Combining spatial extent and peak intensity to test for activations in functional imaging
Abstract
Within the framework of statistical mapping, there are up to now only two tests used to assess the regional significance in functional images. One is based on the magnitude of the foci and tends to detect high intensity signals, while the second is based on the spatial extent of regions defined by a simple thresholding of the statistical map, a test that is more sensitive to extended signals. The aim of this paper is to combine the two tests into a single test that is more sensitive to a wider range of signals. This combined test is based on an analytical approximation of the distribution of these two parameters (size and height) and is applied in the context of statistical maps. The risk of error in noise-only 2D or 3D volumes is assessed under a wide range of experimental conditions obtained by varying both the resolution of the map and the threshold at which clusters are defined. In addition, we have investigated this new test on simulated signals, and applied it to an experimental PET dataset. The experimental risk of error is close to the predicted one, and the overall sensitivity increases when analyzing a volume containing different types of signals.
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Statistical maps were thresholded using a corrected cluster-forming threshold of Z>2.3 and an extent threshold of p<.05 familywise error corrected using Gaussian random fields.
“Thresholded Z statistic images were prepared to show clusters determined by a corrected, cluster-forming threshold of Z>2.3 and an extent threshold of p<.05 familywise error corrected using the theory of Gaussian random fields (Poline et al., 1997).”
From The effects of poor quality sleep on brain function and risk taking in adolescence (2013) · cites this paper as Poline et al., 1997
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- Authors
- Poline, J.-B., Worsley, K. J., Evans, A. C., & Friston, K. J.
- Affiliations
- UCL Queen Square Institute of Neurology (GB)
- McGill University (CA)
- Montreal Neurological Institute and Hospital (CA)
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 1997-02
- Volume
- 5
- Issue
- 2
- Pages
- 83-96
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2054121225
- Cited by
- 670
- References
- 16
- Citations by year
- 2026: 4 · 2025: 6 · 2024: 2 · 2023: 12 · 2022: 18 · 2021: 7 · 2020: 13 · 2019: 17 · 2018: 21 · 2017: 20 · 2016: 20 · 2015: 25 · 2014: 29 · 2013: 41 · 2012: 36
- FWCI
- 7.26
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
- Keywords
- statistical significance testing, spatial extent, peak intensity, combined test, statistical maps, false positive rate, PET
- MeSH terms
- Adult, Arousal, Attention, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Mathematical Computing, Middle Aged, Monte Carlo Method, Sensitivity and Specificity, Tomography, Emission-Computed, Verbal Behavior, Cluster Analysis, Normal Distribution
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