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The Pruritus of Cholestasis
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“Although pruritus is the most common symptom in patients with primary biliary cholangitis, neither its incidence nor its severity correlates with disease stage. 29,30”
From A Placebo-Controlled Trial of Obeticholic Acid in Primary Biliary Cholangitis (2016) · cites this paper as [30]
Citations
Cites
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Self-citationOral naltrexone treatment for cholestatic pruritus: A double-blind, placebo-controlled study
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A controlled trial of naloxone infusions for the pruritus of chronic cholestasis
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Self-citationTreatment of pruritus of primary biliary cirrhosis with rifampin
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Treatment of pruritus in primary biliary cirrhosis with rifampin
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Effects of long-term rifampicin administration in primary biliary cirrhosis
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COMPARISON OF RIFAMPICIN WITH PHENOBARBITONE FOR TREATMENT OF PRURITUS IN BILIARY CIRRHOSIS
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Rifampin-Induced Methadone Withdrawal
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Hypothesis The Pruritus of Cholestasis: From Bile Acids to Opiate Agonists
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Self-citationOpen‐label trial of oral nalmefene therapy for the pruritus of cholestasis
Bergasa, N. V., Schmitt, J. M., Talbot, T. L., Alling, D. W., Swain, M. G., Turner, M. L., Jenkins, J. B., & Jones, A. E. (1998) · Hepatology · doi:10.1002/hep.510270307 · Cited by 182
Self-citationCholestyramine for long term relief of the pruritus complicating intrahepatic cholestasis
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Endogenous opioids accumulate in plasma in a rat model of acute cholestasis
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Self-citationOral S-adenosylmethionine in the symptomatic treatment of intrahepatic cholestasis
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Relief of Intractable Pruritus With Naloxone
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Subhypnotic Doses of Propofol Relieve Pruritus Induced by Epidural and Intrathecal Morphine
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Peptide transport systems for opiates across the blood-brain barrier
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The pruritus of cholestasis: Potential pathogenic and therapeutic implications of opioids
Bergasa, N. V., & Jones, E. A. (1995) · Gastroenterology · doi:10.1016/0016-5085(95)90709-2 · Cited by 128
Self-citationCentral mu-opioid receptors are down-regulated in a rat model of cholestasis
Bergasa, N. V., Rothman, R. B., Vergalla, J., Xu, H., Swain, M. G., & Jones, E. A. (1992) · Journal of Hepatology · doi:10.1016/0168-8278(92)90040-v · Cited by 127
Self-citationPhenobarbital Effects in Cholestatic Liver Disease
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Rifampin relieves pruritus in children with cholestatic liver disease
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Cholestasis in the male rat is associated with naloxone-reversible antinociception
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Self-citationOndansetron for pruritus due to cholestasis
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Gabapentin treatment for brachioradial pruritus
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EXPERIMENTAL STUDY OF ITCH STIMULI IN ANIMALS
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Clinical and biochemical expression of the histopathological lesions of primary biliary cirrhosis
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Role of plasmapheresis in primary biliary cirrhosis.
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Testosterone Therapy for the Pruritus of Obstructive Jaundice
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Cholestasis is associated with preproenkephalin mRNA expression in the adult rat liver
Bergasa, N. V., Sabol, S. L., Young, W. S., Kleiner, D. E., & Jones, E. A. (1995) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.1995.268.2.g346 · Cited by 85
Self-citationPilot study of the use of naltrexone to treat the severe pruritus of cholestatic liver disease.
Carson, K. L., Tran, T. T., Cotton, P. B., Sharara, A. I., & Hunt, C. M. (1996) · PubMed · Cited by 83
Jinks, S. L., & Carstens, E. (2000) · Journal of Neurophysiology · doi:10.1152/jn.2000.84.2.616 · Cited by 81
Effects of central administration of opioids on facial scratching in monkeys
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Improvement of cholestatic pruritus by ondansetron
Schwörer, H., & Ramadori, G. (1993) · The Lancet · doi:10.1016/0140-6736(93)91178-o · Cited by 79
Jones, E. A., & Dekker, L. R. C. (2000) · Gastroenterology · doi:10.1016/s0016-5085(00)70225-3 · Cited by 78
Further studies of scratching during sleep
Savin, J. A., Paterson, W. D., OSWALD, I., & Adam, K. (1975) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1975.tb06495.x · Cited by 78
Subhypnotic doses of propofol relieve pruritus associated with liver disease
Borgeat, A., Wilder‐Smith, O. H. G., & Mentha, G. (1993) · Gastroenterology · doi:10.1016/0016-5085(93)90858-a · Cited by 77
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Pruritus as a Presenting Symptom of Chronic Hepatitis C
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Self-citationTREATMENT OF PRURITUS OF CHOLESTASIS BY PLASMA PERFUSION THROUGH USP-CHARCOAL-COATED GLASS BEADS
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Self-citationRifampicin-induced elevation of serum bile acids in man
Galeazzi, R. L., Lorenzini, I., & Orlandi, F. (1980) · Digestive Diseases and Sciences · doi:10.1007/bf01308307 · Cited by 65
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The Effects of Naloxone Associated with the Intrathecal Use of Morphine in Labor
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Pruritus of cholestasis is related to effects of bile salts on the liver, not the skin.
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Application of piezo film technology for the quantitative assessment of pruritus.
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Self-citationParoxysmal itching in multiple sclerosis
OSTERMAN, P. O. (1976) · British Journal of Dermatology · doi:10.1111/j.1365-2133.1976.tb00869.x · Cited by 59
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Unilateral neurogenic pruritus following stroke.
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Management of the pruritus of cholestasis: potential role of opiate antagonists.
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Treatment of Opioid‐Induced Pruritus with Ondansetron: Report of Four Patients
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Unilateral Pruritus After a Stroke
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Improved device for measuring scratching activity in patients with pruritus
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Itch: scratching more than the surface
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Metadata
- Authors
- Jones, A. E., & Bergasa, N. V.
- Affiliations
- Mount Sinai Beth Israel (US)
- Venue
- Hepatology
- Published
- 1999-04
- Volume
- 29
- Issue
- 4
- Pages
- 1003-1006
- ISSN
- 0270-9139 (ISSN-L)
- OpenAlex
- W1993679764
- Cited by
- 202
- References
- 97
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 6 · 2017: 8 · 2016: 9 · 2015: 9 · 2014: 6 · 2013: 7 · 2012: 5
- FWCI
- 2.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Hepatology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Liver Diseases and Immunity
- Health Sciences › Medicine › Dermatology › Dermatology and Skin Diseases
- Health Sciences › Medicine › Surgery › Pediatric Hepatobiliary Diseases and Treatments
- Keywords
- pruritus, cholestasis, biliary obstruction
- MeSH terms
- Animals, Cholestasis, Humans, Liver, Narcotic Antagonists, Narcotics, Pruritus, Receptors, Opioid, Receptors, Serotonin, Serotonin Antagonists, Skin, Liver Transplantation
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