelination
Mount, C., & Monje, M. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.009 · Cited by 251 · see citing works
Fard, M. K., van der Meer, F., Sánchez, P., Cantuti-Castelvetri, L., Mandad, S., Jäkel, S., Fornasiero, E. F., Schmitt, S., Ehrlich, M., Starost, L., et al. (2017) · Science Translational Medicine · doi:10.1126/scitranslmed.aam7816 · Cited by 247 · see citing works
The Axon-Myelin Unit in Development and Degenerative Disease
Stassart, R. M., Möbius, W., Nave, K.-A., & Edgar, J. M. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00467 · Cited by 246 · see citing works
Wake, H., Ortiz, F. C., Woo, D. H., Lee, P. R., Angulo, M. C., & Fields, R. D. (2015) · Nature Communications · doi:10.1038/ncomms8844 · Cited by 244 · see citing works
Self-citationGlial Biology in Learning and Cognition
Fields, R. D., Araque, A., Johansen-Berg, H., Lim, S.-S., Lynch, G., Nave, K.-A., Nedergaard, M., Perez, R., Sejnowski, T., & Wake, H. (2014) · The Neuroscientist · doi:10.1177/1073858413504465 · Cited by 232 · see citing works
Self-citationOlmos-Serrano, J. L., Kang, H. J., Tyler, W. A., Silbereis, J. C., Cheng, F., Zhu, Y., Pletikos, M., Jankovic-Rapan, L., Cramer, N. P., Galdzicki, Z., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.01.042 · Cited by 239 · see citing works
“For example, recent studies have shown that electrical activity drives myelination (Gibson et al., 2014; Ishibashi et al., 2006; Wake et al., 2011) and that synaptogenesis and myelination are co-regulated.”
Regulation of conduction time along axons
Seidl, A. H. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.06.047 · Cited by 231 · see citing works
Sakry, D., Neitz, A., Singh, J. B., Frischknecht, R., Marongiu, D., Binamé, F., Perera, S. S., Endres, K., Lutz, B., Radyushkin, K., et al. (2014) · PLoS Biology · doi:10.1371/journal.pbio.1001993 · Cited by 210 · see citing works
Aggarwal, S., Snaidero, N., Pähler, G., Frey, S., Sánchez, P., Zweckstetter, M., Janshoff, A., Schneider, A., Weil, M., Schaap, I. A. T., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001577 · Cited by 206 · see citing works
Astrocyte-Derived BDNF Supports Myelin Protein Synthesis after Cuprizone-Induced Demyelination
Fulmer, C. G., VonDran, M. W., Stillman, A. A., Huang, Y., Hempstead, B. L., & Dreyfus, C. F. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.4267-13.2014 · Cited by 204 · see citing works
Feltri, M. L., Poitelon, Y., & Previtali, S. C. (2015) · The Neuroscientist · doi:10.1177/1073858415572361 · Cited by 205 · see citing works
Etxeberria, A., Hokanson, K. C., Dao, D. Q., Mayoral, S. R., Mei, F., Redmond, S., Ullian, E. M., & Chan, J. R. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.0908-16.2016 · Cited by 201 · see citing works
Cellular and molecular introduction to brain development
Jiang, X., & Nardelli, J. (2015) · Neurobiology of Disease · doi:10.1016/j.nbd.2015.07.007 · Cited by 199 · see citing works
Periods of synchronized myelin changes shape brain function and plasticity
de Faria, O., Pivoňková, H., Varga, B. V., Timmler, S., Evans, K. A., & Káradóttir, R. T. (2021) · Nature Neuroscience · doi:10.1038/s41593-021-00917-2 · Cited by 193 · see citing works
Ca2+ activity signatures of myelin sheath formation and growth in vivo
Baraban, M., Koudelka, S., & Lyons, D. A. (2017) · Nature Neuroscience · doi:10.1038/s41593-017-0040-x · Cited by 193 · see citing works
Cholesterol in myelin biogenesis and hypomyelinating disorders
Saher, G., & Stumpf, S. K. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2015.02.010 · Cited by 192 · see citing works
Short-term learning induces white matter plasticity in the fornix
Hofstetter, S., Tavor, I., Tzur Moryosef, S., & Assaf, Y. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4520-12.2013 · Cited by 190 · see citing works
Modulation of oligodendrocyte generation during a critical temporal window after NG2 cell division
Hill, R., Patel, K. D., Gonçalves, C. M., Grutzendler, J., & Nishiyama, A. (2014) · Nature Neuroscience · doi:10.1038/nn.3815 · Cited by 186 · see citing works
And yet it moves: Recovery of volitional control after spinal cord injury
Taccola, G., Sayenko, D., Gad, P., Gerasimenko, Y., & Edgerton, V. R. (2018) · Progress in neurobiology · doi:10.1016/j.pneurobio.2017.10.004 · Cited by 166 · see citing works
Clarke, L. E., Young, K. M., Hamilton, N. B., Li, H., Richardson, W. D., & Attwell, D. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.0928-12.2012 · Cited by 182 · see citing works
Glial Regulation of the Neuronal Connectome through Local and Long-Distant Communication
Fields, R. D., Woo, D. H., & Basser, P. J. (2015) · Neuron · doi:10.1016/j.neuron.2015.01.014 · Cited by 178 · see citing works
Self-citationSnaidero, N., & Simons, M. (2014) · Journal of Cell Science · doi:10.1242/jcs.151043 · Cited by 169 · see citing works
Brain Functional and Structural Predictors of Language Performance
Skeide, M. A., Bräuer, J., & Friederici, A. D. (2015) · Cerebral Cortex · doi:10.1093/cercor/bhv042 · Cited by 180 · see citing works
Li, C., & Götz, J. (2017) · The EMBO Journal · doi:10.15252/embj.201797724 · Cited by 178 · see citing works
The neural androgen receptor: a therapeutic target for myelin repair in chronic demyelination
Hussain, R., Ghoumari, A. M., Bielecki, B., Steibel, J., Boehm, N., Lière, P., Macklin, W. B., Kumar, N., Habert, R., Mhaouty‐Kodja, S., et al. (2013) · Brain · doi:10.1093/brain/aws284 · Cited by 176 · see citing works
Physiological Roles of Non-Neuronal NMDA Receptors
Hogan-Cann, A. D., & Anderson, C. M. (2016) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2016.05.012 · Cited by 171 · see citing works
White matter plasticity in adulthood
Wang, S., & Young, K. M. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.10.018 · Cited by 172 · see citing works
Koudelka, S., Voas, M. G., Almeida, R., Baraban, M., Soetaert, J., Meyer, M. P., Talbot, W. S., & Lyons, D. A. (2016) · Current Biology · doi:10.1016/j.cub.2016.03.070 · Cited by 162 · see citing works
Gundersen, V., Storm‐Mathisen, J., & Bergersen, L. H. (2015) · Physiological Reviews · doi:10.1152/physrev.00024.2014 · Cited by 172 · see citing works
Figlia, G., Gerber, D., & Suter, U. (2018) · Glia · doi:10.1002/glia.23273 · Cited by 165 · see citing works
Panicker, N., Saminathan, H., Jin, H., Neal, M., Harischandra, D. S., Gordon, R., Kanthasamy, K. A., Lawana, V., Sarkar, S., Luo, J. D., et al. (2015) · Journal of Neuroscience · doi:10.1523/jneurosci.0302-15.2015 · Cited by 163 · see citing works
Axo-myelinic neurotransmission: a novel mode of cell signalling in the central nervous system
Micu, I., Plemel, J. R., Caprariello, A. V., Nave, K., & Stys, P. K. (2017) · Nature reviews. Neuroscience · doi:10.1038/nrn.2017.128 · Cited by 162 · see citing works
Promoting remyelination in multiple sclerosis
Cunniffe, N., & Coles, A. (2019) · Journal of Neurology · doi:10.1007/s00415-019-09421-x · Cited by 142 · see citing works
The role of diffusion MRI in neuroscience
Assaf, Y., Johansen‐Berg, H., & Thiebaut de Schotten, M. (2019) · NMR in Biomedicine · doi:10.1002/nbm.3762 · Cited by 158 · see citing works
The translational biology of remyelination: past, present, and future
Franklin, R. J. M., & Gallo, V. (2014) · Glia · doi:10.1002/glia.22622 · Cited by 153 · see citing works
Intrinsic and extrinsic control of oligodendrocyte development
Zuchero, J. B., & Barres, B. A. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.06.005 · Cited by 155 · see citing works
Individual Differences in White Matter Diffusion Affect Sleep Oscillations
Piantoni, G., Poil, S., Linkenkaer‐Hansen, K., Verweij, I. M., Ramautar, J. R., Someren, E. J. W. V., & van der Werf, Y. D. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.2030-12.2013 · Cited by 152 · see citing works
Thomas, A. G., Dennis, A., Rawlings, N. B., Stagg, C. J., Matthews, L., Morris, M., Kolind, S. H., Foxley, S., Jenkinson, M., Nichols, T. E., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.10.090 · Cited by 152 · see citing works
“Neuronal activity-dependent changes in myelination have been observed in cell culture (Wake et al., 2011; Fields, 2010) as well as in recent in vivo experiments (Gibson et al., 2014).”
BackgroundDemyelination as a rational therapeutic target for ischemic or traumatic brain injury
Shi, H., Hu, X., Leak, R. K., Shi, Y., An, C., Suenaga, J., Chen, J., & Gao, Y. (2015) · Experimental Neurology · doi:10.1016/j.expneurol.2015.03.017 · Cited by 148 · see citing works
Intrinsic and adaptive myelination—A sequential mechanism for smart wiring in the brain
Bechler, M. E., Swire, M., & ffrench‐Constant, C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22518 · Cited by 149 · see citing works
Kougioumtzidou, E., Shimizu, T., Hamilton, N. B., Tohyama, K., Sprengel, R., Monyer, H., Attwell, D., & Richardson, W. D. (2017) · eLife · doi:10.7554/elife.28080 · Cited by 151 · see citing works
Myelin management by the 18.5‐kDa and 21.5‐kDa classic myelin basic protein isoforms
Harauz, G., & Boggs, J. M. (2013) · Journal of Neurochemistry · doi:10.1111/jnc.12195 · Cited by 148 · see citing works
Making myelin basic protein -from mRNA transport to localized translation
Müller, C., Bauer, N., Schäfer, I., & White, R. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00169 · Cited by 149 · see citing works
Optimal electrical stimulation boosts stem cell therapy in nerve regeneration
Du, J., Zhen, G., Chen, H. A., Zhang, S., Qing, L., Yang, X., Lee, G., Mao, H., & Jia, X. (2018) · Biomaterials · doi:10.1016/j.biomaterials.2018.07.015 · Cited by 147 · see citing works
Wong, A. W., Xiao, J., Kemper, D., Kilpatrick, T. J., & Murray, S. S. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.3990-12.2013 · Cited by 147 · see citing works
Glial Cell Development and Function in ZebrafishPreprint
Lyons, D. A., & Talbot, W. S. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a020586 · Cited by 143 · see citing works
The molecular physiology of the axo-myelinic synapse
Micu, I., Plemel, J. R., Lachance, C., Proft, J., Jansen, A. J., Cummins, K., van Minnen, J., & Stys, P. K. (2016) · Experimental Neurology · doi:10.1016/j.expneurol.2015.10.006 · Cited by 140 · see citing works
Li, C., Xiao, L., Liu, X., Yang, W., Shen, W., Hu, C., Yang, G., & He, C. (2013) · Glia · doi:10.1002/glia.22469 · Cited by 139 · see citing works
Regulation of myelination by microglia
Santos, E. N., & Fields, R. D. (2021) · Science Advances · doi:10.1126/sciadv.abk1131 · Cited by 137 · see citing works
Self-citationNeurotransmitter signaling in white matter
Butt, A. M., Fern, R. F., & Matute, C. (2014) · Glia · doi:10.1002/glia.22674 · Cited by 133 · see citing works
Pál, B. Z. (2018) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-018-2837-5 · Cited by 135 · see citing works
Neuronal activity in vivo enhances functional myelin repair
Ortíz, F. C., Habermacher, C., Graciarena, M., Houry, P.-Y., Nishiyama, A., Nait‐Oumesmar, B., & Angulo, M. C. (2019) · JCI Insight · doi:10.1172/jci.insight.123434 · Cited by 133 · see citing works
Caglayan, E., Liu, Y., & Konopka, G. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.010 · Cited by 123 · see citing works
Schwann Cell Exosomes Mediate Neuron–Glia Communication and Enhance Axonal Regeneration
López‐Leal, R., & Court, F. A. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-015-0314-3 · Cited by 131 · see citing works
Advances in noninvasive myelin imaging
Heath, F. C., Hurley, S. A., Johansen‐Berg, H., & Sampaio‐Baptista, C. (2017) · Developmental Neurobiology · doi:10.1002/dneu.22552 · Cited by 130 · see citing works
Vanzulli, I., Papanikolaou, M., De-La-Rocha, I. C., Pieropan, F., Rivera, A. D., Gomez-Nicola, D., Verkhratsky, A., Rodríguez, J. J., & Butt, A. M. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.05.016 · Cited by 130 · see citing works
Norbom, L. B., Ferschmann, L., Parker, N., Agartz, I., Andreassen, O. A., Paus, T., Westlye, L. T., & Tamnes, C. K. (2021) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2021.102109 · Cited by 122 · see citing works
Strenziok, M., Parasuraman, R., Clarke, E., Cisler, D., Thompson, J. C., & Greenwood, P. M. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.07.069 · Cited by 127 · see citing works
Advanced MRI techniques to improve our understanding of experience-induced neuroplasticity
Tardif, C. L., Gauthier, C. J., Steele, C. J., Bazin, P.-L., Schäfer, A., Schaefer, A., Turner, R., & Villringer, A. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2015.08.047 · Cited by 127 · see citing works
Myelin plasticity in the central nervous system
Purger, D. A., Gibson, E. M., & Monje, M. (2015) · Neuropharmacology · doi:10.1016/j.neuropharm.2015.08.001 · Cited by 126 · see citing works
- Authors
- Wake, H., Lee, P. R., & Fields, R. D.
- Affiliations
- National Institutes of Health (US)
- Corresponding author
- Fields, R. Douglas
- Venue
- Science
- Published
- 2011-09-16
- Volume
- 333
- Issue
- 6049
- Pages
- 1647-1651
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- PMC
- PMC3482340
- OpenAlex
- W2167904957
- Cited by
- 636
- References
- 24
- Citations by year
- 2026: 23 · 2025: 30 · 2024: 25 · 2023: 28 · 2022: 31 · 2021: 49 · 2020: 38 · 2019: 51 · 2018: 48 · 2017: 63 · 2016: 56 · 2015: 59 · 2014: 50 · 2013: 50 · 2012: 29
- FWCI
- 13.97
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99HD999999, Z99 HL999999, Z99 MH999999, Z99 OD999999, Z99 DA999999)
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
- Keywords
- myelination, action potential, oligodendrocytes, dorsal root ganglion neurons, myelin basic protein, local protein synthesis, glutamate release, synaptic vesicles, Fyn, activity-dependent myelination, neural development
- MeSH terms
- Action Potentials, Adenosine Triphosphate, Animals, Axons, Calcium, Cell Differentiation, Cells, Cultured, Electric Stimulation, Myelin Basic Protein, Ganglia, Spinal, Myelin Sheath, Synaptic Transmission, Oligodendroglia, Receptors, Transferrin, Synaptic Vesicles, Signal Transduction, Glutamic Acid, Calcium Signaling, Proto-Oncogene Proteins c-fyn, Mice, Neural Stem Cells
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