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Cited by 612Gut microbiota and healthMicrobial Community Ecology and PhysiologyBacteriophages and microbial interactions

Gut Microbiota Diversity and Human Diseases: Should We Reintroduce Key Predators in Our Ecosystem?

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Mosca, Alexis, Leclerc, Marion, Hugot, Jean P.·2016·Frontiers in Microbiology
DOI 10.3389/fmicb.2016.00455PMC PMC4815357
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Abstract

Most of the Human diseases affecting westernized countries are associated with dysbiosis and loss of microbial diversity in the gut microbiota. The Western way of life, with a wide use of antibiotics and other environmental triggers, may reduce the number of bacterial predators leading to a decrease in microbial diversity of the Human gut. We argue that this phenomenon is similar to the process of ecosystem impoverishment in macro ecology where human activity decreases ecological niches, the size of predator populations, and finally the biodiversity. Such pauperization is fundamental since it reverses the evolution processes, drives life backward into diminished complexity, stability, and adaptability. A simple therapeutic approach could thus be to reintroduce bacterial predators and restore a bacterial diversity of the host microbiota.

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  • While the inherited genome is essentially stable for the lifetime of the host, the microbiome is immensely diverse, dynamic, and responsive to external input, enhancing its potential as a target for therapeutic intervention.

    “While our inherited genome is essentially stable for the lifetime of the host, the microbiome is immensely diverse (Mosca et al., 2016;Pasolli et al., 2019), dynamic (Lloyd-Price et al., 2017), and responsive to external input, enhancing its potential as a target for therapeutic intervention”

    From The Microbiota-Gut-Brain Axis (2019) · cites this paper as Mosca et al., 2016

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Cited by

Sorted by citations

Authors
Mosca, A., Leclerc, M., & Hugot, J. P.
Affiliations
  • Inserm (FR)
  • AgroParisTech (FR)
Corresponding author
Mosca, Alexis
ORCID
Venue
Frontiers in Microbiology
Publisher
Frontiers Media SA
Published
2016-03-31
Volume
7
Pages
455-455
ISSN
1664-302X (ISSN-L)
DOI
10.3389/fmicb.2016.00455
PMC
PMC4815357
OpenAlex
W2324431491
Cited by
612
References
21
Citations by year
2026: 33 · 2025: 42 · 2024: 72 · 2023: 86 · 2022: 120 · 2021: 89 · 2020: 59 · 2019: 53 · 2018: 30 · 2017: 24 · 2016: 3
FWCI
19.06
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Microbiology (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • Laboratoire d'Excellence Inflamex (ANR-11-IDEX-0005-02)
  • Agence Nationale de la Recherche (ANR 11 IDEX 0005-02, IDEX-0005, ANR-11-IDEX, ANR-11-IDEX-0005)
  • Institut National de la Santé et de la Recherche Médicale
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Physical Sciences › Environmental Science › Ecology › Microbial Community Ecology and Physiology
  • Physical Sciences › Environmental Science › Ecology › Bacteriophages and microbial interactions
Keywords
gut microbiota diversity, dysbiosis, bacterial predators, microbial diversity loss, antibiotic use, biodiversity loss, ecological niche, human disease, microbiota restoration

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