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Cited by 822Neurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology StudiesFunctional Brain Connectivity Studies

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Pupil diameter covaries with BOLD activity in human locus coeruleus

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Murphy, Peter R., O'Connell, Redmond G., O'Sullivan, Michael, Robertson, Ian H., Balsters, Joshua H.·2014·Human Brain Mapping
DOI 10.1002/hbm.22466PMC PMC6869043
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Abstract

The locus coeruleus-noradrenergic (LC-NA) neuromodulatory system has been implicated in a broad array of cognitive processes, yet scope for investigating this system's function in humans is currently limited by an absence of reliable non-invasive measures of LC activity. Although pupil diameter has been employed as a proxy measure of LC activity in numerous studies, empirical evidence for a relationship between the two is lacking. In the present study, we sought to rigorously probe the relationship between pupil diameter and BOLD activity localized to the human LC. Simultaneous pupillometry and fMRI revealed a relationship between continuous pupil diameter and BOLD activity in a dorsal pontine cluster overlapping with the LC, as localized via neuromelanin-sensitive structural imaging and an LC atlas. This relationship was present both at rest and during performance of a two-stimulus oddball task, with and without spatial smoothing of the fMRI data, and survived retrospective image correction for physiological noise. Furthermore, the spatial extent of this pupil/LC relationship guided a volume-of-interest analysis in which we provide the first demonstration in humans of a fundamental characteristic of animal LC activity: phasic modulation by oddball stimulus relevance. Taken together, these findings highlight the potential for utilizing pupil diameter to achieve a more comprehensive understanding of the role of the LC-NA system in human cognition.

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  1. Szabadi E, 1996, Autonomic pharmacology of α2‐adrenoceptors, J Psychopharm, 10, 6

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Metadata

Authors
Murphy, P. R., O'Connell, R. G., O'Sullivan, M., Robertson, I. H., & Balsters, J. H.
Affiliations
  • Trinity College Dublin (IE)
  • Trinity College Institute of Neuroscience and School of Psychology Trinity College Dublin Dublin 2 Ireland
ORCID
Venue
Human Brain Mapping
Publisher
Wiley
Published
2014-02-07
Volume
35
Issue
8
Pages
4140-4154
ISSN
  • 1065-9471 (ISSN-L)
  • 1097-0193
DOI
10.1002/hbm.22466
PMC
PMC6869043
OpenAlex
W1601100579
Cited by
819
References
77
Citations by year
2026: 77 · 2025: 71 · 2024: 83 · 2023: 81 · 2022: 83 · 2021: 85 · 2020: 79 · 2019: 64 · 2018: 60 · 2017: 56 · 2016: 48 · 2015: 24 · 2014: 8
FWCI
20.71
Type
journal article
Language
en
Open access
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Human Brain Mapping (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
Irish Research Council for Science, Engineering and Technology
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
locus coeruleus, noradrenergic system, pupil size, pupillometry, BOLD signal, oddball paradigm, stimulus relevance
MeSH terms
Adult, Attention, Brain Mapping, Cerebrovascular Circulation, Female, Humans, Locus Coeruleus, Magnetic Resonance Imaging, Male, Middle Aged, Monitoring, Physiologic, Neuropsychological Tests, Oxygen, Pupil, Rest, Signal Processing, Computer-Assisted, Visual Perception, Young Adult

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