The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
NG 2‐glia and their functions in the central nervous system
Open accessAbstract
In the central nervous system, NG2‐glia represent a neural cell population that is distinct from neurons, astrocytes, and oligodendrocytes. While in the past the main role ascribed to these cells was that of progenitors for oligodendrocytes, in the last years it has become more obvious that they have further functions in the brain. Here, we will discuss some of the most current and highly debated issues regarding NG2‐glia: Do these cells represent a heterogeneous population? Can they give rise to different progenies, and does this change under pathological conditions? How do they respond to injury or pathology? What is the role of neurotransmitter signaling between neurons and NG2‐glia? We will first give an overview on the developmental origin of NG2‐glia, and then discuss whether their distinct properties in different brain regions are the result of environmental influences, or due to intrinsic differences. We will then review and discuss their in vitro differentiation potential and in vivo lineage under physiological and pathological conditions, together with their electrophysiological properties in distinct brain regions and at different developmental stages. Finally, we will focus on their potential to be used as therapeutic targets in demyelinating and neurodegenerative diseases. Therefore, this review article will highlight the importance of NG2‐glia not only in the healthy, but also in the diseased brain. GLIA 2015;63:1429–1451
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M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination
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PDGFRA/NG2 glia generate myelinating oligodendrocytes and piriform projection neurons in adult mice
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Oligodendrocyte Dynamics in the Healthy Adult CNS: Evidence for Myelin Remodeling
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“NG2-glia are cells with a highly proliferative capacity (Clarke et al. 2012; Simon et al. 2011; Young et al. 2013) and it is nowadays broadly accepted that they can generate oligodendrocytes.”
InfluentialNeurotransmitter-Triggered Transfer of Exosomes Mediates Oligodendrocyte–Neuron Communication
Frühbeis, C., Fröhlich, D., Kuo, W. P., Amphornrat, J., Thilemann, S., Saab, A. S., Kirchhoff, F., Möbius, W., Goebbels, S., Nave, K.-A., et al. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001604 · Cited by 902
Polydendrocytes (NG2 cells): multifunctional cells with lineage plasticity
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Origin of New Glial Cells in Intact and Injured Adult Spinal Cord
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Reich, D. S., Lucchinetti, C. F., & Calabresi, P. A. (2018) · New England Journal of Medicine · doi:10.1056/nejmra1401483 · Cited by 2,491
Myelin in the Central Nervous System: Structure, Function, and Pathology
Stadelmann, C., Timmler, S., Barrantes-Freer, A., & Simons, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00031.2018 · Cited by 728
Glial responses to implanted electrodes in the brain
Salatino, J. W., Ludwig, K. A., Kozai, T. D. Y., & Purcell, E. K. (2017) · Nature Biomedical Engineering · doi:10.1038/s41551-017-0154-1 · Cited by 642
Inflammation, glutamate, and glia: a trio of trouble in mood disorders
Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584
The diversity and disparity of the glial scar
Adams, K. L., & Gallo, V. (2018) · Nature Neuroscience · doi:10.1038/s41593-017-0033-9 · Cited by 419
Self-citation
Metadata
- Authors
- Dimou, L., & Gallo, V.
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2015-05-24
- Volume
- 63
- Issue
- 8
- Pages
- 1429-1451
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- OpenAlex
- W1815520451
- Cited by
- 260
- References
- 32
- FWCI
- 9.79
- Type
- journal article
- Language
- en
- Open access
- green
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