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Cited by 317Dementia and Cognitive Impairment ResearchHealth disparities and outcomesAging, Health, and Disability

The Effect of Social Engagement on Incident Dementia

Saczynski, Jane S., Pfeifer, Lisa A., Masaki, Kamal, Korf, Esther S. C., Laurin, Danielle, White, Lon, Launer, Lenore J.·2006·American Journal of Epidemiology
DOI 10.1093/aje/kwj061
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Abstract

The authors examined whether low levels of social engagement in midlife and late life were associated with the risk of incident dementia in 2,513 Japanese-American men who have been followed since 1965 as part of the Honolulu Heart Program and the Honolulu-Asia Aging Study. In 1991, assessment of dementia began; incident dementia cases (n = 222) were diagnosed in 1994 and 1997. Social engagement was assessed in midlife (1968) and late life (1991). The relation between social engagement and dementia risk was examined using Cox proportional hazards models. No level of midlife social engagement was associated with the risk of dementia. In late life, compared with participants in the highest quartile of late-life social engagement, those in the lowest quartile had a significantly increased risk of dementia (hazard ratio = 2.34, 95% confidence interval: 1.18, 4.65). However, compared with those who were in the highest quartile of social engagement at both midlife and late life, only decreased social engagement from midlife to late life was associated with an increased risk of dementia (hazard ratio = 1.87, 95% confidence interval: 1.12, 3.13). Although low social engagement in late life is associated with risk of dementia, levels of late-life social engagement may already have been modified by the dementing process and may be associated with prodromal dementia.

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Crossref · 10.1093/aje/kwj061

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  • Midlife social engagement did not predict dementia, but a downward shift in engagement from midlife to old age was associated with higher dementia likelihood than consistently high engagement.

    “Midlife engagement did not predict dementia, but individuals who experienced a downward shift in engagement from midlife to old age were more likely to develop dementia than were those who had consistently high engagement.”

    From Enrichment Effects on Adult Cognitive Development: Can the Functional Capacity of Older Adults Be Preserved and Enhanced? (2008) · cites this paper as Saczynski et al. (2006)

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Authors
Saczynski, J. S., Pfeifer, L. A., Masaki, K., Korf, E. S. C., Laurin, D., White, L., & Launer, L. J.
Affiliations
  • National Institutes of Health (US)
  • University of Hawaiʻi at Mānoa (US)
  • Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author
Saczynski, Jane S.
ORCID
Venue
American Journal of Epidemiology
Publisher
Oxford University Press (OUP)
Published
2006-01-12
Volume
163
Issue
5
Pages
433-440
ISSN
  • 0002-9262 (ISSN-L)
  • 1476-6256
DOI
10.1093/aje/kwj061
OpenAlex
W2152347610
Cited by
317
References
4
Citations by year
2026: 6 · 2025: 10 · 2024: 8 · 2023: 10 · 2022: 16 · 2021: 19 · 2020: 18 · 2019: 27 · 2018: 21 · 2017: 21 · 2016: 22 · 2015: 23 · 2014: 18 · 2013: 15 · 2012: 18
FWCI
7.85
Type
journal article
Language
en
Open access
closed
Locations
  • American Journal of Epidemiology (publishedVersion)
  • PubMed (publishedVersion)
  • The Journal of the American Medical Association (JAMA) Network (American Medical Association) (submittedVersion)
Funders
  • National Institutes of Health (n01hc005102-027)
  • National Institute on Aging (N01‐AG‐4‐2149)
  • National Heart, Lung, and Blood Institute (N01 HC 05102, NO1-HC-05102)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Social Sciences › Health › Health disparities and outcomes
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Aging, Health, and Disability
Keywords
social engagement, dementia, incident dementia risk, Japanese-American men, Honolulu Heart Program, Honolulu-Asia Aging Study, prodromal dementia
MeSH terms
Aged, Aging, Asian, Dementia, Family, Follow-Up Studies, Hawaii, Humans, Interpersonal Relations, Japan, Male, Middle Aged, Retrospective Studies, Risk Factors, Social Behavior, Incidence, Confidence Intervals

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