Cited by 169Advanced MRI Techniques and ApplicationsFunctional Brain Connectivity StudiesAttention Deficit Hyperactivity Disorder

The fMRI success rate of children and adolescents: Typical development, epilepsy, attention deficit/hyperactivity disorder, and autism spectrum disorders

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Yerys, Benjamin E., Jankowski, Kathryn F., Shook, Devon, Rosenberger, Lisa R., Barnes, Kelly Anne, Berl, Madison M., Ritzl, Eva K., VanMeter, John +2 more·2009·Human Brain Mapping

Abstract

Functional magnetic resonance imaging (fMRI) in children is increasingly used in clinical application and in developmental research; however, little is known how pediatric patient and typically developing populations successfully complete studies. We examined pediatric success rates with epilepsy, attention deficit/hyperactivity disorder (ADHD), autism spectrum disorders (ASD), and typically developing children (TYP). We also examined the affect of age, and, for ADHD populations, medication status on success rates. We defined a successful fMRI individual run when the data were interpretable and included in group statistics. For unsuccessful runs, datasets with excessive motion or floor task performance were categorized when possible. All clinical groups scanned less successfully than controls; medication status did not affect ADHD success (epilepsy, 80%; ADHD (off methylphenidate), 77%; ADHD (on methylphenidate), 81%; ASD, 70%; TYP, 87%). Ten to 18‐year‐old had a significantly greater scan success rate than 4‐ to 6‐year‐old; adolescents (13‐ to 18‐year‐old) demonstrated greater scan success rates than 7‐ to 9‐year‐old. Success rate for completing an entire battery of experimental runs (n = 2–6), varied between 50–59% for patient populations and 69% for TYP (79% when excluding 4‐ to 6‐year‐old). Success rate for completing one run from a battery was greater than 90% for all groups, except for ASD (81%). These data suggest 20–30% more children should be recruited in these patient groups, but only 10–20% for TYP for research studies. Studies with 4‐ to 6‐year‐olds may require 20–40% additional participants; studies with 10‐ to 18‐year‐olds may require 10–15% additional participants. Hum Brain Mapp, 2009. © 2009 Wiley‐Liss, Inc.

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Authors
Yerys, B. E., Jankowski, K. F., Shook, D., Rosenberger, L. R., Barnes, K. A., Berl, M. M., Ritzl, E. K., VanMeter, J., Vaidya, C. J., & Gaillard, W. D.
Affiliations
  • Children's National (US)
  • Georgetown University (US)
  • National Institutes of Health (US)
Venue
Human Brain Mapping
Publisher
Wiley
Published
2009-04-21
Volume
30
Issue
10
Pages
3426-3435
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
OpenAlex
W2148605740
Cited by
169
References
10
Citations by year
2026: 3 · 2025: 19 · 2024: 7 · 2023: 6 · 2022: 14 · 2021: 11 · 2020: 20 · 2019: 13 · 2018: 8 · 2017: 11 · 2016: 3 · 2015: 10 · 2014: 16 · 2013: 6 · 2012: 4
FWCI
5.51
Type
journal article
Language
en
Open access
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (U54MH066417, R01 MH65395, R01MH065395)
  • National Institute of Neurological Disorders and Stroke (R01-NS44280, R01NS044280)
  • National Center for Research Resources (M01 RR-13297, M01RR013297)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (P30HD40677, T32HD046388, P30HD040677)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
Keywords
children and adolescents, epilepsy, attention deficit hyperactivity disorder, autism spectrum disorder, typically developing children, motion artifacts, age effects, sample size determination, participant recruitment
MeSH terms
Adolescent, Age Factors, Analysis of Variance, Attention Deficit Disorder with Hyperactivity, Autistic Disorder, Brain, Child, Child Development, Child, Preschool, Epilepsy, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mental Processes, Oxygen

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