The Pruritus of Cholestasis

Physicians Desk Reference

Arky, R. A. (1994) · Cited by 2,632

Clinical applications of visual analogue scales: a critical review

McCormack, H. M., Horne, D. J. D. L., & Sheather, S. J. (1988) · Psychological Medicine · doi:10.1017/s0033291700009934 · Cited by 2,108

Primary Biliary Cirrhosis

Kaplan, M. M. (1987) · New England Journal of Medicine · doi:10.1056/nejm198702263160907 · Cited by 2,016

Diseases of the Liver and Biliary System

(2001) · Wiley eBooks · doi:10.1002/9780470986820 · Cited by 1,824

Opioid analgesics and antagonists

Reisine, T. (1996) · Medical Entomology and Zoology · Cited by 1,205

Goodman and Gilman's The Pharmacological Basis of Therapeutics

Hastings, R. C., & Long, G. W. (1991) · JAMA · doi:10.1001/jama.1991.03460200114048 · Cited by 1,063

Specific C-Receptors for Itch in Human Skin

Schmelz, M., Schmidt, R., Bickel, A., Handwerker, H. O., & Torebjörk, H. E. (1997) · Journal of Neuroscience · doi:10.1523/jneurosci.17-20-08003.1997 · Cited by 912

Identification of a human nuclear receptor defines a new signaling pathway for CYP 3 A induction

Bertilsson, G., Heidrich, J., Svensson, K., Åsman, M., Jendeberg, L., Sydow‐Báckman, M., OHLSSON, R. I., Postlind, H., Blomquist, P., & Berkenstam, A. L. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.21.12208 · Cited by 876

Effects of Naloxone Infusions in Patients with the Pruritus of Cholestasis: A Double-Blind, Randomized, Controlled Trial

Bergasa, N. V., Alling, D. W., Talbot, T. L., Swain, M. G., Yurdaydin, C., Turner, M. L., Schmitt, J. M., Walker, E. C., & Jones, E. A. (1995) · Annals of Internal Medicine · doi:10.7326/0003-4819-123-3-199508010-00001 · Cited by 365

Oral naltrexone treatment for cholestatic pruritus: A double-blind, placebo-controlled study

Wolfhagen, F., Sternieri, E., Hop, W., Vitale, G., Bertolotti, M., & Van Buuren, H. (1997) · Gastroenterology · doi:10.1053/gast.1997.v113.pm9322521 · Cited by 343

A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis

Nevens, F., Andreone, P., Mazzella, G., Strasser, S. I., Bowlus, C., Invernizzi, P., Drenth, J. P. H., Pockros, P. J., Regula, J., Beuers, U., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1509840 · Cited by 1,131

Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ

Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. S. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 693

Intrahepatic cholestasis of pregnancy: molecular pathogenesis, diagnosis and management

Lammert, F., Marschall, H., Glantz, A., & Matern, S. (2000) · Journal of Hepatology · doi:10.1016/s0168-8278(00)80139-7 · Cited by 523

Organic Anion-Transporting Polypeptides Mediate Transport of Opioid Peptides across Blood-Brain Barrier

Gao, B., Hagenbuch, B., Kullak-Ublick, G. A., Benke, D., Aguzzi, A., & Meier, P. J. (2000) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)39041-x · Cited by 413

Itch: scratching more than the surface

Twycross, R. (2003) · QJM · doi:10.1093/qjmed/hcg002 · Cited by 412

Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus

Kremer, A. E., Martens, J. J. W. W., Kulik, W., Ruëff, F., Kuiper, E. M. M., van Buuren, H. R., van Erpecum, K. J., Kondrackiene, J., Prieto, J., Rust, C., et al. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.05.009 · Cited by 410

European S2k Guideline on Chronic Pruritus

Weißhaar, E., Szepietowski, J. C., Dalgard, F. J., Garcovich, S., Gieler, U., Giménez‐Arnau, A. M., Lambert, J., Leslie, T. A., Mettang, T., Misery, L., et al. (2019) · Acta Dermato Venereologica · doi:10.2340/00015555-3164 · Cited by 405

Drug-induced cholestasis

Padda, M. S., Sanchez, M. J., Akhtar, A. J., & Boyer, J. L. (2011) · Hepatology · doi:10.1002/hep.24229 · Cited by 399

Itch

Yosipovitch, G., Greaves, M. W., & Schmelz, M. (2003) · The Lancet · doi:10.1016/s0140-6736(03)12570-6 · Cited by 388

Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids

Liu, X., Liu, Z., Sun, Y.-G., Ross, M. H., Kim, S., Tsai, F.-F., Li, Q., Jeffry, J. A., Kim, J.-Y., Loh, H. H., et al. (2011) · Cell · doi:10.1016/j.cell.2011.08.043 · Cited by 289

Development, validation, and evaluation of the PBC-40, a disease specific health related quality of life measure for primary biliary cirrhosis

Jacoby, A., Rannard, A., Buck, D., Bhala, N. B., Newton, J. L., James, O., & Jones, D. E. J. (2005) · Gut · doi:10.1136/gut.2005.065862 · Cited by 272

Neuraxial opioid-induced pruritus: a review

Szarvas, S., Harmon, D. C., & Murphy, D. B. (2003) · Journal of Clinical Anesthesia · doi:10.1016/s0952-8180(02)00501-9 · Cited by 206

Hepatitis and liver dysfunction with rifampicin therapy for pruritus in primary biliary cirrhosis

Prince, M. I., Burt, A. D., & Jones, D. E. J. (2002) · Gut · doi:10.1136/gut.50.3.436 · Cited by 202

Efficacy and safety of oral naltrexone treatment for pruritus of cholestasis, a crossover, double blind, placebo-controlled study

Terg, R., Coronel, E., Sordá, J., Muñoz, A. E., & Findor, J. (2002) · Journal of Hepatology · doi:10.1016/s0168-8278(02)00318-5 · Cited by 199

Mirtazapine for Pruritus

Davis, M. P., Frandsen, J. L., Walsh, D., Andresen, S. W., & Taylor, S. (2003) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(02)00645-0 · Cited by 196

New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms?

Liu, T., & Ji, R. (2013) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-013-1284-2 · Cited by 194

Primary biliary cirrhosis

Hohenester, S. D., Elferink, R. P. J. O., & Beuers, U. H. (2009) · Seminars in Immunopathology · doi:10.1007/s00281-009-0164-5 · Cited by 178

Understanding Pruritus in Systemic Disease

Krajnik, M., & Żylicz, Z. (2001) · Journal of Pain and Symptom Management · doi:10.1016/s0885-3924(00)00256-6 · Cited by 162

Involvement of central μ-opioid system in the scratching behavior in mice, and the suppression of it by the activation of κ-opioid system

Umeuchi, H., Togashi, Y., Honda, T., Nakao, K., Okano, K., Tanaka, T., & Nagase, H. (2003) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2003.08.007 · Cited by 146

Long-Term Efficacy of Sertraline As A Treatment for Cholestatic Pruritus in Patients With Primary Biliary Cirrhosis

Browning, J., Combes, B., & Mayo, M. J. (2003) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2003.08662.x · Cited by 135

Pathogenesis and Treatment of Pruritus in Cholestasis

Kremer, A. E., Beuers, U. H., Elferink, R. P. J. O., & Pusl, T. (2008) · Drugs · doi:10.2165/00003495-200868150-00006 · Cited by 128

Pruritus: Progress toward Pathogenesis and Treatment

Song, J., Xian, D., Yang, L., Xiong, X., Lai, R., & Zhong, J. (2018) · BioMed Research International · doi:10.1155/2018/9625936 · Cited by 124

Characterisation of the associations and impact of symptoms in primary biliary cirrhosis using a disease specific quality of life measure

Newton, J. L., Bhala, N., Burt, J., & Jones, D. E. J. (2006) · Journal of Hepatology · doi:10.1016/j.jhep.2005.12.012 · Cited by 121

Genetic defects in hepatobiliary transport

Elferink, R. P. J. O., & Groen, A. K. (2002) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/s0925-4439(01)00103-x · Cited by 119

Treatment of resistant pruritus from cholestasis with albumin dialysis: Combined analysis of patients from three centers

Parés, A. R., Herrera, M., Avilés, J., Sanz, M., & Mas, A. (2010) · Journal of Hepatology · doi:10.1016/j.jhep.2010.02.031 · Cited by 116

The effect of liver transplantation on fatigue in patients with primary biliary cirrhosis: a prospective study

Carbone, M., Bufton, S., Monaco, A., Griffiths, L., Jones, D. E., & Neuberger, J. M. (2013) · Journal of Hepatology · doi:10.1016/j.jhep.2013.04.017 · Cited by 115

A neural pathway for itch

Schmelz, M. (2001) · Nature Neuroscience · doi:10.1038/82956 · Cited by 113

Opiate antagonist therapy for the pruritus of cholestasis: the avoidance of opioid withdrawal-like reactions

Jones, E. A. (2002) · QJM · doi:10.1093/qjmed/95.8.547 · Cited by 107

Gabapentin in patients with the pruritus of cholestasis: a double-blind, randomized, placebo-controlled trial

Bergasa, N. V., McGee, M., Ginsburg, I. H., & Engler, D. (2006) · Hepatology · doi:10.1002/hep.21370 · Cited by 107

Pathophysiology and current management of pruritus in liver disease

Kremer, A. E., Elferink, R. P. J. O., & Beuers, U. H. (2011) · Clinics and Research in Hepatology and Gastroenterology · doi:10.1016/j.clinre.2010.10.007 · Cited by 107

Efficacy of nalfurafine hydrochloride in patients with chronic liver disease with refractory pruritus: A randomized, double‐blind trial

Kumada, H., Miyakawa, H., Muramatsu, T., Ando, N., Oh, T., Takamori, K., & Nakamoto, H. (2016) · Hepatology Research · doi:10.1111/hepr.12830 · Cited by 105

Effect of ondansetron, a 5-HT 3 receptor antagonist, on fatigue in chronic hepatitis C: a randomised, double blind, placebo controlled study

Piche, T., Vanbiervliet, G., Cherikh, F., Antoun, Z., Huet, P., Gelsi, E., Demarquay, J.-F., Caroli‐Bosc, F., Benzaken, S., Rigault, M.-C., et al. (2005) · Gut · doi:10.1136/gut.2004.055251 · Cited by 101

A Randomized, Controlled, Phase 2 Study of Maralixibat in the Treatment of Itching Associated With Primary Biliary Cholangitis

Mayo, M. J., Pockros, P. J., Jones, D. E., Bowlus, C. L., Levy, C., Patanwala, I., Bacon, B. R., Luketic, V. A., Vuppalanchi, R., MEDENDORP, S. V., et al. (2019) · Hepatology Communications · doi:10.1002/hep4.1305 · Cited by 100

Receptors, cells and circuits involved in pruritus of systemic disorders

Kremer, A. E., Feramisco, J. D., Reeh, P. W., Beuers, U. H., & Elferink, R. P. J. O. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2014.02.007 · Cited by 97

Primary sclerosing cholangitis

Silveira, M. G., & Lindor, K. D. (2008) · Canadian Journal of Gastroenterology · doi:10.1155/2008/824168 · Cited by 94

Long‐term clinical impact and cost‐effectiveness of obeticholic acid for the treatment of primary biliary cholangitis

Samur, S., Klebanoff, M., Banken, R., Pratt, D. S., Chapman, R., Ollendorf, D. A., Loos, A. M., Corey, K., Hur, C., & Chhatwal, J. (2017) · Hepatology · doi:10.1002/hep.28932 · Cited by 89

Effect of oral naltrexone on pruritus in cholestatic patients

Mansour-Ghanaei, F. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i7.1125 · Cited by 89

Pharmacological interventions for pruritus in adult palliative care patients

Siemens, W., Xander, C. J., Meerpohl, J. J., Buroh, S., Antes, G., Schwarzer, G., & Becker, G. (2016) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008320.pub3 · Cited by 88

Pathogenesis and Management of Pruritus in PBC and PSC

Kremer, A. E., Namer, B., Bolier, R., Fischer, M. J. M., Elferink, R. P. J. O., & Beuers, U. H. (2015) · Digestive Diseases · doi:10.1159/000440829 · Cited by 84

Advances in Pathogenesis and Management of Pruritus in Cholestasis

Kremer, A. E., Bolier, R., van Dijk, R., Elferink, R. P. J. O., & Beuers, U. H. (2014) · Digestive Diseases · doi:10.1159/000360518 · Cited by 81

Endogenous opiates: 1999

Vaccarino, A. L., & Kastin, A. J. (2000) · Peptides · doi:10.1016/s0196-9781(00)00345-4 · Cited by 79

Florid opioid withdrawal-like reaction precipitated by naltrexone in a patient with chronic cholestasis

Jones, E. A., & Dekker, L. R. C. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70225-3 · Cited by 78

Pruritus may precede abnormal liver function tests in pregnant women with obstetric cholestasis: a longitudinal analysis

Kenyon, A. P., Piercy, C. N., Girling, J., Williamson, C., Tribe, R. M., & Shennan, A. H. (2001) · BJOG An International Journal of Obstetrics & Gynaecology · doi:10.1016/s0306-5456(01)00281-9 · Cited by 78

Good Maternal and Fetal Outcomes for Pregnant Women With Primary Biliary Cirrhosis

Trivedi, P. J., Kumagi, T., Al-Harthy, N., Coltescu, C., Ward, S., Cheung, A., & Hirschfield, G. M. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.11.030 · Cited by 77

Pain as a complication of use of opiate antagonists for symptom control in cholestasis

Mcrae, C. A., Prince, M. I., Hudson, M., Day, C. P., James, O. F. W., & Jones, D. E. J. (2003) · Gastroenterology · doi:10.1016/s0016-5085(03)00879-5 · Cited by 73

Evaluation of Liver Function

Pincus, M. R., Tierno, P. M., Fenelus, M., Bowne, W. B., & Bluth, M. H. (2011) · Elsevier eBooks · doi:10.1016/b978-1-4377-0974-2.00021-x · Cited by 73

Intrahepatic cholestasis of pregnancy

Lammert, F., Marschall, H., & Matern, S. (2003) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-003-0013-x · Cited by 69

Pruritus in systemic disease: mechanisms and management

Etter, L., & Myers, S. A. (2002) · Dermatologic Clinics · doi:10.1016/s0733-8635(02)00011-6 · Cited by 67

Unmet clinical need in autoimmune liver diseases

Dyson, J. K., Webb, G., Hirschfield, G. M., Lohse, A., Beuers, U., Lindor, K., & Jones, D. E. J. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2014.09.010 · Cited by 66

Role of Spinal Neurotransmitter Receptors in Itch: New Insights into Therapies and Drug Development

Cevikbas, F., Steinhoff, M. S., & Ikoma, A. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00201.x · Cited by 66

A randomized, placebo‐controlled clinical trial of efficacy and safety: modafinil in the treatment of fatigue in patients with primary biliary cirrhosis

Silveira, M. G., Gossard, A. A., Stahler, A. C., Jorgensen, R. A., Petz, J. L., Ali, A. H., & Lindor, K. D. (2017) · American Journal of Therapeutics · doi:10.1097/mjt.0000000000000387 · Cited by 64

Itch: More than Skin Deep

Greaves, M. W., & Khalifa, N. (2004) · International Archives of Allergy and Immunology · doi:10.1159/000080898 · Cited by 64

Liver transplantation for intractable pruritus is contraindicated before an adequate trial of opiate antagonist therapy

Neuberger, J., & Jones, E. A. (2001) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200111000-00022 · Cited by 60

Efficacy of lidocaine in the treatment of pruritus in patients with chronic cholestatic liver diseases

Villamil, A., Bandi, J. C., Galdame, O., Gerona, S., & Gadano, A. C. (2005) · The American Journal of Medicine · doi:10.1016/j.amjmed.2005.05.031 · Cited by 58

Clinical features and management of primary sclerosing Cholangitis

Silveira, M. G., & Lindor, K. D. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3338 · Cited by 59

Systematic review: management options for primary sclerosing cholangitis and its variant forms - IgG4-associated cholangitis and overlap with autoimmune hepatitis

Culver, E. L., & Chapman, R. W. (2011) · Alimentary Pharmacology & Therapeutics · doi:10.1111/j.1365-2036.2011.04658.x · Cited by 57

Itch in systemic disease: therapeutic options

Greaves, M. W. (2005) · Dermatologic Therapy · doi:10.1111/j.1529-8019.2005.00036.x · Cited by 56

Long-term efficacy and safety of nalfurafine hydrochloride on pruritus in chronic liver disease patients: Patient-reported outcome based analyses

Kamimura, K., Yokoo, T., Kamimura, H., Sakamaki, A., Abe, S., Tsuchiya, A., Takamura, M., Kawai, H., Yamagiwa, S., & Terai, S. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178991 · Cited by 55

Treatment of Pruritus Secondary to Liver Disease

Düll, M. M., & Kremer, A. E. (2019) · Current Gastroenterology Reports · doi:10.1007/s11894-019-0713-6 · Cited by 53

Recent advances in the management of pruritus in chronic liver diseases

Tajiri, K., & Shimizu, Y. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i19.3418 · Cited by 55

Fatigue in primary biliary cirrhosis

Abbas, G., Jorgensen, R. A., & Lindor, K. D. (2010) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/nrgastro.2010.62 · Cited by 51

Endogenous Opioids Modulate the Growth of the Biliary Tree in the Course of Cholestasis

Marzioni, M., Alpini, G. D., Saccomanno, S., Minicis, S. D., Glaser, S. S., Francis, H., Trozzi, L., Venter, J., Orlando, F., Fava, G., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.02.021 · Cited by 51

Jaundice associated pruritis: A review of pathophysiology and treatment

Bassari, R. (2015) · World Journal of Gastroenterology · doi:10.3748/wjg.v21.i5.1404 · Cited by 50

A systematic approach to the management of cholestatic pruritus in primary biliary cirrhosis

Hegade, V. S., Bolier, R., Elferink, R. P. J. O., Beuers, U. H., Kendrick, S. F. W., & Jones, D. E. (2015) · Frontline Gastroenterology · doi:10.1136/flgastro-2015-100618 · Cited by 48

Primary biliary cirrhosis

Nguyen, D. L., Juran, B. D., & Lazaridis, K. N. (2010) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2010.07.006 · Cited by 46

Clinical features and management of primary biliary cirrhosis

Crosignani, A., Battezzati, P. M., Invernizzi, P., Selmi, C. F., Prina, E., & Podda, M. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3313 · Cited by 46

Peripheral and spinal 5-HT receptors participate in cholestatic itch and antinociception induced by bile duct ligation in rats

Tian, B., Wang, X., Huang, Y., Chen, L., Cheng, R.-X., Zhou, F.-M., Guo, R., Li, J., & Liu, T. (2016) · Scientific Reports · doi:10.1038/srep36286 · Cited by 45

Extrahepatic manifestations of cholestasis

Glasová, H., & Beuers, U. H. (2002) · Journal of Gastroenterology and Hepatology · doi:10.1046/j.1440-1746.2002.02717.x · Cited by 43

Complications, symptoms, quality of life and pregnancy in cholestatic liver disease

Zakharia, K., Tabibian, A., Lindor, K. D., & Tabibian, J. H. (2018) · Liver International · doi:10.1111/liv.13591 · Cited by 42

Pharmacological interventions for pruritus in adult palliative care patients

Xander, C. J., Meerpohl, J. J., Galandi, D., Buroh, S., Schwarzer, G., Antes, G., & Becker, G. (2013) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008320.pub2 · Cited by 40

Low risk of hepatotoxicity from rifampicin when used for cholestatic pruritus: a cross‐disease cohort study

Webb, G. J., Rahman, S. R., Levy, C., & Hirschfield, G. M. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14579 · Cited by 39

Pruritus in advanced internal diseases Pathogenesis and treatment

Krajnik, M. (2001) · The Netherlands Journal of Medicine · doi:10.1016/s0300-2977(00)00084-x · Cited by 39

Primary sclerosing cholangitis - What is the difference between east and west?

Shorbagi, A., & Bayraktar, Y. (2008) · World Journal of Gastroenterology · doi:10.3748/wjg.14.3974 · Cited by 38

Newer Approaches to the Management of Pruritus in Cholestatic Liver Disease

Düll, M. M., & Kremer, A. E. (2020) · Current Hepatology Reports · doi:10.1007/s11901-020-00517-x · Cited by 42

Diagnostic and therapeutic approach to cholestatic liver disease

Perez, M. T., Serrano, P. L., Tomás, E., Gutiérrez, M. L. G., Lledó, J. L., Cacho, G., Santander, C., & Fernández‐Rodríguez, C. (2004) · Revista Española de Enfermedades Digestivas · doi:10.4321/s1130-01082004000100008 · Cited by 38

Pruritus in cancer patients

Lidstone, V., & Thorns, A. (2001) · Cancer Treatment Reviews · doi:10.1053/ctrv.2001.0231 · Cited by 38

Medical Treatment of Cholestatic Liver Disease

Paumgartner, G., & Pusl, T. (2008) · Clinics in Liver Disease · doi:10.1016/j.cld.2007.11.013 · Cited by 38

Treatment of cholestatic pruritus in children

Cies, J. J., & Giamalis, J. (2007) · American Journal of Health-System Pharmacy · doi:10.2146/ajhp060453 · Cited by 37

How stress triggers itch: a preliminary study of the mechanism of stress‐induced pruritus using f MRI

Kim, H. J., Park, J. B., Lee, J., & Kim, I. H. (2015) · International Journal of Dermatology · doi:10.1111/ijd.12864 · Cited by 36

Autotaxin, Pruritus and Primary Biliary Cholangitis (PBC)

Sun, Y. H., Zhang, W., Evans, J. F., Floreani, A., Zou, Z., Nishio, Y., Qi, R., Leung, P. S. C., Bowlus, C. L., & Gershwin, M. E. (2016) · Autoimmunity Reviews · doi:10.1016/j.autrev.2016.03.019 · Cited by 36

Up-regulation of central mu–opioid receptors in a model of hepatic encephalopathy: A potential mechanism for increased sensitivity to morphine in liver failure

Bergasa, N. V., Rothman, R. B., Mukerjee, E., Vergalla, J., & Jones, E. A. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01487-x · Cited by 36

Molecular Adsorbents Recirculating System dialysis in children with cholestatic pruritus

Schaefer, B., Schaefer, F. S., Wittmer, D., Engelmann, G., Wenning, D., & Schmitt, C. P. (2011) · Pediatric Nephrology · doi:10.1007/s00467-011-2058-8 · Cited by 35

Antidepressants as antipruritic agents: A review

Kaur, R., & Sinha, V. R. (2018) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2018.01.007 · Cited by 34

Control of Cholangiocyte Adaptive Responses by Visceral Hormones and Neuropeptides

Marzioni, M., Fava, G., Alvaro, D., Alpini, G. D., & Benedetti, A. (2008) · Clinical Reviews in Allergy & Immunology · doi:10.1007/s12016-008-8090-1 · Cited by 32

Itch: Cells, Molecules, and Circuits

Patel, K., & Dong, X. (2010) · ACS Chemical Neuroscience · doi:10.1021/cn100085g · Cited by 31

Use of Oral Naltrexone for Severe Pruritus Due to Cholestatic Liver Disease in Children

Zellos, A., Roy, A., & Schwarz, K. B. (2010) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3181eb5ac0 · Cited by 30

Gabapentin for Pruritus in Palliative care

Anand, S. (2012) · American Journal of Hospice and Palliative Medicine® · doi:10.1177/1049909112445464 · Cited by 28

Multidisciplinary approach to benign biliary strictures

Costamagna, G., Familiari, P., Tringali, A., & Mutignani, M. (2007) · Current Treatment Options in Gastroenterology · doi:10.1007/s11938-007-0061-8 · Cited by 28

Fatigue in cholestatic liver disease—a perplexing symptom

Kumar, D., & Tandon, R. K. (2002) · Postgraduate Medical Journal · doi:10.1136/pmj.78.921.404 · Cited by 26

The Value of MRI in the Diagnosis of Primary Biliary Cirrhosis and Assessment of Liver Fibrosis

Meng, Y., Liang, Y., & Liu, M. (2015) · PLoS ONE · doi:10.1371/journal.pone.0120110 · Cited by 26

Treatment of Pruritus Associated with Systemic Disorders in the Elderly

Lonsdale-Eccles, A. A., & Carmichael, A. (2003) · Drugs & Aging · doi:10.2165/00002512-200320030-00004 · Cited by 26

Intestinal inflammation alters the susceptibility to pentylenetetrazole‐induced seizure in mice

Riazi, K., Honar, H., Homayoun, H., Demehri, S., Bahadori, M., & Dehpour, A. R. (2004) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2003.03284.x · Cited by 25

What has dry cough in common with pruritus? treatment of dry cough with paroxetine

Żylicz, Z., & Krajnik, M. (2004) · Journal of Pain and Symptom Management · doi:10.1016/j.jpainsymman.2003.06.007 · Cited by 25

Cholestasis induced antinociception and decreased gene expression of MOR1 in rat brain

Ahmadi, S., Karami, Z., Mohammadian, A., Khosrobakhsh, F., & Rostamzadeh, J. (2014) · Neuroscience · doi:10.1016/j.neuroscience.2014.08.063 · Cited by 24

Understanding and Treating Pruritus in Primary Biliary Cholangitis

Carrion, A. F., Rosen, J. D., & Levy, C. (2018) · Clinics in Liver Disease · doi:10.1016/j.cld.2018.03.005 · Cited by 24

Cholestasis

Elferink, R. P. J. O. (2003) · Gut · doi:10.1136/gut.52.suppl_2.ii42 · Cited by 25

Successful use of the Molecular Adsorbent Recirculating System (MARS) in a patient with primary biliary cirrhosis (PBC) and treatment refractory pruritus

Müllhaupt, B. (2003) · Hepatology Research · doi:10.1016/s1386-6346(02)00310-8 · Cited by 23

Endogenous opioid peptides and chronic liver disease: From bedside to bench

Marzioni, M., Svegliati‐Baroni, G., Alpini, G. D., & Benedetti, A. (2007) · Journal of Hepatology · doi:10.1016/j.jhep.2007.01.006 · Cited by 23

Diagnosis and management of primary biliary cirrhosis

Ali, A. H., Carey, E. J., & Lindor, K. D. (2014) · Expert Review of Clinical Immunology · doi:10.1586/1744666x.2014.979792 · Cited by 23

Recent advances in pathophysiological mechanisms of itch

Tominaga, M., & Takamori, K. (2010) · Expert Review of Dermatology · doi:10.1586/edm.10.7 · Cited by 22

Cholestasis

Kuntz, E., & Kuntz, H.-D. (2002) · Springer eBooks · doi:10.1007/978-3-662-04680-7_13

Pruritis associated with cholestasis

Khandelwal, M., & Malet, P. F. (1994) · Digestive Diseases and Sciences · doi:10.1007/bf02090052 · Cited by 46

[Pruritus and cholestasis].

Baumgarten, R. (1991) · PubMed

The pruritus of cholestasis: treatment options

Bergasa, N. V. (2007) · Springer eBooks · doi:10.1007/1-4020-2916-0_19

The Pruritus of Cholestasis: ten years into the 21th Century

Bergasa, N. V. (2011) · Medicina Universitaria