Preventive effects of an intergenerational program on age‐related hippocampal atrophy in older adults: The REPRINTS study
Abstract
OBJECTIVES: A growing body of literature indicates that social engagements, such as intergenerational programs, are effective strategies to improve a range of cognitive abilities. The present study examined whether the intergenerational program-REPRINTS-prevents age-related hippocampal atrophy. METHODS: After comprehensive baseline assessment, participants were allowed to decide whether to participate in the REPRINTS intervention or in the control group, which required only completion of assessments. REPRINTS participants engaged in group activities that involved reading picture books to children at kindergarten and elementary schools, once every 1 to 2 weeks. A follow-up assessment was conducted after 6 years. Two MRI scans were performed, one immediately after baseline assessment and the other after 6 years. Volumes of the hippocampus, thalamus, and caudate nucleus were derived from automated segmentation. The analysis included 17 REPRINTS and 42 control-group participants. RESULTS: There was no significant difference in any variable of participants' characteristics at baseline between the REPRINTS and control groups. Hippocampal volume significantly declined in the control group but was maintained in the REPRINTS group. No significant differences between groups in thalamus or caudate nucleus volume were observed. Although cognitive function was unaffected by the program, greater decreases in hippocampal volume were significantly correlated with greater decreases in cognitive performance scores. CONCLUSIONS: Our results suggest that the REPRINTS intergenerational program has protective effects on age-related hippocampal atrophy in older adults. These changes precede improvements in cognitive performance, suggesting the validity of the concept of brain plasticity in later life following social engagement.
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Some longer-term social stimulation studies showed potentially beneficial structural changes.
“Some longer-term social stimulation studies showed potentially beneficial structural changes.”
From Internet-Based Conversational Engagement Randomized Controlled Clinical Trial (I-CONECT) Among Socially Isolated Adults 75+ Years Old With Normal Cognition or Mild Cognitive Impairment: Topline Results (2024) · cites this paper as Sakurai et al., 2018
A study conducted in Japan showed reduced atrophy in hippocampal volume among an intervention group 6 years after trial completion.
“Another study conducted in Japan showed reduced atrophy in hippocampal volume among an intervention group 6 years after trial completion (Sakurai et al., 2018).”
From Internet-Based Conversational Engagement Randomized Controlled Clinical Trial (I-CONECT) Among Socially Isolated Adults 75+ Years Old With Normal Cognition or Mild Cognitive Impairment: Topline Results (2024) · cites this paper as Sakurai et al., 2018
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- Authors
- Sakurai, R., Ishii, K., Sakuma, N., Yasunaga, M., Suzuki, H., Murayama, Y., Nishi, M., Uchida, H., Shinkai, S., & Fujiwara, Y.
- Affiliations
- Waseda University (JP)
- Tokyo Metropolitan Institute of Gerontology (JP)
- University of Hyogo (JP)
- Corresponding author
- Sakurai, Ryota
- Fujiwara, Yoshinori
- ORCID
- Venue
- International Journal of Geriatric Psychiatry
- Publisher
- Wiley
- Published
- 2017-08-31
- Volume
- 33
- Issue
- 2
- Pages
- e264-e272
- ISSN
- 0885-6230 (ISSN-L)
- 1099-1166
- OpenAlex
- W2752027278
- Cited by
- 37
- References
- 37
- Citations by year
- 2026: 3 · 2025: 6 · 2024: 8 · 2023: 5 · 2022: 1 · 2021: 6 · 2020: 4 · 2019: 1 · 2018: 2 · 2017: 1
- FWCI
- 1.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Journal of Geriatric Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repositories DataBase (IRDB) (submittedVersion)
- Funders
- Mitsui Sumitomo Insurance Welfare Foundation Research Grant
- TMIG Grant for Annual Studies (2004-2014)
- Health Labour Sciences Research Grant (Comprehensive Research on Aging and Health H16-Cho, Comprehensive Research on Aging and Health H23-Nin)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Social Sciences › Psychology › Neuropsychology and Physiological Psychology › Aging and Gerontology Research
- Social Sciences › Sociology and Political Science › Intergenerational Family Dynamics and Caregiving
- Keywords
- intergenerational programs, reprints, hippocampal atrophy, age-related brain atrophy, older adults, social engagement, reading to children, neuroplasticity, cognitive performance, hippocampal volume, thalamus, caudate nucleus, cognitive aging
- MeSH terms
- Aged, Aging, Analysis of Variance, Atrophy, Caudate Nucleus, Cognition, Female, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Reading, Thalamus, Case-Control Studies, Intergenerational Relations, Cognitive Dysfunction
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