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Cited by 181Hydrogels: synthesis, properties, applicationsbiodegradable polymer synthesis and propertiesWound Healing and Treatments

The DOI matches its Crossref record; 45 of the 45 references it cites were found in a registry or an index.

In vivo biocompatibility studies. I. The cage implant system and a biodegradable hydrogel

Marchant, Roger, Hiltner, Anne, Hamlin, Clive, Rabinovitch, Albert, Slobodkin, Rimma, Anderson, James M.·1983·Journal of Biomedical Materials Research
DOI 10.1002/jbm.820170209
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Abstract

A cage implant system has been utilized to examine the in vivo biocompatibility of a biodegradable hydrogel, poly(2‐hydroxy‐ethyl‐L‐glutamine) (PHEG). This system permits the quantitative determination of the components of the inflammatory exudate which surrounds the implanted polymer within the cage system. This system permits the serial examination of exudate components without sacrificing the animal. In addition, this system allows the subsequent removal of the polymer for surface and mechanical studies. Following implantation of the biodegradable hydrogel, quantitative and differential white cell counts of the exudates were determined over a 21‐day period. In addition, concomitant extracellular enzyme analyses for alkaline phosphatase, acid phosphatase, prostatic acid phosphatase, leucine aminopeptidase, and Cathepsin B1 were determined. Corresponding control samples from exudates of the cage implant without the polymer were also determined. The two‐tailed Student's t‐test for unpaired samples was used to statistically compare the control and implanted polymer values for these respective analyses at the various time periods. A comparison of the cellular response for the control system and the PHEG system did not show statistically significant differences during the first 7 days following implantation. The acute inflammatory response, polymorphonuclear leukocyte predominant, was followed by a mild chronic inflammatory response, macrophage and lymphocyte predominant, and during this time period, 8–14 days, macrophages were present in significantly larger numbers for the PHEG system when compared to the control values. Enzymic analysis of the exudates revealed statistically significant differences between control and PHEG values at time intervals where no differences were noted in cell density or population. These results are discussed in terms of cell‐polymer interactions leading to cellular activation and enhanced enzyme exocytosis by the inflammatory cells. Stress‐strain measurements on implanted PHEG samples showed that significant in vivo degradation had occurred during the acute inflammatory phase of the response, i.e., the first 7 days.

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Crossref · 10.1002/jbm.820170209

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Citations

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Research works printed but not linked: 10

  1. Salthouse T. N., 1981, Fundame Aspects of Biocompatibility, 233
  2. Salthouse T. N., 1976, Quantitative Enzyme Histochemistry in the Evaluation of Tissue Compatibility of Polymers for Surgical Implantation, Ann. Histochim., 21, 105
  3. Ritzmann S. E., 1975, Serum Proteinormalities, 4
  4. Ritzmann S. E., Serum Protein Abnormalities, 5
  5. Wilhelm D. L., 1977, Pathology, 25
  6. Taussig M. J., 1979, Processes in Pathology
  7. Chuang H. Y. K., 1981, Devices and Techgy Branch Contractors Meeting Program, 112
  8. Herzlinger G., 1980, Devices and Technology Branch Contractors Meeting Proceedings, 215
  9. Fehr J., 1975, Complement (C') Mediated Granulocyte (PMN) and Pulmonary Dysfunction During Nylon Fiber Leukapheresis, Clin. Res., 23, 522A
  10. Henson P. M., 1980, Mechanisms of Exocytosis in Phagocytic Inflammatory Cells, Am. J. Pathol., 101, 494

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Metadata

Authors
Marchant, R., Hiltner, A., Hamlin, C., Rabinovitch, A., Slobodkin, R., & Anderson, J. M.
Affiliations
Case Western Reserve University (US)
Corresponding author
Anderson, James M.
ORCID
Anderson, James M.
Venue
Journal of Biomedical Materials Research
Publisher
Wiley
Published
1983-03
Volume
17
Issue
2
Pages
301-325
ISSN
  • 0021-9304 (ISSN-L)
  • 1097-4636
DOI
10.1002/jbm.820170209
OpenAlex
W2128920830
Cited by
181
References
45
Citations by year
2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 2
FWCI
4.41
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 7867 d)
Locations
  • Journal of Biomedical Materials Research (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Health Sciences › Medicine › Surgery › Wound Healing and Treatments
Keywords
biocompatibility, biodegradable hydrogels, inflammatory exudate, white blood cell count, macrophages, extracellular enzymes, alkaline phosphatase, acid phosphatase, prostatic acid phosphatase, leucine aminopeptidase, cathepsin B, in vivo degradation, stress-strain, cell-polymer interactions, chronic inflammation
MeSH terms
Acid Phosphatase, Alkaline Phosphatase, Animals, Biocompatible Materials, Biodegradation, Environmental, Blood Cell Count, Cell Adhesion, Chemotaxis, Extracellular Space, Exudates and Transudates, Inflammation, Neutrophils, Peptides, Proteins, Stainless Steel, Prostheses and Implants, Rats

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