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Cited by 93

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Differential distribution of apolipoprotein E isoforms in human plasma lipoproteins

Steinmetz, A, Jakobs, C, Motzny, S, Kaffarnik, H·1989·Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
DOI 10.1161/01.atv.9.3.405
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Abstract

The polymorphism of apolipoprotein E (apo E) accounts for a substantial amount of the genetic variance of cholesterol levels in man. The epsilon-2 allele and the epsilon-4 allele raises plasma and low density lipoprotein cholesterol levels as compared to the epsilon-3 allele. Whereas the lower cholesterol levels in carriers of the epsilon-2 allele can, at least in part, be attributed to the grossly deficient binding of apo E-2 to the apo B,E receptor, apo E-3 and E-4 bind to the same degree. We used gel filtration and ultracentrifugation to separate lipoproteins and subsequent immunoblotting analysis to study the apo E isoform distribution. We always found lipoproteins of lower density relatively enriched in apo E-4 and high density lipoproteins relatively depleted of apo E-4 as compared to apo E-3. This was also seen in plasma of heterozygous subjects that simultaneously express two apo E isoforms. Also, the apo E-A-II complex was directly shown by immunoblotting. Furthermore, when purified iodinated apo E was incubated with plasma in vitro, apo E-4 also reassociated more with lipoproteins of lower density than apo E-3. We conclude that apo E-3 and apo E-4 have a different lipoprotein particle distribution in vivo. This differential lipoprotein distribution may account for differences in the metabolism between apo E-3 and E-4.

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Crossref · 10.1161/01.atv.9.3.405

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2 of 2 references verified0 citation errors · 0 not checkable

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Claims other papers make about this one

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  • In the blood, APOE4 preferentially associates with VLDL, whereas APOE3 displays a preference for HDL.

    “Early work showed that, in the blood, APOE4 preferentially associates with VLDL, whereas APOE3 displays a preference for HDL (Gregg et al., 1986;Steinmetz et al., 1989;Weisgraber, 1990).”

    From Isoform- and cell-state-specific lipidation of ApoE in astrocytes (2022) · cites this paper as Steinmetz et al., 1989

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Metadata

Authors
Steinmetz, A., Jakobs, C., Motzny, S., & Kaffarnik, H.
Affiliations
Zentrum Innere Medizin, Endokrinologie und Stoffwechsel, Philipps-Universität, Marburg, West Germany.
Venue
Arteriosclerosis: An Official Journal of the American Heart Association, Inc.
Publisher
Ovid Technologies (Wolters Kluwer Health)
Published
1989-05
Volume
9
Issue
3
Pages
405-411
ISSN
0276-5047
DOI
10.1161/01.atv.9.3.405
Cited by
93
References
2
Language
en

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