The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Alterations in the gut microbiome of children with severe ulcerative colitis
Open accessAbstract
BACKGROUND: Although the role of microbes in disease pathogenesis is well established, data describing the variability of the vast microbiome in children diagnosed with ulcerative colitis (UC) are lacking. This study characterizes the gut microbiome in hospitalized children with severe UC and determines the relationship between microbiota and response to steroid therapy. METHODS: Fecal samples were collected from 26 healthy controls and 27 children hospitalized with severe UC as part of a prospective multicenter study. DNA extraction, polymerase chain reaction (PCR) amplification of bacterial 16S rRNA, and microarray hybridization were performed. Results were analyzed in GeneSpring GX 11.0 comparing healthy controls with children with UC, and steroid responsive (n = 17) with nonresponsive patients (n = 10). RESULTS: Bacterial signal strength and distribution showed differences between UC and healthy controls (adjusted P < 0.05) for Phylum, Class, Order, Family, Genus, and Phylospecies levels with reduction in Clostridia and an increase in Gamma-proteobacteria. The number of microbial phylospecies was reduced in UC (266 ± 69) vs. controls (758 ± 3, P < 0.001), as was the Shannon Diversity Index (6.1 ± 0.23 vs. 6.49 ± 0.04, respectively; P < 0.0001). Steroid nonresponders harbored fewer phylospecies than responders (142 ± 49 vs. 338 ± 62, P = 0.013). CONCLUSIONS: Richness, evenness, and biodiversity of the gut microbiome were remarkably reduced in children with UC compared with healthy controls. Children who did not respond to steroids harbored a microbiome that was even less rich than steroid responders. This study is the first to characterize the gut microbiome in a large cohort of pediatric patients with severe UC and describes changes in the gut microbiome as a potential prognostic feature.
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Cites
Bacterial Community Variation in Human Body Habitats Across Space and Time
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Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach
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Dysbiosis of the faecal microbiota in patients with Crohn’s disease and their unaffected relatives
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Decreased Diversity of the Fecal Microbiome in Recurrent Clostridium difficile–Associated Diarrhea
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Gut-associated bacterial microbiota in paediatric patients with inflammatory bowel disease
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Unstable Composition of the Fecal Microbiota in Ulcerative Colitis During Clinical Remission
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Cited by
Moayyedi, P., Surette, M. G., Kim, P. T., Libertucci, J., Wolfe, M., Onischi, C., Armstrong, D., Marshall, J. K., Kassam, Z., Reinisch, W., et al. (2015) · Gastroenterology · doi:10.1053/j.gastro.2015.04.001 · Cited by 1,499
The Intestinal Microbiome in Early Life: Health and Disease
Arrieta, M.-C., Stiemsma, L. T., Amenyogbe, N., Brown, E. M., & Finlay, B. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00427 · Cited by 1,024
Host genetic variation impacts microbiome composition across human body sites
Blekhman, R., Goodrich, J. K., Huang, K., Sun, Q., Bukowski, R., Bell, J. T., Spector, T. D., Keinan, A., Ley, R. E., Gevers, D., et al. (2015) · Genome Biology · doi:10.1186/s13059-015-0759-1 · Cited by 745
Pittayanon, R., Lau, J. T., Leontiadis, G. I., Tse, F., Yuan, Y., Surette, M., & Moayyedi, P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.294 · Cited by 623
Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?
Mosca, A., Leclerc, M., & Hugot, J. P. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00455 · Cited by 612
Metadata
- Authors
- Michail, S., Durbin, M., Turner, D., Griffiths, A. M., Mack, D. R., Hyams, J., Leleiko, N., Kenche, H., Stolfi, A., & Wine, E.
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2012-10
- Volume
- 18
- Issue
- 10
- Pages
- 1799-1808
- ISSN
- 1078-0998 (ISSN-L)
- OpenAlex
- W2124793489
- Cited by
- 284
- References
- 10
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Michail, S., Durbin, M., Turner, D., Griffiths, A. M., Mack, D. R., Hyams, J., Leleiko, N., Kenche, H., Stolfi, A., & Wine, E. (2012). Alterations in the gut microbiome of children with severe ulcerative colitis. Inflammatory Bowel Diseases. https://doi.org/10.1002/ibd.22860
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