Liver-on-a-Chip models of fatty liver disease

Design and validation of a histological scoring system for nonalcoholic fatty liver disease†

Kleiner, D. E., Brunt, E. M., Van Natta, M., Behling, C., Contos, M. J., Cummings, O. W., Ferrell, L. D., Liu, Y., Torbenson, M. S., Unalp‐Arida, A., et al. (2005) · Hepatology · doi:10.1002/hep.20701 · Cited by 10,791 · see citing works

Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers

Peng, L., Li, Z.-R., Green, R. S., Holzmanr, I. R., & Lin, J. (2009) · The Journal of Nutrition · doi:10.3945/jn.109.104638 · Cited by 2,130 · see citing works

Microscale culture of human liver cells for drug development

Khetani, S. R., & Bhatia, S. N. (2008) · Nature Biotechnology · doi:10.1038/nbt1361 · Cited by 1,219 · see citing works

Multisensor-integrated organs-on-chips platform for automated and continual in situ monitoring of organoid behaviors

Zhang, Y. S., Aleman, J., Shin, S. R., Kilic, T., Kim, D., Mousavi Shaegh, S. A., Massa, S., Riahi, R., Chae, S., Hu, N., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1612906114 · Cited by 833 · see citing works

Laminated three-dimensional biodegradable foams for use in tissue engineering

Mikos, A. G., Sarakinos, G., Leite, S. M., Vacant, J. P., & Langer, R. (1993) · Biomaterials · doi:10.1016/0142-9612(93)90049-8 · Cited by 662 · see citing works

Effects of butyrate on intestinal barrier function in a Caco-2 cell monolayer model of intestinal barrier

Peng, L., He, Z., Chen, W., Holzman, I. R., & Lin, J. (2007) · Pediatric Research · doi:10.1203/01.pdr.0000250014.92242.f3 · Cited by 518 · see citing works

An artificial liver sinusoid with a microfluidic endothelial‐like barrier for primary hepatocyte culture

Lee, P. J., Hung, P. J., & Lee, L. P. (2007) · Biotechnology and Bioengineering · doi:10.1002/bit.21360 · Cited by 507 · see citing works

Perfused multiwell plate for 3D liver tissue engineering

Domanský, K., Inman, W., Serdy, J., Dash, A., Lim, M. H. M., & Griffith, L. G. (2009) · Lab on a Chip · doi:10.1039/b913221j · Cited by 446 · see citing works

The Hippo pathway effector YAP controls mouse hepatic stellate cell activation

Mannaerts, I., Leite, S. B., Verhulst, S., Claerhout, S., Eysackers, N., Thoen, L. F. R., Hoorens, A., Reynaert, H., Halder, G., & van Grunsven, L. A. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.011 · Cited by 410 · see citing works

Melt Coaxial Electrospinning: A Versatile Method for the Encapsulation of Solid Materials and Fabrication of Phase Change Nanofibers

McCann, J. T., Márquez, M., & Xia, Y. (2006) · Nano Letters · doi:10.1021/nl0620839 · Cited by 358 · see citing works

Highly Porous Fibers by Electrospinning into a Cryogenic Liquid

McCann, J. T., Márquez, M., & Xia, Y. (2006) · Journal of the American Chemical Society · doi:10.1021/ja056810y · Cited by 337 · see citing works

Adipokines and proinflammatory cytokines, the key mediators in the pathogenesis of nonalcoholic fatty liver disease

Stojsavljević, S. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i48.18070 · Cited by 325 · see citing works

Pathology of non‐alcoholic fatty liver disease

Bédossa, P. (2017) · Liver International · doi:10.1111/liv.13301 · Cited by 324 · see citing works

Use of Electrospinning to Directly Fabricate Hollow Nanofibers with Functionalized Inner and Outer Surfaces

Li, D., McCann, J. T., & Xia, Y. (2004) · Small · doi:10.1002/smll.200400056 · Cited by 313 · see citing works

A microfluidically perfused three dimensional human liver model

Rennert, K., Steinborn, S., Gröger, M., Ungerböck, B., Jank, A., Ehgartner, J., Nietzsche, S., Dinger, J., Kiehntopf, M., Funke, H., et al. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.08.043 · Cited by 258 · see citing works

Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways

Park, K., Min, A.-K., Koh, E. H., Kim, H. S., Kim, M., Park, H., Kim, Y.-D., Yoon, T.-S., Jang, B. K., Hwang, J. S., et al. (2008) · Hepatology · doi:10.1002/hep.22496 · Cited by 178 · see citing works

Investigating Nonalcoholic Fatty Liver Disease in a Liver-on-a-Chip Microfluidic Device

Gori, M., Simonelli, M. C., Giannitelli, S. M., Businaro, L., Trombetta, M., & Rainer, A. (2016) · PLoS ONE · doi:10.1371/journal.pone.0159729 · Cited by 177 · see citing works

Human hepatic 3D spheroids as a model for steatosis and insulin resistance

Kozyra, M., Johansson, I., Nordling, Å., Ullah, S., Lauschke, V. M., & Ingelman‐Sundberg, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-32722-6 · Cited by 173 · see citing works

The Effect of Oleic and Palmitic Acid on Induction of Steatosis and Cytotoxicity on Rat Hepatocytes in Primary Culture

Moravcová, A., Červinková, Z., Kučera, O., Mezera, V., Rychtrmoc, D., & Lotková, H. (2015) · Physiological Research · doi:10.33549/physiolres.933224 · Cited by 165 · see citing works

Bioprinted 3D vascularized tissue model for drug toxicity analysis

Massa, S., Sakr, M. A., Seo, J., Bandaru, P., Arneri, A., Bersini, S., Zare‐Eelanjegh, E., Jalilian, E., Cha, B.-H., Antona, S., et al. (2017) · Biomicrofluidics · doi:10.1063/1.4994708 · Cited by 160 · see citing works

3D in vitro models of liver fibrosis

van Grunsven, L. A. (2017) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2017.07.004 · Cited by 154 · see citing works

Human Multilineage 3D Spheroids as a Model of Liver Steatosis and Fibrosis

Pingitore, P., Sasidharan, K., Ekstrand, M., Prill, S., Lindén, D., & Romeo, S. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071629 · Cited by 152 · see citing works

Design and fabrication of a scalable liver-lobule-on-a-chip microphysiological platform

Banaeiyan, A. A., Theobald, J., Paukštytė, J., Wölfl, S., Adiels, C. B., & Goksör, M. (2017) · Biofabrication · doi:10.1088/1758-5090/9/1/015014 · Cited by 151 · see citing works

Three-dimensional perfused human in vitro model of non-alcoholic fatty liver disease

Kostrzewski, T. M., Cornforth, T. V., Snow, S., Ouro-Gnao, L., Rowe, C., Large, E. M., & Hughes, D. J. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i2.204 · Cited by 149 · see citing works

The Effect of Three-Dimensional Co-Culture of Hepatocytes and Hepatic Stellate Cells on Key Hepatocyte Functions in vitro

Thomas, R. J., Bhandari, R., Barrett, D. A., Bennett, A. J., Fry, J. R., Powe, D. G., Thomson, B. J., & Shakesheff, K. M. (2005) · Cells Tissues Organs · doi:10.1159/000091096 · Cited by 138 · see citing works

Gut–liver on a chip toward an in vitro model of hepatic steatosis

Lee, S. Y., & Sung, J. H. (2018) · Biotechnology and Bioengineering · doi:10.1002/bit.26793 · Cited by 110 · see citing works

Chip-based liver equivalents for toxicity testing – organotypicalness versus cost-efficient high throughput

Dehne, E., Tonevitsky, A., & Marx, U. (2013) · Lab on a Chip · doi:10.1039/c3lc50240f · Cited by 108 · see citing works

Genomic and functional characterization of stellate cells isolated from human cirrhotic livers

Sancho‐Bru, P., Bataller, R. A., Gasull, X., Colmenero, J., Khurdayan, V. K., Gual, A., Nicolás, J. M., Arroyo, V., & Ginès, P. (2005) · Journal of Hepatology · doi:10.1016/j.jhep.2005.02.035 · Cited by 85 · see citing works

Scaffold‐Free Liver‐On‐A‐Chip with Multiscale Organotypic Cultures

Weng, Y., Chang, S., Shih, M., Tseng, S., & Lai, C. (2017) · Advanced Materials · doi:10.1002/adma.201701545 · Cited by 80 · see citing works

Non-alcoholic fatty liver disease (NAFLD) models in drug discovery

Cole, B. K., Feaver, R. E., Wamhoff, B. R., & Dash, A. (2017) · Expert Opinion on Drug Discovery · doi:10.1080/17460441.2018.1410135 · Cited by 79 · see citing works

A liver-chip-based alcoholic liver disease model featuring multi-non-parenchymal cells

Deng, J., Chen, Z., Zhang, X., Luo, Y., Wu, Z., Lu, Y., Liu, T., Zhao, W., & Lin, B. (2019) · Biomedical Microdevices · doi:10.1007/s10544-019-0414-9 · Cited by 67 · see citing works

A 3D alcoholic liver disease model on a chip

Lee, J., Choi, B., No, D. Y., Lee, G., Lee, S.-R., Oh, H., & Lee, S. (2016) · Integrative Biology · doi:10.1039/c5ib00298b · Cited by 66 · see citing works

Development of an in vitro cell culture model of hepatic steatosis using hepatocyte‐derived reporter cells

Janorkar, A. V., King, K. R., Megeed, Z., & Yarmush, M. L. (2008) · Biotechnology and Bioengineering · doi:10.1002/bit.22191 · Cited by 44 · see citing works

Microphysiological flux balance platform unravels the dynamics of drug induced steatosis

Ehrlich, A., Tsytkin-Kirschenzweig, S., Ioannidis, K., Ayyash, M., Riu, A., Note, R., Ouédraogo, G., Vanfleteren, J., Cohen, M., & Nahmias, Y. (2018) · Lab on a Chip · doi:10.1039/c8lc00357b · Cited by 38 · see citing works

Intestinal Permeability in Non-alcoholic Fatty LIVER Disease: The Gut-liver Axis

Scarpellini, E., Lupo, M., Iegri, C., Gasbarrini, A., Santis, A. D., & Tack, J. F. (2015) · Reviews on Recent Clinical Trials · doi:10.2174/1574887109666141216104334 · Cited by 36 · see citing works

Pathology of nonalcoholic fatty liver disease

Tiniakos, C. K. (2007) · Annals of Gastroenterology · Cited by 11 · see citing works

Fabrication and Applications of Microfluidic Devices: A Review

Niculescu, A.-G., Chircov, C., Bîrcă, A. C., & Grumezescu, A. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22042011 · Cited by 702 · see citing works

Liver fibrosis in NAFLD/NASH: from pathophysiology towards diagnostic and therapeutic strategies

Parola, M., & Pinzani, M. (2023) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2023.101231 · Cited by 226 · see citing works

Microfluidic Organ-on-a-Chip System for Disease Modeling and Drug Development

Li, Z., Hui, J., Yang, P., & Mao, H. (2022) · Biosensors · doi:10.3390/bios12060370 · Cited by 131 · see citing works

In Vitro and In Vivo Models of Non-Alcoholic Fatty Liver Disease: A Critical Appraisal

Soret, P.-A., Magusto, J., Housset, C., & Gautheron, J. (2020) · Journal of Clinical Medicine · doi:10.3390/jcm10010036 · Cited by 121 · see citing works

Understanding the cellular interactome of non-alcoholic fatty liver disease

Wallace, S. J., Tacke, F., Schwabe, R. F., & Henderson, N. C. (2022) · JHEP Reports · doi:10.1016/j.jhepr.2022.100524 · Cited by 116 · see citing works

Gut-on-a-chip models for dissecting the gut microbiology and physiology

Valiei, A., Aminian-Dehkordi, J., & Mofrad, M. R. K. (2023) · APL Bioengineering · doi:10.1063/5.0126541 · Cited by 117 · see citing works

Modeling the Human Body on Microfluidic Chips

Jalili‐Firoozinezhad, S., Miranda, C. C., & Cabral, J. M. S. (2021) · Trends in biotechnology · doi:10.1016/j.tibtech.2021.01.004 · Cited by 101 · see citing works

From Organ-on-a-Chip to Human-on-a-Chip: A Review of Research Progress and Latest Applications

Huang, Y., Liu, T., Huang, Q., & Wang, Y. (2024) · ACS Sensors · doi:10.1021/acssensors.4c00004 · Cited by 93 · see citing works

Current Advances in 3D Dynamic Cell Culture Systems

Huang, X., Huang, Z., Gao, W., Gao, W., He, R., Li, Y., Crawford, R., Zhou, Y., Xiao, L., & Xiao, Y. (2022) · Gels · doi:10.3390/gels8120829 · Cited by 83 · see citing works

Microfluidic Organ-on-a-Chip Devices for Liver Disease Modeling In Vitro

Kanabekova, P., Kadyrova, A., & Kulsharova, G. (2022) · Micromachines · doi:10.3390/mi13030428 · Cited by 72 · see citing works

Organoid Technology: Current Standing and Future Perspectives

Shariati, L., Esmaeili, Y., Javanmard, S. H., Bidram, E., & Amini, A. (2021) · Stem Cells · doi:10.1002/stem.3379 · Cited by 69 · see citing works

Application of new approach methodologies for nonclinical safety assessment of drug candidates

Beilmann, M., Adkins, K., Boonen, H. C. M., Hewitt, P. G., Hu, W., Mader, R., Moore, S., Rana, P., Steger‐Hartmann, T., Villenave, R., et al. (2025) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01182-9 · Cited by 70 · see citing works

In Vitro Models for the Study of Liver Biology and Diseases: Advances and Limitations

Kaur, S., Kidambi, S., Ortega‐Ribera, M., Thủy, L. T. T., Nieto, N., Cogger, V. C., Xie, W., Tacke, F., & Gracia‐Sancho, J. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.11.008 · Cited by 67 · see citing works

On-Chip Construction of Liver Lobules with Self-Assembled Perfusable Hepatic Sinusoid Networks

Ya, S., Ding, W., Li, S., Du, K., Zhang, Y., Li, C., Liu, J., Li, F., Li, P., Luo, T., et al. (2021) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.1c00794 · Cited by 65 · see citing works

A scalable and sensitive steatosis chip with long-term perfusion of in situ differentiated HepaRG organoids

Teng, Y., Zhao, Z., Tasnim, F., Huang, X., & Yu, H. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120904 · Cited by 62 · see citing works

Three-dimensional (3D) liver cell models - a tool for bridging the gap between animal studies and clinical trials when screening liver accumulation and toxicity of nanobiomaterials

Tutty, M. A., Movia, D., & Prina‐Mello, A. (2022) · Drug Delivery and Translational Research · doi:10.1007/s13346-022-01147-0 · Cited by 64 · see citing works

Engineered Biomimetic Membranes for Organ-on-a-Chip

Rahimnejad, M., Rasouli, F., Jahangiri, S., Ahmadi, S., Rabiee, N., Farani, M. R., Akhavan, O., Asadnia, M., Fatahi, Y., Hong, S., et al. (2022) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c00531 · Cited by 55 · see citing works

Bioinspired Artificial Liver System with hiPSC‐Derived Hepatocytes for Acute Liver Failure Treatment

Wang, J., Ren, H., Liu, Y., Sun, L., Zhang, Z., Zhao, Y., & Shi, X. (2021) · Advanced Healthcare Materials · doi:10.1002/adhm.202101580 · Cited by 49 · see citing works

Global Literature Analysis of Organoid and Organ‐on‐Chip Research

Shoji, J., Davis, R. P., Mummery, C. L., & Krauss, S. J. K. (2023) · Advanced Healthcare Materials · doi:10.1002/adhm.202301067 · Cited by 48 · see citing works

Shedding light on non-alcoholic fatty liver disease: Pathogenesis, molecular mechanisms, models, and emerging therapeutics

Khairnar, R., Islam, M. A., Fleishman, J. S., & Kumar, S. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121185 · Cited by 46 · see citing works

Constructing biomimetic liver models through biomaterials and vasculature engineering

Lv, W., Zhou, H., Aazmi, A., Yu, M., Xu, X., Yang, H., Huang, Y. Y. S., & Ma, L. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac079 · Cited by 45 · see citing works

Relevance of organ(s)-on-a-chip systems to the investigation of food-gut microbiota-host interactions

García-Gutiérrez, E., & Cotter, P. D. (2021) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2021.1979933 · Cited by 47 · see citing works

3D culture models to study pathophysiology of steatotic liver disease

Caddeo, A. M., Maurotti, S., Kovooru, L., & Romeo, S. (2024) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2024.117544 · Cited by 42 · see citing works

Microfluidic Liver-on-a-Chip for Preclinical Drug Discovery

Fu, J., Qiu, H., & Tan, C. S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041300 · Cited by 42 · see citing works

Development of digital organ-on-a-chip to assess hepatotoxicity and extracellular vesicle-based anti-liver cancer immunotherapy

Wu, G., Wu, J., Li, Z., Shi, S., Wu, D., Wang, X., Han, X., Liu, H., Huang, Y., Wang, R., et al. (2022) · Bio-Design and Manufacturing · doi:10.1007/s42242-022-00188-1 · Cited by 42 · see citing works

Spatial dimension of macrophage heterogeneity in liver diseases

Guillot, A., & Tacke, F. (2023) · eGastroenterology · doi:10.1136/egastro-2023-000003 · Cited by 40 · see citing works

In vitro modelling of bacterial pneumonia: a comparative analysis of widely applied complex cell culture models

Mahieu, L., Moll, L. V., Vooght, L. D., Delputte, P., & Cos, P. (2024) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuae007 · Cited by 41 · see citing works

Analysis of reproducibility and robustness of a human microfluidic four-cell liver acinus microphysiology system (LAMPS)

Sakolish, C., Reese, C. E., Luo, Y., Valdiviezo, A., Schurdak, M. E., Gough, A., Taylor, D. L., Chiu, W. A., Vernetti, L. A., & Rusyn, I. (2020) · Toxicology · doi:10.1016/j.tox.2020.152651 · Cited by 40 · see citing works

Recent Advances in Gut‐ and Gut–Organ‐Axis‐on‐a‐Chip Models

Kim, R., & Sung, J. H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202302777 · Cited by 42 · see citing works

Recent advances in liver‐on‐chips: Design, fabrication, and applications

Qiu, L., Kong, B., Kong, T., & Wang, H. (2023) · Smart Medicine · doi:10.1002/smmd.20220010 · Cited by 37 · see citing works

Liver-on-a-chip: Considerations, advances, and beyond

Yang, Z., Liu, X., Cribbin, E. M., Kim, A. M., Li, J. J., & Yong, K. (2022) · Biomicrofluidics · doi:10.1063/5.0106855 · Cited by 34 · see citing works

Endotheliopathy in the metabolic syndrome: Mechanisms and clinical implications

Furuta, K., Tang, X., Islam, S., Tapia, A., Chen, Z., & Ibrahim, S. H. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108372 · Cited by 34 · see citing works

Organoid-on-a-chip: Current challenges, trends, and future scope toward medicine

Li, Z., Li, Q., Zhou, C., Lu, K., Liu, Y., Xuan, L., & Wang, X. (2023) · Biomicrofluidics · doi:10.1063/5.0171350 · Cited by 33 · see citing works

Islet-on-a-chip: Biomimetic micropillar-based microfluidic system for three-dimensional pancreatic islet cell culture

Sokołowska, P., Żukowski, K., Janikiewicz, J., Jastrzębska, E., Dobrzyń, A., & Brzózka, Z. (2021) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2021.113215 · Cited by 33 · see citing works

Development of a Hybrid Polymer-Based Microfluidic Platform for Culturing Hepatocytes towards Liver-on-a-Chip Applications

Kulsharova, G., Kurmangaliyeva, A., Darbayeva, E., Rojas–Solórzano, L., & Toxeitova, G. (2021) · Polymers · doi:10.3390/polym13193215 · Cited by 33 · see citing works

Recent Developments in Glioblastoma‐On‐A‐Chip for Advanced Drug Screening Applications

Maity, S., Bhuyan, T., Jewell, C., Kawakita, S., Sharma, S., Nguyen, H. T., Najafabadi, A. H., Ermis, M., Falcone, N., Chen, J., et al. (2024) · Small · doi:10.1002/smll.202405511 · Cited by 31 · see citing works

Customizable Microfluidic Origami Liver‐on‐a‐Chip (oLOC)

Xie, X., Maharjan, S., Kelly, C. M., Liu, T., Lang, R. J., Alperin, R. C., Sebastian, S., Bonilla, D., Gandolfo, S., Boukataya, Y., et al. (2021) · Advanced Materials Technologies · doi:10.1002/admt.202100677 · Cited by 30 · see citing works

A Model of Hepatic Steatosis with Declined Viability and Function in a Liver-Organ-on-a-Chip

Wiriyakulsit, N., Keawsomnuk, P., Thongin, S., Ketsawatsomkron, P., & Muta, K. (2023) · Scientific Reports · doi:10.1038/s41598-023-44198-0 · Cited by 29 · see citing works

Fabrication of organ-on-a-chip using microfluidics

Ying-Jin, S., Yuste, I., González‐Burgos, E., & Serrano, D. R. (2025) · Bioprinting · doi:10.1016/j.bprint.2025.e00394 · Cited by 28 · see citing works

Advances in reconstructing intestinal functionalities in vitro: From two/three dimensional-cell culture platforms to human intestine-on-a-chip

Wang, L., Wu, J., Chen, J., Dou, W., Zhao, Q., Han, J., Liu, J., Su, W., Li, A., Liu, P., et al. (2021) · Talanta · doi:10.1016/j.talanta.2021.122097 · Cited by 28 · see citing works

3D human nonalcoholic hepatic steatosis and fibrosis models

Maharjan, S., Bonilla, D., Sindurakar, P., Li, H., Li, W., Duarte, S. M., Zarrinpar, A., & Zhang, Y. S. (2021) · Bio-Design and Manufacturing · doi:10.1007/s42242-020-00121-4 · Cited by 29 · see citing works

State-of-the-art advancements in Liver-on-a-chip (LOC): Integrated biosensors for LOC

Liu, M., Xiang, Y., Yang, Y., Long, X., Xiao, Z., Nan, Y., Jiang, Y., Qiu, Y., Huang, Q., & Ai, K. (2022) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2022.114758 · Cited by 27 · see citing works

Microfluidic systems for modeling digestive cancer: a review of recent progress

Razavi, Z., Soltani, M., Pazoki-Toroudi, H., & Dabagh, M. (2024) · Biomedical Physics & Engineering Express · doi:10.1088/2057-1976/ad6f15 · Cited by 24 · see citing works

Organ-on-a-Chip for Drug Screening: A Bright Future for Sustainability? A Critical Review

Feitor, J. F., Brazaca, L. C., Lima, A. M., Ferreira, V. G., Kassab, G., Bagnato, V. S., Carrilho, E., & Cardoso, D. R. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01454 · Cited by 24 · see citing works

NAFLD-Related HCC: Focus on the Latest Relevant Preclinical Models

Fang, J., Celton‐Morizur, S., & Desdouets, C. (2023) · Cancers · doi:10.3390/cancers15143723 · Cited by 24 · see citing works

Advances in liver and pancreas organoids: how far we have come and where we go next

Sljukic, A., Jenkinson, J. G., Niksic, A., Prior, N., & Huch, M. (2025) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-025-01116-1 · Cited by 23 · see citing works

Liver-on-chip model and application in predictive genotoxicity and mutagenicity of drugs

Kopp, B., Khawam, A., Perna, K. D., Lenart, D., Vinette, M., da Silva, R. M., Zanoni, T. B., Rore, C., Guenigault, G., Richardson, E., et al. (2024) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2024.503762 · Cited by 22 · see citing works

Recent advances in the development of in vitro liver models for hepatotoxicity testing

Lu, S., Zhang, J., Lin, S., Zheng, D., Shen, Y., Qin, J., Li, Y. Y., & Wang, S. (2021) · Bio-Design and Manufacturing · doi:10.1007/s42242-021-00142-7 · Cited by 21 · see citing works

A prognostic molecular signature of hepatic steatosis is spatially heterogeneous and dynamic in human liver

Perry, A., Hadad, N., Chatterjee, E., Ramos, M. J., Farber‐Eger, E. H., Roshani, R., Stolze, L. K., Betti, M. J., Zhao, S., Huang, S., et al. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101871 · Cited by 19 · see citing works

Microneedle array facilitates hepatic sinusoid construction in a large-scale liver-acinus-chip microsystem

Li, S., Li, C., Khan, M. I., Liu, J., Shi, Z., Gao, D. Y., Qiu, B., & Ding, W. (2023) · Microsystems & Nanoengineering · doi:10.1038/s41378-023-00544-w · Cited by 19 · see citing works

Microphysiological systems to advance human pathophysiology and translational medicine

Harriot, A. D., Ward, C. W., & Kim, D. (2024) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00087.2024 · Cited by 20 · see citing works

Convenient rapid prototyping microphysiological niche for mimicking liver native basement membrane: Liver sinusoid on a chip

Ebrahimi, A., Ghorbanpoor, H., Apaydın, E., Cevizlidere, B. D., Özel, C., Tüfekçioğlu, E., Koç, Y., Topal, A. E., Tomsuk, Ö., Güleç, K., et al. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114292 · Cited by 17 · see citing works

Point-of-use, automated fabrication of a 3D human liver model supplemented with human adipose microvessels

Moss, S. M., Schilp, J., Yaakov, M., Cook, M., Schuschke, E., Hanke, B., Strobel, H. A., & Hoying, J. B. (2022) · SLAS DISCOVERY · doi:10.1016/j.slasd.2022.06.003 · Cited by 16 · see citing works

Ex Vivo Tools and Models in MASLD Research

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Porous hydrogel arrays for hepatoma cell spheroid formation and drug resistance investigation

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Validation of HepG2/C3A Cell Cultures in Cyclic Olefin Copolymer Based Microfluidic Bioreactors

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Building Blood Vessel Chips with Enhanced Physiological Relevance

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Real-Time, Continuous Monitoring of Tissue Chips as an Emerging Opportunity for Biosensing

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3D-Printed Impedance Micropump for Continuous Perfusion of the Sample and Nutrient Medium Integrated with a Liver-On-Chip Prototype

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Rapid Prototyping of Thermoplastic Microfluidic 3D Cell Culture Devices by Creating Regional Hydrophilicity Discrepancy

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Three-Dimensional Organoids as a Model to Study Nonalcoholic Fatty Liver Disease

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How effective are nonalcoholic fatty liver disease models for drug discovery?

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Developments and Applications of Liver-on-a-Chip Technology—Current Status and Future Prospects

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Comparison of Two Hydrological Models, the HEC-HMS and Nash Models, for Runoff Estimation in Michałówka River

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Predicting anti-tumor efficacy of multi-functional nanomedicine on decellularized hepatocellular carcinoma-on-a-chip

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Isolation of Hepatocytes from Liver Tissue by a Novel, Semi-Automated Perfusion Technology

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Roadmap to DILI research in Europe. A proposal from COST action ProEuroDILINet

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From fatty hepatocytes to impaired bile flow: Matching model systems for liver biology and disease

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Novel Explanted Human Liver Model to Assess Hepatic Extraction, Biliary Excretion and Transporter Function

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Lessons Learned from Liver-on-Chip Platform

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Electrospun Microfibers Modulate Intracellular Amino Acids in Liver Cells via Integrin β1

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Engineering physiological environments to advance kidney organoid models from human pluripotent stem cells

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Development of an alcoholic liver disease model for drug evaluation from human induced pluripotent stem cell-derived liver organoids

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Multiorgan-on-a-chip: an advanced platform for disease modeling, drug toxicity assessment, and therapeutic screening

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EASL position paper on preclinical models of steatotic liver disease

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Application of microfluidic technologies in veterinary science with a view toward development of animal‐on‐a‐chip models

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Advanced strategies in organoid/organ-on-a-chip for food safety and nutrition

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Biomimic organ architectures and functions by assembling organoid models

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Liver-on-a-Chip (LoC) Models: Case Studies of Academic Platforms and Commercial Products

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Therapeutic potential of TMSC-Exo for non-alcoholic fatty liver disease using the liver-on-a-chip model

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Recent Updates on Metal-Polymer Nanocomposites in 3D Bioprinting for Tissue Engineering Applications

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Experimental Models for Studying Structural and Functional State of the Pathological Liver (Review)

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Progress in the application of organoids for exploring the relationship between macrophages and various lung diseases

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Potential Applications of Microfluidics to Acute Kidney Injury Associated with Viral Infection

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Advances and Challenges in 3D Modelling of Organ-on-a-Chip Devices with a Focus on the Glomerular Basement Membrane (GBM) and Tubular Systems: A Critical Review

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Organs-on-chips Provide Insights into Molecular Mechanisms of Disease and Facilitate the Design of Newer Treatment Strategies: A Concise Review

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Fabrication of a novel porous silicon biomembrane for applications in organ-on-chip technology

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Liver-on-a-chip

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Organs-on-a-Chip: Principles and Applications

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Novel Fabrication Approach of a Porous Silicon Biocompatible Membrane Evaluated within a Alveolar Coculture ModelPreprint

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Allogeneic HLA Humoral Immunogenicity and the Prediction of Donor-Specific HLA Antibody Development

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Extracellular matrix cues as drivers of liver zonation: A framework for in vitro biomaterial design

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Functional Liver Cell–Based Platforms in Biomedical Research

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Revolutionizing drug discovery and development: A comprehensive review of microfluidics in the pharmaceutical industry

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Organ-on-Chip: The Advancing Microfluidic Technology for Theranostics

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Road map for primary hepatocyte qualification in human liver organ models

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Scalable synthetic peptide hydrogel enables self-organized luminal cavity architecture within hiPSC 3D colonies supporting functional hepatocyte differentiation

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Utilization of multicellular liver-on-chip to study non-alcohol-related fatty liver disease

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A perfusable human liver-on-a-chip platform for modeling non-alcoholic hepatic steatosis and drug testing

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