The DOI matches its Crossref record; 137 of the 137 references it cites were found in a registry or an index.
How microglia sense and regulate neuronal activity
Open accessAbstract
Microglia are innate immune cells of the central nervous system that sense extracellular cues. Brain injuries, inflammation, and pathology evoke dynamic structural responses in microglia, altering their morphology and motility. The dynamic motility of microglia is hypothesized to be a critical first step in sensing local alterations and engaging in pattern-specific responses. Alongside their pathological responses, microglia also sense and regulate neuronal activity. In this review, we consider the extracellular molecules, receptors, and mechanisms that allow microglia to sense neuronal activity changes under both hypoactivity and hyperactivity. We also highlight emerging in vivo evidence that microglia regulate neuronal activity, ranging from physiological to pathophysiological conditions. In addition, we discuss the emerging role of calcium signaling in microglial responses to the extracellular environment. The dynamic function of microglia in monitoring and influencing neuronal activity may be critical for brain homeostasis and circuit modification in health and disease.
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“Ca2+ currents have also been implicated in the regulation of microglial motility (reviewed in [50]).”
From Heterozygous expression of the Alzheimer’s disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses (2022) · cites this paper as [50]
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Cites
Calcium's Role in Mechanotransduction during Muscle Development
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
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Microglia Sculpt Postnatal Neural Circuits in an Activity and Complement-Dependent Manner
Schafer, D. P., Lehrman, E. K., Kautzman, A. G., Koyama, R., Mardinly, A. R., Yamasaki, R., Ransohoff, R. M., Greenberg, M. E., Barres, B. A., & Stevens, B. (2012) · Neuron · doi:10.1016/j.neuron.2012.03.026 · Cited by 4,089
ATP mediates rapid microglial response to local brain injury in vivo
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Complement and microglia mediate early synapse loss in Alzheimer mouse models
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“In brief, microglia could potentially express the β2 receptor, the β1 receptor, and the α2A receptor based upon transcriptional analysis (Cahoy et al., 2008; Hertz et al., 2010).”
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Targa Dias Anastacio, H., Matosin, N., & Ooi, L. (2022) · Translational Psychiatry · doi:10.1038/s41398-022-02024-7 · Cited by 401
Wang, X., Fan, W., Li, N., Ma, Y., Yao, M., Wang, G., He, S., Li, W., Tan, J., Lu, Q., et al. (2023) · Genome biology · doi:10.1186/s13059-023-02931-y · Cited by 298
Scheiblich, H., Eikens, F., Wischhof, L., Opitz, S., Jüngling, K., Cserép, C., Schmidt, S. V., Lambertz, J., Bellande, T., Pósfai, B., et al. (2024) · Neuron · doi:10.1016/j.neuron.2024.06.029 · Cited by 207
Regulation of myelination by microglia
Santos, E. N., & Fields, R. D. (2021) · Science Advances · doi:10.1126/sciadv.abk1131 · Cited by 137
Tuning neural circuits and behaviors by microglia in the adult brain
Zhao, S., Umpierre, A. D., & Wu, L. (2024) · Trends in Neurosciences · doi:10.1016/j.tins.2023.12.003 · Cited by 122
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Metadata
- Authors
- Umpierre, A. D., & Wu, L.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Wu, Long‐Jun
- Venue
- Glia
- Publisher
- Wiley
- Published
- 2020-12-28
- Volume
- 69
- Issue
- 7
- Pages
- 1637-1653
- ISSN
- 0894-1491 (ISSN-L)
- 1098-1136
- PMC
- PMC8113084
- OpenAlex
- W3115061260
- Cited by
- 237
- References
- 137
- Citations by year
- 2026: 36 · 2025: 62 · 2024: 52 · 2023: 44 · 2022: 28 · 2021: 14
- FWCI
- 2.24
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Glia (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (NS088627, NS110825, NS110949, NS112144, NS114040)
- National Institute on Aging (AG064159)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- microglia, microglial motility, microglial morphology, microglial receptors, calcium signaling, neuronal hyperactivity, brain homeostasis, neuroinflammation, circuit modification
- MeSH terms
- Brain, Central Nervous System, Neurons, Microglia, Calcium Signaling
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