Cited by 102Alzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsAnesthesia and Neurotoxicity Research

Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells

Ojala, Johanna O., Sutinen, Elina M., Salminen, Antero, Pirttilä, Tuula·2008·Journal of Neuroimmunology

Abstract

Inflammatory cytokines, produced mainly by activated microglia in the brain, can enhance neuronal degeneration and the amyloid-beta-plaque production involved in Alzheimer's disease (AD). We previously demonstrated that the expression of the pro-inflammatory cytokine interleukin-18 (IL-18) colocalizes with plaques and hyperphoshorylated tau containing neurons in AD patients. Here we exposed neuron-like, differentiated SH-SY5Y neuroblastomas to IL-18 and observed that the protein levels of p35, Cdk5, GSK-3beta, and Ser15-phosphorylated p53 increased during 6 h-24 h. Tau phosphorylation and expression of cyclin G1, involved in neuronal regeneration, increased at 72 h. In vivo, over-expression of IL-18 may induce hyperphosphorylation of tau and induce cell cycle activators.

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Crossref · 10.1016/j.jneuroim.2008.09.012

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  • IL-18 may impact hyperphosphorylation of tau via cdk5/p35 and GSK-3β kinases.

    “Another study also found that IL-18 may impact hyperphosphorylation of tau via cdk5/p35 and GSK-3β kinases [168].”

    From Glial contributions to neurodegeneration in tauopathies (2017) · cites this paper as [168]

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Authors
Ojala, J. O., Sutinen, E. M., Salminen, A., & Pirttilä, T.
Affiliations
University of Eastern Finland (FI)
Corresponding author
Ojala, Johanna O.
Venue
Journal of Neuroimmunology
Publisher
Elsevier BV
Published
2008-12
Volume
205
Issue
1-2
Pages
86-93
ISSN
0165-5728 (ISSN-L)
OpenAlex
W1991780813
Cited by
102
References
71
Citations by year
2026: 5 · 2025: 8 · 2024: 7 · 2023: 12 · 2022: 4 · 2021: 7 · 2020: 13 · 2019: 5 · 2018: 6 · 2017: 4 · 2016: 9 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 2
FWCI
2.04
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Neuroimmunology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Anesthesia and Neurotoxicity Research
Keywords
IL-18, tau phosphorylation, SH-SY5Y cells, Alzheimer's disease, inflammatory cytokines, microglia, cyclin-dependent kinase 5, GSK3β, p53 Ser15 phosphorylation, cyclin G1, tau hyperphosphorylation, neuroinflammation
MeSH terms
Humans, L-Lactate Dehydrogenase, Molecular Weight, Neuroblastoma, Phosphorylation, Phosphotransferases, Serine, Time Factors, Gene Expression, tau Proteins, Interleukin-18, Cell Line, Tumor

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