Multimodal magnetic resonance imaging: The coordinated use of multiple, mutually informative probes to understand brain structure and function
Open accessAbstract
Differing imaging modalities provide unique channels of information to probe differing aspects of the brain's structural or functional organization. In combination, differing modalities provide complementary and mutually informative data about tissue organization that is more than their sum. We acquired and spatially coregistered data in four MRI modalities--anatomical MRI, functional MRI, diffusion tensor imaging (DTI), and magnetic resonance spectroscopy (MRS)--from 20 healthy adults to understand how interindividual variability in measures from one modality account for variability in measures from other modalities at each voxel of the brain. We detected significant correlations of local volumes with the magnitude of functional activation, suggesting that underlying variation in local volumes contributes to individual variability in functional activation. We also detected significant inverse correlations of NAA (a putative measure of neuronal density and viability) with volumes of white matter in the frontal cortex, with DTI-based measures of tissue organization within the superior longitudinal fasciculus, and with the magnitude of functional activation and default-mode activity during simple visual and motor tasks, indicating that substantial variance in local volumes, white matter organization, and functional activation derives from an underlying variability in the number or density of neurons in those regions. Many of these imaging measures correlated with measures of intellectual ability within differing brain tissues and differing neural systems, demonstrating that the neural determinants of intellectual capacity involve numerous and disparate features of brain tissue organization, a conclusion that could be made with confidence only when imaging the same individuals with multiple MRI modalities.
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Both brain structure and function may serve as susceptibility mechanisms.
“Thus, both brain structure and function, which may interrelate and whose development inform each other (Hao et al., 2013, Honey et al., 2010, Paus, 2013, Power et al., 2010, Zielinski et al., 2010), may both serve as susceptibility mechanisms.”
From Adolescent neurobiological susceptibility to social context (2016) · cites this paper as Hao et al., 2013
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Adolescent neurobiological susceptibility to social context
Schriber, R. A., & Guyer, A. E. (2016) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2015.12.009 · Cited by 246 · see citing works
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Duncan, N. W., Wiebking, C., Tiret, B., Marjańska, M., Hayes, D. J., Lyttleton, O., Doyon, J., & Northoff, G. (2013) · PLoS ONE · doi:10.1371/journal.pone.0060312 · Cited by 95 · see citing works
- Authors
- Hao, X., Xu, D., Bansal, R., Dong, Z., Liu, J., Wang, Z., Kangarlu, A., Liu, F., Duan, Y., Shova, S., Gerber, A. J., & Peterson, B. S.
- Affiliations
- New York State Psychiatric Institute (US)
- ORCID
- Venue
- Human Brain Mapping
- Publisher
- Wiley
- Published
- 2011-11-11
- Volume
- 34
- Issue
- 2
- Pages
- 253-271
- ISSN
- 1065-9471 (ISSN-L)
- 1097-0193
- PMC
- PMC4284056
- OpenAlex
- W1974103289
- Cited by
- 63
- References
- 59
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 1 · 2023: 7 · 2022: 8 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 3 · 2016: 6 · 2015: 3 · 2014: 6 · 2013: 6 · 2012: 2
- FWCI
- 3.42
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Human Brain Mapping (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k02mh074677-05)
- U.S. Public Health Service (K-02-74677)
- National Institute of Mental Health (MH 36197, R01MH036197, R01MH068318, MH 068318, R01MH089582, MH089582, P50MH090966, K02-MH-074677)
- National Institute on Drug Abuse (R01DA027100, DA027100)
- National Institute of Environmental Health Sciences (ES015579, R01ES015579)
- National Institute of Biomedical Imaging and Bioengineering (R03EB008235)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Keywords
- multimodal MRI, interindividual variability, brain structure-function relationship, diffusion tensor imaging, magnetic resonance spectroscopy, N-acetylaspartate, white matter organization, superior longitudinal fasciculus, intellectual ability, frontal cortex, neuronal density
- MeSH terms
- Acoustic Stimulation, Adult, Algorithms, Attention, Brain, Brain Chemistry, Cognition, Data Interpretation, Statistical, Female, Humans, Image Processing, Computer-Assisted, Intelligence Tests, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Magnetic Resonance Spectroscopy, Psychomotor Performance, Young Adult, Diffusion Tensor Imaging
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