Photochemoprevention of UVB‐induced skin carcinogenesis in SKH‐1 mice by brown algae polyphenols
Open accessAbstract
Chronic exposure of the skin to ultraviolet B (UVB) radiation induces oxidative stress, which plays a crucial role in the induction of skin cancer. In this study, the effect of dietary feeding and topical application of brown algae polyphenols on UVB radiation‐induced skin carcinogenesis in SKH‐1 mice was investigated. SKH‐1 hairless mice were randomly divided into 9 groups, including control, UVB control and treatment groups. They were treated orally (0.1% and 0.5% with AIN‐76 diet, w/w) and topically (3 and 6 mg/0.2 ml of vehicle) with brown algae polyphenols and irradiated with UVB for 26 weeks. Dietary feeding (0.1% and 0.5%) of brown algae polyphenols significantly reduced tumor multiplicity (45% and 56%) and tumor volume (54% and 65%), and topical administration (3 and 6 mg) significantly decreased tumor multiplicity (60% and 46%) and tumor volume (66% and 57%), respectively, per tumor‐bearing mouse. Dietary feeding and topical administration of the polyphenols also inhibited tumor incidence by 6% and 21%, respectively, but the results were not significant. Dietary and topical administration of the polyphenols markedly inhibited cyclooxygenase‐2 activity and cell proliferation. These observations show that brown algae polyphenols have an antiphotocarcinogenic effect which may be associated with the prevention of UVB‐induced oxidative stress, inflammation, and cell proliferation in the skin. © 2006 Wiley‐Liss, Inc.
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Ingestion (and topical application) of polyphenols of brown algae inhibited UVB radiation-induced skin carcinogenesis in mice.
“The ingestion (and topical application) of polyphenols of brown algae inhibited UVB radiation-induced skin carcinogenesis in mice (Hwang et al. 2006)”
From Algae as nutritional and functional food sources: revisiting our understanding. (2017) · cites this paper as Hwang et al. 2006
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Cites
Oxidants, oxidative stress and the biology of ageing
Finkel, T., & Holbrook, N. J. (2000) · Nature · doi:10.1038/35041687 · Cited by 9,413 · see citing works
(1968) · American Association of Industrial Nurses Journal · doi:10.1177/216507996801601208 · Cited by 8,811 · see citing works
Oxidative stress and gene regulation
Allen, R. G., & Tresini, M. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00242-7 · Cited by 1,297 · see citing works
Buckman, S. (1998) · Carcinogenesis · doi:10.1093/carcin/19.5.723 · Cited by 593 · see citing works
Phlorotannins, brown algal polyphenols
Ragan, M. A., & Glombitza, K. (1986) · Medical Entomology and Zoology · Cited by 503 · see citing works
Bactericidal activity of phlorotannins from the brown alga Ecklonia kurome
Nagayama, K. (2002) · Journal of Antimicrobial Chemotherapy · doi:10.1093/jac/dkf222 · Cited by 412 · see citing works
UV-induced reactive oxygen species in photocarcinogenesis and photoaging.
Scharffetter‐Kochanek, K., Wlaschek, M., Brenneisen, P., Schauen, M., Blaudschun, R., & Wenk, J. (1997) · PubMed · Cited by 406 · see citing works
Mechanisms of UV-Induced Inflammation
Hruza, L. L., & Pentland, A. P. (1993) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12355240 · Cited by 364 · see citing works
Protective effects of silymarin against photocarcinogenesis in a mouse skin model
Katiyar, S. K., Korman, N. J., Mukhtar, H., & Agarwal, R. (1997) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/89.8.556 · Cited by 355 · see citing works
Induction of oxidative DNA base damage in human skin cells by UV and near visible radiation
Kvam, E. (1997) · Carcinogenesis · doi:10.1093/carcin/18.12.2379 · Cited by 344 · see citing works
Reduction of UV-induced skin tumors in hairless mice by selective COX-2 inhibition
Pentland, A. P., Schoggins, J. W., Scott, G., Khan, K. N. M., & Han, R. (1999) · Carcinogenesis · doi:10.1093/carcin/20.10.1939 · Cited by 328 · see citing works
Aisa, Y., Miyakawa, Y., Nakazato, T., Shibata, H., Saito, K., Ikeda, Y., & Kizaki, M. (2005) · American Journal of Hematology · doi:10.1002/ajh.20182 · Cited by 307 · see citing works
Afaq, F., Adhami, V. M., & Ahmad, N. (2003) · Toxicology and Applied Pharmacology · doi:10.1016/s0041-008x(02)00014-5 · Cited by 262 · see citing works
Photocarcinogenesis: an overview
Black, H. S., deGruijl, F. R., Forbes, P. D., Cleaver, J. E., Ananthaswamy, H. N., DeFabo, E. C., Ullrich, S. E., & Tyrrell, R. M. (1997) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/s1011-1344(97)00021-3 · Cited by 258 · see citing works
Inhibitory activity of brown algal phlorotannins against hyaluronidase
Shibata, T., Fujimoto, K., Nagayama, K., Yamaguchi, K., & Nakamura, T. (2002) · International Journal of Food Science & Technology · doi:10.1046/j.1365-2621.2002.00603.x · Cited by 242 · see citing works
Mittal, A., Elmets, C. A., & Katiyar, S. K. (2003) · Carcinogenesis · doi:10.1093/carcin/bgg095 · Cited by 224 · see citing works
Skin Cancer: Mechanisms and Human Relevance
Mukhtar, H. (1994) · Medical Entomology and Zoology · Cited by 212 · see citing works
Antioxidant Activity of Phlorotannins Isolated from the Brown Alga Eisenia bicyclis
Nakamura, T., Nagayama, K., Uchida, K., & Tanaka, R. (1996) · Fisheries Science · doi:10.2331/fishsci.62.923 · Cited by 196 · see citing works
(2003) · PubMed · Cited by 170 · see citing works
Matsumura, Y., & Ananthaswamy, H. N. (2002) · Expert Reviews in Molecular Medicine · doi:10.1017/s146239940200532x · Cited by 163 · see citing works
Tripp, C. S., Blomme, E. A. G., Chinn, K. S., Hardy, M. M., LaCelle, P. T., & Pentland, A. P. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12495.x · Cited by 151 · see citing works
Seaweed Prevents Breast Cancer?
Funahashi, H., Imai, T., Mase, T., Sekiya, M., YOKOI, K., Hayashi, H., Shibata, A., Hayashi, T., Nishikawa, M., Suda, N., et al. (2001) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.2001.tb01119.x · Cited by 147 · see citing works
Agarwal, R., Katiyar, S. K., Khan, S. G., & Mukhtar, H. (1993) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1993.tb04954.x · Cited by 142 · see citing works
Kang, K., Park, Y.-J., Hwang, H. J., Kim, S. H., Lee, J. G., & Shin, H. (2003) · Archives of Pharmacal Research · doi:10.1007/bf02976957 · Cited by 142 · see citing works
Self-citationWilgus, T. A., Ross, M. S., Parrett, M. L., et al. (2000) · Prostaglandins & Other Lipid Mediators · doi:10.1016/s0090-6980(00)00089-7 · Cited by 129 · see citing works
González, S., Astner, S., An, W., Pathak, M. A., & Goukassian, D. A. (2003) · Journal of Investigative Dermatology · doi:10.1046/j.1523-1747.2003.12355.x · Cited by 127 · see citing works
Ultraviolet B (UVB)-Induced COX-2 Expression in Murine Skin: An Immunohistochemical Study
Athar, M., An, K. P., Morel, K. D., Kim, A. L., Aszterbaum, M., Longley, J. B., Epstein, E. H., & Bickers, D. R. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.4201 · Cited by 125 · see citing works
Chemoprevention of human skin cancer
Einspahr, J. G., Stratton, S. P., Bowden, G. T., & Alberts, D. S. (2002) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(01)00185-8 · Cited by 122 · see citing works
Okuzumi, J., Takahashi, T., Yamane, T., Kitao, Y., Inagake, M., Ohya, K., Nishino, H., & Tanaka, Y. Y. (1993) · Cancer Letters · doi:10.1016/0304-3835(93)90142-v · Cited by 113 · see citing works
Sunlight, Immunosuppression And Skin Cancer: Role Of Histamine And Mast Cells
Hart, P. H., Grimbaldeston, M. A., & Finlay-Jones, J. (2001) · Clinical and Experimental Pharmacology and Physiology · doi:10.1046/j.1440-1681.2001.03392.x · Cited by 96 · see citing works
Fukuyama, Y., Kodama, M., Miura, I., et al. (1989) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.37.349 · Cited by 93 · see citing works
Funahashi, H., Imai, T., Tanaka, Y., Tsukamura, K., Hayakawa, Y., Kikumori, T., Mase, T., Itoh, T., Nishikawa, M., Hayashi, H., et al. (1999) · Japanese Journal of Cancer Research · doi:10.1111/j.1349-7006.1999.tb00836.x · Cited by 92 · see citing works
Clinical and histologic trends of melanoma
Johnson, T. M., Dolan, O. M., Hamilton, T. A., Lu, M., Swanson, N. A., & Lowe, L. (1998) · Journal of the American Academy of Dermatology · doi:10.1016/s0190-9622(98)70196-3 · Cited by 87 · see citing works
Novel Approaches to Chemoprevention of Skin Cancer
Bickers, D. R., & Athar, M. S. (2000) · The Journal of Dermatology · doi:10.1111/j.1346-8138.2000.tb02259.x · Cited by 85 · see citing works
Hiqashi-Okaj, K., Otani, S., & Okai, Y. (1999) · Cancer Letters · doi:10.1016/s0304-3835(99)00047-6 · Cited by 83 · see citing works
Shibata, T., Yamaguchi, K., Nagayama, K., Kawaguchi, S., & Nakamura, T. (2002) · European Journal of Phycology · doi:10.1017/s0967026202003918 · Cited by 75 · see citing works
Chemoprevention of Skin Cancer: Current Status and Future Prospects
Gupta, S., & Mukhtar, H. (2002) · Cancer and Metastasis Reviews · doi:10.1023/a:1021275330385 · Cited by 64 · see citing works
Gu, M., Dhanalakshmi, S., Singh, R. P., & Agarwal, R. (2005) · Cancer Epidemiology Biomarkers & Prevention · doi:10.1158/1055-9965.epi-04-0664 · Cited by 61 · see citing works
Chemoprevention of Ultraviolet Radiation-Induced Skin Cancer
Ley, R. D., & Reeve, V. E. (1997) · Environmental Health Perspectives · doi:10.1289/ehp.97105s4981 · Cited by 56 · see citing works
Immunological Effects of Ultraviolet Radiation
Kripke, M. L. (1991) · The Journal of Dermatology · doi:10.1111/j.1346-8138.1991.tb03111.x · Cited by 53 · see citing works
The skin's antioxidant systems.
Pugliese, P. T. (1998) · PubMed · Cited by 52 · see citing works
Histogenesis and Progression of Ultraviolet Light-Induced Tumors in Hairless Mice 2
Kligman, L. H., & Kligman, A. M. (1981) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/67.6.1289 · Cited by 48 · see citing works
Synthesis and antiinflammatory activity of novel indazolones
Abouzid, K. A. M., & El‐Abhar, H. S. (2003) · Archives of Pharmacal Research · doi:10.1007/bf03179922 · Cited by 47 · see citing works
Athar, M. S., An, K. P., Tang, X., et al. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2003.09.030 · Cited by 31 · see citing works
Oncogenes and Tumor Suppressor Genes in Photocarcinogenesis
Ananthaswamy, H. N., & Kanjilal, S. (1996) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.1996.tb03063.x · Cited by 24 · see citing works
Implications of UV-induced inflammation and immunomodulation.
Cooper, K. D., Baron, E. D., & Matsui, M. S. (2003) · PubMed · Cited by 11 · see citing works
Ultraviolet Radiation and Health: from Hazard Identification to Effective Prevention
Yamaguchi, N., Kinjo, Y., Akiba, S., et al. (1999) · Journal of Epidemiology · doi:10.2188/jea.9.6sup_1 · Cited by 9 · see citing works
Flagged first, then by citations
Research works printed but not linked: 3
- Black HS, deGruijl FR, Forbes PD, Cleaver JE, Ananthaswamy HN, deFabo EC, Ullrich SE, Tyrrell RM. Photocarcinogenesis: an over- view. J Photochem Photobiol B 1997;40:29-47.
- Afaq F, Adhami VM, Ahmad N. Prevention of short-term ultraviolet B radiation-mediated damages by resveratrol in SKH-1 hairless mice. Toxicol Appl Pharmacol 2003;186:28-37.
- Kligman LH, Kligman AM. Histogenesis and progression in ultravio- let light-induced tumors in hairless mice. J Natl Cancer Inst 1981;67: 1289-93.
Cited by
Sorted by citations
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Suganya, T., Varman, M., Masjuki, H. H., & Renganathan, S. (2016) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2015.11.026 · Cited by 793 · see citing works
Bosch, R., Philips, N., Suárez-Pérez, J., Juarranz, A., Devmurari, A., Chalensouk-Khaosaat, J., & González, S. (2015) · Antioxidants · doi:10.3390/antiox4020248 · Cited by 407 · see citing works
Antioxidants from macroalgae: potential applications in human health and nutrition
Cornish, M. L., & Garbary, D. J. (2010) · ALGAE · doi:10.4490/algae.2010.25.4.155 · Cited by 290 · see citing works
Potential pharmacological applications of polyphenolic derivatives from marine brown algae
Thomas, N. V., & Kim, S.-K. (2011) · Environmental Toxicology and Pharmacology · doi:10.1016/j.etap.2011.09.004 · Cited by 269 · see citing works
Applying Seaweed Compounds in Cosmetics, Cosmeceuticals and Nutricosmetics
López-Hortas, L., Flórez-Fernández, N., Torres, M. D., Ferreira-Anta, T., Casas, M. P., Balboa, E. M., Falqué, E., & Domínguez, H. (2021) · Marine Drugs · doi:10.3390/md19100552 · Cited by 168 · see citing works
- Authors
- Hwang, H., Chen, T., Nines, R. G., Shin, H., & Stoner, G. D.
- Affiliations
- The Ohio State University (US)
- Hanbat National University (KR)
- Corresponding author
- Stoner, Gary D.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 2006-10-26
- Volume
- 119
- Issue
- 12
- Pages
- 2742-2749
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W2168268348
- Cited by
- 106
- References
- 47
- Citations by year
- 2026: 2 · 2025: 5 · 2024: 4 · 2023: 7 · 2022: 3 · 2021: 5 · 2020: 6 · 2019: 10 · 2018: 1 · 2017: 1 · 2016: 4 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 8
- FWCI
- 2.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- International Journal of Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- UVB-induced skin carcinogenesis, SKH-1 mice, cyclooxygenase-2, oxidative stress, cell proliferation, topical administration, dietary supplementation, tumor multiplicity, skin cancer prevention
- MeSH terms
- Administration, Cutaneous, Administration, Oral, Phaeophyceae, Animals, Benzofurans, Dioxins, Epidermis, Female, Flavonoids, Immunohistochemistry, Neoplasms, Radiation-Induced, Phenols, Random Allocation, Skin, Skin Neoplasms, Ultraviolet Rays, Blotting, Western, Dinoprostone, Molecular Structure, Gene Expression, Proliferating Cell Nuclear Antigen, Reverse Transcriptase Polymerase Chain Reaction, Cell Proliferation, Mice, Cyclooxygenase 2, Polyphenols
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