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In vivo biocompatibility studies. I. The cage implant system and a biodegradable hydrogel
Abstract
A cage implant system has been utilized to examine the in vivo biocompatibility of a biodegradable hydrogel, poly(2‐hydroxy‐ethyl‐L‐glutamine) (PHEG). This system permits the quantitative determination of the components of the inflammatory exudate which surrounds the implanted polymer within the cage system. This system permits the serial examination of exudate components without sacrificing the animal. In addition, this system allows the subsequent removal of the polymer for surface and mechanical studies. Following implantation of the biodegradable hydrogel, quantitative and differential white cell counts of the exudates were determined over a 21‐day period. In addition, concomitant extracellular enzyme analyses for alkaline phosphatase, acid phosphatase, prostatic acid phosphatase, leucine aminopeptidase, and Cathepsin B1 were determined. Corresponding control samples from exudates of the cage implant without the polymer were also determined. The two‐tailed Student's t‐test for unpaired samples was used to statistically compare the control and implanted polymer values for these respective analyses at the various time periods. A comparison of the cellular response for the control system and the PHEG system did not show statistically significant differences during the first 7 days following implantation. The acute inflammatory response, polymorphonuclear leukocyte predominant, was followed by a mild chronic inflammatory response, macrophage and lymphocyte predominant, and during this time period, 8–14 days, macrophages were present in significantly larger numbers for the PHEG system when compared to the control values. Enzymic analysis of the exudates revealed statistically significant differences between control and PHEG values at time intervals where no differences were noted in cell density or population. These results are discussed in terms of cell‐polymer interactions leading to cellular activation and enhanced enzyme exocytosis by the inflammatory cells. Stress‐strain measurements on implanted PHEG samples showed that significant in vivo degradation had occurred during the acute inflammatory phase of the response, i.e., the first 7 days.
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“the cage implant allows for the examination of the inflammatory response to a substrate of interest over time.113”
From Biocompatible Materials for Continuous Glucose Monitoring Devices (2013) · cites this paper as [113]
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Huang, B., Marois, Y., Roy, R., Julien, M., & Guidoin, R. (1992) · Biomaterials · doi:10.1016/0142-9612(92)90186-r · Cited by 34
Biocompatibility and Bioresponse to Biomaterials
Anderson, J. M. (2019) · Principles of Regenerative Medicine · doi:10.1016/b978-0-12-809880-6.00039-4 · Cited by 33
Self-citationSandor, M., Harris, J., & Mathiowitz, E. (2002) · Biomaterials · doi:10.1016/s0142-9612(02)00183-7 · Cited by 31
In vivo leucocyte interactions on Pellethane® surfaces
Brunstedt, M. R., Anderson, J. M., Spilizewski, K. L., Marchant, R. E., & Hiltner, A. (1990) · Biomaterials · doi:10.1016/0142-9612(90)90089-9 · Cited by 32
Self-citationHazer, D. B., & Hazer, B. (2010) · Journal of Polymer Research · doi:10.1007/s10965-010-9413-5 · Cited by 32
The biocompatibility of solution cast and acetone‐extracted cast biomer
Marchant, R. E., Anderson, J., Hiltner, A., Castillo, E. J., Gleit, J., & Ratner, B. D. (1986) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820200611 · Cited by 30
Self-citationDoty, A. C., Hirota, K., Olsen, K. F., Sakamoto, N., Ackermann, R., Feng, M. R., Wang, Y., Choi, S. H., Qu, W., Schwendeman, A. A., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.07.041 · Cited by 30
A new biological glue from gelatin and poly (L-glutamic acid)
Otani, Y., Tabata, Y., & Ikada, Y. (1996) · Journal of Biomedical Materials Research · doi:10.1002/(sici)1097-4636(199606)31:2 · Cited by 118
Metadata
- Authors
- Marchant, R., Hiltner, A., Hamlin, C., Rabinovitch, A., Slobodkin, R., & Anderson, J. M.
- Affiliations
- Case Western Reserve University (US)
- Corresponding author
- Anderson, James M.
- ORCID
- Anderson, James M.
- Venue
- Journal of Biomedical Materials Research
- Publisher
- Wiley
- Published
- 1983-03
- Volume
- 17
- Issue
- 2
- Pages
- 301-325
- ISSN
- 0021-9304 (ISSN-L)
- 1097-4636
- OpenAlex
- W2128920830
- Cited by
- 181
- References
- 45
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2022: 1 · 2021: 3 · 2020: 4 · 2018: 2 · 2017: 1 · 2016: 7 · 2015: 1 · 2014: 4 · 2013: 2 · 2012: 2
- FWCI
- 4.41
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Biomedical Materials Research (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Health Sciences › Medicine › Surgery › Wound Healing and Treatments
- Keywords
- biocompatibility, biodegradable hydrogels, inflammatory exudate, white blood cell count, macrophages, extracellular enzymes, alkaline phosphatase, acid phosphatase, prostatic acid phosphatase, leucine aminopeptidase, cathepsin B, in vivo degradation, stress-strain, cell-polymer interactions, chronic inflammation
- MeSH terms
- Acid Phosphatase, Alkaline Phosphatase, Animals, Biocompatible Materials, Biodegradation, Environmental, Blood Cell Count, Cell Adhesion, Chemotaxis, Extracellular Space, Exudates and Transudates, Inflammation, Neutrophils, Peptides, Proteins, Stainless Steel, Prostheses and Implants, Rats
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