Inflammasomes in the CNS

The Inflammasome

Martinon, F., Burns, K., & Tschopp, J. (2002) · Molecular Cell · doi:10.1016/s1097-2765(02)00599-3 · Cited by 6,066 · see citing works

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602 · see citing works

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326 · see citing works

Mechanisms underlying inflammation in neurodegeneration

Glass, C. K., Saijo, K., Winner, B., Marchetto, M. C., & Gage, F. H. (2010) · Cell · doi:10.1016/j.cell.2010.02.016 · Cited by 3,580 · see citing works

Pyroptosis: host cell death and inflammation

Bergsbaken, T., Fink, S. L., & Cookson, B. T. (2009) · Nature Reviews Microbiology · doi:10.1038/nrmicro2070 · Cited by 3,185 · see citing works

Cryopyrin activates the inflammasome in response to toxins and ATP

Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., Weinrauch, Y., Monack, D. M., & Dixit, V. M. (2006) · Nature · doi:10.1038/nature04515 · Cited by 3,080 · see citing works

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A., & Latz, E. (2008) · Nature Immunology · doi:10.1038/ni.1631 · Cited by 3,065 · see citing works

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Nakahira, K., Haspel, J. A., Rathinam, V. A. K., Lee, S.-J., Dolinay, T., Lam, H. C., Englert, J. A., Rabinovitch, M., Cernadas, M., Kim, H. P., et al. (2011) · Nature Immunology · doi:10.1038/ni.1980 · Cited by 3,049 · see citing works

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Bauernfeind, F. G., Horvath, G. L., Stutz, A., Alnemri, E. S., MacDonald, K. L., Speert, D. P., Fernandes‐Alnemri, T., Wu, J., Monks, B. G., Fitzgerald, K. A., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901363 · Cited by 3,006 · see citing works

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

Heneka, M. T., Kummer, M. P., Stutz, A., Delekate, A., Schwartz, S., Vieira-Saecker, A., Griep, A., Axt, D., Remus, A., Tzeng, T.-C., et al. (2013) · Nature · doi:10.1038/nature11729 · Cited by 2,898 · see citing works

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

Zhou, R., Tardivel, A., Thorens, B., Choi, I., & Tschopp, J. (2010) · Nature Immunology · doi:10.1038/ni.1831 · Cited by 2,708 · see citing works

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

Dostert, C., Pétrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T., & Tschopp, J. (2008) · Science · doi:10.1126/science.1156995 · Cited by 2,658 · see citing works

Apoptosis: controlled demolition at the cellular level

Taylor, R. C., Cullen, S. P., & Martin, S. J. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2312 · Cited by 2,617 · see citing works

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A., Latz, E., Moore, K. J., & Golenbock, D. T. (2008) · Nature Immunology · doi:10.1038/ni.1636 · Cited by 2,441 · see citing works

Oxidized mitochondrial DNA activates the NLRP3 inflammasome during apoptosis

Shimada, K., Crother, T. R., Karlin, J., Dagvadorj, J., Chiba, N., Chen, S., Ramanujan, V. K., Wolf, A. J., Vergnes, L., Ojcius, D. M., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.009 · Cited by 2,282 · see citing works

K+ Efflux Is the Common Trigger of NLRP3 Inflammasome Activation by Bacterial Toxins and Particulate Matter

Muñoz-Planillo, R., Kuffa, P., Martínez-Colón, G. J., Smith, B. L., Rajendiran, T. M., & Núñez, G. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.016 · Cited by 2,167 · see citing works

NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis

Elinav, E., Strowig, T., Kau, A. L., Henao-Mejia, J., Thaiss, C. A., Booth, C. J., Peaper, D. R., Bertin, J., Eisenbarth, S. C., Gordon, J. I., et al. (2011) · Cell · doi:10.1016/j.cell.2011.04.022 · Cited by 2,024 · see citing works

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

Fernandes-Alnemri, T., Yu, J.-W., Datta, P., Wu, J., & Alnemri, E. S. (2009) · Nature · doi:10.1038/nature07710 · Cited by 1,831 · see citing works

Brain interleukin 1 and S-100 immunoreactivity are elevated in Down syndrome and Alzheimer disease.

Griffin, W. S., Stanley, L. C., Ling, C., White, L., MacLeod, V, Perrot, L. J., White, C. L., & Araoz, C. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.19.7611 · Cited by 1,777 · see citing works

NALP3 Forms an IL-1β-Processing Inflammasome with Increased Activity in Muckle-Wells Autoinflammatory Disorder

Agostini, L., Martinon, F., Burns, K., McDermott, M. F., Hawkins, P. N., & Tschopp, J. (2004) · Immunity · doi:10.1016/s1074-7613(04)00046-9 · Cited by 1,768 · see citing works

Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration

Pétrilli, V, Papin, S., Dostert, C., Mayor, A., Martinon, F., & Tschopp, J. (2007) · Cell Death & Differentiation · doi:10.1038/sj.cdd.4402195 · Cited by 1,445 · see citing works

Pannexin‐1 mediates large pore formation and interleukin‐1β release by the ATP‐gated P2X7 receptor

Pelegrı́n, P., & Surprenant, A. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601378 · Cited by 1,428 · see citing works

Necroptosis: The Release of Damage-Associated Molecular Patterns and Its Physiological Relevance

Kaczmarek, A., Vandenabeele, P., & Krysko, D. V. (2013) · Immunity · doi:10.1016/j.immuni.2013.02.003 · Cited by 1,411 · see citing works

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

Rathinam, V. A. K., Jiang, Z., Waggoner, S. N., Sharma, S., Cole, L. E., Waggoner, L., Vanaja, S. K., Monks, B. G., Ganesan, S., Latz, E., et al. (2010) · Nature Immunology · doi:10.1038/ni.1864 · Cited by 1,331 · see citing works

Activation of the NLRP3 inflammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes

Masters, S. L., Dunne, A., Subramanian, S. L., Hull, R. L., Tannahill, G. M., Sharp, F. A., Becker, C., Franchi, L., Yoshihara, E., Chen, Z., et al. (2010) · Nature Immunology · doi:10.1038/ni.1935 · Cited by 1,330 · see citing works

The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Zhao, Y., Yang, J., Shi, J., Gong, Y., Lu, Q., Xu, H., Liu, L., & Shao, F. (2011) · Nature · doi:10.1038/nature10510 · Cited by 1,273 · see citing works

Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1β via Ipaf

Miao, E. A., Alpuche-Aranda, C. M., Dors, M., Clark, A. E., Bader, M. W., Miller, S. I., & Aderem, A. (2006) · Nature Immunology · doi:10.1038/ni1344 · Cited by 1,127 · see citing works

Cytokines and acute neurodegeneration

Allan, S. M., & Rothwell, N. J. (2001) · Nature reviews. Neuroscience · doi:10.1038/35094583 · Cited by 1,126 · see citing works

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

Lu, J., Qiang, W., Yau, W., Schwieters, C. D., Meredith, S. C., & Tycko, R. (2013) · Cell · doi:10.1016/j.cell.2013.08.035 · Cited by 1,087 · see citing works

Innate immunity in the central nervous system

Ransohoff, R. M., & Brown, M. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58644 · Cited by 1,034 · see citing works

Sensing and reacting to microbes through the inflammasomes

Franchi, L., Muñoz-Planillo, R., & Núñez, G. (2012) · Nature Immunology · doi:10.1038/ni.2231 · Cited by 1,013 · see citing works

Interleukin-1 and neuronal injury

Allan, S. M., Tyrrell, P. J., & Rothwell, N. J. (2005) · Nature Reviews Immunology · doi:10.1038/nri1664 · Cited by 992 · see citing works

Regulation of inflammasome signaling

Rathinam, V. A. K., Vanaja, S. K., & Fitzgerald, K. A. (2012) · Nature Immunology · doi:10.1038/ni.2237 · Cited by 927 · see citing works

Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity

Kofoed, E. M., & Vance, R. E. (2011) · Nature · doi:10.1038/nature10394 · Cited by 894 · see citing works

Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin

Boyden, E. D., & Dietrich, W. F. (2006) · Nature Genetics · doi:10.1038/ng1724 · Cited by 860 · see citing works

Active Caspase-1 Is a Regulator of Unconventional Protein Secretion

Keller, M., Rüegg, A., Werner, S., & Beer, H. (2008) · Cell · doi:10.1016/j.cell.2007.12.040 · Cited by 851 · see citing works

Glyburide inhibits the Cryopyrin/Nalp3 inflammasome

Lamkanfi, M., Mueller, J. L., Vitari, A. C., Misaghi, S., Fedorova, A., Deshayes, K., Lee, W. P., Hoffman, H. M., & Dixit, V. M. (2009) · Journal of Cell Biology · doi:10.1083/jcb.200903124 · Cited by 820 · see citing works

Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome

Miao, E. A., Mao, D. P., Yudkovsky, N., Bonneau, R., Lorang, C. G., Warren, S. E., Leaf, I. A., & Aderem, A. A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0913087107 · Cited by 800 · see citing works

ATP Activates a Reactive Oxygen Species-dependent Oxidative Stress Response and Secretion of Proinflammatory Cytokines in Macrophages

Cruz, C. M., Rinna, A., Forman, H. J., Ventura, A. L. M., Persechini, P. M., & Ojcius, D. M. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m608083200 · Cited by 786 · see citing works

Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation

Yan, Y., Jiang, W., Spinetti, T., Tardivel, A., Castillo, R., Bourquin, C., Guarda, G., Tian, Z., Tschopp, J., & Zhou, R. (2013) · Immunity · doi:10.1016/j.immuni.2013.05.015 · Cited by 784 · see citing works

Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases

Deveraux, Q. L., Leo, E., Stennicke, H. R., Welsh, K., Salvesen, G. S., & Reed, J. C. (1999) · The EMBO Journal · doi:10.1093/emboj/18.19.5242 · Cited by 751 · see citing works

TRIF Licenses Caspase-11-Dependent NLRP3 Inflammasome Activation by Gram-Negative Bacteria

Rathinam, V. A. K., Vanaja, S. K., Waggoner, L., Sokolovska, A., Becker, C., Stuart, L. M., Leong, J. M., & Fitzgerald, K. A. (2012) · Cell · doi:10.1016/j.cell.2012.07.007 · Cited by 729 · see citing works

Two Randomized Trials of Canakinumab in Systemic Juvenile Idiopathic Arthritis

Ruperto, N., Brunner, H. I., Quartier, P., Constantin, T., Wulffraat, N. M., Horneff, G., Brik, R., McCann, L. J., Kasapçopur, Ö., Rutkowska‐Sak, L., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1205099 · Cited by 710 · see citing works

Reconstituted NALP1 Inflammasome Reveals Two-Step Mechanism of Caspase-1 Activation

Faustin, B., Lartigue, L., Bruey, J., Luciano, F., Sergienko, E. A., Bailly‐Maitre, B., Volkmann, N., Hanein, D., Rouiller, I., & Reed, J. C. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.01.032 · Cited by 709 · see citing works

Inflammasome recognition of influenza virus is essential for adaptive immune responses

Ichinohe, T., Lee, H. K., Ogura, Y., Flavell, R. A., & Iwasaki, A. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20081667 · Cited by 682 · see citing works

The Adaptor MAVS Promotes NLRP3 Mitochondrial Localization and Inflammasome Activation

Subramanian, N., Natarajan, K., Clatworthy, M. R., Wang, Z., & Germain, R. N. (2013) · Cell · doi:10.1016/j.cell.2013.02.054 · Cited by 675 · see citing works

Heterogeneity of CNS myeloid cells and their roles in neurodegeneration

Prinz, M., Priller, J., Sisodia, S. S., & Ransohoff, R. M. (2011) · Nature Neuroscience · doi:10.1038/nn.2923 · Cited by 674 · see citing works

Excitotoxicity: Bridge to various triggers in neurodegenerative disorders

Mehta, A., Prabhakar, M., Kumar, P., Deshmukh, R. R., & Sharma, P. L. (2012) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2012.10.032 · Cited by 662 · see citing works

Extracellular ATP triggers IL-1 beta release by activating the purinergic P2Z receptor of human macrophages

Ferrari, D., Chiozzi, P., Falzoni, S., Susino, M. D., Melchiorri, L., Baricordi, O. R., & Virgilio, F. D. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.159.3.1451 · Cited by 616 · see citing works

DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88

Tarallo, V., Hirano, Y., Gelfand, B. D., Dridi, S., Kerur, N., Kim, Y., Cho, W. G., Kaneko, H., Fowler, B. J., Bogdanovich, S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.036 · Cited by 592 · see citing works

Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies

Codolo, G., Plotegher, N., Pozzobon, T., Brucale, M., Tessari, I., Bubacco, L., & de Bernard, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0055375 · Cited by 585 · see citing works

Caspase signalling controls microglia activation and neurotoxicity

Burguillos, M. A., Deierborg, T., Kavanagh, E., Persson, A., Hajji, N., Garcia-Quintanilla, A., Cano, J., Brundin, P., Englund, E., Venero, J. L., et al. (2011) · Nature · doi:10.1038/nature09788 · Cited by 585 · see citing works

Structures of the HIN Domain:DNA Complexes Reveal Ligand Binding and Activation Mechanisms of the AIM2 Inflammasome and IFI16 Receptor

Jin, T., Perry, A., Jiang, J., Smith, P. T., Curry, J. A., Unterholzner, L., Jiang, Z., Horvath, G. L., Rathinam, V. A. K., Johnstone, R. W., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.02.014 · Cited by 571 · see citing works

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

Broz, P., Ruby, T., Belhocine, K., Bouley, D. M., Kayagaki, N., Dixit, V. M., & Monack, D. M. (2012) · Nature · doi:10.1038/nature11419 · Cited by 535 · see citing works

The Pannexin 1 Channel Activates the Inflammasome in Neurons and Astrocytes

Silverman, W. R., Vaccari, J. P. D. R., Locovei, S., Qiu, F., Carlsson, S. K., Scemes, E., Keane, R. W., & Dahl, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.004804 · Cited by 534 · see citing works

Caspase-3 Activation via Mitochondria Is Required for Long-Term Depression and AMPA Receptor Internalization

Li, Z., Jo, J., Jia, J., Lo, S., Whitcomb, D. J., Jiao, S., Cho, K., & Sheng, M. (2010) · Cell · doi:10.1016/j.cell.2010.03.053 · Cited by 533 · see citing works

Inflammasome Components NALP 1 and 3 Show Distinct but Separate Expression Profiles in Human Tissues Suggesting a Site-specific Role in the Inflammatory Response

Kummer, J. A., Broekhuizen, R., Everett, H., Agostini, L., Kuijk, L., Martinon, F., Bruggen, R. V., & Tschopp, J. (2007) · Journal of Histochemistry & Cytochemistry · doi:10.1369/jhc.6a7101.2006 · Cited by 531 · see citing works

Role of IL-1α and IL-1β in Ischemic Brain Damage

Boutin, H., Feuvre, R. A. L., Horai, R., Asano, M., Iwakura, Y., & Rothwell, N. J. (2001) · Journal of Neuroscience · doi:10.1523/jneurosci.21-15-05528.2001 · Cited by 521 · see citing works

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

Karataş, H., Erdener, Ş. E., Özdemir, Y., Lüle, S., Eren‐Koçak, E., Şen, Z. D., & Dalkara, T. (2013) · Science · doi:10.1126/science.1231897 · Cited by 516 · see citing works

Interleukin-1β Promotes Repair of the CNS

Mason, J. L., Suzuki, K., Chaplin, D. D., & Matsushima, G. K. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-18-07046.2001 · Cited by 502 · see citing works

Inhibitor of Apoptosis Proteins Limit RIP3 Kinase-Dependent Interleukin-1 Activation

Vince, J. E., Wong, W. W.-L., Gentle, I., Lawlor, K. E., Allam, R., O'Reilly, L., Mason, K., Gross, O., Ma, S., Guarda, G., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.01.012 · Cited by 491 · see citing works

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

Lightfield, K. L., Persson, J., Brubaker, S. W., Witte, C. E., von Moltke, J., Dunipace, E. A., Henry, T., Sun, Y., Cado, D., Dietrich, W. F., et al. (2008) · Nature Immunology · doi:10.1038/ni.1646 · Cited by 487 · see citing works

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1β and IL-18 secretion in an autocrine way

Piccini, A., Carta, S., Tassi, S., Lasigliè, D., Fossati, G., & Rubartelli, A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709684105 · Cited by 460 · see citing works

Activation of neuronal P2X7 receptor–pannexin-1 mediates death of enteric neurons during colitis

Gulbransen, B. D., Bashashati, M., Hirota, S. A., Gui, X. S., Roberts, J. A., MacDonald, J. A., Muruve, D. A., McKay, D. M., Beck, P. L., Mawe, G. M., et al. (2012) · Nature Medicine · doi:10.1038/nm.2679 · Cited by 444 · see citing works

Rapid induction of inflammatory lipid mediators by the inflammasome in vivo

von Moltke, J., Trinidad, N. J., Moayeri, M., Kintzer, A. F., Wang, S. B., van Rooijen, N., Brown, C. R., Krantz, B. A., Leppla, S. H., Gronert, K., et al. (2012) · Nature · doi:10.1038/nature11351 · Cited by 438 · see citing works

Sustained hippocampal IL-1β overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology

Shaftel, S. S., Kyrkanides, S., Olschowka, J. A., Miller, J.-N. H., Johnson, R. E., & O’Banion, M. K. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31450 · Cited by 433 · see citing works

NLRP3 Plays a Critical Role in the Development of Experimental Autoimmune Encephalomyelitis by Mediating Th1 and Th17 Responses

Gris, D., Ye, Z., Iocca, H. A., Wen, H., Craven, R. R., Gris, P., Huang, M., Schneider, M., Miller, S. D., & Ting, J. P.-Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0904145 · Cited by 429 · see citing works

Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms

Fink, S. L., Bergsbaken, T., & Cookson, B. T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0707370105 · Cited by 403 · see citing works

Malarial Hemozoin Is a Nalp3 Inflammasome Activating Danger Signal

Dostert, C., Guarda, G., Romero, J. F., Menu, P., Groß, O., Tardivel, A., Suvà, M.-L., Stehle, J., Köpf, M., Stamenkovic, I., et al. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006510 · Cited by 397 · see citing works

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

Compan, V., Baroja‐Mazo, A., López‐Castejón, G., Gomez, A. I., Martínez, C. M., Angosto-Bazarra, D., Montero, M. T., Herranz, A. S., Bazán, E., Reimers, D., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.06.013 · Cited by 390 · see citing works

The NLRP12 Inflammasome Recognizes Yersinia pestis

Vladimer, G. I., Weng, D., Paquette, S. W. M., Vanaja, S. K., Rathinam, V. A. K., Aune, M. H., Conlon, J. E., Burbage, J. J., Proulx, M. K., Liu, Q., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.07.006 · Cited by 367 · see citing works

Pannexin-1 Is Required for ATP Release during Apoptosis but Not for Inflammasome Activation

Qu, Y., Misaghi, S., Newton, K., Gilmour, L. L., Louie, S., Cupp, J. E., Dubyak, G., Hackos, D. H., & Dixit, V. M. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100478 · Cited by 365 · see citing works

Pneumolysin Activates the NLRP3 Inflammasome and Promotes Proinflammatory Cytokines Independently of TLR4

McNeela, E. A., Burke, Á., Neill, D. R., Baxter, C., Fernandes, V. E., Ferreira, D. M., Smeaton, S., El-Rachkidy, R. G., McLoughlin, R. M., Mori, A., et al. (2010) · PLoS Pathogens · doi:10.1371/journal.ppat.1001191 · Cited by 354 · see citing works

Differential Expression of NLRP3 among Hematopoietic Cells

Guarda, G., Zenger, M., Yazdi, A. S., Schroder, K., Ferrero, I., Menu, P., Tardivel, A., Mattmann, C., & Tschopp, J. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002720 · Cited by 350 · see citing works

Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

Friedlander, R. M., Gagliardini, V., Hara, H., Fink, K., Li, W., MacDonald, G. C., Fishman, M. C., Greenberg, A. H., Moskowitz, M. A., & Yuan, J. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.185.5.933 · Cited by 349 · see citing works

Caspase-1–Processed Cytokines IL-1β and IL-18 Promote IL-17 Production by γδ and CD4 T Cells That Mediate Autoimmunity

Lalor, S. J., Dungan, L. S., Sutton, C. E., Basdeo, S. A., Fletcher, J. M., & Mills, K. H. G. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003597 · Cited by 347 · see citing works

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

de Rivero Vaccari, J. P., Lotocki, G., Marcillo, A. E., Dietrich, W. D., & Keane, R. W. (2008) · The Journal of Neuroscience · doi:10.1523/jneurosci.0157-08.2008 · Cited by 332 · see citing works

Human astrocytes express a novel NLRP2 inflammasome

Minkiewicz, J., Vaccari, J. P. D. R., & Keane, R. W. (2013) · Glia · doi:10.1002/glia.22499 · Cited by 328 · see citing works

Inhibition of the Inflammasome Complex Reduces the Inflammatory Response after Thromboembolic Stroke in Mice

Abulafia, D. P., de Rivero Vaccari, J. P., Lozano, J. D., Lotocki, G., Keane, R. W., & Dietrich, W. D. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2008.143 · Cited by 322 · see citing works

Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1

Bruey, J., Bruey-Sédano, N., Luciano, F., Zhai, D., Balpai, R., Xu, C., Kress, C. L., Bailly‐Maitre, B., Li, X., Osterman, A. L., et al. (2007) · Cell · doi:10.1016/j.cell.2007.01.045 · Cited by 319 · see citing works

Mutant superoxide dismutase 1-induced IL-1β accelerates ALS pathogenesis

Meissner, F., Molawi, K., & Zychlinsky, A. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1002396107 · Cited by 319 · see citing works

Anthrax Lethal Factor Cleavage of Nlrp1 Is Required for Activation of the Inflammasome

Levinsohn, J. L., Newman, Z. L., Hellmich, K. A., Fattah, R. J., Getz, M. A., Liu, S., Sastalla, I., Leppla, S. H., & Moayeri, M. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1002638 · Cited by 317 · see citing works

Therapeutic Neutralization of the NLRP1 Inflammasome Reduces the Innate Immune Response and Improves Histopathology after Traumatic Brain Injury

de Rivero Vaccari, J. P., Lotocki, G., Alonso, O. F., Bramlett, H. M., Dietrich, W. D., & Keane, R. W. (2009) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2009.46 · Cited by 312 · see citing works

The Inflammasome Sensor, NLRP3, Regulates CNS Inflammation and Demyelination via Caspase-1 and Interleukin-18

Jha, S., Srivastava, S. Y., Brickey, W. J., Iocca, H., Toews, A., Morrison, J. P., Chen, V. S., Gris, D., Matsushima, G. K., & Ting, J. P.-Y. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4088-10.2010 · Cited by 310 · see citing works

Reduced Ischemic Brain Injury in Interleukin-1β Converting Enzyme—Deficient Mice

Schielke, G. P., Yang, G., Shivers, B. D., & Betz, A. L. (1998) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199802000-00009 · Cited by 302 · see citing works

Interleukin 18 in the CNS

Alboni, S., Cervia, D., Sugama, S., & Conti, B. (2010) · Journal of Neuroinflammation · doi:10.1186/1742-2094-7-9 · Cited by 301 · see citing works

Involvement of the AIM2, NLRC4, and NLRP3 Inflammasomes in Caspase-1 Activation by Listeria monocytogenes

Wu, J., Fernandes‐Alnemri, T., & Alnemri, E. S. (2010) · Journal of Clinical Immunology · doi:10.1007/s10875-010-9425-2 · Cited by 291 · see citing works

NLRP3 inflammasome induces chemotactic immune cell migration to the CNS in experimental autoimmune encephalomyelitis

Inoue, M., Williams, K. L., Gunn, M. D., & Shinohara, M. L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1201836109 · Cited by 288 · see citing works

Neisseria gonorrhoeae Activates the Proteinase Cathepsin B to Mediate the Signaling Activities of the NLRP3 and ASC-Containing Inflammasome

Duncan, J. A., Gao, X., Huang, M. T.-H., O’Connor, B. P., Thomas, C. E., Willingham, S. B., Bergstralh, D. T., Jarvis, G. A., Sparling, P. F., & Ting, J. P. ‐. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802696 · Cited by 278 · see citing works

Granzyme B-Dependent Proteolysis Acts as a Switch to Enhance the Proinflammatory Activity of IL-1α

Afonina, I. S., Tynan, G. A., Logue, S. E., Cullen, S. P., Bots, M. L., Lüthi, A. U., Reeves, E. P., McElvaney, N. G., Medema, J. P., Lavelle, E. C., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.037 · Cited by 275 · see citing works

Non-junction functions of pannexin-1 channels

MacVicar, B. A., & Thompson, R. J. (2009) · Trends in Neurosciences · doi:10.1016/j.tins.2009.11.007 · Cited by 259 · see citing works

Autolytic Proteolysis within the Function to Find Domain (FIIND) Is Required for NLRP1 Inflammasome Activity

Finger, J. N., Lich, J. D., Dare, L. C., Cook, M. N., Brown, K. K., Duraiswami, C., Bertin, J., & Gough, P. J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.378323 · Cited by 257 · see citing works

Apoptotic and non-apoptotic roles of caspases in neuronal physiology and pathophysiology

Hyman, B. T., & Yuan, J. (2012) · Nature reviews. Neuroscience · doi:10.1038/nrn3228 · Cited by 249 · see citing works

IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection

Ramos, H. J., Lanteri, M. C., Blahnik, G., Negash, A. A., Suthar, M. S., Brassil, M. M., Sodhi, K., Treuting, P. M., Busch, M. P., Norris, P. J., et al. (2012) · PLoS Pathogens · doi:10.1371/journal.ppat.1003039 · Cited by 240 · see citing works

Inflammatory Stimuli Regulate Caspase Substrate Profiles

Agard, N. J., Maltby, D. A., & Wells, J. A. (2010) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m900528-mcp200 · Cited by 219 · see citing works

Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles

Yang, E.-J., Kim, S.-J., Kim, J. S., & Choi, I. (2012) · Biomaterials · doi:10.1016/j.biomaterials.2012.06.016 · Cited by 218 · see citing works

IL‐1‐regulated responses in astrocytes: Relevance to injury and recovery

John, G. R., Lee, S. C., Song, X., Rivieccio, M. A., & Brosnan, C. F. (2004) · Glia · doi:10.1002/glia.20109 · Cited by 218 · see citing works

Fundamental role of the Rip2/caspase-1 pathway in hypoxia and ischemia-induced neuronal cell death

Zhang, W., Wang, X., Narayanan, M. V., Zhang, Y., Huo, C., Reed, J. C., & Friedlander, R. M. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2534856100 · Cited by 212 · see citing works

CARD8 and NLRP1 Undergo Autoproteolytic Processing through a ZU5-Like Domain

D’Osualdo, A., Weichenberger, C. X., Wagner, R. N., Godzik, A., Wooley, J., & Reed, J. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027396 · Cited by 211 · see citing works

The immunology of neurodegeneration

Czirr, E., & Wyss‐Coray, T. (2012) · Journal of Clinical Investigation · doi:10.1172/jci58656 · Cited by 211 · see citing works

The NLRP3 inflammasome contributes to brain injury in pneumococcal meningitis and is activated through ATP-dependent lysosomal cathepsin B release

Hoegen, T., Tremel, N., Klein, M., Angele, B., Wagner, H., Kirschning, C., Pfister, H.-W., Fontana, A., Hammerschmidt, S., & Koedel, U. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1100790 · Cited by 211 · see citing works

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

Schorn, C., Frey, B., Lauber, K., Janko, C., Strysio, M., Keppeler, H., Gaipl, U. S., Voll, R. E., Springer, E., Munoz, L. E., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.139048 · Cited by 207 · see citing works

Intracellular Interleukin-1 Receptor 2 Binding Prevents Cleavage and Activity of Interleukin-1α, Controlling Necrosis-Induced Sterile Inflammation

Zheng, Y., Humphry, M., Maguire, J. J., Bennett, M. R., & Clarke, M. C. H. (2013) · Immunity · doi:10.1016/j.immuni.2013.01.008 · Cited by 205 · see citing works

The contrasting roles of ICE family proteases and interleukin-1beta in apoptosis induced by trophic factor withdrawal and by copper/zinc superoxide dismutase down-regulation.

Troy, C. M., Stefanis, L., Prochiantz, A., Greene, L., & Shelanski, M. L. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.11.5635 · Cited by 190 · see citing works

Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization

Akhter, A., Caution, K., Khweek, A. A., Tazi, M., Abdulrahman, B., Abdelaziz, D. H., Voss, O. H., Doseff, A. I., Hassan, H., Azad, A. K., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.05.001 · Cited by 185 · see citing works

The Neuronal Apoptosis Inhibitory Protein Is a Direct Inhibitor of Caspases 3 and 7

Maier, J. K. X., Lahoua, Z., Gendron, N. H., Fetni, R., Johnston, A., Davoodi, J., Rasper, D., Roy, S., Slack, R. S., Nicholson, D. W., et al. (2002) · Journal of Neuroscience · doi:10.1523/jneurosci.22-06-02035.2002 · Cited by 185 · see citing works

Inflammasomes are Differentially Expressed in Cardiovascular and other Tissues

Yin, Y., Yan, Y., Jiang, X., Mai, J., Chen, N., Wang, H., & Yang, X.-F. (2009) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463200902200208 · Cited by 177 · see citing works

Cellular Inhibitors of Apoptosis Proteins cIAP1 and cIAP2 Are Required for Efficient Caspase-1 Activation by the Inflammasome

Labbè, K., McIntire, C. R., Doiron, K., LeBlanc, P. M., & Saleh, M. (2011) · Immunity · doi:10.1016/j.immuni.2011.10.016 · Cited by 169 · see citing works

Inflammasome proteins in cerebrospinal fluid of brain-injured patients as biomarkers of functional outcome

Adamczak, S. E., Dale, G. A., Vaccari, J. P. D. R., Bullock, M. R., Dietrich, W. D., & Keane, R. W. (2012) · Journal of neurosurgery · doi:10.3171/2012.9.jns12815 · Cited by 166 · see citing works

Tumor Necrosis Factor–α and Interleukin‐1β Play a Critical Role in the Resistance against Lethal Herpes Simplex Virus Encephalitis

Sergerie, Y., Rivest, S., & Boivin, G. (2007) · The Journal of Infectious Diseases · doi:10.1086/520094 · Cited by 165 · see citing works

Inflammasome activation and IL‐1β/IL‐18 processing are influenced by distinct pathways in microglia

Hanamsagar, R. M., Torres, V. J., & Kielian, T. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07481.x · Cited by 160 · see citing works

NLRP3 Inflammasome: Key Mediator of Neuroinflammation in Murine Japanese Encephalitis

Kaushik, D. K., Gupta, M., Kumawat, K. L., & Basu, A. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032270 · Cited by 146 · see citing works

MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

Deroide, N., Li, X., Lerouet, D., Vré, E. A. V., Baker, L. L., Harrison, J., Poittevin, M., Masters, L. M., Nih, L. R., Margaill, I., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci65167 · Cited by 143 · see citing works

Cholesterol-dependent cytolysins induce rapid release of mature IL-1β from murine macrophages in a NLRP3 inflammasome and cathepsin B-dependent manner

Chu, J., Thomas, L. M., Watkins, S. C., Franchi, L., Núñez, G., & Salter, R. D. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0309164 · Cited by 142 · see citing works

The Cytokine Release Inhibitory Drug CRID3 Targets ASC Oligomerisation in the NLRP3 and AIM2 Inflammasomes

Coll, R. C., & O'Neill, L. A. J. (2011) · PLoS ONE · doi:10.1371/journal.pone.0029539 · Cited by 137 · see citing works

Delayed Administration of Interleukin-1 Receptor Antagonist Reduces Ischemic Brain Damage and Inflammation in Comorbid Rats

Pradillo, J. M., Dénes, Á., Greenhalgh, A. D., Boutin, H., Drake, C., McColl, B. W., Barton, E. C., Proctor, S. D., Russell, J. C., Rothwell, N. J., et al. (2012) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.101 · Cited by 130 · see citing works

Caspase-6 and neurodegeneration

Graham, R. K., Ehrnhoefer, D. E., & Hayden, M. R. (2011) · Trends in Neurosciences · doi:10.1016/j.tins.2011.09.001 · Cited by 127 · see citing works

NF-κB activation by the Toll-IL-1 receptor domain protein MyD88 adapter-like is regulated by caspase-1

Miggin, S. M., Pålsson‐McDermott, E. M., Dunne, A., Jefferies, C. A., Pinteaux, E., Banahan, K., Murphy, C., Moynagh, P. N., Yamamoto, M., Akira, S., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608100104 · Cited by 126 · see citing works

NAIP and Ipaf Control Legionella pneumophila Replication in Human Cells

Vinzing, M., Eitel, J., Lippmann, J., Hocke, A. C., Zahlten, J., Slevogt, H., N’Guessan, P. D., Günther, S., Schmeck, B., Hippenstiel, S., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.10.6808 · Cited by 124 · see citing works

Inflammasome Adaptor Protein Apoptosis-Associated Speck-Like Protein Containing CARD (ASC) Is Critical for the Immune Response and Survival in West Nile Virus Encephalitis

Kumar, M., Roe, K., Orillo, B., Muruve, D. A., Nerurkar, V. R., Gale, M., & Verma, S. (2013) · Journal of Virology · doi:10.1128/jvi.02667-12 · Cited by 113 · see citing works

Necrostatin-1 attenuates mitochondrial dysfunction in neurons and astrocytes following neonatal hypoxia–ischemia

Chavez‐Valdez, R., Martin, L. J., Flock, D. L., & Northington, F. J. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.05.002 · Cited by 112 · see citing works

The NALP3 inflammasome is involved in neurotoxic prion peptide-induced microglial activation

Shi, F., Yang, L., Kouadir, M., Yang, Y., Wang, J., Zhou, X., Yin, X., & Zhao, D. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-73 · Cited by 109 · see citing works

Instrumental Activation of Bid by Caspase-1 in a Transgenic Mouse Model of ALS

Guégan, C. (2002) · Molecular and Cellular Neuroscience · doi:10.1006/mcne.2002.1136 · Cited by 105 · see citing works

NALP1/NLRP1 Genetic Variants are Associated With Alzheimer Disease

Pontillo, A., Catamo, E., Arosio, B., Mari, D., & Crovella, S. (2011) · Alzheimer Disease & Associated Disorders · doi:10.1097/wad.0b013e318231a8ac · Cited by 98 · see citing works

Interleukin 1 receptor antagonist knockout mice show enhanced microglial activation and neuronal damage induced by intracerebroventricular infusion of human β-amyloid

Craft, J. M., Watterson, D. M., Hirsch, E., & Van Eldik, L. J. (2005) · Journal of Neuroinflammation · doi:10.1186/1742-2094-2-15 · Cited by 96 · see citing works

NLRP3 inflammasome activation in macrophage cell lines by prion protein fibrils as the source of IL-1β and neuronal toxicity

Hafner‐Bratkovič, I., Benčina, M., Fitzgerald, K. A., Golenbock, D. T., & Jerala, R. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1140-0 · Cited by 92 · see citing works

Anthrax and the inflammasome

Moayeri, M., Sastalla, I., & Leppla, S. H. (2011) · Microbes and Infection · doi:10.1016/j.micinf.2011.12.005 · Cited by 90 · see citing works

Mycobacterium abscessus activates the NLRP3 inflammasome via Dectin‐1–Syk and p62/SQSTM1

Lee, H., Yuk, J., Kim, K., Jang, J., Kang, G., Park, J. B., Son, J. W., & Jo, E. (2011) · Immunology and Cell Biology · doi:10.1038/icb.2011.72 · Cited by 90 · see citing works

Human leukocyte antigens and cytokine expression in cerebral inflammatory demyelinative lesions of X-linked adrenoleukodystrophy and multiple sclerosis

McGuinness, M. C., Powers, J. M., Bias, W. B., Schmeckpeper, B. J., Segal, A. H., Gowda, V. C., Wesselingh, S. L., Berger, J., Griffin, D. E., & Smith, K. D. (1997) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(97)00020-9 · Cited by 89 · see citing works

Asc Modulates the Function of NLRC4 in Response to Infection of Macrophages by Legionella pneumophila

Case, C. L., & Roy, C. R. (2011) · mBio · doi:10.1128/mbio.00117-11 · Cited by 85 · see citing works

Staphylococcus aureus activation of caspase 1/calpain signaling mediates invasion through human keratinocytes

Soong, G., Chun, J., Parker, D., & Prince, A. (2012) · The Journal of Infectious Diseases · doi:10.1093/infdis/jis244 · Cited by 84 · see citing works

Interleukin-18 in acute ischaemic stroke patients

Zaremba, J., & Losy, J. (2003) · Neurological Sciences · doi:10.1007/s10072-003-0096-0 · Cited by 74 · see citing works

Experimental cerebral malaria progresses independently of the Nlrp3 inflammasome

Reimer, T., Shaw, M. H., Franchi, L., Coban, C., Ishii, K. J., Akira, S., Horii, T., Rodrı́guez, A., & Núñez, G. (2009) · European Journal of Immunology · doi:10.1002/eji.200939996 · Cited by 73 · see citing works

Promises and pitfalls of a Pannexin1 transgenic mouse line

Hanstein, R., Negoro, H., Patel, N. K., Charollais, A., Meda, P., Spray, D. C., Suadicani, S. O., & Scemes, E. (2013) · Frontiers in Pharmacology · doi:10.3389/fphar.2013.00061 · Cited by 72 · see citing works

Inflammasome-Dependent IFN-γ Drives Pathogenesis in Streptococcus pneumoniae Meningitis

Mitchell, A. J., Yau, B., McQuillan, J. A., Ball, H. J., Too, L. K., Abtin, A., Hertzog, P. J., Leib, S. L., Jones, C., Gerega, S. K., et al. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201687 · Cited by 70 · see citing works

Microglial activation of the NLRP3 inflammasome by the priming signals derived from macrophages infected with mycobacteria

Lee, H., Kang, J., Lee, S. J., & Jo, E. (2012) · Glia · doi:10.1002/glia.22448 · Cited by 65 · see citing works

Evidence For Multiple Cell Death Pathways during Development of Experimental Cytomegalovirus Retinitis in Mice with Retrovirus-Induced Immunosuppression: Apoptosis, Necroptosis, and Pyroptosis

Chien, H., & Dix, R. D. (2012) · Journal of Virology · doi:10.1128/jvi.01275-12 · Cited by 64 · see citing works

Impaired Microglial Activation in the Brain of IL-18-Gene-Disrupted Mice after Neurovirulent Influenza A Virus Infection

Mori, I., Hossain, M. J., Takeda, K., Okamura, H., Imai, Y., Kohsaka, S., & Kimura, Y. (2001) · Virology · doi:10.1006/viro.2001.1029 · Cited by 59 · see citing works

Functional outcome of pannexin-deficient mice after cerebral ischemia

Bargiotas, P., Krenz, A., Monyer, H., & Schwaninger, M. (2012) · Channels · doi:10.4161/chan.22315 · Cited by 59 · see citing works

Antiviral Antibodies Target Adenovirus to Phagolysosomes and Amplify the Innate Immune Response

Zaiss, A. K., Vilaysane, A., Cotter, M. J., Clark, S. A., Meijndert, H. C., Colarusso, P., Yates, R. M., Pétrilli, V., Tschopp, J., & Muruve, D. A. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0804269 · Cited by 58 · see citing works

HMG-CoA reductase inhibitors activate caspase-1 in human monocytes depending on ATP release and P2X7 activation

Liao, Y.-H., Lin, Y.-C., Tsao, S.-T., Lin, Y., Yang, A.-J., Huang, C.-T., Huang, K., & Lin, W. (2012) · Journal of Leukocyte Biology · doi:10.1189/jlb.0812409 · Cited by 56 · see citing works

Interleukin-18 gene-deficient mice show enhanced defense and reduced inflammation during pneumococcal meningitis

Zwijnenburg, P. J. G., van der Poll, T., Florquin, S., Akira, S., Takeda, K., Roord, J. J., & van Furth, A. M. (2003) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(03)00088-2 · Cited by 56 · see citing works

Targeting interleukin-1β in CAPS (cryopyrin-associated periodic) syndromes

Koné‐Paut, I., & Piram, M. (2012) · Autoimmunity Reviews · doi:10.1016/j.autrev.2012.07.026 · Cited by 49 · see citing works

No Role for Interleukin-18 in Acute Murine Stroke-Induced Brain Injury

Wheeler, R. D., Boutin, H., Touzani, O., Luheshi, G. N., Takeda, K., & Rothwell, N. J. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000059587.71206.ba · Cited by 47 · see citing works

Contribution of Lethal Toxin and Edema Toxin to the Pathogenesis of Anthrax Meningitis

Ebrahimi, C. M., Sheen, T. R., Renken, C. W., Gottlieb, R. A., & Doran, K. S. (2011) · Infection and Immunity · doi:10.1128/iai.00006-11 · Cited by 46 · see citing works

Inflammasome activation restricts Legionella pneumophila replication in primary microglial cells through flagellin detection

Jamilloux, Y., Pierini, R., Querenet, M., Juruj, C., Fauchais, A. L., Jauberteau, M., Jarraud, S., Lina, G., Étienne, J., Roy, C. R., et al. (2013) · Glia · doi:10.1002/glia.22454 · Cited by 45 · see citing works

Genetic variation in inflammasome genes is associated with outcome in bacterial meningitis

Geldhoff, M., Mook-Kanamori, B. B., Brouwer, M. C., Serón, M. V., Baas, F., ENDE, A. V. D., & van de Beek, D. (2012) · Immunogenetics · doi:10.1007/s00251-012-0653-x · Cited by 32 · see citing works

Induced expression of death domain genes NALP1 and NALP5 following neuronal injury

Lo, C. F., Ning, X., Gonzales, C., & Ozenberger, B. A. (2008) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.11.174 · Cited by 28 · see citing works

Inflammasome activation and regulation: toward a better understanding of complex mechanisms

Zheng, D., Liwinski, T., & Elinav, E. (2020) · Cell Discovery · doi:10.1038/s41421-020-0167-x · Cited by 1,042 · see citing works

Inflammasome inhibition prevents α-synuclein pathology and dopaminergic neurodegeneration in mice

Gordon, R., Albornoz, E. A., Christie, D. C., Langley, M. R., Kumar, V., Mantovani, S., Robertson, A. A. B., Butler, M. S., Rowe, D. B., O’Neill, L. A., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aah4066 · Cited by 897 · see citing works

Neuroimmunology of Traumatic Brain Injury: Time for a Paradigm Shift

Jassam, Y. N., Izzy, S., Whalen, M., McGavern, D. B., & El Khoury, J. (2017) · Neuron · doi:10.1016/j.neuron.2017.07.010 · Cited by 799 · see citing works

Inflammasomes in neuroinflammatory and neurodegenerative diseases

Voet, S., Srinivasan, S., Lamkanfi, M., & van Loo, G. (2019) · EMBO Molecular Medicine · doi:10.15252/emmm.201810248 · Cited by 761 · see citing works

Cytokine networks in neuroinflammation

Becher, B., Spath, S., & Goverman, J. M. (2016) · Nature reviews. Immunology · doi:10.1038/nri.2016.123 · Cited by 681 · see citing works

Integrating neuroimmune systems in the neurobiology of depression

Wohleb, E. S., Franklin, T., Iwata, M., & Duman, R. S. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.69 · Cited by 668 · see citing works

Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight

Shi, Y., & Holtzman, D. M. (2018) · Nature Reviews Immunology · doi:10.1038/s41577-018-0051-1 · Cited by 595 · see citing works

Inflammation, glutamate, and glia: a trio of trouble in mood disorders

Haroon, E., Miller, A. H., & Sanacora, G. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.199 · Cited by 584 · see citing works

Energy metabolism and inflammation in brain aging and Alzheimer’s disease

Yin, F., Sancheti, H., Patil, I., & Cadenas, E. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.04.200 · Cited by 538 · see citing works

Inflammatory Response in the CNS: Friend or Foe?

Sochocka, M., Diniz, B. S., & Leszek, J. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0297-1 · Cited by 573 · see citing works

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

McKenzie, B., Mamik, M. K., Saito, L. B., Boghozian, R., Monaco, M. C., Major, E. O., Lu, J., Branton, W. G., & Power, C. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1722041115 · Cited by 515 · see citing works

The role of interleukin-6 signaling in nervous tissue

Rothaug, M., Becker-Pauly, C., & Rose-John, S. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.03.018 · Cited by 491 · see citing works

An xQTL map integrates the genetic architecture of the human brain's transcriptome and epigenome

Ng, B., White, C. C., Klein, H.-U., Sieberts, S. K., McCabe, C., Patrick, E., Xu, J., Yu, L., Gaiteri, C., Bennett, D. A., et al. (2017) · Nature Neuroscience · doi:10.1038/nn.4632 · Cited by 452 · see citing works

MicroRNA-7 targets Nod-like receptor protein 3 inflammasome to modulate neuroinflammation in the pathogenesis of Parkinson’s disease

Zhou, Y., Lu, M., Du, R.-H., Qiao, C., Jiang, C.-Y., Zhang, K.-Z., Ding, J.-H., & Hu, G. (2016) · Molecular Neurodegeneration · doi:10.1186/s13024-016-0094-3 · Cited by 455 · see citing works

Advanced oxidation protein products induce microglia-mediated neuroinflammation via MAPKs-NF-κB signaling pathway and pyroptosis after secondary spinal cord injury

Liu, Z., Yao, X., Jiang, W., Li, W., Zhu, S., Liao, C., Zou, L., Ding, R., & Chen, J. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01751-2 · Cited by 430 · see citing works

InflammasomesPreprint

de Zoete, M. R., Palm, N. W., Zhu, S., & Flavell, R. A. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a016287 · Cited by 382 · see citing works

NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings

Kaufmann, F. N., Costa, A. P., Ghisleni, G., Diaz, A. P., Rodrigues, A. L. S., Peluffo, H., & Kaster, M. P. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.03.002 · Cited by 370 · see citing works

The role of innate immune responses and neuroinflammation in amyloid accumulation and progression of Alzheimer's disease

Webers, A., Heneka, M. T., & Gleeson, P. A. (2019) · Immunology and Cell Biology · doi:10.1111/imcb.12301 · Cited by 371 · see citing works

NLRP3 inflammasome is expressed and functional in mouse brain microglia but not in astrocytes

Gustin, A., Kirchmeyer, M., Koncina, E., Felten, P., Losciuto, S., Heurtaux, T., Tardivel, A., Heuschling, P., & Dostert, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130624 · Cited by 369 · see citing works

Dealing with danger in the CNS: the response of the immune system to injury

Gadani, S. P., Walsh, J. T., Lukens, J. R., & Kipnis, J. (2015) · Neuron · doi:10.1016/j.neuron.2015.05.019 · Cited by 342 · see citing works

Systemic inflammation impairs microglial Aβ clearance through NLRP3 inflammasome

Tejera, D., Mercan, D., Sanchez‐Caro, J. M., Hanan, M., Greenberg, D., Soreq, H., Latz, E., Golenbock, D., & Heneka, M. T. (2019) · The EMBO Journal · doi:10.15252/embj.2018101064 · Cited by 351 · see citing works

Recording, analysis, and interpretation of spreading depolarizations in neurointensive care: Review and recommendations of the COSBID research group

Dreier, J. P., Fabricius, M., Ayata, C., Sakowitz, O. W., William Shuttleworth, C., Dohmen, C., Graf, R., Vajkoczy, P., Helbok, R., Suzuki, M., et al. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16654496 · Cited by 350 · see citing works

Fiery Cell Death: Pyroptosis in the Central Nervous System.

McKenzie, B. A., Dixit, V., & Power, C. (2019) · Trends in Neurosciences · doi:10.1016/j.tins.2019.11.005 · Cited by 289 · see citing works

Autophagy and inflammation in ischemic stroke

Mo, Y., Sun, Y., & Liu, K. (2020) · Neural Regeneration Research · doi:10.4103/1673-5374.274331 · Cited by 325 · see citing works

Neuronal NLRP1 inflammasome activation of Caspase-1 coordinately regulates inflammatory interleukin-1-beta production and axonal degeneration-associated Caspase-6 activation

Kaushal, V, Dye, R., Pakavathkumar, P., Foveau, B., Flores, J., Hyman, B., Ghetti, B., Koller, B. H., & LeBlanc, A. C. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2015.16 · Cited by 297 · see citing works

The role of astrocytes in oxidative stress of central nervous system: A mixed blessing

Chen, Y., Chen, Q., Huang, J., Tang, X., Liu, C., Huang, K., Xu, J., Guo, G. F., Tong, A., & Zhou, L. (2020) · Cell Proliferation · doi:10.1111/cpr.12781 · Cited by 308 · see citing works

Focus on the Role of NLRP3 Inflammasome in Diseases

Fusco, R., Siracusa, R., Genovese, T., Cuzzocrea, S., & Paola, R. D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21124223 · Cited by 292 · see citing works

Interleukin-1β Induces Blood–Brain Barrier Disruption by Downregulating Sonic Hedgehog in Astrocytes

Wang, Y., Jin, S., Sonobe, Y., Cheng, Y., Horiuchi, H., Parajuli, B., Kawanokuchi, J., Mizuno, T., Takeuchi, H., & Suzumura, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110024 · Cited by 286 · see citing works

Immune dysregulation and cognitive vulnerability in the aging brain: Interactions of microglia, IL-1β, BDNF and synaptic plasticity

Patterson, S. L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.12.020 · Cited by 281 · see citing works

Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse

Lacagnina, M. J., Rivera, P. D., & Bilbo, S. D. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.121 · Cited by 271 · see citing works

NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia

Ward, R., Li, W., Abdul, Y., Jackson, L., Dong, G., Jamil, S., Filosa, J. A., Fagan, S. C., & Ergul, A. (2019) · Pharmacological Research · doi:10.1016/j.phrs.2019.01.035 · Cited by 274 · see citing works

Migraine and neuroinflammation: the inflammasome perspective

Kurşun, O., Yemisci, M., van den Maagdenberg, A. M., & Karatas, H. (2021) · The Journal of Headache and Pain · doi:10.1186/s10194-021-01271-1 · Cited by 209 · see citing works

Emerging Roles for the Immune System in Traumatic Brain Injury

McKee, C. A., & Lukens, J. R. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00556 · Cited by 265 · see citing works

Fyn kinase regulates misfolded α-synuclein uptake and NLRP3 inflammasome activation in microglia

Panicker, N., Sarkar, S., Harischandra, D. S., Neal, M. P., Kam, T., Jin, H., Saminathan, H., Langley, M. R., Charli, A., Samidurai, M., et al. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20182191 · Cited by 255 · see citing works

Inflammasome: Its role in traumatic brain and spinal cord injury

Mortezaee, K., Khanlarkhani, N., Beyer, C., & Zendedel, A. (2017) · Journal of Cellular Physiology · doi:10.1002/jcp.26287 · Cited by 254 · see citing works

Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders

Zengeler, K. E., & Lukens, J. R. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-020-00487-7 · Cited by 254 · see citing works

Neurosteroids as regulators of neuroinflammation

Yılmaz, C., Karali, K., Fodelianaki, G., Gravanis, A., Chavakis, T., Charalampopoulos, I., & Alexaki, V. I. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100788 · Cited by 245 · see citing works

Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway

Ye, Y., Jin, T., Zhang, X. D., Zeng, Z. R., Ye, B., Wang, J., Zhong, Y., Xiong, X., & Gu, L. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00553 · Cited by 239 · see citing works

CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling

Xu, S., Wang, J., Zhong, J., Shao, M., Jiang, J., Song, J., Zhu, W. P., Zhang, F., Xu, H., Xu, G., et al. (2020) · Clinical and Translational Medicine · doi:10.1002/ctm2.269 · Cited by 236 · see citing works

The role of NLRP3-CASP1 in inflammasome-mediated neuroinflammation and autophagy dysfunction in manganese-induced, hippocampal-dependent impairment of learning and memory ability

Wang, D., Zhang, J., Jiang, W., Cao, Z., Zhao, F., Cai, T., Aschner, M., & Luo, W. (2017) · Autophagy · doi:10.1080/15548627.2017.1293766 · Cited by 236 · see citing works

Rapid inflammasome activation in microglia contributes to brain disease in HIV/AIDS

Walsh, J. G., Reinke, S. N., Mamik, M. K., McKenzie, B., Maingat, F. G., Branton, W. G., Broadhurst, D., & Power, C. (2014) · Retrovirology · doi:10.1186/1742-4690-11-35 · Cited by 228 · see citing works

Targeting Microglial α-Synuclein/TLRs/NF-kappaB/NLRP3 Inflammasome Axis in Parkinson’s Disease

Li, Y., Xia, Y., Yin, S., Wan, F., Hu, J., Kou, L., Sun, Y., Wu, J., Zhou, Q., Huang, J., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.719807 · Cited by 230 · see citing works

Systemic activation of NLRP3 inflammasome and plasma α-synuclein levels are correlated with motor severity and progression in Parkinson’s disease

Fan, Z., Pan, Y.-T., Zhang, Z.-Y., Yang, H., Yu, S.-Y., Zheng, Y., Ma, J.-H., & Wang, X.-M. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1670-6 · Cited by 228 · see citing works

A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation

Voet, S., Mc Guire, C., Hagemeyer, N., Martens, A., Schroeder, A., Wieghofer, P., Daems, C., Staszewski, O., Vande Walle, L., Jordao, M. J. C., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04376-5 · Cited by 227 · see citing works

AIM2 inflammasome surveillance of DNA damage shapes neurodevelopment

Lammert, C. R., Frost, E. L., Bellinger, C. E., Bolte, A. C., McKee, C. A., Hurt, M. E., Paysour, M. J., Ennerfelt, H. E., & Lukens, J. R. (2020) · Nature · doi:10.1038/s41586-020-2174-3 · Cited by 223 · see citing works

Beclin1‐driven autophagy modulates the inflammatory response of microglia via NLRP3

Houtman, J., Freitag, K., Gimber, N., Schmoranzer, J., Heppner, F. L., & Jendrach, M. (2019) · The EMBO Journal · doi:10.15252/embj.201899430 · Cited by 212 · see citing works

Andrographolide suppresses NLRP3 inflammasome activation in microglia through induction of parkin-mediated mitophagy in in-vitro and in-vivo models of Parkinson disease

Ahmed, S., Kwatra, M., Panda, S. R., Murty, U. S. N., & Naidu, V. G. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.09.017 · Cited by 218 · see citing works

Alzheimer’s disease as an inflammatory disease

Bolós, M., Perea, J. R., & Avila, J. (2017) · BioMolecular Concepts · doi:10.1515/bmc-2016-0029 · Cited by 216 · see citing works

Danger Signals and Inflammasomes: Stress-Evoked Sterile Inflammation in Mood Disorders

Fleshner, M., Frank, M., & Maier, S. F. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.125 · Cited by 216 · see citing works

A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury

Kuwar, R., Rolfe, A., Di, L., Xu, H., Liu, H., Jiang, Y., Zhang, S., & Sun, D. (2019) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1471-y · Cited by 208 · see citing works

Pretreatment with kaempferol attenuates microglia-mediate neuroinflammation by inhibiting MAPKs–NF–κB signaling pathway and pyroptosis after secondary spinal cord injury

Liu, Z., Yao, X., Sun, B., Jiang, W., Liao, C., Dai, X., Chen, Y., Chen, J., & Ding, R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.03.037 · Cited by 194 · see citing works

Neuroinflammation and Parkinson’s Disease—From Neurodegeneration to Therapeutic Opportunities

Araújo, B., Caridade-Silva, R., Soares-Guedes, C., Martins‐Macedo, J., Gomes, E. D., Monteiro, S., & Teixeira, F. G. (2022) · Cells · doi:10.3390/cells11182908 · Cited by 198 · see citing works

NLRP1 inflammasome is activated in patients with medial temporal lobe epilepsy and contributes to neuronal pyroptosis in amygdala kindling-induced rat model

Tan, C., Zhang, J., Tan, M., Chen, H., Meng, D., Jiang, T., Meng, X.-F., Li, Y., Sun, Z., Li, M., et al. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0233-0 · Cited by 185 · see citing works

NLRP3 expression in mesencephalic neurons and characterization of a rare NLRP3 polymorphism associated with decreased risk of Parkinson’s disease

von Herrmann, K. M., Salas, L. A., Martinez, E. M., Young, A. L., Howard, J. M., Feldman, M. S., Christensen, B. C., Wilkins, O. M., Lee, S., Hickey, W. F., et al. (2018) · npj Parkinson s Disease · doi:10.1038/s41531-018-0061-5 · Cited by 185 · see citing works

Glucocorticoid-Driven NLRP3 Inflammasome Activation in Hippocampal Microglia Mediates Chronic Stress-Induced Depressive-Like Behaviors

Feng, X., Zhao, Y., Yang, T., Song, M., Wang, C., Yao, Y., & Fan, H. (2019) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2019.00210 · Cited by 185 · see citing works

Recent Advances of the NLRP3 Inflammasome in Central Nervous System Disorders

Zhou, K., Shi, L., Wang, Y., Chen, S., & Zhang, J. (2016) · Journal of Immunology Research · doi:10.1155/2016/9238290 · Cited by 175 · see citing works

Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

Santoni, G., Cardinali, C., Morelli, M. B., Santoni, M., Nabissi, M., & Amantini, C. (2015) · Journal of Neuroinflammation · doi:10.1186/s12974-015-0239-2 · Cited by 176 · see citing works

Baicalein Attenuates Neuroinflammation by Inhibiting NLRP3/Caspase-1/GSDMD Pathway in MPTP-Induced Mice Model of Parkinson’s Disease

Rui, W., Li, S., Xiao, H., Xiao, M., & Shi, J. (2020) · The International Journal of Neuropsychopharmacology · doi:10.1093/ijnp/pyaa060 · Cited by 175 · see citing works

Activation and Regulation of NLRP3 Inflammasome by Intrathecal Application of SDF-1a in a Spinal Cord Injury Model

Zendedel, A., Johann, S., Mehrabi, S., Joghataei, M. T., Hassanzadeh, G., Kipp, M., & Beyer, C. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9203-5 · Cited by 174 · see citing works

TLR4 promotes microglial pyroptosis via lncRNA-F630028O10Rik by activating PI3K/AKT pathway after spinal cord injury

Xu, S., Wang, J. Q., Jiang, J., Song, J., Zhu, W. P., Zhang, F., Shao, M., Xu, H., Ma, X., & Lyu, F. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02824-z · Cited by 171 · see citing works

NLRP3 Inflammasome: A Starring Role in Amyloid-β- and Tau-Driven Pathological Events in Alzheimer’s Disease

Zeller, M. V., Dias, D., Sebastião, A. M., & Valente, C. A. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210268 · Cited by 173 · see citing works

A brain in flame; do inflammasomes and pyroptosis influence stroke pathology?

Barrington, J., Lemarchand, E., & Allan, S. M. (2016) · Brain Pathology · doi:10.1111/bpa.12476 · Cited by 166 · see citing works

Dexmedetomidine inhibits astrocyte pyroptosis and subsequently protects the brain in in vitro and in vivo models of sepsis

Sun, Y., Zhao, H., Mu, D.-L., Zhang, W., Jiang, C., Wu, L., Alam, A., Wang, D., & Ma, D. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1416-5 · Cited by 168 · see citing works

Low-density lipoprotein receptor (LDLR) regulates NLRP3-mediated neuronal pyroptosis following cerebral ischemia/reperfusion injury

Sun, R., Peng, M., Xu, P., Huang, F., Xie, Y., Li, J., Hong, Y., Guo, H., Liu, Q., & Zhu, W. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01988-x · Cited by 166 · see citing works

Celastrol inhibits microglial pyroptosis and attenuates inflammatory reaction in acute spinal cord injury rats

Dai, W.-Y., Wang, X., Teng, H., Li, C., Wang, B., & Wang, J. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.11.029 · Cited by 159 · see citing works

Structure and assembly of the mouse ASC inflammasome by combined NMR spectroscopy and cryo-electron microscopy

Sborgi, L., Ravotti, F., Dandey, V., Dick, M. S., Mazur, A., Reckel, S., Chami, M., Scherer, S. A., Huber, M., Böckmann, A., et al. (2015) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1507579112 · Cited by 153 · see citing works

Inflammasomes, hormesis, and antioxidants in neuroinflammation: Role of NRLP3 in Alzheimer disease

Pennisi, M., Crupi, R., Di Paola, R., Ontario, M. L., Bella, R., Calabrese, E. J., Crea, R., Cuzzocrea, S., & Calabrese, V. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23986 · Cited by 157 · see citing works

The P2X7 Receptor Primes IL-1β and the NLRP3 Inflammasome in Astrocytes Exposed to Mechanical Strain

Albalawi, F., Lu, W., Beckel, J. M., Lim, J. C., McCaughey, S. A., & Mitchell, C. H. (2017) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2017.00227 · Cited by 155 · see citing works

Inflammasomes and human autoimmunity: A comprehensive review

Yang, C., & Chiang, B. (2015) · Journal of Autoimmunity · doi:10.1016/j.jaut.2015.05.001 · Cited by 155 · see citing works

Innate and adaptive immune responses in the CNS

Waisman, A., Liblau, R., & Becher, B. (2015) · The Lancet Neurology · doi:10.1016/s1474-4422(15)00141-6 · Cited by 151 · see citing works

Inhibiting neuroinflammation: The role and therapeutic potential of GABA in neuro-immune interactions

Crowley, T., Cryan, J. F., Downer, E. J., & O’Leary, O. F. (2016) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2016.02.001 · Cited by 150 · see citing works

Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances

Haapakoski, R., Ebmeier, K. P., Alenius, H., & Kivimäki, M. (2016) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.11.012 · Cited by 137 · see citing works

Lipocalin-2-mediated astrocyte pyroptosis promotes neuroinflammatory injury via NLRP3 inflammasome activation in cerebral ischemia/reperfusion injury

Li, J., Xu, P., Hong, Y., Xie, Y., Peng, M., Sun, R., Guo, H., Zhang, X., Zhu, W., Wang, J., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02819-5 · Cited by 152 · see citing works

Inflammation in Traumatic Brain Injury

Postolache, T. T., Wadhawan, A., Can, A., Lowry, C. A., Woodbury, M., Makkar, H., Hoisington, A. J., Scott, A. J., Potocki, E., Benros, M. E., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191150 · Cited by 150 · see citing works

Microglial inflammation and phagocytosis in Alzheimer's disease: Potential therapeutic targets

Nizami, S., Hall‐Roberts, H., Warrier, S., Cowley, S. A., & Di Daniel, E. (2019) · British Journal of Pharmacology · doi:10.1111/bph.14618 · Cited by 147 · see citing works

Stress induced microglial activation contributes to depression

Li, B., Yang, W., Ge, T., Wang, Y., & Cui, R. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106145 · Cited by 147 · see citing works

Diet in Parkinson’s Disease: Critical Role for the Microbiome

Jackson, A., Forsyth, C. B., Shaikh, M., Voigt, R. M., Engen, P. A., Ramirez, V., & Keshavarzian, A. (2019) · Frontiers in Neurology · doi:10.3389/fneur.2019.01245 · Cited by 145 · see citing works

Exploring New Inflammatory Biomarkers and Pathways during LPS-Induced M1 Polarization

Cunha, C., Gomes, C., Vaz, A. R., & Brites, D. (2016) · Mediators of Inflammation · doi:10.1155/2016/6986175 · Cited by 153 · see citing works

Neuroinflammatory responses in Alzheimer’s disease

Dansokho, C., & Heneka, M. T. (2017) · Journal of Neural Transmission · doi:10.1007/s00702-017-1831-7 · Cited by 143 · see citing works

The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling

Qiu, J., Wang, M., Zhang, J., Cai, Q., Lu, D., Li, Y., Dong, Y., Zhao, T., & Chen, D. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.09.024 · Cited by 143 · see citing works

New Insights on NLRP3 Inflammasome: Mechanisms of Activation, Inhibition, and Epigenetic Regulation

Kodi, T., Sankhe, R., Gopinathan, A., Nandakumar, K., & Kishore, A. (2024) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-024-10101-5 · Cited by 138 · see citing works

Inhibition of the P2X7–PANX1 complex suppresses spreading depolarization and neuroinflammation

Chen, S., Qin, T., Seidel, J. L., Zheng, Y. Z., Eikermann, M., Ferrari, M. D., van den Maagdenberg, A. M. J. M., Moskowitz, M. A., Ayata, C., & Eikermann‐Haerter, K. (2017) · Brain · doi:10.1093/brain/awx085 · Cited by 137 · see citing works

Structural Insights of Benzenesulfonamide Analogues as NLRP3 Inflammasome Inhibitors: Design, Synthesis, and Biological Characterization

Fulp, J., Liu, H., Toldo, S. A., Jiang, Y., Boice, A., Guo, C., Li, X., Rolfe, A., Sun, D., Abbate, A., et al. (2018) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.8b00733 · Cited by 137 · see citing works

Neuroinflammation in neurological disorders: pharmacotherapeutic targets from bench to bedside

Mishra, A., Bandopadhyay, R., Singh, P. K., Mishra, P. S., Sharma, N., & Khurana, N. (2021) · Metabolic Brain Disease · doi:10.1007/s11011-021-00806-4 · Cited by 132 · see citing works

Crosstalk Between the Oxidative Stress and Glia Cells After Stroke: From Mechanism to Therapies

Zhu, G., Wang, X., Chen, L., Lenahan, C., Fu, Z., Fang, Y., & Yu, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.852416 · Cited by 135 · see citing works

Inhibition of the NLRP3 inflammasome provides neuroprotection in rats following amygdala kindling-induced status epilepticus

Meng, X., Tan, L., Tan, M., Jiang, T., Tan, C., Li, M., Wang, H.-F., & Yu, J. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0212-5 · Cited by 131 · see citing works

Inflammasomes as therapeutic targets for A lzheimer's disease

White, C., Lawrence, C. B., Brough, D., & Rivers‐Auty, J. (2016) · Brain Pathology · doi:10.1111/bpa.12478 · Cited by 131 · see citing works

Inflammasome and α-synuclein in Parkinson's disease: A cross-sectional study

Chatterjee, K., Roy, A., Banerjee, R., Choudhury, S., Mondal, B., Halder, S., Basu, P., Shubham, S., Dey, S., & Kumar, H. (2019) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2019.577089 · Cited by 130 · see citing works

Activated protein C, protease activated receptor 1, and neuroprotection

Griffin, J. H., Zloković, B. V., & Mosnier, L. O. (2018) · Blood · doi:10.1182/blood-2018-02-769026 · Cited by 129 · see citing works

The Role of Neuronal NLRP1 Inflammasome in Alzheimer’s Disease: Bringing Neurons into the Neuroinflammation Game

Yap, J. K. Y., Pickard, B. S., Chan, E. W. L., & Gan, S. Y. (2019) · Molecular Neurobiology · doi:10.1007/s12035-019-1638-7 · Cited by 127 · see citing works

Age-related cerebral small vessel disease and inflammaging

Li, T., Huang, Y., Cai, W., Chen, X., Men, X., Lü, T., Wu, A., & Lu, Z. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-03137-x · Cited by 127 · see citing works

Inflammasomes and autoimmune and rheumatic diseases: A comprehensive review

Shin, J. I., Lee, K. H., Joo, Y. H., Lee, J. M., Jeon, J., Jung, H. J., Shin, M., Cho, S., Kim, T.-H., Park, S., et al. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.06.010 · Cited by 125 · see citing works

NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury

Chang, Y., Zhu, J., Wang, D., Li, H., He, Y., Liu, K., Wang, X., Peng, Y., Pan, S., & Huang, K. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01879-1 · Cited by 123 · see citing works

Poststroke Inflammasome Expression and Regulation in the Peri-Infarct Area by Gonadal Steroids after Transient Focal Ischemia in the Rat Brain

Lammerding, L., Slowik, A., Johann, S., Beyer, C., & Zendedel, A. (2015) · Neuroendocrinology · doi:10.1159/000439435 · Cited by 115 · see citing works

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β

Lynch, M. A. (2015) · Brain Research · doi:10.1016/j.brainres.2014.08.040 · Cited by 115 · see citing works

Estrogen Attenuates Local Inflammasome Expression and Activation after Spinal Cord Injury

Zendedel, A., Mönnink, F., Hassanzadeh, G., Zaminy, A., Ansar, M. M., Habib, P., Slowik, A., Kipp, M., & Beyer, C. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0400-2 · Cited by 119 · see citing works

NADPH Oxidase 2 Regulates NLRP3 Inflammasome Activation in the Brain after Traumatic Brain Injury

Ma, M. W., Wang, J., Dhandapani, K. M., & Brann, D. W. (2017) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2017/6057609 · Cited by 116 · see citing works

Modulation of microglia polarization dynamics during diabetic retinopathy in db / db mice

Arroba, A. I., Alcalde‐Estévez, E., García‐Ramírez, M., Cazzoni, D., de la Villa, P., Sánchez‐Fernández, E. M., Mellet, C. O., Fernández, J. M. G., Hernández, C., Simó, R., et al. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2016.05.024 · Cited by 114 · see citing works

High resolution dissection of reactive glial nets in Alzheimer’s disease

Bouvier, D. S., Jones, E. V., Quesseveur, G., Davoli, M. A., A. Ferreira, T., Quirion, R., Mechawar, N., & Murai, K. K. (2016) · Scientific Reports · doi:10.1038/srep24544 · Cited by 111 · see citing works

Microglial CMPK2 promotes neuroinflammation and brain injury after ischemic stroke

Guan, X., Zhu, S., Song, J.-Q., Liu, K., Liu, M., Xie, L., Wang, Y., Wu, J. S., Xu, X., & Pang, T. (2024) · Cell Reports Medicine · doi:10.1016/j.xcrm.2024.101522 · Cited by 111 · see citing works

Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts

Mamik, M. K., & Power, C. (2017) · Brain : a journal of neurology · doi:10.1093/brain/awx133 · Cited by 151 · see citing works

Targeting Inflammasomes to Treat Neurological Diseases

Lünemann, J. D., Malhotra, S., Shinohara, M. L., Montalbán, X., & Comabella, M. (2021) · Annals of Neurology · doi:10.1002/ana.26158 · Cited by 73 · see citing works

Immune Sensors and Effectors of Health and Disease

Mamik, M. K., & Power, C. (2016) · Springer eBooks · doi:10.1007/978-3-319-44022-4_8 · Cited by 2 · see citing works

Activation and Regulation of Cellular Inflammasomes: Gaps in Our Knowledge for Central Nervous System Injury

Vaccari, J. P. D. R., Dietrich, W. D., & Keane, R. W. (2014) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.227 · Cited by 315 · see citing works

A role of inflammasomes in the pathogenesis of neurological and mental diseases

Пирожков, С. В., Terebilina, N. N., & Litvitskiy, P. F. (2018) · S S Korsakov Journal of Neurology and Psychiatry · doi:10.17116/jnevro201811812181 · Cited by 6 · see citing works