The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
The role of hyaluronan in tumour neovascularization (review)
Abstract
Tumour growth and metastasis are totally dependant upon neovascularization. The target cell for tumour neovascularization is the blood‐vessel endothelial cell, and specific angiogenic molecules produced or induced by the tumour are believed to initiate the process. In this report, we review one of these angiogenic molecules, the glycosaminoglycan hyaluronan (HA), which appears to have differing roles in neovascularization depending on its molecular mass. High‐molecular‐mass HA is anti‐angiogenic whereas oligosaccharides of HA, of specific size, actively stimulate endothelial‐cell proliferation and migration, 2 of the key events associated with neovascularization, and induce angiogenesis in vivo. We provide details of the action of HA oligosaccharides on endothelial cells, from binding to cell‐surface receptors, through activation of signal transduction pathways and gene expression to protein synthesis, cell proliferation and cell migration. We also suggest a model to account for HA of differing molecular mass being present, at different locations, within a single tumour and how this HA aids both general tumour growth and tumour metastasis.
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Studies on anticancer activities of antimicrobial peptides
Hoskin, D. W., & Ramamoorthy, A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2007.11.008 · Cited by 1,296
Signaling Properties of Hyaluronan Receptors
Turley, E. A., Noble, P. W., & Bourguignon, L. Y. W. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100038200 · Cited by 1,041
Chung, C., & Burdick, J. A. (2008) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2007.08.027 · Cited by 760
Angiogenesis: regulators and clinical applications
Liekens, S., De Clercq, E., & Neyts, J. (2001) · Biochemical Pharmacology · doi:10.1016/s0006-2952(00)00529-3 · Cited by 748
Gerecht, S., Burdick, J. A., Ferreira, L. S., Townsend, S. A., Langer, R., & Vunjak-Novakovic, G. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0703723104 · Cited by 664
Metadata
- Authors
- Rooney, P., Kumar, S., Ponting, J., & Wang, M.
- Venue
- International Journal of Cancer
- Publisher
- Wiley
- Published
- 1995-03-03
- Volume
- 60
- Issue
- 5
- Pages
- 632-636
- ISSN
- 0020-7136 (ISSN-L)
- 1097-0215
- OpenAlex
- W1991755452
- Cited by
- 271
- References
- 73
- FWCI
- 2.75
- Type
- journal article
- Language
- en
- Open access
- closed
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- Rooney, P., Kumar, S., Ponting, J., & Wang, M. (1995). The role of hyaluronan in tumour neovascularization (review). International Journal of Cancer. https://doi.org/10.1002/ijc.2910600511
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
