Biodegradable electrospun poly(L‐lactide‐co‐ε‐caprolactone)/polyethylene glycol/ bioactive glass composite scaffold for bone tissue engineering
Open accessAbstract
The field of tissue engineering has witnessed significant advancements in recent years, driven by the pursuit of innovative solutions to address the challenges of bone regeneration. In this study, we developed an electrospun composite scaffold for bone tissue engineering. The composite scaffold is made of a blend of poly(L‐lactide‐co‐ε‐caprolactone) (PLCL) and polyethylene glycol (PEG), with the incorporation of calcined and lyophilized silicate‐chlorinated bioactive glass (BG) particles. Our investigation involved a comprehensive characterization of the scaffold's physical, chemical, and mechanical properties, alongside an evaluation of its biological efficacy employing alveolar bone‐derived mesenchymal stem cells. The incorporation of PEG and BG resulted in elevated swelling ratios, consequently enhancing hydrophilicity. Thermal gravimetric analysis confirmed the efficient incorporation of BG, with the scaffolds demonstrating thermal stability up to 250°C. Mechanical testing revealed enhanced tensile strength and Young's modulus in the presence of BG; however, the elongation at break decreased. Cell viability assays demonstrated improved cytocompatibility, especially in the PLCL/PEG+BG group. Alizarin red staining indicated enhanced osteoinductive potential, and fluorescence analysis confirmed increased cell adhesion in the PLCL/PEG+BG group. Our findings suggest that the PLCL/PEG/BG composite scaffold holds promise as an advanced biomaterial for bone tissue engineering.
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Composite scaffold based on PEG and PLCL doped with bioactive glass has significantly enhanced tensile strength and Young's modulus, and its surface promotes cell adhesion and mineralization, conducive to repair of bone defects.
“The results showed that the tensile strength and Young’s modulus of the composite scaffold doped with BG were significantly enhanced. The results of cell experiments showed that the composite scaffold surface can promote cell adhesion and mineralization, which is conducive to the repair of bone defects [207].”
From Application of PLCL as a biodegradable polymer in biomedical engineering (2026) · cites this paper as [207]
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- [41]Kukulka EC, de Souza JR, de Araújo JCR, de Vasconcellos LMR, Campos TMB, Thim GP, Borges ALS. Polycaprolactone/chlorinated bioglass scaffolds doped with Mg and Li ions: Morphological, physicochemical, and biological analysis. J Biomed Mater Res B Appl Biomater. John Wiley and Sons Inc; 2023; 111: 140– 50. 35852036
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- Authors
- de Souza, J. R., Cardoso, L. M., de Toledo, P. T. A., Rahimnejad, M., Kito, L. T., Thim, G. P., Campos, T. M. B., Borges, A. L. S., & Bottino, M. C.
- Affiliations
- Department of Cariology, Restorative Sciences and Endodontics University of Michigan School of Dentistry Ann Arbor Michigan USA
- Universidade Estadual Paulista (Unesp) (BR)
- Department of Preventive and Restorative Dentistry School of Dentistry, São Paulo State University (UNESP) Araçatuba SP Brazil
- University of Michigan (US)
- Instituto Tecnológico de Aeronáutica (BR)
- Universidade de São Paulo (BR)
- Corresponding author
- Bottino, Marco C.
- ORCID
- Venue
- Journal of Biomedical Materials Research Part B: Applied Biomaterials
- Publisher
- Wiley
- Published
- 2024-04-27
- Volume
- 112
- Issue
- 5
- Pages
- e35406-e35406
- ISSN
- 1552-4973 (ISSN-L)
- 1552-4981
- PMC
- PMC11288622
- OpenAlex
- W4395688460
- Cited by
- 30
- References
- 51
- Citations by year
- 2026: 13 · 2025: 14 · 2024: 3
- FWCI
- 3.29
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Journal of Biomedical Materials Research Part B Applied Biomaterials (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (publishedVersion, other-oa)
- PubMed Central (acceptedVersion)
- Deep Blue (University of Michigan) (submittedVersion)
- LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (88887)
- National Institutes of Health
- National Institute of Dental and Craniofacial Research (R01DE031476)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
- Keywords
- bone tissue engineering, electrospun scaffolds, poly(L-lactide-co-ε-caprolactone), polyethylene glycol, bioactive glass, composite scaffolds, mesenchymal stem cells, osteoinduction, cytocompatibility, mechanical properties, swelling ratio, hydrophilicity, biodegradable biomaterials
- MeSH terms
- Glass, Humans, Materials Testing, Polyesters, Polyethylene Glycols, Tissue Engineering, Tissue Scaffolds, Mesenchymal Stem Cells
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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