The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas†
Open accessAbstract
This study analyzed gene expression patterns and global genomic alterations in hepatocellular carcinomas (HCC), hepatoblastomas (HPBL), tissue adjacent to HCC and normal liver tissue derived from normal livers and hepatic resections. We found that HCC and adjacent non-neoplastic cirrhotic tissue have considerable overlap in gene expression patterns compared to normal liver. Several genes including Glypican 3, spondin-2, PEG10, EDIL3 and Osteopontin are over-expressed in HCC vs. adjacent tissue whereas Ficolin 3 is the most consistently under-expressed gene. HCC can be subdivided into three clusters based on gene expression patterns. HCC and HPBL have clearly different patterns of gene expression, with genes IGF2, Fibronectin, DLK1, TGFb1, MALAT1 and MIG6 being over-expressed in HPBL versus HCC. In addition, specific areas of the genome appear unstable in HCC, with the same regions undergoing either deletion or increased gene dosage in all HCC. In conclusion, a set of specific genes and areas of genomic instability are found across the board in liver neoplasia.
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Cites
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Yarden, Y., & Sliwkowski, M. X. (2001) · Nature Reviews Molecular Cell Biology · doi:10.1038/35052073 · Cited by 6,974
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A novel prognostic subtype of human hepatocellular carcinoma derived from hepatic progenitor cells
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Self-citationClassification and prediction of survival in hepatocellular carcinoma by gene expression profiling
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Self-citationGlypican-3: a novel serum and histochemical marker for hepatocellular carcinoma
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TGF-β: Regulation of extracellular matrix
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Glypican-3 Promotes the Growth of Hepatocellular Carcinoma by Stimulating Canonical Wnt Signaling
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Glypican-3 as a Serum Marker for Hepatocellular Carcinoma
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Glypican-3, overexpressed specifically in human hepatocellular carcinoma, is a novel tumor marker
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The erbB3 gene product is a receptor for heregulin.
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Cited by
Michalopoulos, G. K. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21172 · Cited by 1,384
Self-citationLiver regeneration: biological and pathological mechanisms and implications
Michalopoulos, G. K., & Bhushan, B. (2021) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0342-4 · Cited by 998
Self-citationLiver Regeneration after Partial Hepatectomy
Michalopoulos, G. K. (2010) · The American Journal of Pathology · doi:10.2353/ajpath.2010.090675 · Cited by 713
Self-citationThe long noncoding RNA Malat1: Its physiological and pathophysiological functions
Zhang, X., Hamblin, M. H., & Yin, K.-J. (2017) · RNA Biology · doi:10.1080/15476286.2017.1358347 · Cited by 482
Long noncoding RNAs in cancer: mechanisms of action and technological advancements
Bartonicek, N., Maag, J. L. V., & Dinger, M. E. (2016) · Molecular Cancer · doi:10.1186/s12943-016-0530-6 · Cited by 459
Metadata
- Authors
- Luo, J., Ren, B., Keryanov, S., Tseng, G. C., Rao, U. N. M., Monga, S. P., Strom, S., Demetris, A. J., Nalesnik, M., Yu, Y. P., Ranganathan, S., & Michalopoulos, G. K.
- Venue
- Hepatology
- Published
- 2006-10
- Volume
- 44
- Issue
- 4
- Pages
- 1012-1024
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W2119389886
- Cited by
- 339
- References
- 35
- FWCI
- 7.04
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Luo, J., Ren, B., Keryanov, S., Tseng, G. C., Rao, U. N. M., Monga, S. P., Strom, S., Demetris, A. J., Nalesnik, M., Yu, Y. P., Ranganathan, S., & Michalopoulos, G. K. (2006). Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas†. Hepatology. https://doi.org/10.1002/hep.21328
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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