Microglial modulation of neuronal activity in the healthy brain

York, Elisa M.; Bernier, Louis‐Philippe; MacVicar, Brian A.

doi:10.1002/dneu.22571

Cited by 98Neuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology ResearchNeurogenesis and neuroplasticity mechanisms

Microglial modulation of neuronal activity in the healthy brain

York, Elisa M., Bernier, Louis‐Philippe, MacVicar, Brian A.·2018·Developmental Neurobiology

DOI 10.1002/dneu.22571

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Abstract

Investigations on the role of microglia in the brain have traditionally been focused on their contributions to disease states. However, recent observations have now convincingly shown that microglia in the healthy brain are not passive bystanders, but instead play a critical role in both central nervous system development and homeostasis of synaptic circuits in the adult. Here, we review the various mechanisms by which microglia impact neuronal communication in the healthy adult brain, both by sensing nearby synaptic responses and by actively modulating neuronal function. © 2017 Wiley Periodicals, Inc. Develop Neurobiol 78: 593-603, 2018.

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Microglia express many neurotransmitter receptors such as glutamate and purinergic receptors that sense changes in neural activity.
“Similar to astrocytes, microglia express many neurotransmitter receptors such as glutamate and purinergic receptors that sense changes in neural activity (York et al., 2018).”
From Adult neurogenesis, glia, and the extracellular matrix (2019) · cites this paper as York et al., 2018

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Authors: York, E. M., Bernier, L., & MacVicar, B. A.
Affiliations: University of British Columbia (CA)
Corresponding author: MacVicar, Brian A.
ORCID: York, Elisa M.
Bernier, Louis‐Philippe
MacVicar, Brian A.
Venue: Developmental Neurobiology
Publisher: Wiley
Published: 2017-12-26
Volume: 78
Issue: 6
Pages: 593-603
ISSN: 1932-8451 (ISSN-L)
1932-846X
DOI: 10.1002/dneu.22571
OpenAlex: W2778605439
Cited by: 98
References: 101
Citations by year: 2026: 5 · 2025: 4 · 2024: 7 · 2023: 8 · 2022: 11 · 2021: 17 · 2020: 23 · 2019: 9 · 2018: 14
FWCI: 1.21
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: Developmental Neurobiology (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (#148397, #8545, #115121)
Topics: Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords: microglia, neuronal activity, synaptic modulation, synaptic homeostasis, central nervous system development
MeSH terms: Animals, Brain, Cell Communication, Humans, Neurons, Microglia

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Microglial modulation of neuronal activity in the healthy brain

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