Cited by 328Lipid metabolism and disordersLipoproteins and Cardiovascular HealthCholesterol and Lipid Metabolism

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Apolipoprotein E isoforms and lipoprotein metabolism

Phillips, Michael C.·2014·IUBMB Life

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Abstract

Apolipoprotein (apo) E is a 299‐residue protein which functions as a key regulator of plasma lipid levels. Human apoE exists as three common isoforms and the parent form, apoE3, operates optimally in promoting clearance of triglyceride (TG)‐rich lipoproteins and is associated with normal plasma lipid levels. This result occurs because apoE3 possesses both the requisite lipid‐binding ability and affinity for the low density lipoprotein receptor (LDLR) to mediate appropriate lipolytic processing and endocytosis of TG‐rich lipoprotein remnant particles. ApoE2 which differs from apoE3 by the single amino acid substitution Arg158Cys located near the LDLR recognition site exhibits impaired binding to the receptor and an inability to promote clearance of TG‐rich lipoprotein remnant particles; this isoform is associated with Type‐III hyperlipoproteinemia. ApoE4 which differs from apoE3 by the single amino acid substitution Cys112Arg is also associated with dyslipidemia although binding of this isoform to the LDLR is unaffected. The amino acid substitution affects the organization and stability of both the N‐terminal helix bundle domain and separately folded C‐terminal domain so that apoE4 has enhanced lipid binding ability. As a consequence, apoE4 binds better than apoE3 to the surface of very low density lipoprotein (VLDL) particles and impairs their lipolytic processing in the circulation so that apoE4 is associated with a more pro‐atherogenic lipoprotein‐cholesterol distribution (higher VLDL‐cholesterol/high density lipoprotein‐cholesterol ratio). This review summarizes current understanding of the structural differences between apoE2, apoE3, and apoE4, and the molecular mechanisms responsible for the alterations in lipoprotein metabolism resulting from this polymorphism of apoE. Detailed knowledge of how expression of structurally distinct apoE variants modifies lipoprotein metabolism provides a basis for developing ways to manipulate the functionality of apoE in vivo. © 2014 IUBMB Life, 66(9):616–623, 2014

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Apolipoprotein E polymorphism and atherosclerosis.
Davignon, J., Gregg, R. E., & Sing, C. F. (1988) · Arteriosclerosis: An Official Journal of the American Heart Association, Inc. · doi:10.1161/01.atv.8.1.1 · Cited by 1,981
The amphipathic helix in the exchangeable apolipoproteins: a review of secondary structure and function.
Segrest, J., Jones, M., Loof, H. D., Brouillette, C. G., Venkatachalapathi, Y. V., & Anantharamaiah, G. M. (1992) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)41536-6 · Cited by 868
Apolipoprotein E: Structure-Function Relationships
Weisgraber, K. H. (1994) · Advances in Protein Chemistry · doi:10.1016/s0065-3233(08)60642-7 · Cited by 830
Remnant lipoprotein metabolism: key pathways involving cell-surface heparan sulfate proteoglycans and apolipoprotein E
Mahley, R. W., & Ji, Z.-S. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)33334-4 · Cited by 693
Abnormal lipoprotein receptor‐binding activity of the human E apoprotein due to cysteine‐arginine interchange at a single site
Weisgraber, K. H., Innerarity, T. L., & Mahley, R. W. (1982) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)34954-8 · Cited by 673
Apolipoprotein E structure: insights into function
Hatters, D. M., Peters-Libeu, C. A., & Weisgraber, K. H. (2006) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2006.06.008 · Cited by 583 · cited 1×
“The latter interaction occurs in quasi-spherical apoE/dipalmitoyl phosphatidylcholine particles where the two apoE molecules adopt a horseshoe shape (7,26).”
Background
Apolipoprotein E: structure determines function, from atherosclerosis to Alzheimer's disease to AIDS
Mahley, R. W., Weisgraber, K. H., & Huang, Y. (2009) · Journal of Lipid Research · doi:10.1194/jlr.r800069-jlr200 · Cited by 580
Pathogenesis of type III hyperlipoproteinemia (dysbetalipoproteinemia): questions, quandaries, and paradoxes
Mahley, R. W., Huang, Y., & Rall, S. C. (1999) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)32417-2 · Cited by 447
Apo E structure determines VLDL clearance and atherosclerosis risk in mice
Knouff, C., Hinsdale, M. E., Mezdour, H., Altenburg, M. K., Watanabe, M., Quarfordt, S. H., Sullivan, P. M., & Maeda, N. (1999) · Journal of Clinical Investigation · doi:10.1172/jci6172 · Cited by 324
Human apolipoprotein E: Role of arginine 61 in mediating the lipoprotein preferences of the E3 and E4 isoforms
Dong, L. M., Wilson, C., Wardell, M. R., Simmons, T., Mahley, R. W., Weisgraber, K. H., & Agard, D. A. (1994) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(17)31797-0 · Cited by 320

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Items 201–300 of 328

“Association of APOE gene polymorphisms with primary open angle glaucoma in Brazilian patients”
Occhiutto, M. L., de Melo, M. B., de Vasconcellos, J. P. C., Rodrigues, T. A. R., Bajano, F. F., Costa, F. F., & Costa, V. P. (2020) · Ophthalmic Genetics · doi:10.1080/13816810.2020.1849314 · Cited by 6
Reassessing Diabetes and APOE Genotype as Potential Interacting Risk Factors for Alzheimer’s Disease
Ravipati, K., Chen, Y., & Manns, J. R. (2022) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/15333175211070912 · Cited by 6
Apolipoprotein E genetic variation, atherogenic index and cardiovascular disease risk assessment in an African population: An analysis of HIV and malaria patients in Ghana
Thomford, N. E., Anyanful, A., Ateko, R. O., Blackhurst, D., Biney, R. P., Boadi, D., Nyarko, S. B., Ekor, M., & Kyei, G. B. (2023) · PLoS ONE · doi:10.1371/journal.pone.0284697 · Cited by 5
Purple perilla frutescens extracts containing α-asarone inhibit inflammatory atheroma formation and promote hepatic HDL cholesterol uptake in dyslipidemic apoE-deficient mice
Park, S., Sim, Y. E., Kang, M., Kim, D. Y., Kang, I., Lim, S. S., & Kang, Y. (2023) · Nutrition Research and Practice · doi:10.4162/nrp.2023.17.6.1099 · Cited by 5
Apolipoprotein E3 and E4 isoforms exhibit differing effects in countering endotoxins
Puthia, M., Marzinek, J. K., Veselá, K., Larsson, A., Schmidtchen, A., Bond, P. J., & Petrlová, J. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.108236 · Cited by 5
Xanthoma striatum palmare
Tian, Q., & Zhao, X. (2015) · Gut · doi:10.1136/gutjnl-2015-310460 · Cited by 5
Polymorphism of PPARG (P12A), APOA1 (G75A), and APOE (C112A and A158C) Genes in Children with Obesity and Arterial Hypertension: A Case-Control Study
Kovtun, O. P., & Ustiuzhanina, M. A. (2018) · Вопросы современной педиатрии · doi:10.15690/vsp.v17i4.1924 · Cited by 5
Association of ApoE haplotype with clinical evidence of pituitary adenoma
Sidaraitė, A., Vilkevičiūtė, A., Glebauskienė, B., Kriaučiūnienė, L., Žaliūnienė, D., & Liutkevičienė, R. (2019) · Gene · doi:10.1016/j.gene.2019.04.090 · Cited by 5
Prevalence and Impact of Apolipoprotein E7 on LDL Cholesterol Among Patients With Familial Hypercholesterolemia
Tada, H., Yamagami, K., Kojima, N., Shibayama, J., Nishikawa, T., Okada, H., Nomura, A., Usui, S., Sakata, K., Takamura, M., et al. (2021) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2021.625852 · Cited by 5
Eruptive xanthomas in a patient with soft-drink diabetic ketosis and apolipoprotein E4/2
Tsuchiya, S., Sawada, S., Takeda, K., Takahashi, K. A., Nakajima, T., Kohata, M., Kurosawa, S., Satake, C., Imai, J., Kikuchi, K., et al. (2018) · Endocrine Journal · doi:10.1507/endocrj.ej18-0356 · Cited by 5
Neurodegenerative diseases
Gupta, A. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-820122-0.00004-2 · Cited by 6
ApoE isoform leading to hypertriglyceridemia in new onset type 1 diabetes
Keefe, C., & Lawson, S. A. (2018) · Clinical Case Reports · doi:10.1002/ccr3.1584 · Cited by 5
Lipoprotein Metabolism and Cholesterol Balance
Acuña, M., & Cohen, D. E. (2020) · Wiley eBooks · doi:10.1002/9781119436812.ch22 · Cited by 5
The impact of APOE ε4 in Alzheimer’s disease: a meta-analysis of voxel-based morphometry studiesPreprint
Bailey, M., Ilchovska, Z. G., Hosseini, A. A., & Jung, J. (2024) · medRxiv · doi:10.1101/2024.05.10.24307165 · Cited by 5
APOE genotype and sex drive microbiome divergence after microbiome standardization in APOE -humanized mice
Aries, M. L., Gasvoda, H., Michelotti, M., Rodriguez-Caro, F., Gooman, A., Perez, A., & Hensley‐McBain, T. (2025) · mSphere · doi:10.1128/msphere.00429-25 · Cited by 4
Impact of Apolipoprotein E4 on blood-brain barrier integrity in target replacement murine models: a systematic review and meta-analysis
Laing, K. K., Fialova, N., Wardlaw, J. M., & Montagne, A. (2026) · Alzheimer s Research & Therapy · doi:10.1186/s13195-026-02018-3 · Cited by 4
Apolipoprotein E3 Containing Nanodiscs as Vehicles for Transport and Targeted Delivery of Flavonoid Luteolin
Benedicto, V., Haguar, Z., Abdulhasan, A., & Narayanaswami, V. (2024) · ACS Omega · doi:10.1021/acsomega.3c09120 · Cited by 4
Unraveling APOE4's Role in Alzheimer's Disease: Pathologies and Therapeutic Strategies
Tripathi, S., Sharma, Y., & Kumar, D. (2024) · Current Protein and Peptide Science · doi:10.2174/0113892037326839241014054430 · Cited by 5
Conformational analysis of apolipoprotein E3/E4 heteromerization
Tu, K., Abhari, D., & Narayanaswami, V. (2019) · The FEBS Journal · doi:10.1111/febs.14794 · Cited by 4
Apolipoprotein E (epsilon) genotype has a greater impact on apoB‐48 than apoB‐100 responses to dietary fat manipulation—insights from the SATgenε study
Jackson, K. G., Lockyer, S., Carvalho-Wells, A. L., Williams, C. M., Minihane, A. M., & Lovegrove, J. A. (2016) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201600688 · Cited by 4
Discrepant modulating effects of dietary docosahexaenoic acid on cerebral lipids, fatty acid transporter expression and soluble beta‐amyloid levels in ApoE −/− and C57BL/6J mice
Xu, J., Huang, X., Guo, Y., Ma, X., Li, P., Zhou, S., Zhang, C., Chen, R., Halm‐Lutterodt, N. V., & Yuan, L. (2022) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12855 · Cited by 4
Personalized Nutrition to Treat and Prevent Obesity and Diabetes
Panduro, A., Román, S., Milán, R. G., Torres-Reyes, L. A., & González-Aldaco, K. (2020) · Royal Society of Chemistry eBooks · doi:10.1039/9781839160608-00272 · Cited by 4
Familial Hypercholesterolemia: Real-World Data of 1236 Patients Attending a Czech Lipid Clinic. A Retrospective Analysis of Experience in More than 50 years. Part I: Genetics and Biochemical Parameters
Todorovová, V., Altschmiedová, T., Vrablík, M., & Češka, R. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.849008 · Cited by 4
Effect of protective mutation on structure and dynamics of APOE: a molecular dynamics simulation study
Ihoeghian, N. A., Abbas, U. L., Imam, I. A., & Shao, Q. (2025) · Physical Chemistry Chemical Physics · doi:10.1039/d5cp03829d · Cited by 3
Insights into the C-terminal domain of apolipoprotein E from chimera studies with apolipophorin III
Horn, J. V. C., Kakutani, L. M., Narayanaswami, V., & Weers, P. M. M. (2023) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04497-y · Cited by 3
The associations of PON1 and APOE polymorphisms with plasma lipid levels and the risk for late complications in type 2 diabetes patients
Klen, J., Goričar, K., & Dolžan, V. (2023) · Journal of Medical Biochemistry · doi:10.5937/jomb0-43154 · Cited by 4
APOE‐E4 allele as a potential marker for implantation failure: A comparison between fertile women, ART success and RIF patients
Darabi, N., Mashayekhy, M., Boroujeni, P. B., Mohtasebi, P., Talab, Z. R., & Zamanian, M. (2024) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.15537 · Cited by 3
Human APOE ɛ3 and APOE ɛ4 Alleles Have Differential Effects on Mouse Olfactory Epithelium
Khan, N., Alimova, Y. V., Clark, S. J., Vekaria, H. J., Walsh, A. E., Williams, H. C., Hawk, G. S., Sullivan, P. G., Johnson, L. A., & McClintock, T. S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-215152 · Cited by 5
Variations in high density cholesterol levels based on apolipoprotein E variant and exercise type
Chang, C.-M., Nfor, O. N., Ho, C., Chen, P.-H., & Liaw, Y. (2023) · Frontiers in Genetics · doi:10.3389/fgene.2023.1136483 · Cited by 3
Apolipoprotein E isoforms differentially affect LCAT-dependent cholesterol esterification
Vitali, C., Pavanello, C., Turri, M., Lund‐Katz, S., Phillips, M. C., Catapano, A. L., Baragetti, A., Norata, G. D., Veglia, F., & Calabresi, L. (2023) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2023.117266 · Cited by 3
Self-citation
Interaction of Two Amphipathic α-Helix Bundle Proteins, ApoLp-III and ApoE 3, with the Oil–Aqueous Interface
Mirheydari, M., Putta, P., Mann, E. K., & Kooijman, E. E. (2021) · The Journal of Physical Chemistry B · doi:10.1021/acs.jpcb.1c00271 · Cited by 3
Mining the potential therapeutic targets for coronary artery disease by bioinformatics analysis
Wang, W., Xu, Z., Zhu, X., & Chang, X. (2018) · Molecular Medicine Reports · doi:10.3892/mmr.2018.9551 · Cited by 3
Identification of APOE4 Modulators, Targeted Therapeutic Candidates in Coronary Artery Disease, Using Molecular Docking Studies
Hazarika, L., Sen, S., Zawar, A., & Doshi, J. (2021) · Journal of Drug Design and Medicinal Chemistry · doi:10.11648/j.jddmc.20210702.11 · Cited by 3
Apolipoprotein E interacts with amyloid-β oligomers via positively cooperative multivalent bindingPreprint
Ghosh, S., Sil, T. B., Dolai, S., & Garai, K. (2018) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/473892 · Cited by 3
[A short discharge letter with a copy to the patient--satisfactory for patients and practitioners].
Nielsen, F. T., Rosholm, J.-U., Søndergaard, J., Gohr, T., & Tougaard, L. (1994) · PubMed · Cited by 3
Effects of West Nile virus on behavioral and cognitive performance, cortical Aβ pathology, viral loads, and immune measures of middle-aged NL-G-F/E3 and NL-G-F/E4 mice
O’Niel, A., Parkins, C. J., Pederson, A., Saltonstall, E., Bunnell, E., Aggarwal, R., Sandholm, P., Kessler, K., Harrison, H. F., Smith, J. R., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1600119 · Cited by 2
The APOE Gene Cluster in Normal Aging
Florczak‐Wyspianska, J., Hurła, M., Pikor, D., Poszwa, J., Korczowska-Łącka, I., Szymanowicz, O., Pluto-Prądzyńska, A., Goutor, U., Wiszniewska, M., Kozubski, W. P., et al. (2025) · Journal of Integrative Neuroscience · doi:10.31083/jin36401 · Cited by 3
The Structure of the Apolipoprotein A-I Monomer Provides Insights Into Its Oligomerisation and Lipid-binding Mechanisms
Tou, H. I., Rosenes, Z., Khandokar, Y. B., Zlatic, C. O., Metcalfe, R. D., Mok, Y.-F., Morton, C. J., Gooley, P. R., & Griffin, M. D. W. (2025) · Journal of Molecular Biology · doi:10.1016/j.jmb.2025.169394 · Cited by 2
Impact of APOE ε4 Genotype Load on Cognitive Function and Lipid Metabolism in Patients With Cerebral Small Vessel Disease
Jin, T., Yang, H., Liu, F., Lin, S., Hu, J., Wang, J., & Gou, Y. (2025) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.70224 · Cited by 2
Identification of different lipoprotein response types in people following a Mediterranean diet pattern with and without whole eggs
Picklo, M. J., RUST, B. M., Yeater, K. M., & Raatz, S. K. (2022) · Nutrition Research · doi:10.1016/j.nutres.2022.06.005 · Cited by 2
Cardiac Autonomic Neuropathy Is Not Associated with Apolipoprotein E Gene Isoforms in the Kazakh Population: A Case–Control Study
Bekenova, N., Aitkaliyev, A., Vochshenkova, T. A., Kassiyeva, B., & Benberin, V. V. (2024) · Diagnostics · doi:10.3390/diagnostics14171978 · Cited by 2
Effects of APOE isoforms in diabetic nephropathy patients of South India
Basavaraju, P., Moorthi, P. V., Meyyazhagan, A., Devaraj, I., Babu, K., Panza, E., & Orlacchio, A. (2024) · Acta Diabetologica · doi:10.1007/s00592-024-02374-2 · Cited by 2
Radiolabeling lipoproteins to study and manage disease
Pérez‐Medina, C., Fisher, E. A. A., Fayad, Z. A., Mulder, W. J. M., & Teunissen, A. J. P. (2025) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-025-07281-4 · Cited by 2
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King, R. I., & Brennan, S. O. (2016) · Clinica Chimica Acta · doi:10.1016/j.cca.2016.03.021 · Cited by 2
Pediatric dyslipidemias: lipoprotein metabolism disorders in children
Ballout, R. A., & Remaley, A. T. (2021) · Elsevier eBooks · doi:10.1016/b978-0-12-817962-8.00002-0 · Cited by 3
Interaction between arteriosclerosis and the APOE4 gene in cognitive decline in older adults: a cross‐sectional study in rural minority areas in western China
Qu, F., Yang, X., Yang, J., Zhou, Q., Yang, X., Chen, M., Xiong, Y., & Hu, Y. (2022) · Psychogeriatrics · doi:10.1111/psyg.12808 · Cited by 2
Isolation of recombinant apolipoprotein E4 N-terminal domain by foam fractionation
Lethcoe, K., Fox, C. A., Hafiane, A., Kiss, R. S., & Ryan, R. O. (2023) · Protein Expression and Purification · doi:10.1016/j.pep.2023.106319 · Cited by 2
The Significance of Genetic Marker Studies in the Treatment and Prevention of Obesity in Children and Adolescents
Пересецкая, О. В., Kozlova, L. V., Larionova, V. I., & Smolensk, R. F. (2024) · Doctor Ru · doi:10.31550/1727-2378-2024-23-3-67-72 · Cited by 2
Protein corona critically affects the bio-behaviors of SARS-CoV-2Preprint
Yin, Y.-W., Sheng, Y.-J., Wang, M., Ni, S., Ding, H.-M., & Ma, Y. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2102.05440 · Cited by 4
Apolipoprotein E deficiency enhances the anti-tumor immunity via repressing T cell exhaustion
Zhao, B., Wang, W., Chen, Z., & Jin, S. (2021) · All Life · doi:10.1080/26895293.2021.2001382 · Cited by 1
Association between genetic polymorphisms and other attributing factors with lipid profiles among statin users: a cross-sectional retrospective study
Shamsudin, A. F., Sulong, S., Ahmad, I., & Bakar, N. S. (2024) · Egyptian Journal of Medical Human Genetics · doi:10.1186/s43042-024-00523-4 · Cited by 1
Apolipoprotein-ε4 (APOE) Gene Is a Risk Factor for Human Coronary Artery Disease
Hazarika, L., & Sen, S. (2025) · Springer eBooks · doi:10.1007/978-3-031-52641-1_61-1 · Cited by 1
Age-related macular degeneration and cerebral amyloid angiopathy have similar pathologies from cholesterol-APOE-amyloid-β-complement mediated inflammation
Sambhariya, W. S., Rickman, C. B., D'Amore, P. A., Corradetti, G., Hageman, G. S., Howell, G. R., Marola, O. J., Phatnani, H. P., Philp, N. J., Sinha, D., et al. (2026) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2026.101449 · Cited by 1
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Xiang, C., Zhu, Y., Gao, X., Guo, F., He, X., Luo, W., Liu, W., & Gu, R. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s591179 · Cited by 1
APOE, Inflammation, and T Cells in Translational Disease Models and Clinical Medicine
Adlimoghaddam, A., Cervantes, D., & Wheeler, C. J. (2026) · Springer eBooks · doi:10.1007/978-3-031-96089-5_35 · Cited by 1
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He, C., Wang, D., Hu, T., Gonzalez, D., Thakur, R., Matysniak, D. P., King, R. J., Kollala, S. S., Markov, S. D., Fujii, Y., et al. (2026) · Molecular Cancer · doi:10.1186/s12943-025-02340-8 · Cited by 1
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Gorshkova, I. N., & Atkinson, D. (2017) · PubMed · Cited by 1
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Jeelani, H., Nabi, J., Akhter, Y., Tabasum, N., Afroze, D., Pottoo, F. H., & Ali, F. (2022) · Springer eBooks · doi:10.1007/978-981-16-7606-2_1 · Cited by 2
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Lusiki, Z., Blom, D. J., Soko, N. D., Malema, S., Jones, E. S. W., Rayner, B. L., Blackburn, J. M., Sinxadi, P., Dandara, M. T. L., & Dandara, C. (2023) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2023.0122 · Cited by 1
Association of Apolipoprotein E Gene Polymorphism with Lipid Profile in Patients with Acute Coronary Syndrome in Han Chinese: A Critical Review
Nawabi, A. Q., Yang, M., Cai, X., Gou, W., Hou, J., Nizami, V., & Dai, Q. (2019) · World Journal of Cardiovascular Diseases · doi:10.4236/wjcd.2019.911074 · Cited by 1
Purification and Analysis of Circulating Lipid Particles
Roper, B. W. R., Alsayejh, B., Al-Aufi, A., Cuthbert, G. A., Lacey, K., Homer‐Vanniasinkam, S., Harrison, M. A., Tomlinson, D. C., Ajjan, R., & Ponnambalam, S. (2022) · Methods in molecular biology · doi:10.1007/978-1-0716-1924-7_12 · Cited by 1
Effects of C-Terminal-Ethyl-Esterification in a Snake-Venom-Based Peptide Against the Neurotoxicity of Acrolein in PC12 Cells
Bernardes, C. P., dos Santos, N. A. G., Costa, T. R., Menaldo, D. L., Sisti, F., Amstalden, M. K., Ribeiro, D. L., Antunes, L. M. G., Sampaio, S. V., & dos Santos, A. C. (2023) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-023-10517-2 · Cited by 1
Treatment Resistant Persister Cells Exploit Macrophage Lipid Metabolism to Sustain Glioblastoma GrowthPreprint
Chakraborty, A., Changlin, Y., Silver, A., Feier, D., Tian, G., Pittu, A., Roemeling, C. A. V., Thomas, N. J., Andrews, M., Conforti, C., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.07.658345 · Cited by 1
Lipoproteins and Health Outcomes: Cognitive and Physical Function in Older Adults
Chanti‐Ketterl, M. (2015) · Digital Commons - University of South Florida (University of South Florida)
Evolutionary Imprints on Cardiovascular Physiology and Pathophysiology
Danziger, R. S. (2016) · Springer eBooks · doi:10.1007/978-3-319-29716-3_11
OBSOLETE: Animal Models of Ischemic Heart Disease: From Atherosclerosis and Thrombosis to Myocardial Infarction
Gumina, R. J. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-801238-3.10920-1
Pharmacogenetics and Pharmacogenomics in Cardiovascular Medicine and Surgery
Turner, R. M., & Pirmohamed, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-66114-8_5
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Ishida, N., Ishida, T., Morisawa, S., Iizuka, M., Yagi, Y., Jobu, K., Morita, Y., Oishi, M., Moriyama, H., Shimamura, T., et al. (2020) · Food Science and Technology Research · doi:10.3136/fstr.26.509
Apolipoproteina E şi progresia nefropatiei la pacienţii diabetici
Facultatea de Medicină Universitatea de Vest „Vasile Goldiş“, A., Moldovan, S. D., Popețiu, R. O., Facultatea de Medicină Universitatea de Vest „Vasile Goldiş“, A., Amza, O. L., Facultatea de Medicină Universitatea de Vest „Vasile Goldiş“, A., Pușchiță, M., & Facultatea de Medicină Universitatea de Vest „Vasile Goldiş“, A. (2019) · Romanian Medical Journal · doi:10.37897/rmj.2019.3.9
The interactive impact of omega-3 fatty acids, APOE genotype and sex hormones on cognition
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Authors: Phillips, M. C.
Affiliations: University of Pennsylvania (US)
Corresponding author: Phillips, Michael C.
ORCID: Phillips, Michael C.
Venue: IUBMB Life
Publisher: Wiley
Published: 2014-09
Volume: 66
Issue: 9
Pages: 616-623
ISSN: 1521-6543 (ISSN-L)
1521-6551
DOI: 10.1002/iub.1314
OpenAlex: W1841798962
Cited by: 328
References: 59
Citations by year: 2026: 20 · 2025: 25 · 2024: 41 · 2023: 35 · 2022: 36 · 2021: 38 · 2020: 27 · 2019: 27 · 2018: 24 · 2017: 23 · 2016: 22 · 2015: 8
FWCI: 2.85
Type: journal article
Language: en
Open access: closed
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor, 49 d)
Locations: IUBMB Life (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipid metabolism and disorders
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Keywords: apolipoprotein E, apolipoprotein E isoforms, apolipoprotein E2, apolipoprotein E3, APOE ε4, lipoprotein metabolism, LDL receptor binding, type III hyperlipoproteinemia, dyslipidemia, VLDL cholesterol, protein structure, lipid binding, genetic polymorphism
MeSH terms: Apolipoproteins E, Humans, Lipoproteins, Models, Molecular, Protein Binding, Amino Acid Substitution, Protein Isoforms, Lipid Metabolism Disorders

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Apolipoprotein E isoforms and lipoprotein metabolism

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